Sustained virological and biochemical responses to lamivudine and adefovir dipivoxil combination in a chronic hepatitis B infection despite mutations conferring resistance to both drugs

Comparative Hepatology

Volumn 7, Issue , 2008, Pages

  Larrat, Sylvie ^a   Hilleret, Marie Noëlle ^a   Germi, Raphaele ^a   Lupo, Julien ^a   Nicod, Sandrine ^a   Zarski, Jean Pierre ^a   Seigneurin, Jean Marie ^a   Morand, Patrice ^a  

^a GRENOBLE UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADEFOVIR DIPIVOXIL; ALANINE AMINOTRANSFERASE; HEPATITIS B CORE ANTIBODY; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; LAMIVUDINE; VIRUS DNA;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANTIBIOTIC RESISTANCE; ARTICLE; CASE REPORT; CHRONIC DISEASE; COMBINATION CHEMOTHERAPY; DRUG RESPONSE; GENE MUTATION; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN TISSUE; LIVER BIOPSY; MALE; MONOTHERAPY; SEQUENCE ANALYSIS; VIRUS LOAD;

EID: 42449139202     PISSN: None     EISSN: 14765926     Source Type: Journal    
DOI: 10.1186/1476-5926-7-3     Document Type: Article

References (20)

1. Locarnini S Molecular virology and the development of resistant mutants: implications for therapy Semin Liver Dis 2005, 25(Suppl 1):9-19. 10.1055/ s-2005-915645 16103977
2. Angus P Vaughan R Xiong S Yang H Delaney W Gibbs C Brosgart C Colledge D Edwards R Ayres A Bartholomeusz A Locarnini S Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase Gastroenterology 2003, 125(2):292-297. 10.1016/ S0016-5085(03)00939-9 12891527
3. Fung SK Andreone P Han SH Rajender Reddy K Regev A Keeffe EB Hussain M Cursaro C Richtmyer P Marrero JA Lok AS Adefovir-resistant hepatitis B can be associated with viral rebound and hepatic decompensation J Hepatol 2005, 43(6):937-43. Epub 2005 Jul 7. 10.1016/j.jhep.2005.05.037 16168522
4. Fung SK Chae HB Fontana RJ Conjeevaram H Marrero J Oberhelman K Hussain M Lok AS Virologic response and resistance to adefovir in patients with chronic hepatitis B J Hepatol 2006, 44(2):283-90. Epub 2005 Nov 15. 10.1016/j.jhep.2005.10.018 16338024
5. Villeneuve JP Durantel D Durantel S Westland C Xiong S Brosgart CL Gibbs CS Parvaz P Werle B Trepo C Zoulim F Selection of a hepatitis B virus strain resistant to adefovir in a liver transplantation patient J Hepatol 2003, 39(6):1085-1089. 10.1016/j.jhep.2003.09.022 14642631
6. Lai CL Dienstag J Schiff E Leung NW Atkins M Hunt C Brown N Woessner M Boehme R Condreay L Prevalence and clinical correlates of YMDD variants during lamivudine therapy for patients with chronic hepatitis B Clin Infect Dis 2003, 36(6):687-96. Epub 2003 Mar 5. 10.1086/368083 12627352
7. Hadziyannis SJ Tassopoulos NC Heathcote EJ Chang TT Kitis G Rizzetto M Marcellin P Lim SG Goodman Z Ma J Arterburn S Xiong S Currie G Brosgart CL Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B N Engl J Med 2005, 352(26):2673-2681. 10.1056/NEJMoa042957 15987916
8. Westland CE Yang H Delaney WE Gibbs CS Miller MD Wulfsohn M Fry J Brosgart CL Xiong S Week 48 resistance surveillance in two phase 3 clinical studies of adefovir dipivoxil for chronic hepatitis B Hepatology 2003, 38(1):96-103. 10.1053/jhep.2003.50288 12829991
9. Locarnini SQ X. Arterburn, S. Snow, A. Brosgart, C.L. Currie, G. Wulfsohn, M. Miller, M.D. Xiong, S. Incidence and predictors of emergence of adefovir resistant HBV during four years of Adefovir Dipivoxil (ADV) therapy for patients with chronic hepatitis b (CHB). 40th Annual Meeting of EASL, Paris, France 2005
10. Hussain M Fung S Libbrecht E Sablon E Cursaro C Andreone P Lok AS Sensitive line probe assay that simultaneously detects mutations conveying resistance to lamivudine and adefovir J Clin Microbiol 2006, 44(3):1094-1097. 1393162 16517902 10.1128/JCM.44.3.1094-1097.2006
11. Lok AS Zoulim F Locarnini S Mangia A Niro G Decraemer H Maertens G Hulstaert F De Vreese K Sablon E Monitoring drug resistance in chronic hepatitis B virus (HBV)-infected patients during lamivudine therapy: evaluation of performance of INNO-LiPA HBV DR assay J Clin Microbiol 2002, 40(10):3729-3734. 130856 12354872 10.1128/JCM.40.10.3729-3734.2002
12. Newton CR Graham A Heptinstall LE Powell SJ Summers C Kalsheker N Smith JC Markham AF Analysis of any point mutation in DNA. The amplification refractory mutation system (ARMS) Nucleic Acids Res 1989, 17(7):2503-2516. 317639 2785681 10.1093/nar/17.7.2503
13. Punia P Cane P Teo CG Saunders N Quantitation of hepatitis B lamivudine resistant mutants by real-time amplification refractory mutation system PCR J Hepatol 2004, 40(6):986-992. 10.1016/S0168-8278(04)00062-5 15158340
14. Villet S Pichoud C Villeneuve JP Trepo C Zoulim F Selection of a multiple drug-resistant hepatitis B virus strain in a liver-transplanted patient Gastroenterology 2006, 131(4):1253-1261. 10.1053/ j.gastro.2006.08.013 17030194
15. Karatayli E Karayalcin S Kayhan H Turkyilmaz AR Sahin F Yurdaydin C Bozdayi AM A novel mutation pattern developed during lamivudine treatment shows cross-resistance to adefovir dipivoxil treatment. 41st Annual Meeting of the European Association for the Study of the Liver 2006 abstr 484
16. Osiowy C Villeneuve JP Heathcote EJ Giles E Borlang J Detection of rtN236T and rtA181V/T mutations associated with resistance to adefovir dipivoxil in samples from patients with chronic hepatitis B virus infection by the INNO-LiPA HBV DR line probe assay (version 2) J Clin Microbiol 2006, 44(6):1994-1997. 1489409 16757589 10.1128/JCM.02477-05
17. Lim SG Hadziyannis S Tassopoulos N Chang TT Hathcote J Kitis G Rizzetto M Marcellin P Arterburn S Qi X Brosgart C Currie G for the Adefovir 438 Study group Clinical Profile of HBeAg chronic Hepatitis B patients with Adefovir dipivoxil resistance mutations 40th Annual Meeting of the European Association for the Study of the Liver 2005 abstr 508
18. Brunelle MN Jacquard AC Pichoud C Durantel D Carrouee-Durantel S Villeneuve JP Trepo C Zoulim F Susceptibility to antivirals of a human HBV strain with mutations conferring resistance to both lamivudine and adefovir Hepatology 2005, 41(6):1391-1398. 10.1002/hep.20723 15915463
19. Ratziu V Thibault V Benhamou Y Poynard T Successful rescue therapy with tenofovir in a patient with hepatic decompensation and adefovir resistant HBV mutant Comp Hepatol 2006, 5:1. 1363728 16405720 10.1186/ 1476-5926-5-1
20. Lok AS Zoulim F Locarnini S Bartholomeusz A Ghany MG Pawlotsky JM Liaw YF Mizokami M Kuiken C Antiviral drug-resistant HBV: Standardization of nomenclature and assays and recommendations for management Hepatology 2007, 46(1):254-265. 10.1002/hep.21698 17596850