Suppression of renal α-dicarbonyl compounds generated following ureteral obstruction by kidney-specific α-dicarbonyl/L-xylulose reductase

Annals of the New York Academy of Sciences

Volumn 1126, Issue , 2008, Pages 320-324

  Odani, Hiroko ^a   Asami, Jun ^b   Ishii, Aiko ^b   Oide, Kayoko ^b   Sudo, Takako ^b   Nakamura, Atsushi ^b   Miyata, Noriyuki ^b   Otsuka, Noboru ^b   Maeda, Kenji ^c   Nakagawa, Junichi ^b,d  

^a FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TAISHO PHARMACEUTICAL CO LTD   (Japan)

^c Daikou Medical Engineering Institute   (Japan)

^d TOKYO UNIVERSITY OF AGRICULTURE   (Japan)

Author keywords

3 deoxyglucosone; ESI LC MS; Methylglyoxal; Renal failure; Unilateral ureteral obstruction; UUO animal model; dicarbonyl L xylulose reductase; dicarbonyls

Indexed keywords

1,2 DICARBONYL DERIVATIVE; 3 DEOXYGLUCOSONE; COLLAGEN TYPE 3; GLYOXAL; METHYLGLYOXAL; XYLULOSE REDUCTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; ELECTROSPRAY; ELECTROSPRAY MASS SPECTROMETRY; IN SITU HYBRIDIZATION; KIDNEY FIBROSIS; MASS SPECTROMETRY; MOUSE; NONHUMAN; TRANSGENIC ANIMAL; URETER OBSTRUCTION; WILD TYPE;

ANIMALIA; MUS; MUS MUSCULUS;

EID: 42549110366     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1433.003     Document Type: Conference Paper

References (6)

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4. 4 Nakagawa, J. & A. Hara. 2002. Molecular characterization of mammalian dicarbonyl/l‐xylulose reductase and its localization in kidney. J. Biol. Chem. 277: 17883–17891.
5. 5 Sudo, T. & J. Nakagawa. 2005. Transgenic mice over‐expressing dicarbonyl/l‐xylulose reductase gene crossed with KK‐Ay diabetic model mice: an animal model for the metabolism of renal carbonyl compounds. Exp. Anim. 54: 385–394.
6. 6 Asami, J. & J. Nakagawa. 2006. Suppression of AGE precursor formation following unilateral ureteral obstruction in mouse kidneys by transgenic expression of α‐dicarbonyl/l‐xylulose reductase. Biosci. Biotechnol. Biochem. 70: 2899–2905.