5-HT1A/7 receptor agonist excites cardiac vagal neurons via inhibition of both GABAergic and glycinergic inputs

Acta Pharmacologica Sinica

Volumn 29, Issue 5, 2008, Pages 529-538

  Chen, Yong Hua ^a   Hou, Li Li ^a   Wang, Ji Jiang ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

5 hydroxytryptamine; 8 hydroxy 2 (di N propylamino) tetralin; Cardiac vagal preganglionic neurons; Spontaneous inhibitory postsynaptic currents

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 4 AMINOBUTYRIC ACID; GLYCINE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN 7 RECEPTOR; SEROTONIN 7 RECEPTOR AGONIST; TETRODOTOXIN; SEROTONIN AGONIST;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; GABAERGIC SYSTEM; HEART INNERVATION; INHIBITORY POSTSYNAPTIC POTENTIAL; NERVE CELL STIMULATION; NEUROTRANSMITTER RELEASE; NONHUMAN; PREGANGLIONIC NERVE CELL; RAT; REFLEX ARC; SEROTONINERGIC SYSTEM; SOLITARY TRACT NUCLEUS; SYNAPSE; VAGUS NERVE; ANIMAL; DOSE RESPONSE; DRUG POTENTIATION; ELECTROPHYSIOLOGY; HEART; INNERVATION; NERVE CELL; NEWBORN; PATCH CLAMP; PHYSIOLOGY; SPRAGUE DAWLEY RAT; SYNAPTIC TRANSMISSION;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; ANIMALS, NEWBORN; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; GAMMA-AMINOBUTYRIC ACID; GLYCINE; HEART; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN AGONISTS; SYNAPTIC TRANSMISSION; VAGUS NERVE;

EID: 42649088420     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2008.00745.x     Document Type: Article

References (36)

1. Loewy AD, Spyer KM. Central regulation of autonomic function. NY: Oxford University Press 1990.
2. Mendelowitz D. Advances in parasympathetic control of heart rate and cardiac function. News Physiol Sci 1999 14: 155 61.
3. Nosaka S, Yasunaga K, Tamai S. Vagal cardiac preganglionic neurons: distribution, cell types, and reflex discharges. Am J Physiol 1982 243: R92 8.
4. Stuesse SL. Origins of cardiac vagal preganglionic fibers: a retrograde transport study. Brain Res 1982 236: 15 25.
5. Standish A, Enquist LW, Escardo JA, Schwaber JS. Central neuronal circuit innervating the rat heart defined by transneuronal transport of pseudorabies virus. J Neurosci 1995 15: 1998 2012.
6. Mendelowitz D. Firing properties of identified parasympathetic cardiac neurons in nucleus ambiguus. Am J Physiol 1996 271: H2609 14.
7. Steinbusch HWM. Distribution of serotonin immunoreactivity in the central nervous system of the rat - cell bodies and terminals. Neuroscience 1981 6: 557 618.
8. Sykes RM, Spyer KM, Izzo PN. Central distribution of substance P, calcitonin gene-related peptide, 5-hydroxytryptamine in vagal sensory afferents in the rat dorsal medulla. Neuroscience 1994 59: 195 210.
9. Izzo PN, Jordan D, Ramage AG. Anatomical and pharmacological evidence supporting the involvement of serotonin in the central control of cardiac vagal motoneurones in the anaesthetized cat. J Physiol (London) 1988 406: 19.
10. Izzo PN, Deuchars J, Spyer KM. Localization of cardiac vagal preganglionic motoneurones in the rat: Immunocytochemical evidence of synaptic inputs containing 5-hydroxytryptamine. J Comp Neurol 1993 327: 572 83.
11. 1A binding sites in the brainstem of the cat. Br J Pharmacol 1988 94: 386.
12. Pazos A, Palacios JM. Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Res 1985 346: 205 30.
13. Thor KB, Blitz-siebert A, Helke CJ. Autoradiographic localization of 5HT1 binding sites in autonomic areas of the rat dorsomedial medulla oblongata. Synapse 1992 10: 217 27.
14. Pazos A, Probst A, Palacios JM. Serotonin receptors in the human brain. III. Autoradiographic mapping of serotonin-1 receptors. Neuroscience 1987 21: 97 122.
15. 1A receptor agonists, 8-OH-DPAT, ipsapirone, have a central hypotensive action that differs from that of clonidine in anaesthetised cats. Eur J Pharmacol 1987 138: 179 91.
16. 1A receptor agonists. J Pharmacol Exp Ther 1994 271: 777 81.
17. McCall RB, Escandon NA, Harris LT, Clement ME, Shepheard SL, Jordan D et al. Comparison of the effects of IVth ventricular administration of some tryptamine analogues with those of 8-OH-DPAT on autonomic outflow in the anaesthetized cat. Br J Pharmacol 1994 111: 616 24.
18. Shepheard SL, Jordan D, Ramage AG. Comparison of the effects of IVth ventricular administration of some tryptamine analogues with those of 8-OH-DPAT on autonomic outflow in the anaesthetized cat. Br J Pharmacol 1994 111: 616 24.
19. 1A agonists into the dorsal motor vagal nucleus produce a bradycardia in the atenolol-pretreated anaesthetized rat. Br J Pharmacol 1991 104: 467 70.
20. Chitravanshi VC, Calaresu FR. Additive effects of dopamine and 8-OH-DPAT microinjected into the nucleus ambiguus in eliciting vagal bradycardia in rats. J Auto Nerv Syst 1992 41: 121 8.
21. Wang Y, Ramage AG. The role of central 5-HT (1A) receptors in the control of B-fibre cardiac and bronchoconstrictor vagal preganglionic neurones in anaesthetized cats. J Physiol (London) 2001 536: 753 67.
22. 1A receptors play a role in the von Bezold-Jarisch reflex in the rat. Br J Pharmacol 1990 100: 757 60.
23. 1A receptors on baroreceptor and cardiopulmonary receptor reflexes in anaesthetized rabbits. J Physiol (London) 1998 513P: 85.
24. Dando SB, Skinner MR, Jordan D, Ramage AG. Modulation of the vagal bradycardia evoked by stimulation of upper airway receptors by central 5-HT1 receptors in anaesthetized rabbits. Br J Pharmacol 1998 125: 409 17.
25. Colino A, Halliwell JV. Differential modulation of three separate K-conductances in hippocampal CA1 neurons by serotonin. Nature 1987 328: 73 7.
26. Melena J, Chidlow G, Osborne NN. Blockade of voltage-sensitive Na(+) channels by the 5-HT(1A) receptor agonist 8-OH-DPAT: possible significance for neuroprotection. Eur J Pharmacol 2000 406: 319 24.
27. Wang J, Wang X, Irnaten M, Venkatesan P, Evans C, Baxi S, et al. Endogenous acetylcholine and nicotine activation enhances GABAergic and glycinergic inputs to cardiac vagal neurons. J Neurophysiol 2003 89: 2473 81.
28. Wang J, Irnaten M, Mendelowitz D. Characteristics of spontaneous and evoked GABAergic synaptic currents in cardiac vagal neurons in rats. Brain Res 2001 889: 78 83.
29. Wang X, Dergacheva O, Kamendi H, Gorini C, Mendelowitz D. 5-Hydroxytryptamine 1A/7 and 4α receptors differentially prevent opioid-induced inhibition of brain stem cardiorespiratory function. Hypertension 2007 doi:10.1161/HYPERTENSIONAHA.107.091009.
30. Gatti PJ, Johnson TA, Phan P, Jordan IK, Coleman W, Massari VJ. The physiological and anatomical demonstration of functionally selective parasympathetic ganglia located in discrete fat pads on the feline myocardium. J Auton Nerv Syst 1995 51: 255 99.
31. Grkovic I, Fernandez K, McAllen RM, Anderson CR. Misidentification of cardiac vagal pre-ganglionic neurons after injections of retrograde tracer into the pericardial space in the rat. Cell Tissue Res 2005 321: 335 40.
32. Irnaten M, Neff RA, Wang J, Loewy AD, Mettenleiter TC, Mendelowitz D. Activity of cardiorespiratory networks revealed by transsynaptic virus expressing GFP. J Neurophysiol 2001 85: 435 8.
33. Neff RA, Wang J, Baxi S, Evans C, Mendelowitz D. Respiratory sinus arrhythmia: endogenous activation of nicotinic receptors mediates respiratory modulation of brainstem cardioinhibitory parasympathetic neurons. Circ Res 2003 93: 565 72.
34. Bobker DH, Williams JT. Serotonin-mediated inhibitory postsynaptic potential in guinea-pig prepositus hypoglossi and feedback inhibition by serotonin. J Physiol 1990 422: 447 62.
35. Wang J, Chen Y, Li K, Hou L. Blockade of inhibitory neurotransmission evoked seizure-like firing of cardiac parasympathetic neurons in brainstem slices of newborn rats: implications for sudden deaths in patients of epilepsy. Epilepsy Res 2006 70: 172 83.
36. Browning KN, Travagli RA. Characterization of the in vitro effects of 5-hydroxytryptamine (5-HT) on identified neurons of the rat dorsal motor nucleus of the vagus (DMV). Br J Pharmacol 1999 128: 1307 15.