Changes and distributions of peptides derived from proadrenomedullin in left-to-right shunt pulmonary hypertension of rats

Circulation Journal

Volumn 72, Issue 3, 2008, Pages 476-481

  Cuifen, Zhao ^a,c   Lijuan, Wang ^a   Li, Gao ^a   Wei, Xia ^a   Zhiyu, Wang ^b   Fuhai, Li ^a  

^a SHANDONG UNIVERSITY   (China)

^b Medical and Biological Technique Centre of Shandong Province   (China)

^c SHANDONG UNIVERSITY   (China)

Author keywords

Intramolecular regulation; Left to right shunt; Peptides; Proadrenomedullin; Pulmonary hypertension

Indexed keywords

ADRENOMEDULLIN; ADRENOTENSIN; MESSENGER RNA; PEPTIDE; PROADRENOMEDULLIN;

ADVENTITIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CUFF; HEART CATHETERIZATION; HEART LEFT RIGHT SHUNT; HEART LEFT VENTRICLE; HEART RIGHT VENTRICLE; HEART VENTRICLE SEPTUM; HEART VENTRICLE WALL; HEART WEIGHT; IMMUNOHISTOCHEMISTRY; LUNG ARTERY; LUNG ARTERY PRESSURE; LUNG BLOOD FLOW; MALE; MESSENGER RNA SYNTHESIS; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PULMONARY HYPERTENSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; SYSTOLIC BLOOD PRESSURE; WISTAR RAT;

ADRENOMEDULLIN; ANIMALS; ARTERIOVENOUS SHUNT, SURGICAL; CAROTID ARTERIES; DISEASE MODELS, ANIMAL; HYPERTENSION, PULMONARY; JUGULAR VEINS; LUNG; MALE; PEPTIDE FRAGMENTS; PROTEIN PRECURSORS; RATS; RATS, WISTAR; RNA, MESSENGER;

EID: 42649085057     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.72.476     Document Type: Article

References (26)

1. Sakata J, Shimokubo T, Kitamura K, Nakamura S, Kangawa K, Matsuo H, et al. Molecular cloning and biological activities of rat adrenomedullin, a hypotensive peptide. Biochem Biophys Res Commun 1993; 195: 921-927.
2. Hinson JP, Kapas S, Smith DM. Adrenomedullin, a multifunctional regulatory peptide. Endocr Rev 2000; 21: 138-167.
3. Zhao CF, Chang P, Xia W, Wang YW. Development of cervical left to right shunt pulmonary hypertension model by using cuff technique in rats. J Shandong Uni (Health Sci) 2004; 42: 661-664 (in Chinese).
4. He RX, Gu CL, Shex F, Zhang XM. Changes in expression of adrenomedullin in the myocardium of streptozotocin-induced diabetic rats. Chin Med J 2007; 120: 187-191.
5. Cameron VA, Autelitano DJ, Evans JJ, Elmors LJ, Espner EA, Nicholls MG, et al. Adrenomedullin expression in tat uterus is correlated with plasma estradiol. Am J Physiol Endocrinol Metab 2002; 282: E139-E146.
6. Martinez A, Miller MJ, Unsworth EJ, Siegfried JM, Cuttitta F. Expression of adrenomedullin in normal human lung and in pulmonary tumors. Endocrinology 1995; 136: 4099-4105.
7. Eguchi S, Hirata Y, Kano H, Sato K, Watanabe Y, Sato K, et al. Specific receptors for adrenomedullin in cultured rat vascular smooth muscle cells. FEBS Lett 1994; 340: 226-230.
8. Sakata J, Shimokubo T, Kitamura K, Nishizono M, Iehiki Y, Kangawa K, et al. Distribution and characterization of immunoreactive adrenomedullin in rat tissue and plasma. FEBS Lett 1994; 352: 105-108.
9. Sugo S, Minamino N, Shoji H, Kangawa K, Kitamura K, Eto T, et al. Production and secretion of adrenomedullin from vascular smooth muscle cells: Augmented production by tumor necrosis factor-alpha. Biochem Biophys Res Commun 1994; 203: 719-726.
10. Bean AJ, Zhang X, Hoekfelt T. Peptide secretion: What do we know? FASEB J 1994; 8: 630-638.
11. Murakami S, Kimura H, Kangawa K, Nagaya N. Physiological significance and therapeutic potential of adrenomedullin in pulmonary hypertension. Cardiovasc Hematol Disord Drug Targets 2006; 6: 125-132.
12. Naik JS, Walker BR. Heme oxygenase-mediated vasodilation involves vascular smooth muscle cell hyperpolarization. Am J Physiol Heart Circ Physiol 2003; 285: H220-H228.
13. Gumusel B, Chang JK, Hao Q, Lippton H. Adrenotensin: An adrenomedullin gene product contracts pulmonary blood vessels. Peptides 1996; 17: 461-465.
14. Champion HC, Czapla MA, Friedman DE, Lambert DG, Murphy WA, Coy DH, et al. Tone-dependent vasodilator responses to proadrenomedullin NH2-terminal 20 peptide in the hindquarters vascular bed of the rat. Peptides 1997; 18: 513-519.
15. 2-terminal 20 peptide has direct vasodilator activity in the cat. Am J Physiol 1997; 272: R1047-R1054.
16. Eto T, Kato J, Kitamura K. Regultation of production and secretion of adrenomedullin in the cardiovascular system. Regul Pept 2003; 112: 61-69.
17. Martinez A, Hodge DL, Garayoa M, Young HA, Cuttitta F. Alternative splicing of the proadrenomedullin gene results in differential expression of gene products. J Mol Endocrinol 2001; 27: 31-41.
18. Kamohara M, Matsuo A, Takasaki J, Kohda M, Matsumoto M, Matsumoto S, et al. Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. Biochem Biophys Res Commun 2005; 330: 1146-1152.
19. Qi YF, Dong LW, Pan CS, Zhanfg J, Geng B, Zhao J, et al. Adrenomedullin induces heme oxygenase-1 gene expression and cGMP formation in rat vascular smooth muscle cells. Peptides 2005; 26: 1257-1263.
20. Qi YF, Bu DF, Shi YR, Li JX, Pang YZ, Tang CS. Levels of adrenomedulin and proadrenomedullin N-terminal 20 peptide in myocardium and aorta of spontaneously hypertensive rats and Wistar-Kyoto rats. Sheng Li Xue Bao (Acta Physiol Sin) 2003; 55: 260-264.
21. Qi YF, Bu DF, Niu DD, Shi YR, Wang SH, Pang YZ, et al. Effect of different peptide fragments derived from Proadrenomedullin on gene expression of adrenomedullin gene. Peptides 2002; 23: 1141-1147.
22. Li J, Ren Y, Dong X, Zhong G, Wu S, Tang C. Roles of different peptide fragments derived from proadrenomedullin in the regulation of vascular tone in isolated rat aorta. Peptides 2003; 24: 563-568.
23. Zhao CF, Wang YW, Xia W, Yang XJ. Changes and influencing factors of plasma endothelin concentrations in children associated with congenital heart defects. Acta Acad Med Shandong 2001; 39: 59-61 (in Chinese).
24. 123 on synthesis of collagens type I and III in the lungs of rats with left to right shunt pulmonary hypertension. J Shandong Uni (Health Sci) 2005; 43: 28-31 (in Chinese).
25. Wang LJ, Zhao CF, Xia W, Wang ZY. Role of ET-1 receptors in pulmonary hypertension due to left to right shunt. J Shandong Uni (Health Sci) 2007; 45: 142-145 (in Chinese).
26. Zhao CF, Xia W, Wang YW, Yang J, Yang XJ. Relationship of ET-1 and collagen synthesis in pulmonary tissue of children with congenital heart disease complicated pulmonary hypertension. J Clin Pediatr 2006; 24: 374-376 (in Chinese).