Drug-induced alterations to gene and protein expression in intestinal epithelial cell 6 cells suggest a role for calpains in the gastrointestinal toxicity of nonsteroidal anti-inflammatory agents

Journal of Pharmacology and Experimental Therapeutics

Volumn 325, Issue 2, 2008, Pages 389-399

  Raveendran, N N ^a   Silver, K ^a   Freeman, L C ^a   Narvaez, D ^a   Weng, K ^a   Ganta, S ^a   Lillich, James D ^a  

^a KANSAS STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; CALPAIN; CALPAIN 1; CALPAIN 2; CALPAIN 8; CALPASTATIN; INDOMETACIN; MESSENGER RNA; METHIONINE DERIVATIVE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N ACETYLLEUCYLLEUCYL METHIONINAL; N ACETYLLEUCYLLEUCYL NORLEUCINAL; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEASOME INHIBITOR; UNCLASSIFIED DRUG; N-(2-CYCLOHEXYLOXY-4-NITROPHENYL)METHANESULFONAMIDE; NITROBENZENE DERIVATIVE; PROSTAGLANDIN SYNTHASE INHIBITOR; PYRAZOLE DERIVATIVE; SULFONAMIDE;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; GASTROINTESTINAL TOXICITY; GENE EXPRESSION; IMMUNOBLOTTING; INTESTINE EPITHELIUM CELL; MICROARRAY ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; ANIMAL; CELL LINE; CELL MOTION; CYTOLOGY; DNA MICROARRAY; DRUG EFFECT; EPITHELIUM CELL; GENETICS; INTESTINE MUCOSA; METABOLISM;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CALPAIN; CELL LINE; CELL MOVEMENT; CYCLOOXYGENASE INHIBITORS; EPITHELIAL CELLS; GENE EXPRESSION; INDOMETHACIN; INTESTINAL MUCOSA; NITROBENZENES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PYRAZOLES; RATS; RNA, MESSENGER; SULFONAMIDES;

EID: 42449134526     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.127720     Document Type: Article

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