Chemotherapy-associated osteonecrosis in cancer patients with solid tumours: A systematic review

Drug Safety

Volumn 31, Issue 5, 2008, Pages 359-371

  Shim, Katharine ^a   MacKenzie, Mary J ^a,b   Winquist, Eric ^a,b  

^a WESTERN UNIVERSITY   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Antineoplastics, adverse reactions; Osteonecrosis, drug induced; Solid tumours

Indexed keywords

BEVACIZUMAB; BLEOMYCIN; CARBOPLATIN; CISPLATIN; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYTOTOXIC AGENT; DACTINOMYCIN; DEXAMETHASONE; DOCETAXEL; DOXORUBICIN; EPIRUBICIN; ETOPOSIDE; FLUOROURACIL; IFOSFAMIDE; IRINOTECAN; MELPHALAN; METHOTREXATE; MITOXANTRONE; PACLITAXEL; PREDNISONE; SORAFENIB; SUNITINIB; TOPOTECAN; VINBLASTINE; VINCA ALKALOID; VINCRISTINE;

BONE NECROSIS; BONE RADIOGRAPHY; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER SURVIVAL; COMBINATION CHEMOTHERAPY; DECOMPRESSION SURGERY; DIFFERENTIAL DIAGNOSIS; HUMAN; HYPERLIPIDEMIA; LUNG SMALL CELL CANCER; MEDICAL LITERATURE; NONHUMAN; OSTEOSARCOMA; OSTEOTOMY; OVARY CANCER; PATHOPHYSIOLOGY; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PHYSICAL EXAMINATION; PHYSIOTHERAPY; PRIORITY JOURNAL; PROPHYLAXIS; REVIEW; RISK FACTOR; SOLID TUMOR; TESTIS CANCER; TOTAL HIP PROSTHESIS;

ANTINEOPLASTIC AGENTS; HUMANS; NEOPLASMS; OSTEONECROSIS;

EID: 42449142614     PISSN: 01145916     EISSN: None     Source Type: Journal    
DOI: 10.2165/00002018-200831050-00001     Document Type: Review

References (65)

1. Winquist EW, Bauman GS, Balogh J. Nontraumatic osteonecrosis after chemotherapy for testicular cancer. Am J Clin Oncol 2001; 24: 603-6
2. Herbst RS, Bajorin DF, Bleiberg H, et al. Clinical cancer advances 2005: major research advances in cancer treatment, prevention and screening. A report from the American Society of Clinical Oncology. J Clin Oncol 2006; 24: 190-205
3. Van Poznak D, Estilo C. Osteonecrosis of the jaw in cancer patients receiving IV bisphosphonates. Oncology (Williston Park) 2006; 20: 1053-62
4. Obrist R, Hartmann D, Obrecht JP. Osteonecrosis after chemotherapy. Lancet 1978; I: 1316
5. Perloff M, Lesnik GJ. Avascular necrosis of femoral head: association with adjuvant chemotherapy for breast carcinoma. Cancer Treat Rep 1980; 64: 361-2
6. Harper PG, Trask C, Souhami RL. Avascular necrosis of bone caused by combination chemotherapy without corticosteroids. BMJ 1984; 288: 267-8
7. Marymont JV, Kaufmann EE. Osteonecrosis of bone associated with combination chemotherapy without corticosteroids. Clin Orthop 1986; 204: 150-3
8. Kolin E, Sherry H. Avascular necrosis of the femoral head in patients being treated for malignancy. Mt Sinai J Med 1987; 54: 516-21
9. Meneghello A, Presacco D, Di Maggio C. Aseptic necrosis of the femoral head in cancer patients affected with vincristine/vinblastine-induced neuropathy [in Italian]. Radiol Med (Torino) 1989; 77: 626-30
10. Wuisman R, Erlemann R, Roessner A, et al. Case report 669. Skeletal Radiol 1991; 20: 294-8
11. Forrai G, Baki M, Bodrogi I. Incidence of osteoporosis and aseptic femur head necrosis following complex therapy of germ cell testicular tumors [in Hungarian]. Orv Hetil 1994; 135: 1695-700
12. Jones DN. Multifocal osteonecrosis following chemotherapy and short-term corticosteroid therapy in a patient with small-cell bronchogenic carcinoma. J Nucl Med 1994; 35: 1327-50
13. Gogas H, Fennelly D. Avascular necrosis following extensive chemotherapy and dexamethasone treatment in a patient with advanced ovarian cancer: case report and review of the literature. Gynecol Oncol 1996; 63: 379-81
14. Besson C, Stelianides S, Belmatoug N, et al. Multifocal osteonecrosis after chemotherapy in a patient with breast cancer. J Rheumatol 1998; 25: 2479-80
15. Cook AM, Patterson H, Nicholls J, et al. Avascular necrosis in patients treated with BEP chemotherapy for testicular tumours. Clin Oncol (R Coll Radiol) 1999; 11: 126-7
16. Cook AM, Dzik-Jurasz ASK, Padhani AR, et al. The prevalence of avascular necrosis in patients treated with chemotherapy for testicular tumours. Br J Cancer 2001; 85: 1624-6
17. Coles C, Williams M. Avascular necrosis in patients treated with BEP chemotherapy for testicular tumours. Clin Oncol (R Coll Radiol) 2000; 12: 69
18. Dawson LK, Nussey F, Oliver TB, et al. Osteonecrosis of the femoral head following adjuvant chemotherapy for breast cancer. Breast 2001; 10: 447-9
19. Magné N, Foa C, Bruneton JN, et al. Séminome du testicule et ostéonécrose aseptique multifocale au décours d'une chimiothérapie. Rev Med Interne 2001; 22: 62-4
20. Virik K, Karapetis C, Droufakou S, et al. Avascular necrosis of bone: the hidden risk of glucocorticoids used as antiemetics in cancer chemotherapy. Int J Clin Pract 2001; 55: 344-5
21. Bojko P, Hilger RA, Ruehm SG, et al. Femoral head necrosis in three patients with relapsed ovarian cancer receiving high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation. Bone Marrow Transplant 2003; 31: 487-91
22. van den Berkmortel, de Wit R, de Rooy J, et al. Osteronecrosis in patients with testicular tumours treated with chemotherapy. Neth J Med 2004; 62: 23-7
23. Beckmann J, Götz J, Grifka J, et al. Skaphoidnekrose nach chemotherapie. Orthopade 2005; 34: 938-40
24. Kaila R, Wolman RL. Groin pain in athletes: a consequence of femoral head avascular necrosis after testicular cancer chemotherapy. Clin J Sport Med 2006; 16: 175-6
25. Jones Jr JP. Coagulopathies and osteonecrosis. Acta Orthop Belg 1999; 65 Suppl. 1: 5-8
26. Assouline-Daya Y, Chang C, Greenspan A, et al. Pathogenesis and natural history of osteonecrosis. Semin Arthritis Rheum 2002; 32: 94-124
27. Motomura G, Yamamoto T, Miyanishi K, et al. Bone marrow fat-cell enlargement in early steroid-induced osteonecrosis: a histomorphometric study of autopsy cases. Pathol Res Pract 2005; 100: 807-11
28. Wang G, Cui Q, Balian G. The pathogenesis and prevention of steroid-induced osteonecrosis. Clin Orthop Relat Res 2000; 370: 295-310
29. Li X, Jin L, Cui Q, et al. Steroid effects on osteogenesis through mesenchymal cell gene expression. Osteoporos Int 2005; 16: 101-8
30. Deitcher SR. Cancer and thrombosis: mechanisms and treatment. J Thromb Thrombolysis 2003; 16: 21-31
31. Zalavras C, Dailian Z, Elisaf M, et al. Potential aetiological factors concerning the development of osteonecrosis of the femoral head. Eur J Clin Invest 2000; 30: 215-21
32. Wada M, Kumagai K, Murata M, et al. Warfarin reduces the incidence of osteonecrosis of the femoral head in spontaneously hypertensive rats. J Orthop Sci 2004; 9: 585-90
33. Smith DW. Is avascular necrosis of the femoral head the result of inhibition of angiogenesis? Med Hypotheses 1997; 49: 497-500
34. Vadasz Z, Misselevich I, Norman D, et al. Localization of vascular endothelial growth factor during the early reparative phase of the rats' vessels deprivation-induced osteonecrosis of the femoral heads. Exp Mol Pathol 2004; 77: 145-8
35. Yang C, Yang S, Du J, et al. Vascular endothelial growth factor gene transfection to enhance the repair of avascular necrosis of the femoral head of rabbit. Chin Med J 2003; 116: 1544-8
36. Nakame A, Sunagawa T, Ishida O, et al. Acceleration of surgical angiogenesis in necrotic bone with a single injection of fibroblast growth factor-2 (FGF-2). J Orthop Res 2004; 22: 509-13
37. Hong JM, Kim TH, Chae Sc, et al. Association study of hypoxia inducible factor 1 alpha with osteonecrosis of the femoral head in a Korean population. Osteoarthritis Cartilage 2007; 15 (6): 688-94
38. Miller KD, Sweeney CJ, Sledge GW. Redefining the target: chemotherapeutics as anti-angiogenics. J Clin Oncol 2001; 19: 1195-206
39. Wong SY, Evans RA, Needs C, et al. The pathogenesis of osteoarthritis of the hip: evidence for primary osteocyte death. Clin Orthop Rel Relat Res 1987; 214: 305-12
40. Spencer JD, Humphreys S, Tighe JR, et al. Early avascular necrosis of the femoral head: report of a case and review of the literature. J Bone Joint Surg Br 1986; 68: 414-7
41. Calder JDF, Buttery L, Revell PA, et al. Apoptosis: a significant cause of bone cell death in osteonecrosis of the femoral head. J Bone Joint Surg Br 2004; 86: 1209-11
42. Gangji V, Hauzeur J, Schoutens A, et al. Abnormalities in the replicative capacity of osteoblastic cells in the proximal femur of patients with osteonecrosis of the femoral head. J Rheum 2003; 30: 348-50
43. Banfi A, Podest M, Fazzuoli L, et al. High-dose chemotherapy shows a dose-dependent toxicity to bone marrow osteoprogenitors. Cancer 2001; 92: 2419-28
44. Davies JH, Evans BA, Jenney MEM, et al. In vitro effects of combination chemotherapy on osteoblasts: implications for osteopenia in childhood malignancy. Bone 2002; 31: 319-26
45. Xian CJ, Howarth GS, Cool JC, et al. effects of 5-fluorouracil chemotherapy and insulin-like growth factor-I pretreatment on growth plate cartilage and metaphyseal bone in rats. Bone 2004; 35: 739-49
46. Inoue S, Horii M, Asano T, et al. Risk factors for nontraumatic osteonecrosis of the femoral head after renal transplantation. J Orthop Sci 2003; 8: 751-6
47. Fink B, Degenhardt S, Paselk C, et al. Early detection of avascular necrosis of the femoral head following renal transplantation. Arch Orthop Trauma Surg 1997; 116: 151-6
48. Koo KH, Kim R, Kim YS, et al. Risk period for developing osteonecrosis of the femoral head in patients on steroid treatment. Clin Rheum 2002; 21: 299-303
49. Griffith JF, Antonio GE, Kumta SM, et al. Osteonecrosis of the hip and knee in patients with severe acute respiratory syndrome treated with steroids. Radiology 2005; 235: 168-75
50. Steinberg ME, Mont MA. Osteonecrosis. In: Chapman's orthopaedic surgery. 3rd ed. Philadelphia (PA): Lippincott Williams & Wilkins, 2001: 3263-75
51. Mont MA, Jones LC, Hungerford DS. Nontraumatic osteonecrosis of the femoral head: ten years later. J Bone Joint Surg Am 2006; 88: 1117-32
52. Watson RM, Roach NA, Dalinka MK. Avascular necrosis and bone marrow edema syndrome. Radiol Clin N Am 2004; 42: 207-19
53. Radke S, Kenn W, Eulert J. Transient bone marrow edema syndrome progressing to avascular necrosis of the hip: a case report and review of the literature. Clin Rheumatol 2004; 23: 83-8
54. Vande Berg BE, Malghem JJ, Labaisse MA, et al. MR imaging of avascular necrosis and transient marrow edema of the femoral head. Radiographics 1993; 13: 501-20
55. Janssens AM, Offner FC, Van Hove WZ. Bone marrow necrosis. Cancer 2000; 88 (8): 1769-80
56. Mont MA, Ragland PS, Khaled Saleh J, et al. Analysis of classification systems for avascular necrosis of the femoral head [abstract]. J Bone Joint Surg Br 2006; 88-B Suppl. II: 308
57. Gardeniers JWM. Report of the committee of staging and nomenclature. ARCO News Lett 1993; 5: 79-82
58. Pritchett JW. Statin therapy decreases the risk of osteonecrosis in patients receiving steroids. Clin Orthop Relat Res 2001; 386: 173-8
59. Jones LC, Hungerford DS. Osteonecrosis: etiology, diagnosis, and treatment. Curr Opin Rheumatol 2004; 16: 443-9
60. Hungerford DS, Jones LC. Asymptomatic osteonecrosis. Clin Ortho 2004; 429: 124-30
61. Hernigou P, Habibi A, Bachir D. The natural history of asymptomatic osteonecrosis of the femoral head in adults with sickle cell disease. J Bone Joint Surg Am 2006; 88: 2565-72
62. Koo KH, Kim R, Ko GH, et al. Preventing collapse in early osteonecrosis of the femoral head: a randomised clinical trial of core decompression. J Bone Joint Surg Br 1995 Nov; 77 (6): 870-4
63. Hernigou P, Beaujean F. Treatment of osteonecrosis with autologous bone marrow grafting. Clin Orthop Relat Res 2002 Dec; (405): 14-23
64. Hernigou P, Poignard A, Manicom O, et al. The use of percutaneous autologous bone marrow transplantation in nonunion and avascular necrosis of bone. J Bone Joint Surg Br 2005; 87: 896-902
65. Dhadda AS, Chan S. Bilateral avascular necrosis of the hips after chemoradiotherapy for cervical cancer. Clin Oncol (R Coll Radiol) 2006 Sep; 18 (7): 576-7