Fetal spina bifida repair - Current trends and prospects of intrauterine neurosurgery

Fetal Diagnosis and Therapy

Volumn 23, Issue 4, 2008, Pages 271-286

  Fichter, M A ^a   Dornseifer, U ^a   Henke, J ^b   Schneider, K T M ^a   Kovacs, L ^a   Biemer, E ^a   Bruner, J ^d   Adzick, N S ^c   Harrison, M R ^e   Papadopulos, N A ^a,f  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b Institute for Experimental Oncology and Therapy Research   (Germany)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Dysraphic syndromes; Fetal surgery; Myelomeningocele; Open neural tube defects; Spina bifida

Indexed keywords

ARNOLD CHIARI MALFORMATION; BRAIN HERNIA; CHILDHOOD MORTALITY; CLINICAL FEATURE; EMBRYO DEVELOPMENT; FETUS RISK; FETUS SURGERY; HUMAN; HYDROCEPHALUS; INCIDENCE; MEMBRANE RUPTURE; MENINGOMYELOCELE; NEUROSURGERY; NONHUMAN; POSTNATAL CARE; PREMATURE LABOR; PRENATAL SCREENING; PRIORITY JOURNAL; PROGNOSIS; REVIEW; RHOMBENCEPHALON; SENSORIMOTOR FUNCTION; SPINA BIFIDA; SURGICAL TECHNIQUE; WOUND HEALING;

ANIMALS; ARNOLD-CHIARI MALFORMATION; DISEASE MODELS, ANIMAL; FEMALE; FETOSCOPY; HUMANS; HYDROCEPHALUS; HYSTEROTOMY; INFANT, NEWBORN; MENINGOMYELOCELE; NERVE REGENERATION; NEURAL TUBE DEFECTS; NEUROSURGICAL PROCEDURES; POSTOPERATIVE CARE; PREGNANCY; SPINAL DYSRAPHISM; ULTRASONOGRAPHY, PRENATAL; WOUND HEALING;

EID: 42449151724     PISSN: 10153837     EISSN: None     Source Type: Journal    
DOI: 10.1159/000123614     Document Type: Review

References (160)

1. Centers for Disease Control and Prevention: Folic acid and prevention of spina bifida and anencephaly. MMWR 2002;51(RR-13):9-11.
2. Boockvar JA, Loudon W, Sutton LN: Development of the Spitz-Holter valve in Philadelphia. J Neurosurg 2001;95:145-147.
3. Moore CA, Li S, Hong S, et al: Elevated rates of severe neural tube defects in a high-prevalence area in northern China. Am J Med Genet 1997;73:113-118.
4. Feuchtbaum LB, Currier RJ, Riggle S, Robertson M, Lorey FW, Cunningham GC: Neural tube defect prevalence in California (1990-1994): eliciting patterns by type of defect and maternal race/ethnicity. Genet Test 1999;3:265-272.
5. Colas JF, Schoenwolf GC: Towards a cellular and molecular understanding of neurulation. Dev Dyn 2001;221:117-145.
6. Bannister CM: The case for and against intrauterine surgery for myelomeningoceles. Eur J Obstet Gynecol Reprod Biol 2000;92:109-113.
7. Warkany J, Wilson JG, Geiger JF: Myeloschisis and myelomeningocele produced experimentally in the rat. J Comp Neurol 1958;109:35-64.
8. Padget DH: Spina bifida and embryonic neuroschisis - a causal relationship. Definition of the postnatal conformations involving a bifid spine. Johns Hopkins Med J 1968;123:233-252.
9. Gardner W: The Dysraphic States from Syringomyelia to Anencephaly. Amsterdam, Excerpta Medica, 1973, pp 1-201.
10. Manning SM, Jennings R, Madsen JR: Pathophysiology, prevention, and potential treatment of neural tube defects. Ment Retard Dev Disabil Res Rev 2000;6:6-14.
11. Aguiar MJ, Campos AS, Aguiar RA, Lana AM, Magalhaes RL, Babeto LT: Neural tube defects and associated factors in liveborn and stillborn infants. J Pediatr 2003;79:129-134.
12. Coerdt W, Miller K, Holzgreve W, Rauskolb R, Schwinger E, Rehder H: Neural tube defects in chromosomally normal and abnormal human embryos. Ultrasound Obstet Gynecol 1997;10:410-415.
13. Lynch SA: Non-multifactorial neural tube defects. Am J Med Genet C Semin Med Genet 2005;135:69-76.
14. Rinke U, Koletzko B: Prävention von Neuralrohrdefekten durch Folsäurezufuhr in der Frühschwangerschaft. Dtsch Aerztebl 1994;91:A0-A37.
15. Bässler KH GILD, Pietrik K: Vitamin-Lexikon für Ärzte, Apotheker und Ernährungswissenschaftler, ed 3. München, Urban & Fischer, 2002.
16. Harris MJ: Why are the genes that cause risk of human neural tube defects so hard to find? Teratology 2001;63:165-166.
17. Ray JG, Vermeulen MJ, Meier C, Wyatt PR: Risk of congenital anomalies detected during antenatal serum screening in women with pregestational diabetes. QJM 2004;97:651-653.
18. Dietl J: Maternal obesity and complications during pregnancy. J Perinat Med 2005;33:100-105.
19. Moretti ME, Bar-Oz B, Fried S, Koren G: Maternal hyperthermia and the risk for neural tube defects in offspring: systematic review and meta-analysis. Epidemiology 2005;16:216-219.
20. Suarez L, Felkner M, Hendricks K: The effect of fever, febrile illnesses, and heat exposures on the risk of neural tube defects in a Texas-Mexico border population. Birth Defects Res [A] 2004;70:815-819.
21. Richter B, Stegmann K, Roper B, Boddeker I, Ngo ET, Koch MC: Interaction of folate and homocysteine pathway genotypes evaluated in susceptibility to neural tube defects (NTD) in a German population. J Hum Genet 2001;46:105-109.
22. Morrison K, Papapetrou C, Hol FA, Mariman EC, Lynch SA, Burn J, Edwards YH: Susceptibility to spina bifida; an association study of 5 candidate genes. Ann Hum Genet 1998;62:379-396.
23. MRC Vitamin Study Research Group: Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 1991;338:131-137.
24. Brent RL, Oakley GP Jr: The folate debate. Pediatrics 2006;117:1418-1419.
25. Choumenkovitch SF, Selhub J, Wilson PW, Rader JI, Rosenberg IH, Jacques PF: Folic acid intake from fortification in United States exceeds predictions. J Nutr 2002;132:2792-2798.
26. Brock DJ, Barron L, Raab GM: The potential of mid-trimester maternal plasma alpha-fetoprotein measurement in predicting infants of low birth weight. Br J Obstet Gynaecol 1980;87:582-585.
27. Bruner JP, Davis G, Tulipan N: Intrauterine shunt for obstructive hydrocephalus - still not ready. Fetal Diagn Ther 2006;21:532-539.
28. Braithwaite JM, Armstrong MA, Economides DL: Assessment of fetal anatomy at 12 to 13 weeks of gestation by transabdominal and transvaginal sonography. Br J Obstet Gynaecol 1996;103:82-85.
29. Nicolaides KH, Campbell S, Gabbe SG, Guidetti R: Ultrasound screening for spina bifida: cranial and cerebellar signs. Lancet 1986;ii:72-74.
30. Levine D, Barnes PD, Madsen JR, Abbott J, Wong GP, Hulka C, Mehta T, Li W, Edelman RR: Fetal CNS anomalies revealed on ultrafast MR imaging. AJR 1999;172:813-818.
31. Levine D, Barnes PD, Robertson RR, Wong G, Mehta TS: Fast MR imaging of fetal central nervous system abnormalities. Radiology 2003;229:51-61.
32. von Koch CS, Glenn OA, Goldstein RB, Barkovich AJ: Fetal magnetic resonance imaging enhances detection of spinal cord anomalies in patients with sonographically detected bony anomalies of the spine. J Ultrasound Med 2005;24:781-789.
33. Cochrane DD, Wilson RD, Steinbok P, Farquharson DF, Irwin B, Irvine B, Chambers K: Prenatal spinal evaluation and functional outcome of patients born with myelomeningocele: information for improved prenatal counselling and outcome prediction. Fetal Diagn Ther 1996;11:159-168.
34. Lorber J: Results of treatment of myelomeningocele: an analysis of 524 unselected cases, with special reference to possible selection for treatment. Dev Med Child Neurol 1971;13:279-303.
35. Steinbok P, Irvine B, Cochrane DD, Irwin BJ: Long-term outcome and complications of children born with meningomyelocele. Childs Nerv Syst 1992;8:92-96.
36. Bowman RM, McLone DG, Grant JA, Tomita T, Ito JA: Spina bifida outcome: a 25-year prospective. Pediatr Neurosurg 2001;34:114-120.
37. McLaurin R: Myelomeningocele: outcome and late complication; in Section of Pediatric Neurosurgery of the American Association of Neurological Surgeons (ed): Pediatric Neurosurgery: Surgery of the Development Nervous System, ed 2. Saunders, Philadelphia, 1989, pp 53-70.
38. McLone DG: Continuing concepts in the management of spina bifida. Pediatr Neurosurg 1992;18:254-256.
39. Hirose S, Meuli-Simmen C, Meuli M: Fetal surgery for myelomeningocele: panacea or peril? World J Surg 2003;27:87-94.
40. Singhal B, Mathew KM: Factors affecting mortality and morbidity in adult spina bifida. Eur J Pediatr Surg 1999;9(suppl 1):31-32.
41. McLone DG, Knepper PA: The cause of Chiari II malformation: a unified theory. Pediatr Neurosci 1989;15:1-12.
42. Rauzzino M, Oakes WJ: Chiari II malformation and syringomyelia. Neurosurg Clin N Am 1995;6:293-309.
43. Cochrane DD, Adderley R, White CP, Norman M, Steinbok P: Apnea in patients with myelomeningocele. Pediatr Neurosurg 1990;16:232-239.
44. McLone D: The cause of the Chiari malformation; in Matsumoto S, Sato H (eds): International Symposium on Spina Bifida, School Age and Adolescence. Part II. Tokyo, Springer, 1997.
45. Park TS, Hoffman HJ, Hendrick EB, Humphreys RP: Experience with surgical decompression of the Arnold-Chiari malformation in young infants with myelomeningocele. Neurosurgery 1983;13:147-152.
46. Cameron AH: The Arnold-Chiari and other neuro-anatomical malformations associated with spina bifida. J Path Bact 1957;73:195-211.
47. Mackenzie NG, Emery JL: Deformities of the cervical cord in children with neurospinal dysraphism. Dev Med Child Neurol 1971;13:59-67.
48. La Marca F, Grant JA, Tomita T, McLone DG: Spinal lipomas in children: outcome of 270 procedures. Pediatr Neurosurg 1997;26:8-16.
49. Rintoul NE, Sutton LN, Hubbard AM, Cohen B, Melchionni J, Pasquariello PS, Adzick NS: A new look at myelomeningoceles: functional level, vertebral level, shunting, and the implications for fetal intervention. Pediatrics 2002;109:409-413.
50. Tulipan N, Bruner JP, Hernanz-Schulman M, Lowe LH, Walsh WF, Nickolaus D, Oakes WJ: Effect of intrauterine myelomeningocele repair on central nervous system structure and function. Pediatr Neurosurg 1999;31:183-188.
51. Bruner JP, Tulipan N, Paschall RL, Boehm FH, Walsh WF, Silva SR, Hernanz-Schulman M, Lowe LH, Reed GW: Fetal surgery for myelomeningocele and the incidence of shunt-dependent hydrocephalus. JAMA 1999;282:1819-1825.
52. Chumas P, Tyagi A, Livingston J: Hydrocephalus - what's new? Arch Dis Child 2001;85:F149-F154.
53. Drake JM, Kestle JR, Milner R, Cinalli G, Boop F, Piatt J Jr, Haines S, Schiff SJ, Cochrane DD, Steinbok P, MacNeil N: Randomized trial of cerebrospinal fluid shunt valve design in pediatric hydrocephalus. Neurosurgery 1998;43:294-303, discussion 303-305.
54. Langley JM, LeBlanc JC, Drake J, Milner R: Efficacy of antimicrobial prophylaxis in placement of cerebrospinal fluid shunts: meta-analysis. Clin Infect Dis 1993;17:98-103.
55. Iskandar BJ, Tubbs S, Mapstone TB, Grabb PA, Bartolucci AA, Oakes WJ: Death in shunted hydrocephalic children in the 1990s. Pediatr Neurosurg 1998;28:173-176.
56. Hunt GM: The Casey Holter lecture. Nonselective intervention in newborn babies with open spina bifida: the outcome 30 years on for the complete cohort. Eur J Pediatr Surg 1999;9(suppl 1):5-8.
57. Mataro M, Poca MA, Sahuquillo J, Cuxart A, Iborra J, de la Calzada MD, Junque C: Cognitive changes after cerebrospinal fluid shunting in young adults with spina bifida and assumed arrested hydrocephalus. J Neurol Neurosurg Psychiatry 2000;68:615-621.
58. Phuong LK, Schoeberl KA, Raffel C: Natural history of tethered cord in patients with meningomyelocele. Neurosurgery 2002;50:989-993, discussion 993-995.
59. Stoodley MA, Gutschmidt B, Jones NR: Cerebrospinal fluid flow in an animal model of noncommunicating syringomyelia. Neurosurgery 1999;44:1065-1075, discussion 1075-1066.
60. Tani S, Yamada S, Knighton RS: Extensibility of the lumbar and sacral cord. Pathophysiology of the tethered spinal cord in cats. J Neurosurg 1987;66:116-123.
61. Anderson FM: Occult spinal dysraphism: a series of 73 cases. Pediatrics 1975;55:826-835.
62. Boor R, Schwarz M, Reitter B, Voth D: Tethered cord after spina bifida aperta: a longitudinal study of somatosensory evoked potentials. Childs Nerv Syst 1993;9:328-330.
63. Heinz ER, Rosenbaum AE, Scarff TB, Reigel DH, Drayer BP: Tethered spinal cord following meningomyelocele repair. Radiology 1979;131:153-160.
64. Linder M, Rosenstein J, Sklar FH: Functional improvement after spinal surgery for the dysraphic malformations. Neurosurgery 1982;11:622-624.
65. McLone DG, Dias MS: Complications of myelomeningocele closure. Pediatr Neurosurg 1991;17:267-273.
66. Oi S, Yamada H, Matsumoto S: Tethered cord syndrome versus low-placed conus medullaris in an over-distended spinal cord following initial repair for myelodysplasia. Childs Nerv Syst 1990;6:264-269.
67. Ohe N, Futamura A, Kawada R, Minatsu H, Kohmura H, Hayashi K, Miwa K, Sakai N: Secondary tethered cord syndrome in spinal dysraphism. Childs Nerv Syst 2000;16:457-461.
68. Pang D, Wilberger JE Jr: Tethered cord syndrome in adults. J Neurosurg 1982;57:32-47.
69. Selber P, Dias L: Sacral-level myelomeningocele: long-term outcome in adults. J Pediatr Orthop 1998;18:423-427.
70. Tamaki N, Shirataki K, Kojima N, Shouse Y, Matsumoto S: Tethered cord syndrome of delayed onset following repair of myelomeningocele. J Neurosurg 1988;69:393-398.
71. Begeer JH, Meihuizen de Regt MJ, Hogen-Esch I, Ter Weeme CA, Mooij JJ, Vencken LM: Progressive neurological deficit in children with spina bifida aperta. Z Kinderchir 1986;41(suppl 1):13-15.
72. Roberts HE, Moore CA, Cragan JD, Fernhoff PM, Khoury MJ: Impact of prenatal diagnosis on the birth prevalence of neural tube defects, Atlanta, 1990-1991. Pediatrics 1995;96:880-883.
73. Garne E, Loane M, Dolk H, De Vigan C, Scarano G, Tucker D, Stoll C, Gener B, Pierini A, Nelen V, Rosch C, Gillerot Y, Feijoo M, Tincheva R, Queisser-Luft A, Addor MC, Mosquera C, Gatt M, Barisic I: Prenatal diagnosis of severe structural congenital malformations in Europe. Ultrasound Obstet Gynecol 2005;25:6-11.
74. Sutton LN, Adzick NS, Johnson MP: Fetal surgery for myelomeningocele. Childs Nerv Syst 2003;19:587-591.
75. Luthy DA, Wardinsky T, Shurtleff DB, Hollenbach KA, Hickok DE, Nyberg DA, Benedetti TJ: Cesarean section before the onset of labor and subsequent motor function in infants with meningomyelocele diagnosed antenatally. N Engl J Med 1991;324:662-666.
76. Shurtleff DB, Luthy DA, Nyberg DA, Benedetti TJ, Mack LA: Meningomyelocele: management in utero and post natum. Ciba Found Symp 1994; 181: 270-280, discussion 280-286.
77. Cochrane D, Aronyk K, Sawatzky B, Wilson D, Steinbok P: The effects of labor and delivery on spinal cord function and ambulation in patients with meningomyelocele. Childs Nerv Syst 1991;7:312-315.
78. Lewis D, Tolosa JE, Kaufmann M, Goodman M, Farrell C, Berghella V: Elective cesarean delivery and long-term motor function or ambulation status in infants with meningomyelocele. Obstet Gynecol 2004;103:469-473.
79. Hill AE, Beattie F: Does caesarean section delivery improve neurological outcome in open spina bifida? Eur J Pediatr Surg 1994;4(suppl 1):32-34.
80. Merrill DC, Goodwin P, Burson JM, Sato Y, Williamson R, Weiner CP: The optimal route of delivery for fetal meningomyelocele. Am J Obstet Gynecol 1998;179:235-240.
81. Sakala EP, Andree I: Optimal route of delivery for meningomyelocele. Obstet Gynecol Surv 1990;45:209-212.
82. Anteby E, Yagel S: Route of delivery of fetuses with structural anomalies. Eur J Obstet Gynecol Reprod Biol 2003;106:5-9.
83. ACOG Committee on Practice Bulletins: ACOG practice bulletin. Clinical management guidelines for obstetrician-gynecologists. Number 44, July 2003. (Replaces Committee Opinion Number 252, March 2001). Obstet Gynecol 2003;102:203-213.
84. Bayer C: Zur Technik der Operation der Spina Bifida und Encephalocele. PragMed Wschr 1892:317-345.
85. Machado HR, Santos De Oliveira R: Simultaneous repair of myelomeningocele and shunt insertion. Childs Nerv Syst 2004;20:107-109.
86. Miller PD, Pollack IF, Pang D, Albright AL: Comparison of simultaneous versus delayed ventriculoperitoneal shunt insertion in children undergoing myelomeningocele repair. J Child Neurol 1996;11:370-372.
87. Epstein NE, Rosenthal AD, Zito J, Osipoff M: Shunt placement and myelomeningocele repair: simultaneous vs. sequential shunting. Review of 12 cases. Childs Nerv Syst 1985;1:145-147.
88. Pang D: Surgical complications of open spinal dysraphism. Neurosurg Clin N Am 1995;6:243-257.
89. Chadduck WM, Reding DL: Experience with simultaneous ventriculo- peritoneal shunt placement and myelomeningocele repair. J Pediatr Surg 1988;23:913-916.
90. Burrington JD: Wound healing in the fetal lamb. J Pediatr Surg 1971;6:523-528.
91. Somasundaram K, Prathap K: Intra-uterine healing of skin wounds in rabbit foetuses. J Pathol 1970;100:81-86.
92. Huhn EA, Jannowitz C, Boos H, Papadopulos MA, Zeilhofer HF, Henke J, Muller D, Kovacs L, Biemer E, Papadopulos NA: Fetal wound healing: current status and new perspectives. Chirurg 2004;75:498-507.
93. Papadopulos NA, Papadopoulos MA, Zeilhofer HF, Boos H, Henke J, Erhardt W, Boettcher P, Stolla R, Kovacs L, Biemer E: Intrauterine autogenous foetal bone transplantation for the repair of cleft-like defects in the mid-gestational sheep model. J Craniomaxillofac Surg 2004;32:199-210.
94. Steeves JD, Keirstead HS, Ethell DW, Hasan SJ, Muir GD, Pataky DM, McBride CB, Petrausch B, Zwimpfer TJ: Permissive and restrictive periods for brainstem-spinal regeneration in the chick. Prog Brain Res 1994;103:243-262.
95. Keirstead HS, Hasan SJ, Muir GD, Steeves JD: Suppression of the onset of myelination extends the permissive period for the functional repair of embryonic spinal cord. Proc Natl Acad Sci USA 1992;89:11664-11668.
96. Hasan SJ, Keirstead HS, Muir GD, Steeves JD: Axonal regeneration contributes to repair of injured brainstem-spinal neurons in embryonic chick. J Neurosci 1993;13:492-507.
97. Shimizu I, Oppenheim RW, O'Brien M, Shneiderman A: Anatomical and functional recovery following spinal cord transection in the chick embryo. J Neurobiol 1990;21:918-937.
98. Brunelli G, Brunelli F: Experimental foetal microsurgery as related to myelomeningocele. Microsurgery 1984;5:24-29.
99. Weidenheim KM, Kress Y, Epshteyn I, Rashbaum WK, Lyman WD: Early myelination in the human fetal lumbosacral spinal cord: characterization by light and electron microscopy. J Neuropathol Exp Neurol 1992;51:142-149.
100. Heffez DS, Aryanpur J, Hutchins GM, Freeman JM: The paralysis associated with myelomeningocele: clinical and experimental data implicating a preventable spinal cord injury. Neurosurgery 1990;26:987-992.
101. Osaka K, Tanimura T, Hirayama A, Matsumoto S: Myelomeningocele before birth. J Neurosurg 1978;49:711-724.
102. Korenromp MJ, van Gool JD, Bruinese HW, Kriek R: Early fetal leg movements in myelomeningocele. Lancet 1986;1:917-918.
103. Sival DA, Begeer JH, Staal-Schreinemachers AL, Vos-Niel JM, Beekhuis JR, Prechtl HF: Perinatal motor behaviour and neurological outcome in spina bifida aperta. Early Hum Dev 1997;50:27-37.
104. Drewek MJ, Bruner JP, Whetsell WO, Tulipan N: Quantitative analysis of the toxicity of human amniotic fluid to cultured rat spinal cord. Pediatr Neurosurg 1997;27:190-193.
105. Hutchins GM, Meuli M, Meuli-Simmen C, Jordan MA, Heffez DS, Blakemore KJ: Acquired spinal cord injury in human fetuses with myelomeningocele. Pediatr Pathol Lab Med 1996;16:701-712.
106. Meuli M, Meuli-Simmen C, Hutchins GM, Seller MJ, Harrison MR, Adzick NS: The spinal cord lesion in human fetuses with myelomeningocele: implications for fetal surgery. J Pediatr Surg 1997;32:448-452.
107. George TM, Cummings TJ: The immunohistochemical profile of the myelomeningocele placode: is the placode normal? Pediatr Neurosurg 2003;39:234-239.
108. Adzick NS, Walsh DS: Myelomeningocele: prenatal diagnosis, pathophysiology and management. Semin Pediatr Surg 2003;12:168-174.
109. Pang D, Dias MS: Cervical myelomeningoceles. Neurosurgery 1993;33:363-372, discussion 372-363.
110. Sutton LN: Lipomyelomeningocele. Neurosurg Clin N Am 1995;6:325-338.
111. Duckworth T, Sharrard WJ, Lister J, Seymour N: Hemimyelocele. Dev Med Child Neurol 1968(suppl 16):69-75.
112. Michejda M: Intrauterine treatment of spina bifida: primate model. Z Kinderchir 1984;39:259-261.
113. Pedreira DA, Valente PR, Abou-Jamra RC, Pelarigo CL, Silva LM, Goldenberg S: Successful fetal surgery for the repair of a 'myelomeningocele-like' defect created in the fetal rabbit. Fetal Diagn Ther 2003;18:201-206.
114. Meuli-Simmen C, Meuli M, Adzick NS, Harrison MR: Latissimus dorsi flap procedures to cover myelomeningocele in utero: a feasibility study in human fetuses. J Pediatr Surg 1997;32:1154-1156.
115. Copeland ML, Bruner JP, Richards WO, Sundell HW, Tulipan NB: A model for in utero endoscopic treatment of myelomeningocele. Neurosurgery 1993;33:542-544, discussion 545.
116. Heffez DS, Aryanpur J, Rotellini NA, Hutchins GM, Freeman JM: Intrauterine repair of experimental surgically created dysraphism. Neurosurgery 1993;32:1005-1010.
117. Meuli M, Meuli-Simmen C, Yingling CD, Hutchins GM, Hoffman KM, Harrison MR, Adzick NS: Creation of myelomeningocele in utero: a model of functional damage from spinal cord exposure in fetal sheep. J Pediatr Surg 1995;30:1028-1032, discussion 1032-1033.
118. Meuli M, Meuli-Simmen C, Hutchins GM, Yingling CD, Hoffman KM, Harrison MR, Adzick NS: In utero surgery rescues neurological function at birth in sheep with spina bifida. Nat Med 1995;1:342-347.
119. Meuli-Simmen C, Meuli M, Hutchins GM, Harrison MR, Buncke HJ, Sullivan KM, Adzick NS: Fetal reconstructive surgery: experimental use of the latissimus dorsi flap to correct myelomeningocele in utero. Plast Reconstr Surg 1995;96:1007-1011.
120. Meuli M, Meuli-Simmen C, Yingling CD, Hutchins GM, Timmel GB, Harrison MR, Adzick NS: In utero repair of experimental myelomeningocele saves neurological function at birth. J Pediatr Surg 1996;31:397-402.
121. Paek BW, Farmer DL, Wilkinson CC, Albanese CT, Peacock W, Harrison MR, Jennings RW: Hindbrain herniation develops in surgically created myelomeningocele but is absent after repair in fetal lambs. Am J Obstet Gynecol 2000;183:1119-1123.
122. Bouchard S, Davey MG, Rintoul NE, Walsh DS, Rorke LB, Adzick NS: Correction of hindbrain herniation and anatomy of the vermis after in utero repair of myelomeningocele in sheep. J Pediatr Surg 2003;38:451-458, discussion 451-458.
123. Yoshizawa J, Sbragia L, Paek BW, Sydorak RM, Yamazaki Y, Harrison MR, Farmer DL: Fetal surgery for repair of myelomeningocele allows normal development of anal sphincter muscles in sheep. Pediatr Surg Int 2004;20:14-18.
124. Yoshizawa J, Sbragia L, Paek BW, Sydorak RM, Yamazaki Y, Harrison MR, Farmer DL: Fetal surgery for repair of myelomeningocele allows normal development of the rectum in sheep. Pediatr Surg Int 2003;19:162-166.
125. Danzer E, Kiddoo DA, Redden RA, Robinson L, Radu A, Zderic S, Doolin EJ, Adzick NS, Flake AW: Structural and functional characterization of bladder smooth muscle in fetal rats with retinoic acid induced myelomeningocele. Am J Physiol 2007;292:F197-F206.
126. Bruner JP, Tulipan NE, Richards WO: Endoscopic coverage of fetal open myelomeningocele in utero. Am J Obstet Gynecol 1997;176:256-257.
127. Bruner JP, Richards WO, Tulipan NB, Arney TL: Endoscopic coverage of fetal myelomeningocele in utero. Am J Obstet Gynecol 1999;180:153-158.
128. Tulipan N, Bruner JP: Myelomeningocele repair in utero: a report of three cases. Pediatr Neurosurg 1998;28:177-180.
129. Adzick NS, Sutton LN, Crombleholme TM, Flake AW: Successful fetal surgery for spina bifida. Lancet 1998;352:1675-1676.
130. Tulipan N, Hernanz-Schulman M, Lowe LH, Bruner JP: Intrauterine myelomeningocele repair reverses preexisting hindbrain herniation. Pediatr Neurosurg 1999;31:137-142.
131. Kohl T, Hering R, Heep A, Schaller C, Meyer B, Greive C, Bizjak G, Buller T, Van de Vondel P, Gogarten W, Bartmann P, Knopfle G, Gembruch U: Percutaneous fetoscopic patch coverage of spina bifida aperta in the human-early clinical experience and potential. Fetal Diagn Ther 2006;21:185-193.
132. Tulipan N, Sutton LN, Bruner JP, Cohen BM, Johnson M, Adzick NS: The effect of intrauterine myelomeningocele repair on the incidence of shunt-dependent hydrocephalus. Pediatr Neurosurg 2003;38:27-33.
133. Johnson MP, Sutton LN, Rintoul N, Crombleholme TM, Flake AW, Howell LJ, Hedrick HL, Wilson RD, Adzick NS: Fetal myelomeningocele repair: short-term clinical outcomes. Am J Obstet Gynecol 2003;189:482-487.
134. Farmer DL, von Koch CS, Peacock WJ, Danielpour M, Gupta N, Lee H, Harrison MR: In utero repair of myelomeningocele: experimental pathophysiology, initial clinical experience, and outcomes. Arch Surg 2003;138:872-878.
135. Zambelli H, Barini R, Iscaife A, Cursino K, Braga Ade F, Marba S, Sbragia L: Successful developmental outcome in intrauterine myelomeningocele repair. Childs Nerv Syst 2007;23:123-126.
136. Bruner JP, Tulipan N: Intrauterine repair of spina bifida. Clin Obstet Gynecol 2005;48:942-955.
137. Bruner JP, Tulipan N, Reed G, Davis GH, Bennett K, Luker KS, Dabrowiak ME: Intrauterine repair of spina bifida: preoperative predictors of shunt-dependent hydrocephalus. Am J Obstet Gynecol 2004;190:1305-1312.
138. Tubbs RS, Chambers MR, Smyth MD, Bartolucci AA, Bruner JP, Tulipan N, Oakes WJ: Late gestational intrauterine myelomeningocele repair does not improve lower extremity function. Pediatr Neurosurg 2003;38:128-132.
139. Holzbeierlein J, Pope JI, Adams MC, Bruner J, Tulipan N, Brock JW 3rd: The urodynamic profile of myelodysplasia in childhood with spinal closure during gestation. J Urol 2000;164:1336-1339.
140. Holmes NM, Nguyen HT, Harrison MR, Farmer DL, Baskin LS: Fetal intervention for myelomeningocele: effect on postnatal bladder function. J Urol 2001;166:2383-2386.
141. Mazzola CA, Albright AL, Sutton LN, Tuite GF, Hamilton RL, Pollack IF: Dermoid inclusion cysts and early spinal cord tethering after fetal surgery for myelomeningocele. N Engl J Med 2002;347:256-259.
142. Scott RM, Wolpert SM, Bartoshesky LE, Zimbler S, Klauber GT: Dermoid tumors occurring at the site of previous myelomeningocele repair. J Neurosurg 1986;65:779-783.
143. Hamdan AH, Walsh W, Bruner JP, Tulipan N: Intrauterine myelomeningocele repair: effect on short-term complications of prematurity. Fetal Diagn Ther 2004;19:83-86.
144. Hamdan AH, Walsh W, Heddings A, Bruner JP, Tulipan N: Gestational age at intrauterine myelomeningocele repair does not influence the risk of prematurity. Fetal Diagn Ther 2002;17:66-68.
145. Farrell JA, Albanese CT, Jennings RW, Kilpatrick SJ, Bratton BJ, Harrison MR: Maternal fertility is not affected by fetal surgery. Fetal Diagn Ther 1999;14:190-192.
146. Longaker MT, Golbus MS, Filly RA, Rosen MA, Chang SW, Harrison MR: Maternal outcome after open fetal surgery: a review of the first 17 human cases. JAMA 1991;265:737-741.
147. Lyerly AD, Cefalo RC, Socol M, Fogarty L, Sugarman J: Attitudes of maternal-fetal specialists concerning maternal-fetal surgery. Am J Obstet Gynecol 2001;185:1052-1058.
148. Chervenak FA, Duncan C, Ment LR, Tortora M, McClure M, Hobbins JC: Perinatal management of meningomyelocele. Obstet Gynecol 1984;63:376-380.
149. Tulipan N: Intrauterine closure of myelomeningocele: an update. Neurosurg Focus 2004;16:E2.
150. Aaronson OS, Tulipan NB, Cywes R, Sundell HW, Davis GH, Bruner JP, Richards WO: Robot-assisted endoscopic intrauterine myelomeningocele repair: a feasibility study. Pediatr Neurosurg 2002;36:85-89.
151. Papadopulos NA, Dumitrascu I, Ordonez JL, Decaluwe H, Lerut TE, Barki G, Deprest JA: Fetoscopy in the pregnant rabbit at midgestation. Fetal Diagn Ther 1999;14:118-121.
152. Papadopulos NA, Van Ballaer PP, Ordonez JL, Laermans IJ, Vandenberghe K, Lerut TE, Deprest JA: Fetal membrane closure techniques after hysteroamniotomy in the midgestational rabbit model. Am J Obstet Gynecol 1998;178:938-942.
153. Deprest JA, Papadopulos NA, Decaluw H, Yamamoto H, Lerut TE, Gratacos E: Closure techniques for fetoscopic access sites in the rabbit at mid-gestation. Hum Reprod 1999;14:1730-1734.
154. Gratacos E, Yamamoto H, Papadopulos NA, Adriaenssens T, Phlips T, Lerut TE, Deprest JA: The midgestational rabbit as a model for the creation of membrane defects after needle fetoscopy. Am J Obstet Gynecol 1999;180:1263-1267.
155. Papadopulos NA, Klotz S, Raith A, Henke J, Klöpperl M, Brill T, Müller D, Kovacs L, Erhardt W, Biemer E: Closure of fetoscopic defects of the fetal membranes in a midgestational rabbit model. Geburtshilfe Frauenheilkd 2003;63:651-657.
156. Papadopulos NA, Klotz S, Raith A, Foehn M, Schillinger U, Henke J, Kovacs L, Horch RE, Biemer E: Amnion cells engineering: a new perspective in fetal membrane healing after intrauterine surgery? Fetal Diagn Ther 2006;21:494-500.
157. Portmann-Lanz CB, Ochsenbein-Kolble N, Marquardt K, Luthi U, Zisch A, Zimmermann R: Manufacture of a cell-free amnion matrix scaffold that supports amnion cell outgrowth in vitro. Placenta 2007;28:6-13.
158. Ochsenbein-Kölble N, Jani J, Lewi L, Verbist L, Vercruyse L, Portmann-Lanz B: Enhancing sealing of fetal membrane defects using tissue engineered native amniotic scaffolds in the rabbit model. Am J Obstet Gynecol 2007;196:263.
159. Chervenak FA, McCullough LB, Birnbach DJ: Ethical issues in fetal surgery research. Best Pract Res Clin Anaesthesiol 2004;18:221-230.
160. Olutoye OO, Adzick NS: Fetal surgery for myelomeningocele. Semin Perinatol 1999;23:462-473.