Non-immediate reactions to β-lactams: Diagnostic value of skin testing and drug provocation test

Clinical and Experimental Allergy

Volumn 38, Issue 5, 2008, Pages 822-828

  Padial, A ^a   Antunez, C ^b   Blanca Lopez, N ^c   Fernandez, T D ^b   Cornejo Garcia, J A ^b   Mayorga, C ^b   Torres, M J ^c   Blanca, M ^c  

^a Clinica Norsalud   (Spain)

^b HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^c HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

Author keywords

lactam; Cytokine; Drug provocation test; Non immediate reactions; Skin tests; T cells

Indexed keywords

AMINOPENICILLIN; AMOXICILLIN; AMPICILLIN; BETA LACTAM; CEFACLOR; CEFALEXIN; CEFAZOLIN; CEFUROXIME; CLOXACILLIN; GAMMA INTERFERON; INTERLEUKIN 4; PENICILLIN G;

ADULT; AGED; ARTICLE; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DOSE INCREASE; DRUG HYPERSENSITIVITY; DRUG TOLERABILITY; DRUG TOLERANCE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRACUTANEOUS TEST; MACULOPAPULAR RASH; MEMORY CELL; MONONUCLEAR CELL; PATCH TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROVOCATION TEST; RASH; SKIN BIOPSY; SKIN TEST; URTICARIA;

ADULT; AGED; ANTI-BACTERIAL AGENTS; BETA-LACTAMS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DRUG HYPERSENSITIVITY; EXANTHEMA; HUMANS; HYPERSENSITIVITY, DELAYED; MIDDLE AGED; SKIN TESTS; URTICARIA;

EID: 42449126139     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2008.02961.x     Document Type: Article

References (39)

1. Amos HE. The problem of adverse drug reactions. In:+ Amos HE, ed. Allergic drug reactions. London : Arnold, 1976 1 5.
2. Weiss ME, Adkinson NF, Jr. Immediate hypersensitivity reactions to penicillin and related antibiotics. Clin Allergy 1988 18 : 515 40.
3. Roujeau JC, Stern RS. Severe cutaneous adverse reactions to drugs. N Engl J Med 1994 331 : 1272 85.
4. Barbaud A, Reichert-Penetrat S, Tréchot P et al. The use of skin testing in the investigation of cutaneous adverse drug reactions. Br J Dermatol 1998 139 : 49 58.
5. Lewis JH. Drug induced liver disease. Med Clin North Am 2000 84 : 1211 75.
6. Beaune PH, Lecoeur S. Immunotoxicology of the liver: adverse reactions to drugs. J Hepatol 1997 26 : 37 42.
7. Stejskal VDM, Forsbeck M, Olin R. Side Chain specific lymphocyte responses in workers with occupational allergy induced by penicillins. Int Archs Allergy Appl Immunol 1987 82 : 261 4.
8. Padovan E, Mauri-Hellweg D, Pichler WJ, Weltzien HU. T cell recognition of penicillin G: structural features determining antigenic specificity. Eur J Immunol 1996 26 : 42 8.
9. Brugnolo F, Annunziato F, Sampognaro S et al. Highly Th2-skewed cytokine profile of beta-lactam-specific T cells from nonatopic subjects with adverse drug reactions. J Immunol 1999 163 : 1053 9.
10. Hertl M, Geisel J, Boecker C, Merk HF. Selective generation of CD8+ T-cell clones from the peripheral blood of patients with cutaneous reactions to beta-lactam antibiotics. Br J Dermatol 1993 128 : 619 26.
11. Hertl M, Bohlen H, Jugert F, Boecker C, Knaup R, Merk HF. Predominance of epidermal CD8+ T lymphocytes in bullous cutaneous reactions caused by beta-lactam antibiotics. J Invest Dermatol 1993 101 : 794 9.
12. Weltzien HU, Padovan E. Molecular features of penicillin allergy. J Invest Dermatol 1998 110 : 203 6.
13. Torres MJ, Mayorga C, Pamies R et al. Immunologic response to different determinants of benzylpenicillin, amoxicillin and ampicillin. Comparison between urticaria and anaphylactic shock. Allergy 1999 54 : 936 43.
14. Terrados S, Blanca M, Garcia J et al. Non-immediate reactions to beta-lactams: prevalence and role of the different penicillins. Allergy 1995 50 : 563 7.
15. Tatum AJ, Ditto AM, Patterson R. Severe serum sickness-like reaction to oral penicillin drugs: three cases reports. Ann Allergy Astm Immunol 2001 86 : 330 4.
16. Romano A, Mayorga C, Torres MJ et al. Immediate allergic reactions to cephalosporins: cross-reactivity and selective responses. J Allergy Clin Immunol 2000 106 : 1177 83.
17. Torres MJ, Sanchez-Sabaté E, Alvarez J et al. Skin tests evaluation in non immediate allergic reactions to penicillins. Allergy 2004 59 : 219 24.
18. Barbaud A, Goncalo M, Bruynzeel D, Bircher A. Guidelines for performing skin tests with drugs in the investigation of cutaneous adverse drugs reactions. Contact Dermatitis 2001 45 : 321 8.
19. Romano A, Blanca M, Torres MJ et al. Diagnosis of non-immediate reactions to beta-lactam antibiotics. Allergy 2004 59 : 1153 60.
20. Osawa J, Naito S, Aihara M, Kitamura K, Ikezawa Z, Nakajima H. Evaluation of skin test reactions in patients with non-immediate type drug eruptions. J Dermatol 1990 17 : 235 9.
21. Bruynzeel DP, Van Ketel W G. Patch testing in drug eruptions. Sem Dermatol 1989 8 : 196 203.
22. Schiavino D, Nucera E, De Pasquale T et al. Delayed allergy to aminopenicillins: clinical and immunological findings. Int J Immunopathol Pharmacol 2006 19 : 831 40.
23. Pichler WJ. Delayed drug hypersensitivity reactions. Ann Intern Med 2003 139 : 683 93.
24. Luque I, Leyva L, Torres MJ et al. In vitro T lymphocyte responses to betalactam drugs in immediate and nonimmediate allergic reactions. Allergy 2001 56 : 611 8.
25. Koponen M, Pichler Wj, De Weck AL. T cell reactivity to penicillin: phenotypic analysis of in vitro activated cell subsets. J Allergy Clin Immunol 1986 78 : 645 52.
26. Torres MJ, Blanca M, Fernández J et al. Diagnosis of immediate allergic reactions to beta-lactam antibiotics. Allergy 2003 58 : 961 72.
27. Blanca M, Mayorga C, Torres MJ et al. Clinical evaluation of Pharmacia CAP System TM RAST FEIA amoxicilloyl and benzylpenicilloyl in patients with penicillin allergy. Allergy 2001 56 : 862 70.
28. Antunez C, Blanca-Lopez N, Torres MJ et al. Immediate allergic reactions to cephalosporins: evaluation of cross-reactivity with a panel of penicillins and cephalosporins. J Allergy Clin Immunol 2006 117 : 404 10.
29. Lee CE, Zembower TR, Fotis MA et al. The incidence of antimicrobial allergies in hospitalised patients: implications regarding prescribing patterns and emerging bacterial resistence. Arch Int Med 2000 160 : 2819 22.
30. Berstein I, Gruchalla RS, Lee R et al. Executive summary of disease management of drug hypersensitivity: a practice parameter. Ann Allergy Asthma Immunol 1999 83 : 665 700.
31. Valsecchi R, Serra M, Pansera B, Foiadelli L, Cainelli T. Patch testing in adverse drug reactions to penicillin and cephalosporin. Contact Dermatitis 1981 7 : 158.
32. Blanca M, Torres MJ, Garcia JJ et al. Natural evolution of skin test sensitivity in patients allergic to betalactam antibiotics. J Allergy Clin Immunol 1999 103 : 918 24.
33. Romano A, Di Fonso M, Papa G et al. Evaluation of adverse cutaneous reactions to aminopenicillins with emphasis on those manifested by maculopapular rashes. Allergy 1995 50 : 113 8.
34. Hausermen P, Bircher AJ. Immediate and delayed hypersensitivity to ceftriaxone and anaphylaxis to intradermal testing with other beta latcam antibiotics, in a previously amoxicillin sensitised patient. Contact Dermatitis 2002 47 : 311 12.
35. Moreno F, Blanca M, Mayorga C et al. Studies of the specificities of IgE antibodies found in sera from subjects with allergic reactions to penicillins. Int Arch Allergy Immunol 1995 108 : 74 81.
36. Antunez C, Fernandez T, Blanca-Lopez N et al. IgE antibodies to betalactams: relationship between the triggering hapten and the specificity of the immune response. Allergy 2006 61 : 940 6.
37. Schnyder B, Helbling A, Kappeler A, Pichler WJ. Drug-induced papulovesicular exanthema. Allergy 1998 53 : 817 8.
38. Caproni M, Volpi W, Macchia D et al. Infiltrating cells and related cytokines in lesional skin of patients with chronic idiopathic urticaria and positive autologous serum skin test. Exp Dermatol 2003 12 : 621 8.
39. Tharp MD. Chronic urticaria: pathophysiology and treatment approaches. J Allergy Clin Immunol 1996 98 : S325 30.