Effects of early experience and genotype on serotonin transporter regulation in infant rhesus macaques

Genes, Brain and Behavior

Volumn 7, Issue 4, 2008, Pages 481-486

  Kinnally, E L ^a,b,c   Lyons, L A ^a,b   Abel, K ^b   Mendoza, S ^a,b   Capitanio, J P ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NONE   (United States)

Author keywords

Experience; Gene expression; Genotype; Rhesus macaque; Serotonin transporter

Indexed keywords

DEXAMETHASONE; HYDROCORTISONE; SEROTONIN TRANSPORTER;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE CONTROL; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; GENOTYPE; MALE; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY;

ANIMALS; BRAIN; BRAIN CHEMISTRY; DEXAMETHASONE; ENVIRONMENT DESIGN; FEMALE; GENOTYPE; GLUCOCORTICOIDS; HYDROCORTISONE; MACACA MULATTA; MALE; MATERNAL DEPRIVATION; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SOCIAL ISOLATION; STRESS, PSYCHOLOGICAL; UP-REGULATION; VARIATION (GENETICS);

MACACA MULATTA;

EID: 42549156560     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2007.00383.x     Document Type: Article

References (32)

1. Adell, A., Casanovas, J.M. Artigas, F 1997) Comparative study in the rat of the actions of different types of stress on the release of 5-HT in raphe nuclei and forebrain areas. Neuropharmacology 36, 735 741.
2. Anderson, G.M., Czarkowski, K., Ravski, N. Epperson, C.N 2004) Platelet serotonin in newborns and infants: ontogeny, heritability, and effect of in utero exposure to selective serotonin reuptake inhibitors. Pediatr Res 56, 418 422.
3. Arango, V., Underwood, M.D. Mann, J.J 2002) Serotonin brain circuits involved in major depression and suicide. Prog Brain Res 136, 443 453.
4. Asberg, M., Thoren, P., Traskman, L., Bertilsson, L. Ringberger, V 1976) "Serotonin depression" - a biochemical subgroup within the affective disorders? Science 191, 478 480.
5. Barr, C.S., Newman, T.K., Lindell, S., Becker, M.L., Shannon, C., Champoux, M., Suomi, S.J. Higley, J.D 2004) Early experience and sex interact to influence limbic-hypothalamic-pituitary-adrenal-axis function after acute alcohol administration in rhesus macaques (Macaca mulatta). Alcohol Clin Exp Res 28, 1114 1119.
6. Bennett, A.J., Lesch, K.P., Heils, A., Long, J.C., Lorenz, J.G., Shoaf, S.E., Champoux, M., Suomi, S.J., Linnoila, M.V. Higley, J.D 2002) Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol Psychiatry 7, 118 122.
7. Bradley, S.L., Dodelzon, K., Sandhu, H.K. Philibert, R.A 2005) Relationship of Serotonin transporter gene polymorphisms and haplotypes to mRNA transcription. Am J Med Genet B Neuropsychiatr Genet 136B, 58 61.
8. Capitanio, J.P., Mendoza, S.P. Lerche, N.W 1998) Individual differences in peripheral blood immunological and hormonal measures in adult male rhesus macaques (Macaca mulatta): evidence for temporal and situational consistency. Am J Primatol 44, 29 41.
9. Capitanio, J.P., Mendoza, S.P., Mason, W.A. Maninger, N 2005) Rearing environment and hypothalamic-pituitary-adrenal regulation in young rhesus monkeys (Macaca mulatta). Dev Psychobiol 46, 318 330.
10. Fairbanks, L.A., Melega, W.P., Jorgensen, M.J., Kaplan, J.R. McGuire, M.T 2001) Social impulsivity inversely associated with CSF 5-HIAA and fluoxetine exposure in vervet monkeys. Neuropsychopharmacology 24, 370 378.
11. Glatz, K., Mossner, R., Heils, A. Lesch, K.P 2003) Glucocorticoid- regulated human serotonin transporter (5-HTT) expression is modulated by the 5-HTT gene-promotor-linked polymorphic region. J Neurochem 86, 1072 1078.
12. Heils, A., Teufel, A., Petri, S., Stober, G., Riederer, P., Bengel, D. Lesch, K.P 1996) Allelic variation of human serotonin transporter gene expression. J Neurochem 66, 2621 2624.
13. Higley, J.D. Linnoila, M 1997) Low central nervous system serotonergic activity is traitlike and correlates with impulsive behavior. A nonhuman primate model investigating genetic and environmental influences on neurotransmission. Ann NY Acad Sci 836, 39 56.
14. Higley, J.D., Thompson, W.W., Champoux, M., Goldman, D., Hasert, M.F., Kraemer, G.W., Scanlan, J.M., Suomi, S.J. Linnoila, M 1993) Paternal and maternal genetic and environmental contributions to cerebrospinal fluid monoamine metabolites in rhesus monkeys (Macaca mulatta). Arch Gen Psychiatry 50, 615 623.
15. Hranilovic, D., Stefulj, J., Schwab, S., Borrmann-Hassenbach, M., Albus, M., Jernej, B. Wildenauer, D 2004) Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expression. Biol Psychiatry 1, 1090 1094.
16. Hranilovic, D., Cicin-Sain, L., Bordukalo-Niksic, T. Jernej, B 2005) Rats with constitutionally upregulated/downregulated platelet 5HT transporter: differences in anxiety-related behavior. Behav Brain Res 165, 271 277.
17. Ichise, M., Vines, D.C., Gura, T., Anderson, G.M., Suomi, S.J., Higley, J.D. Innis, R.B 2006) Effects of early life stress on [11C]DASB positron emission tomography imaging of serotonin transporters in adolescent peer- and mother-reared rhesus monkeys. J Neurosci 26, 4638 4643.
18. Kinnally, E.L., Jensen, H.A., Ewing, J.H. French, J.A 2006) Serotonin function is associated with behavioral response to a novel conspecific in marmosets. Am J Primatol 68, 812 824.
19. Langer, S.Z., Galzin, A.M., Lee, C.R. Schoemaker, H 1986) Antidepressant-binding sites in brain and platelets. Ciba Found Symp 123, 3 29.
20. Lesch, K.P., Meyer, J., Glatz, K., Flugge, G., Hinney, A., Hebebrand, J., Klauck, S.M., Poustka, A., Poustka, F., Bengel, D., Mossner, R., Riederer, P. Heils, A 1997) The 5-HT transporter gene-linked polymorphic region (5-HTTLPR) in evolutionary perspective: alternative biallelic variation in rhesus monkeys. Rapid communication. J Neural Transm 104, 1259 1266.
21. Levine, S 1994) The ontogeny of the hypothalamic-pituitary-adrenal axis: The influence of maternal factors. Ann NY Acad Sci 746, 275 288.
22. Mehlman, P.T., Higley, J.D., Faucher, I., Lilly, A.A., Taub, D.M., Vickers, J., Suomi, S.J. Linnoila, M 1994) Low CSF 5-HIAA concentrations and severe aggression and impaired impulse control in nonhuman primates. Am J Psychiatry 151, 1485 1491.
23. Paul, S.M., Rehavi, M., Skolnick, P., Ballenger, J.C. Goodwin, F.K 1981) Depressed patients have decreased binding of tritiated imipramine to platelet serotonin "transporter". Arch Gen Psychiatry 38, 1315 1317.
24. Racca, S., Spaccamiglio, A., Esculapio, P., Abbadessa, G., Cangemi, L., DiCarlo, F. Portaleone, P 2005) Effects of swim stress and alpha-MSH acute pre-treatment on brain 5-HT transporter and corticosterone receptor. Pharmacol Biochem Behav 81, 894 900.
25. Rogers, J., Martin, L.J., Comuzzie, A.G., Mann, J.J., Manuck, S.B., Leland, M. Kaplan, J.R 2004) Genetics of monoamine metabolites in baboons: overlapping sets of genes influence levels of 5-hydroxyindolacetic acid, 3-hydroxy-4-methoxyphenylglycol, and homovanillic acid. Biol Psychiatry 55, 739 744.
26. Roy, A 2002) Self-rated childhood emotional neglect and CSF monoamine indices in abstinent cocaine-abusing adults: possible implications for suicidal behavior. Psychiatry Res 112, 69 75.
27. Senkowski, D., Linden, M., Zubragel, D., Bar, T. Gallinat, J 2003) Evidence for disturbed cortical signal processing and altered serotonergic neurotransmission in generalized anxiety disorder. Biol Psychiatry 53, 304 314.
28. Shannon, C., Champoux, M. Suomi, S.J 1998) Rearing condition and plasma cortisol in rhesus monkey infants. Am J Primatol 46, 311 321.
29. Slotkin, T.A., Kreider, M.L., Tate, C.A. Seidler, F.J 2006) Critical prenatal and postnatal periods for persistent effects of dexamethasone on serotonergic and dopaminergic systems. Neuropsychopharmacology 31, 904 911.
30. Suomi, S.J 1983) Models of depression in primates. Psychol Med 13, 465 468.
31. Suomi, S.J 2005) Aggression and social behaviour in rhesus monkeys. Novartis Found Symp 268, 216 222.
32. Tafet, G.E., Toister-Achituv, M. Shinitzky, M 2001) Enhancement of serotonin uptake by cortisol: a possible link between stress and depression. Cogn Affect Behav Neurosci 1, 96 104.