Why are the genes that cause risk of human neural tube defects so hard to find?

Teratology

Volumn 63, Issue 5, 2001, Pages 165-166

  Harris, Muriel J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ACTIN; DNA BASE; FOLIC ACID;

ANENCEPHALUS; BIRTH DEFECT; CELL CYCLE; DEVELOPMENTAL GENETICS; DNA SEQUENCE; EDITORIAL; GENE MAPPING; GENE MUTATION; GENETIC RISK; HUMAN; METHYLATION; NEURAL TUBE DEFECT; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; SPINA BIFIDA; TELOMERE;

ALLELES; ANIMALS; FAMILY HEALTH; HUMANS; LINKAGE (GENETICS); MICE; MICE, KNOCKOUT; MUTATION; NEURAL TUBE DEFECTS; PHENOTYPE; RISK FACTORS;

EID: 0035003372     PISSN: 00403709     EISSN: None     Source Type: Journal    
DOI: 10.1002/tera.1030     Document Type: Editorial

References (9)

1. The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development
2. Mini-review: Toward understanding mechanisms of genetic neural tube defects in mice
3. Exencephaly and hydrocephaly in mice with targeted modification of the apolipoprotein B (Apob) gene
4. Multifactorial genetics of excencephaly is SELH/Bc mice
5. Mouse models for neural tube closure defects
6. Genetic epidemiology of birth defects: Nonsyndromic cleft lip and neural tube defects
7. Maternal vitamin use, genetic variation of infant methylenetetrahydrofolate reductase, and risk for spina bifida
8. A screen for mutations in human homologs of mice exencephaly genes Tcfap2a and Msx2 in patients with neural tube defects