Vaginal microbicides: The importance of effective distribution, retention and coating of the mucosa

AIDS

Volumn 22, Issue 7, 2008, Pages 908-909

  das Neves, José ^a,b   Santos, Bárbara ^b   Cunha, Teresa ^b   Teixeira, Branca ^b   Rocha, Patrocínia ^b   Dias, Gustavo ^b  

^a UNIVERSITY OF PORTO   (Portugal)

^b HOSPITAL DE SANTO ANTÓNIO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

MICROBICIDE;

DRUG COATING; DRUG DELIVERY SYSTEM; DRUG FORMULATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LETTER; PRIORITY JOURNAL; SEXUAL INTERCOURSE; TISSUE DISTRIBUTION; TREATMENT OUTCOME; VAGINA FLORA; VAGINA MUCOSA;

ANTI-INFECTIVE AGENTS; DRUG DELIVERY SYSTEMS; FEMALE; HIV INFECTIONS; HUMANS; MALE; MUCOUS MEMBRANE; VAGINA;

EID: 42449127868     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAD.0b013e3282f73870     Document Type: Letter

References (8)

1. van de Wijgert JH, Shattock RJ. Vaginal microbicides: moving ahead after an unexpected setback. AIDS 2007; 21:2369-2376.
2. Katz DF, Henderson MH, Owen DH, Plenys AM, Walmer DK. What is needed to advance vaginal formulation technology? In: Vaginal microbicide formulations workshop. Edited by Rencher WF. Philadelphia: Lippincott-Raven Publishers; 1998. pp. 90-99.
3. Lai BE, Xie YQ, Lavine ML, Szeri AJ, Owen DH, Katz DF. Dilution of microbicide gels with vaginal fluid and semen simulants: effect on rheological properties and coating flow. J Pharm Sci 2008; 97:1028-1036.
4. Woolfson AD, Malcolm RK, Toner CF, Morrow RJ, Lowry D, Jamil A, et al. Potential use of vaginal rings for prevention of heterosexual transmission of HIV: a controlled release strategy for HIV microbicides. Am J Drug Deliv 2006; 4:7-20.
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6. Rao S, Hu S, McHugh L, Lueders K, Henry K, Zhao Q, et al. Toward a live microbial microbicide for HIV: commensal bacteria secreting an HIV fusion inhibitor peptide. Proc Natl Acad Sci U S A 2005; 102:11993-11998.
7. Pretorius ES, Timbers K, Malamud D, Barnhart K. Magnetic resonance imaging to determine the distribution of a vaginal gel before, during, and after both simulated and real intercourse. Contraception 2002; 66:443-451.
8. Braun KE, Boyer JD, Henderson MH, Katz DF, Wax A. Label-free measurement of microbicidal gel thickness using low-coherence interferometry [letter]. J Biomed Opt 2006; 11:020504.1-020504.3.