Neoplastic transformation and induction of H+,K +-adenosine triphosphatase by N-methyl-N′-nitro-N- nitrosoguanidine in the gastric epithelial RGM-1 cell line

In Vitro Cellular and Developmental Biology - Animal

Volumn 44, Issue 1-2, 2008, Pages 26-30

  Shimokawa, Osamu ^a   Matsui, Hirofumi ^a   Nagano, Yumiko ^a   Kaneko, Tsuyoshi ^a   Shibahara, Takeshi ^a   Nakahara, Akira ^a   Hyodo, Ichinosuke ^a   Yanaka, Akinori ^b   Majima, Hideyuki J ^c   Nakamura, Yukio ^d   Matsuzaki, Yasushi ^e  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

^c KAGOSHIMA UNIVERSITY   (Japan)

^d RIKEN BIORESOURCE CENTER   (Japan)

^e TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

H+,K+ adenosine triphosphatase (H +,K+ ATPase); N methyl N nitro N nitrosoguanidine (MNNG); Neoplastic transformation; RGM 1

Indexed keywords

HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; METHYLNITRONITROSOGUANIDINE; CARCINOGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL GROWTH; CELL MUTANT; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; EPITHELIUM CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INTESTINE EPITHELIUM; MALE; MOUSE; NEOPLASM; NONHUMAN; RAT; STEM CELL; STOMACH CANCER; ANIMAL; CELL LINE; CYTOLOGY; METABOLISM; PHYSIOLOGY; STOMACH MUCOSA; ULTRASTRUCTURE; WISTAR RAT;

ANIMALIA; MURINAE; MUS MUSCULUS; RATTUS;

ANIMALS; CARCINOGENS; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; EPITHELIAL CELLS; GASTRIC MUCOSA; H(+)-K(+)-EXCHANGING ATPASE; METHYLNITRONITROSOGUANIDINE; RATS; RATS, WISTAR;

EID: 42449102301     PISSN: 10712690     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11626-007-9067-8     Document Type: Article

References (23)

1. Bae, D.S.; Hanneman, W.H.; Yang, R.S.; Campain, J.A. Characterization of gene expression changes associated with MNNG, arsenic, or metal mixture treatment in human keratinocytes: application of cDNA microarray technology. Environ. Health. Perspect. 110(Suppl 6):931-941; 2002.
2. Barranco, S.C.; Townsend, C.M. Jr.; Casartelli, C.; Macik B.G.; Burger, N.L.; Boerwinkle, W.R.; Gourley, W.K. Establishment and characterization of an in vitro model system for human adenocarcinoma of the stomach. Cancer Res. 43:1703-1709; 1983.
3. Beales, I.L.; Calam, J. Effect of N alpha-methyl-histamine on acid secretion in isolated cultured rabbit parietal cells: implications for Helicobacter pylori associated gastritis and gastric physiology. Gut 40:14-19; 1997.
4. Borek, C.; Guernsey, D.L.; Ong, A.; Edelman, I.S. Critical role played by thyroid hormone in induction of neoplastic transformation by chemical carcinogens in tissue culture. Proc. Natl. Acad. Sci. U. S. A. 80:5749-5752; 1983.
5. Gichner, T.; Veleminsky, J. Genetic effects of N-methyl-N′-nitro-N- nitrosoguanidine and its homologs. Mutat. Res. 99:129-242; 1982.
6. Hassan, S.; Kinoshita, Y.; Min, D.; Nakata, H.; Kishi, K.; Matsushima, Y.; Asahara, M.; Wang, H.Y.; Okada, A.; Maekawa, T.; Matsui, H.; Chiba, T. Presence of prostaglandin EP4 receptor gene expression in a rat gastric mucosal cell line. Digestion 57:196-200; 1996.
7. Jain, R.N.; Samuelson, L.C. Differentiation of the gastric mucosa. II. Role of gastrin in gastric epithelial cell proliferation and maturation. Am. J. Physiol. Gastrointest. Liver Physiol. 291:G762-G765; 2006.
8. Kakunaga, T. Neoplastic transformation of human diploid fibroblast cells by chemical carcinogens. Proc. Natl. Acad. Sci. U. S. A. 75:1334-1338; 1978.
9. Karam, S.M.; Leblond, C.P. Dynamics of epithelial cells in the corpus of the mouse stomach. I. Identification of proliferative cell types and pinpointing of the stem cell. Anat. Rec. 236:259-279; 1993.
10. Karam, S.M.; Straiton, T.; Hassan, W.M.; Leblond, C.P. Defining epithelial cell progenitors in the human oxyntic mucosa. Stem Cells 21: 322-336; 2003.
11. Katada, K.; Naito, Y.; Mizushima, K.; Takagi, T.; Handa, O.; Kokura, S.; Ichikawa, H.; Yoshida, N.; Matsui, H.; Yoshikawa, T. Gene expression profiles on hypoxia and reoxygenation in rat gastric epithelial cells: a high-density DNA microarray analysis. Digestion 73:89-100; 2006.
12. Kobayashi, I.; Kawano, S.; Tsuji, S.; Matsui, H.; Nakama, A.; Sawaoka, H.; Masuda, E.; Takei, Y.; Nagano, K.; Fusamoto, H.; Ohno, T.; Fukutomi, H.; Kamada, T. RGM1, a cell line derived from normal gastric mucosa of rat. In Vitro Cell. Dev. Biol. Anim. 32:259-261; 1996
13. Matsui, H.; Murata, Y.; Hirano, K.; Sasaki, T.; Shiba, R.; Muto, H.; Ohno, T. Hydrogen peroxide-induced cellular injury is associated with increase in endogenous fluorescence from rat gastric mucosal epithelial cell culture: A new method for detecting oxidative cellular injury by fluorescence measurement. J. Gastroenterol. 33:318-325; 1998.
14. Motoyama, T.; Hojo, H.; Watanabe, H. Comparison of seven cell lines derived from human gastric carcinomas. Acta. Pathol. Jpn. 36:65-83; 1986.
15. Nagano, Y.; Matsui, H.; Muramatsu, M.; Shimokawa, O.; Shibahara, T.; Yanaka, A.; Nakahara, A.; Matsuzaki, Y.; Tanaka, N.; Nakamura, Y. Rebamipide significantly inhibits indomethacin-induced mitochondrial damage, lipid peroxidation, and apoptosis in gastric epithelial RGM-1 cells. Dig. Dis. Sci. 50(Suppl 1):S76-S83; 2005.
16. Naito, Y.; Kajikawa, H.; Mizushima, K.; Shimozawa, M.; Kuroda, M.; Katada, K.; Takagi, T.; Handa, O.; Kokura, S.; Ichikawa, H.; Yoshida, N.; Matsui, H.; Yoshikawa, T. Rebamipide, a gastro-protective drug, inhibits indomethacin-induced apoptosis in cultured rat gastric mucosal cells: association with the inhibition of growth arrest and DNA damage-induced 45 alpha expression. Dig. Dis. Sci. 50(Suppl 1):S104-S112; 2005.
17. Santala, P.; Larjava, H.; Nissinen, L.; Riikonen, T.; Maatta, A.; Heino, J. Suppressed collagen gene expression and induction of alpha 2 beta 1 integrin-type collagen receptor in tumorigenic derivatives of human osteogenic sarcoma (HOS) cell line. J. Biol. Chem. 269:1276-1283; 1994.
18. Sawaoka, H.; Tsuji, S.; Tsujii, M.; Gunawan, E.S.; Nakama, A.; Takei, Y.; Nagano, K.; Matsui, H.; Kawano, S.; Hori, M. Expression of the cyclooxygenase-2 gene in gastric epithelium. J. Clin. Gastroenterol. 25(Suppl 1):S105-S110; 1997.
19. Senger, D.R.; Perruzzi, C.A.; Ali, I.U. T24 human bladder carcinoma cells with activated Ha-ras protooncogene: nontumorigenic cells susceptible to malignant transformation with carcinogen. Proc. Natl. Acad. Sci. U. S. A. 85:5107-5111; 1988.
20. Sugimura, T.; Fujimura, S. Tumour production in glandular stomach of rat by N-methyl-N′-nitro-N-nitrosoguanidine. Nature 216:943-944; 1967.
21. Tatematsu, M.; Tsukamoto, T.; Inada, K. Stem cells and gastric cancer: role of gastric and intestinal mixed intestinal metaplasia. Cancer Sci. 94:135-141; 2003.
22. Thomassen, D.G.; Gray, T.E.; Mass, M.J.; Barrett, J.C. High frequency of carcinogen-induced early, preneoplastic changes in rat tracheal epithelial cells in culture. Cancer Res. 43:5956-5963; 1983.
23. Wattel, W.; Geuze, J.J.; de Rooij, D.G. Ultrastructural and carbohydrate histochemical studies on the differentiation and renewal of mucous cells in the rat gastric fundus. Cell Tissue Res. 176:445-462; 1977.