Histopathologic, immunohistochemical, and cytologic analysis of feline myeloma-related disorders: Further evidence for primary extramedullary development in the cat

Veterinary Pathology

Volumn 45, Issue 2, 2008, Pages 159-173

  Mellor, P J ^a,j   Haugland, S ^a   Smith, K C ^b   Powell, R M ^a   Archer, J ^a   Scase, T J ^a   Villiers, E J ^a   McNeil, P E ^c   Nixon, C ^d   Knott, C ^c   Fournier, D ^c   Murphy, S ^e   Polton, G A ^f   Belford, C ^g   Philbey, A W ^d   Argyle, D J ^h   Herrtage, M E ^a   Day, M J ⁱ  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ROYAL VETERINARY COLLEGE   (United Kingdom)

^c Finn Pathologists ^*  (United Kingdom)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

^e ANIMAL HEALTH TRUST   (United Kingdom)

^f DAVIES VETERINARY SPECIALISTS   (United Kingdom)

^g Cytopath Ltd   (United Kingdom)

^h UNIVERSITY OF EDINBURGH   (United Kingdom)

ⁱ UNIVERSITY OF BRISTOL   (United Kingdom)

^j Worldwide Veterinary Service   (United Kingdom)

more..

Author keywords

Cats; Extramedullary plasmacytoma; Lymphoproliferative; Monoclonal gammopathy; Myeloma; Paraproteinemia; Plasma cell

Indexed keywords

ANIMAL; ANIMAL DISEASE; ARTICLE; CAT; CAT DISEASE; CLINICAL TRIAL; FEMALE; IMMUNOHISTOCHEMISTRY; KAPLAN MEIER METHOD; MALE; MULTICENTER STUDY; MULTIPLE MYELOMA; PATHOLOGY; RETROSPECTIVE STUDY;

ANIMALS; CAT DISEASES; CATS; FEMALE; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIERS ESTIMATE; MALE; MULTIPLE MYELOMA; RETROSPECTIVE STUDIES;

FELIDAE;

EID: 42449143893     PISSN: 03009858     EISSN: 15442217     Source Type: Journal    
DOI: 10.1354/vp.45-2-159     Document Type: Article

References (80)

1. Aboulafia D, Gown AM, Kidd P: AIDS-associated B-cell non-Hodgkin's lymphoma masquerading as a cutaneous T-cell neoplasm: an aberrant immunophenotype requiring comprehensive analysis for lineage resolution. Am J Dermatopathol 19:66-72, 1997
2. Aquino SM, Hamor RE, Valli VE, Kitchell BE, Tunev SS, Bailey KL, Ehrhart EJ: Progression of an orbital T-cell rich B-cell lymphoma to a B-cell lymphoma in a dog. Vet Pathol 37:465-469, 2000
3. Arun SS, Breuer W, Hermanns W: Immunohistochemical examination of light-chain expression in canine, feline, equine, bovine and porcine plasma cells. J Vet Med 43:573-576, 1996
4. Bakkus MH, Schots R, Gomez La Fuente PB, Van Riet I, Thielemans K, De Waele M, Van Camp B: Clonally related IgA- and IgE- secreting plasma cells in a myeloma patient. Eur J Haematol 65:348-355, 2000
5. Bangerter M, Hildebrand A, Waidmann O, Griesshammer M: Fine needle aspiration cytology in extramedullary plasmacytoma. Acta Cytol 44:287-291, 2000
6. Bartl R, Frisch B, Burkhardt R, Fateh-Moghadam A, Mahl G, Gierster P, Sund M, Kettner G: Bone marrow histology in myeloma: its importance in diagnosis, prognosis, classification and staging. Br J Haematol 51:361-375, 1982
7. Bayrd ED: The bone marrow on sternal aspiration in multiple myeloma. Blood 3:987-1018, 1948
8. Blacking TM, Wilson H, Argyle DJ: Is cancer a stem cell disease? Theory, evidence and implications. Vet Comp Oncol 5:76-89, 2007
9. Breuer W, Colbatzky F, Platz S, Hermanns W: Immunoglobulin-producing tumours in dogs and cats. J Comp Pathol 109:203-216, 1993
10. Carothers MA, Johnson GC, DiBartola SP, Liepnicks J, Benson MD: Extramedullary plasmacytoma and immunoglobulin-associated amyloidosis in a cat. J Am Vet Med Assoc 195:1593-1597, 1989
11. Carpenter JL, Andrews LK, Holzworth J: Tumours and tumour like lesions. In: Diseases of the Cat: Medicine and Surgery, ed. Holzworth J, pp. 406-596. WB Saunders, Philadelphia, PA, 1987
12. Carter A, Hocherman I, Linn S, Cohen Y, Tatarsky I: Prognostic significance of plasma cell morphology in multiple myeloma. Cancer 60:1060-1065, 1987
13. Das DK, Gupta SK, Sehgal S: Extramedullary plasma cell tumours: diagnosis by fine-needle aspiration cytology. Diagn Cytopathol 2:248-251, 1986
14. Day MJ, Kyaw-Tanner M, Silkstone MA, Lucke VM, Robinson WF: T-cell-rich B-cell lymphoma in the cat. J Comp Pathol 120:155-167, 1999
15. Di Guglielmo R: Unusual morphologic and humoral conditions in the field of plasmacytomas and Mdysproteinaemia. Acta Med Scand 445:206-211, 1966
16. Drazner FH: Multiple myeloma in the cat. Comp Cont Educ Pract Vet 4:206-216, 1982
17. Dust A, Norris AM, Valli VEO: Cutaneous lymphosarcoma with IgG immunoglobulin monoclonal gammopathy, serum hyperviscosity and hypercalcaemia in a cat. Can Vet J 23:235-239, 1982
18. Eastman CA: Plasma cell tumours in a cat. Feline Pract 24:26-30, 1996
19. Engle GC, Brody RS: A retrospective study of 395 feline neoplasms. J Am Anim Hosp Assoc 5:21-31, 1969
20. Farrow BR, Penny R: Multiple myeloma in a cat. J Am Vet Med Assoc 158:606-611, 1971
21. Forrester SD, Greco DS, Relford RL: Serum hyperviscosity syndrome associated with multiple myeloma in two cats. J Am Vet Med Assoc 200:79-82, 1992
22. Garand R, Avet-Loiseau H, Accard F, Moreau P, Harousseau JL, Bataille R: t(11;14) and t(4;14) translocations correlated with mature lymphoplasmacytoid and immature morphology, respectively, in multiple myeloma. Leukemia 17:2032-2035, 2003
23. Gatter KM, Rader A, Braziel RM: Fine-needle aspiration biopsy of anaplastic large cell lymphoma, small cell variant with prominent plasmacytoid features: case report. Diagn Cytopathol 26:113-116, 2002
24. Greenberg MJ, Schatzberg SJ, deLahunta A, Stokol T, Summers BA: Intracerebral plasma cell tumour in a cat: a case report and literature review. J Vet Intern Med 18:581-585, 2004
25. Greipp PR, Leong T, Bennett JM, Gaillard JP, Klein B, Stewart JA, Oken MM, Kay NE, Van Ness B, Kyle RA: Plasmablastic morphology: an independent prognostic factor with clinical and laboratory correlates: Eastern Cooperative Oncology Group (ECOG) myeloma trial E9486 report by the ECOG Myeloma Laboratory Group. Blood 91:2501-2507, 1998
26. Greipp PR, Raymond NM, Kyle RA, O'Fallon WM: Multiple myeloma: significance of plasmablastic subtype in morphological classification. Blood 65:305-310, 1985
27. Grogan TM: Plasma cell myeloma marrow diagnosis including morphologic and phenotypic features. Semin Diagn Pathol 20:211-225, 2003
28. Hallek M, Bergsagel PL, Anderson KC: Multiple myeloma: increasing evidence for a multistep transformation process. Blood 91:3-21, 1998
29. Hanna F: Multiple myelomas in cats. J Feline Med Surg 7:275-287, 2005
30. Harbison ML: Plasma cell myeloma and plasmacytoma. In: Diseases of the Cat: Medicine and Surgery, ed. Holzworth J, pp. 442-444. WB Saunders, Philadelphia, PA, 1987
31. Hedvat CV, Comenzo RL, Teruya-Feldstein J, Olshen AB, Ely SA, Osman K, Zhang Y, Kalakonda N, Nimer SD: Insights into extramedullary tumour cell growth revealed by expression profiling of human plasmacytomas and multiple myeloma. Br J Haematol 122:728-744, 2003
32. Hickford FH, Stokol T, vanGessel YA, Randolph JF, Schermerhorn T: Monoclonal immunoglobulin G cryoglobulinemia and multiple myeloma in a domestic shorthair cat. J Am Vet Med Assoc 217:1029-1033, 1007-1028, 2000
33. Holzworth J, Meier H: Reticulum cell myeloma in a cat. Cornell Vet 47:302-316, 1957
34. Hopper JE, Haren JM, Kmiecik TE: Evidence for shared idiotypy expressed by the IgM, IgG, and IgA serum proteins of a patient with a complex multiple paraprotein disorder. J Immunol 122:2000-2006, 1979
35. Jaffe ES, Harris NL, Stein H, Vardima JW: World Health Organization Classification of Tumors: Tumors of Haematopoietic and Lymphoid Tissues. IARC Press, Lyon, 2001
36. Kapadia SB: Multiple myeloma: a clinicopathologic study of 62 consecutively autopsied cases. Medicine (Baltimore) 59:380-392, 1980
37. Kapadia SB, Desai U, Cheng VS: Extramedullary plasmacytoma of the head and neck. Medicine 61:317-329, 1982
38. Katz MH: Multivariable analysis: a practical guide for clinicians. Cambridge University Press, Cambridge, 2001
39. King AJ, Davies DR, Irwin PJ: Feline multiple myeloma: literature review and four case reports. Aust Vet Pract 32:146-151, 2002
40. Kyriazidou A, Brown PJ, Lucke VM: Immunohistochemical staining of neoplastic and inflammatory plasma cell lesions in feline tissues. J Comp Pathol 100:337-341, 1989
41. Lin P, Hao S, Handy BC, Bueso-Ramos CE, Medeiros LJ: Lymphoid neoplasms associated with IgM paraprotein: a study of 382 patients. Am J Clin Path 123:200-205, 2005
42. th ed., pp. 712-718. McGraw-Hill, New York, NY, 1998
43. Lucke VM: Primary cutaneous plasmacytomas in the dog and cat. J Small Anim Pract 28:49-55, 1987
44. Ludbrook J: Multiple comparison procedures updated. Clin Exp Pharmacol Physiol 25:1032-1037, 1998
45. MacEwen EG, Hurvitz AI: Diagnosis and management of monoclonal gammopathies. Vet Clin North Am Small Anim Pract 7:119-132, 1977
46. Majzoub M, Breuer W, Platz SJ, Linke RP, Linke W, Hermanns W: Histopathologic and immunophenotypic characterization of extramedullary plasmacytomas in nine cats. Vet Pathol 40:249-253, 2003
47. Mandel NS, Esplin DG: A retroperitoneal extramedullary plasmacytoma in a cat with monoclonal gammopathy. J Am Anim Hosp Assoc 20:603-608, 1994
48. Matsui W, Huff CA, Wang Q, Malehorn MT, Barber J, Tanhehco Y, Smith BD, Civin CI, Jones RJ: Characterization of clonogenic multiple myeloma cells. Blood 103:2332-2336, 2004
49. Mellor PJ, Haugland S, Murphy S, Smith KC, Holloway A, Archer J, Powell RM, Polton G, Tasker S, McCormick D, Tempest ME, McNeil PE, Scase TJ, Knott CD, Bonfanti U, Villiers EJ, Argyle DJ, Herrtage ME, Day MJ: Myeloma-related disorders in cats commonly present as extramedullary neoplasms in contrast to myeloma in human patients: 24 cases with clinical follow up. J Vet Intern Med 20:1376-1383, 2006
50. Mellor PJ, Polton GA, Brearley M, Haugland S, Smith KC, Scase TJ, McNeil PE, Holloway A, Archer J, Powell RM, Villiers EJ, Herrtage ME, Argyle DJ, Day MJ: Solitary plasmacytoma of bone in two successfully treated cats. J Feline Med Surg 9:72-77, 2007
51. Mitcham SA, McGillivray SR, Haines DM: Plasma cell sarcoma in a cat. Can Vet J 26:98-100, 1985
52. nd ed. Teton NewMedia, Jackson, WY, 2002
53. Park CH, Bergsagel DE, McCulloch EA: Mouse myeloma tumor stem cells: a primary cell culture assay. J Natl Cancer Inst 46:411-422, 1971
54. Patel RT, Caceres A, French AF, McManus PM: Multiple myeloma in 16 cats: a retrospective study. Vet Clin Pathol 34:341-352, 2005
55. Platz SJ, Breuer W, Geisel O, Linke RP, Hermanns W: Identification of lambda light chain amyloid in eight canine and two feline extramedullary plasmacytomas. J Comp Pathol 116:45-54, 1997
56. Ponce F, Magnol JP, Marchal T, Chabanne L, Ledieu D, Bonnefont C, Felman P, Fournel-Fleury C: High-grade canine T-cell lymphoma/leukemia with plasmacytoid morphology: a clinical pathological study of nine cases. J Vet Diagn Invest 15:330-337, 2003
57. Potter M: Neoplastic development in plasma cells. Immunol Rev 194:177-195, 2003
58. Priester WA: The occurrence of tumours in domestic animals. NCI monograph 54, NIH Publication No. 80-2046. U.S. Government Printing Office, Washington, DC, 1980
59. Radhakrishnan A, Risbon RE, Patel RT, Ruiz B, Clifford CA: Progression of a solitary, malignant cutaneous plasma-cell tumour to multiple myeloma in a cat. Vet Comp Oncol 2:36-42, 2004
60. Regezi JA, Zarbo RJ, Keren DF: Plasma cell lesions of the head and neck: immunofluorescent determination of clonality from formalin-fixed, paraffin-embedded tissue. Oral Surg Oral Med Oral Pathol 56:616-621, 1983
61. Robillard N, Jego G, Pellat-Deceunynck C, Pineau D, Puthier D, Mellerin MP, Barille S, Rapp MJ, Harousseau JL, Amiot M, Bataille R: CD28, a marker associated with tumoral expansion in multiple myeloma. Clin Cancer Res 4:1521-1526, 1998
62. Rosenberg MP, Hohenhaus AE, Matus RE: Monoclonal gammopathy and lymphoma in a cat infected with FIV. J Am Anim Hosp Assoc 27:335-337, 1991
63. Rowland PH, Linke RP: Immunohistochemical characterization of lambda light-chain-derived amyloid in one feline and five canine plasma cell tumors. Vet Pathol 31:390-393, 1994
64. Russell RG: Bisphosphonates: mode of action and pharmacology. Pediatrics 119 (Suppl 2): S150-S162, 2007
65. Seidl S, Kaufmann H, Drach J: New insights into the pathophysiology of multiple myeloma. Lancet Oncol 4:557-564, 2003
66. Sheafor SE, Gamblin RM, Couto CG: Hypercalcaemia in two cats with multiple myeloma. J Am Anim Hosp Assoc 32:503-508, 1996
67. Sirohi B, Powles R: Multiple myeloma. Lancet 363:875-887, 2004
68. Spier CM, Grogan TM, Durie BG, Richter LC, Vela E, Frutiger Y, Rangel CS: T-cell antigen-positive multiple myeloma. Mod Pathol 3:302-307, 1990
69. Sukpanichnant S, Cousar JB, Leelasiri A, Graber SE, Greer JP, Collins RD: Diagnostic criteria and histologic grading in multiple myeloma: histologic and immunohistologic analysis of 176 cases with clinical correlation. Hum Pathol 25:308-318, 1994
70. Takishita M, Kosaka M, Goto T, Saito S: Cellular origin and extent of clonal involvement in multiple myeloma: genetic and phenotypic studies. Br J Haematol 87:735-742, 1994
71. Tani E, Santos GC, Svedmyr E, Skoog L: Fine needle aspiration cytology and immunocytochemistry of soft-tissue extramedullary plasma cell neoplasms. Diagn Cytopathol 20:120-124, 1998
72. Terpos E, Dimopoulos MA, Sezer O: The effect of novel anti-myeloma agents on bone metabolism of patients with multiple myeloma. Leukemia 21:1875-1884, 2007
73. Thiry A, Delvenne P, Fontaine M.-A, Boniver J: Comparison of bone marrow sections, smears and immunohistological staining for immunoglobulin light chains in the diagnosis of benign and malignant plasma cell proliferations. Histopathology 22:423-428, 1993
74. Valli VE, Jacobs RM, Norris A, Couto CG, Morrison WB, McCaw D, Cotter S, Ogilvie G, Moore A: The histologic classification of 602 cases of feline lymphoproliferative disease using the National Cancer Institute working formulation. J Vet Diagn Invest 12:295-306, 2000
75. Ward DA, McEntee MF, Weddle DL: Orbital plasmacytoma in a cat. J Small Anim Pract 38:576-578, 1997
76. Weh HJ, Bartl R, Seeger D, Selbach J, Kuse R, Hossfeld DK: Correlations between karyotype and cytologic findings in multiple myeloma. Leukemia 9:2119-2122, 1995
77. Williams DA, Goldschmidt MH: Hyperviscosity syndrome with IgM monoclonal gammopathy and hepatic plasmacytoid lymphosarcoma in a cat. J Small Anim Pract 23:311-323, 1982
78. Woodruff RK, Whittle JM, Malpas JS: Solitary plasmacytoma. I: Extramedullary soft tissue plasmacytoma. Cancer 43:2340-2343, 1979
79. Wutke K, Varbiro M, Rudiger KD, Kelenyi G: Cytological and histological classification of multiple myeloma. Haematologia 14:315-329, 1981
80. Zandecki M, Obein V, Bernardi F, Soenen V, Flactif M, Lai JL, Francois M, Facon T: Monoclonal gammopathy of undetermined significance: chromosome changes are a common finding within bone marrow plasma cells. Br J Haematol 90:693-696, 1995