Immunological mechanisms in glaucoma

Seminars in Immunopathology

Volumn 30, Issue 2, 2008, Pages 121-126

  Grus, F ^a,c   Sun, D ^b  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b University of Louisville School of Medicine   (United States)

^c NONE   (Germany)

Author keywords

Autoantibodies; Autoimmunity; Glaucoma; Natural autoimmunity

Indexed keywords

ANTIGEN; AUTOANTIBODY; ENOLASE; GLUTATHIONE TRANSFERASE; GLYCOSAMINOGLYCAN; NEURON SPECIFIC ENOLASE; PHOSPHATIDYLSERINE ANTIBODY; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ANTIBODY DETECTION; AUTOIMMUNITY; GLAUCOMA; HUMAN; IMMUNE SYSTEM; PRIORITY JOURNAL; REVIEW; RISK FACTOR;

ANIMALS; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNITY; GLAUCOMA; HUMANS;

EID: 42449130879     PISSN: 18632297     EISSN: 18632300     Source Type: Journal    
DOI: 10.1007/s00281-008-0105-8     Document Type: Review

References (56)

1. Avrameas S (1991) Natural autoantibodies: from 'horror autotoxicus' to 'gnothi seauton'. Immunol Today 12:154-159
2. Erlanger BF (1989) Some thoughts on the structural basis of internal imagery. Immunol Today 10:151-152
3. Fernandez-Shaw C, Marina A, Cazorla P, Valdivieso F, Vazquez J (1997) Anti-brain spectrin immunoreactivity in Alzheimer's disease: degradation of spectrin in an animal model of cholinergic degeneration. J Neuroimmunol 77:91-98
4. Fisher J, Levkovitch-Verbin H, Schori H, Yoles E, Butovsky O, Kaye JF, Ben-Nun A, Schwartz M (2001) Vaccination for neuroprotection in the mouse optic nerve: implications for optic neuropathies. J Neurosci 21:136-142
5. George J, Gilburd B, Shoenfeld Y (1997) The emerging concept of pathogenic natural autoantibodies. Hum Antibodies 8:70-75
6. Graus YM, De Baets MH (1993) Myasthenia gravis: an autoimmune response against the acetylcholine receptor. Immunol Res 12:78-100
7. Grus FH, Joachim SC, Bruns K, Lackner KJ, Pfeiffer N, Wax MB (2006) Serum autoantibodies to {alpha}-fodrin are present in glaucoma patients from Germany and the United States. Invest Ophthalmol Vis Sci 47:968-976
8. Grus FH, Joachim SC, Hoffmann EM, Pfeiffer N (2004) Complex autoantibody repertoires in patients with glaucoma. Mol Vis 10:132-137
9. Grus FH, Joachim SC, Pfeiffer N (2003) Analysis of complex autoantibody repertoires by surface-enhanced laser desorption/ionization-time of flight mass spectrometry. Proteomics 3:957-961
10. Hughes BW, Moro De Casillas ML, Kaminski HJ (2004) Pathophysiology of myasthenia gravis. Semin Neurol 24:21-30
11. Ikeda Y, Maruyama I, Nakazawa M, Ohguro H (2002) Clinical significance of serum antibody against neuron-specific enolase in glaucoma patients. Jpn J Ophthalmol 46:13-17
12. Janicke RU, Ng P, Sprengart ML, Porter AG (1998) Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis. J Biol Chem 273:15540-15545
13. Joachim SC, Bruns K, Lackner KJ, Pfeiffer N, Grus FH (2007) Antibodies to alpha B-crystallin, vimentin, and heat shock protein 70 in aqueous humor of patients with normal tension glaucoma and IgG antibody patterns against retinal antigen in aqueous humor. Curr Eye Res 32:501-509
14. Joachim SC, Bruns K, Lackner KJ, Pfeiffer N, Grus FH (2007) Analysis of IgG antibody patterns against retinal antigens and antibodies to alpha-crystallin, GFAP, and alpha-enolase in sera of patients with "wet" age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 245:619-626
15. Joachim SC, Grus FH, Pfeiffer N (2003) Analysis of autoantibody repertoires in sera of patients with glaucoma. Eur J Ophthalmol 13:752-758
16. Joachim SC, Kraft D, Pfeiffer N, Wax MB, Grus FH (2006) Antibody profile analysis via western blot and protein-chip methods in a retinal ganglion cell degeneration animal model. From Genome to Proteome Meeting
17. Joachim SC, Pfeiffer N, Grus FH (2005) Autoantibodies in patients with glaucoma: a comparison of IgG serum antibodies against retinal, optic nerve, and optic nerve head antigens. Graefes Arch Clin Exp Ophthalmol 243:817-823
18. Joachim SC, Reichelt J, Pfeiffer N, Grus FH (2006) Autoantibody profiles against human retina in sera of glaucoma patients. DOG Meeting
19. Joachim SC, Wuenschig D, Pfeiffer N, Grus FH (2007) IgG antibody patterns in aqueous humor of patients with primary open angle glaucoma and pseudoexfoliation glaucoma. Mol Vis 13:1573-1579
20. Johnson EM Jr., Gorin PD, Osborne PA, Rydel RE, Pearson J (1982) Effects of autoimmune NGF deprivation in the adult rabbit and offspring. Brain Res 240:131-140
21. Kremmer S, Kreuzfelder E, Klein R, Bontke N, Henneberg-Quester KB, Steuhl KP, Grosse-Wilde H (2001) Antiphosphatidylserine antibodies are elevated in normal tension glaucoma. Clin Exp Immunol 125:211-215
22. Kulberg AY (1999) Immunoglobulins and Antibodies. Russ J Immunol 4:241-242
23. Li WH, Zhao J, Li HY, Liu H, Li AL, Wang HX, Wang J, He K, Liang B, Yu M, Shen BF, Zhang XM (2006) Proteomics-based identification of autoantibodies in the sera of healthy Chinese individuals from Beijing. Proteomics 6:4781-4789
24. Maruyama I, Ohguro H, Ikeda Y (2000) Retinal ganglion cells recognized by serum autoantibody against gamma-enolase found in glaucoma patients. Invest Ophthalmol Vis Sci 41:1657-1665
25. McKinnon SJ (2003) Glaucoma: ocular Alzheimer's disease? Front Biosci 8:s1140-1156
26. Nobrega A, Haury M, Grandien A, Malanchere E, Sundblad A, Coutinho A (1993) Global analysis of antibody repertoires. II. Evidence for specificity, self-selection and the immunological "homunculus" of antibodies in normal serum. Eur J Immunol 23:2851-2859
27. Poletaev A, Osipenko L (2003) General network of natural autoantibodies as immunological homunculus (Immunculus). Autoimmun Rev 2:264-271
28. Poletaev AB, Abrosimova AA, Sokolov MA, Gekht AB, Alferova VV, Gusev EI, Nikolaeva TY, Selmi C (2004) Dialectics and implications of natural neurotropic autoantibodies in neurological disease and rehabilitation. Clin Dev Immunol 11:151-156
29. Poletaev AB, Gnedenko BB, Makarova AA, Krasnopolsky VI, Budykina TS, Petrukhin VA, Morozov SG (2000) Possible mechanisms of diabetic fetopathy. Hum Antibodies 9:189-197
30. Poletaev AB, Morozov SG, Gnedenko BB, Zlunikin VM, Korzhenevskey DA (2000) Serum anti-S100b, anti-GFAP and anti-NGF autoantibodies of IgG class in healthy persons and patients with mental and neurological disorders. Autoimmunity 32:33-38
31. Quigley HA (1996) Number of people with glaucoma worldwide. Br J Ophthalmol 80:389-393
32. Quigley HA, Broman AT (2006) The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol 90:262-267
33. Reichelt J, Joachim SC, Pfeiffer N, Grus FH (2006) Analysis of autoantibodies against human retinal antigens in sera of patients with glaucoma and ocular hypertension. Graefes Arch Clin Exp Ophthalmol DOI 10.1007/s00417-007-0737-8
34. Scofield RH (2004) Autoantibodies as predictors of disease. Lancet 363:1544-1546
35. Sihag RK, Cataldo AM (1996) Brain beta-spectrin is a component of senile plaques in Alzheimer's disease. Brain Res 743:249-257
36. Singer HS, Loiselle CR, Lee O, Garvey MA, Grus FH (2003) Anti-basal ganglia antibody abnormalities in Sydenham chorea. J Neuroimmunol 136:154-161
37. Sommer A, Tielsch JM, Katz J, Quigley HA, Gottsch JD, Javitt J, Singh K (1991) Relationship between intraocular pressure and primary open angle glaucoma among white and black Americans. The Baltimore Eye Survey. Arch Ophthalmol 109:1090-1095
38. Tahzib NG, Ransom NL, Reitsamer HA, McKinnon SJ (2004) Alpha-fodrin is cleaved by caspase-3 in a chronic ocular hypertensive (COH) rat model of glaucoma. Brain Res Bull 62:491-495
39. Terzoglou AG, Routsias JG, Avrameas S, Moutsopoulos HM, Tzioufas AG (2006) Preferential recognition of the phosphorylated major linear B-cell epitope of La/SSB 349-368 aa by anti-La/SSB autoantibodies from patients with systemic autoimmune diseases. Clin Exp Immunol 144:432-439
40. Tezel G, Wax MB (2004) The immune system and glaucoma. Curr Opin Ophthalmol 15:80-84
41. Tezel G, Wax MB (2007) Glaucoma. Chem Immunol Allergy 92:221-227
42. Tezel G, Edward DP, Wax MB (1999) Serum autoantibodies to optic nerve head glycosaminoglycans in patients with glaucoma. Arch Ophthalmol 117:917-924
43. Tezel G, Hernandez R, Wax MB (2000) Immunostaining of heat shock proteins in the retina and optic nerve head of normal and glaucomatous eyes. Arch Ophthalmol 118:511-518
44. Tezel G, Luo C, Yang X (2007) Accelerated aging in glaucoma: immunohistochemical assessment of advanced glycation end products in the human retina and optic nerve head. Invest Ophthalmol Vis Sci 48:1201-1211
45. Tezel G, Seigel GM, Wax MB (1998) Autoantibodies to small heat shock proteins in glaucoma. Invest Ophthalmol Vis Sci 39:2277-2287
46. Tezel G, Yang X, Cai J (2005) Proteomic identification of oxidatively modified retinal proteins in a chronic pressure-induced rat model of glaucoma. Invest Ophthalmol Vis Sci 46:3177-3187
47. Tezel G, Yang X, Luo C, Peng Y, Sun SL, Sun D (2007) Mechanisms of immune system activation in glaucoma: oxidative stress-stimulated antigen presentation by the retina and optic nerve head glia. Invest Ophthalmol Vis Sci 48:705-714
48. Vazquez J, Fernandez-Shaw C, Marina A, Haas C, Cacabelos R, Valdivieso F (1996) Antibodies to human brain spectrin in Alzheimer's disease. J Neuroimmunol 68:39-44
49. Vincent A, McConville J, Farrugia ME, Newsom-Davis J (2004) Seronegative myasthenia gravis. Semin Neurol 24:125-133
50. Wax MB, Tezel G (2002) Neurobiology of glaucomatous optic neuropathy: diverse cellular events in neurodegeneration and neuroprotection. Mol Neurobiol 26:45-55
51. Wax MB, Barrett DA, Pestronk A (1994) Increased incidence of paraproteinemia and autoantibodies in patients with normal-pressure glaucoma. Am J Ophthalmol 117:561-568
52. Wax MB, Tezel G, Saito I, Gupta RS, Harley JB, Li Z, Romano C (1998) Anti-Ro/SS-A positivity and heat shock protein antibodies in patients with normal-pressure glaucoma. Am J Ophthalmol 125:145-157
53. Weinreb RN, Khaw PT (2004) Primary open-angle glaucoma. Lancet 363:1711-1720
54. Yang J, Tezel G, Patil RV, Romano C, Wax MB (2001) Serum autoantibody against glutathione S-transferase in patients with glaucoma. Invest Ophthalmol Vis Sci 42:1273-1276
55. Zimmermann CW, Eblen F (1993) Repertoires of autoantibodies against homologous eye muscle in ocular and generalized myasthenia gravis differ. Clin Investig 71:445-451
56. Zimmermann CW, Weiss G (1987) Antibodies not directed against the acetylcholine receptor in myasthenia gravis. An immunoblot study. J Neuroimmunol 16:225-236