Label-free measurement of microbicidal gel thickness using lowcoherence interferometry

Journal of Biomedical Optics

Volumn 11, Issue 2, 2006, Pages

  Braun, Kelly E ^a   Boyer, Jeffrey D ^a   Henderson, Marcus H ^a   Katz, David F ^a   Wax, Adam ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

Drug delivery; Low coherence interferometry; Microbicides; Thickness measurements

Indexed keywords

CALIBRATION; CONTROLLED DRUG DELIVERY; DISEASES; FLUORESCENCE; INTERFEROMETRY; MEDICAL IMAGING; MICROBIOLOGY; THICKNESS MEASUREMENT; VIRUSES;

LOW-COHERENCE INTERFEROMETRY (LCI); MICROBICIDAL GELS;

COHERENT LIGHT;

HUMAN IMMUNODEFICIENCY VIRUS;

ANTIINFECTIVE AGENT;

CHEMISTRY; DRUG SCREENING; GEL; INTERFEROMETRY; LETTER; MATERIALS TESTING; METHODOLOGY; OPTICAL COHERENCE TOMOGRAPHY; STAINING;

ANTI-INFECTIVE AGENTS; DRUG EVALUATION; GELS; INTERFEROMETRY; MATERIALS TESTING; STAINING AND LABELING; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 33746430150     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.2192767     Document Type: Article

References (7)

1. J. Brown et al., "Spreading and retention of vaginal formulations in post-menopausal women as assessed by gamma scintigraphy", Pharm. Res. 14(8), 1073-1078 (1997). (Pubitemid 27371409)
2. K. T. Barnhart, E. S. Pretorius, A. Stolpen, and D. Malamud, "Distribution of topical medication in the human vagina as imaged by magnetic resonance imaging", Fertil. Steril. 76(1), 189-195 (2001). (Pubitemid 32600980)
3. K. T. Barnhart, A. Stolpen, E. S. Pretorius, and D. Malamud, "Distribution of a spermicide containing Nonoxynol-9 in the vaginal canal and the upper female reproductive tract", Hum. Reprod. 16(6), 1151-1154 (2001). (Pubitemid 32544685)
4. E. S. Pretorius, K. Timbers, D. Malamud, and K. Barnhart, "Magnetic resonance imaging to determine the distribution of a vaginal gel: before, during, and after both simulated and real intercourse", Contraception 66(6), 443-451 (2002). (Pubitemid 37338061)
5. M. H. Henderson, J. J. Peters, D. K. Walmer, G. M. Couchman, and D. F. Katz, "Optical instrument for measurement of vaginal coating thickness by drug delivery formulations", Rev. Sci. Instrum. 76(3), 034302 (2005).
6. A. R. Geonnotti, J. J. Peters, and D. F. Katz, "Erosion of microbicide formulation coating layers: Effects of contact and shearing with vaginal fluid or semen", J. Pharm. Sci. 94, 1705-1712 (2005). (Pubitemid 41360865)
7. D. F. Katz et al., "Optical imaging and analysis of human vaginal coating by drug delivery formulations", (in preparation).