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Volumn 149, Issue 5, 2008, Pages 2612-2619

Effect of glutathione depletion on Leydig cell steroidogenesis in young and old Brown Norway rats

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DITHIOLE 3 THIONE DERIVATIVE; 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; ALPHA TOCOPHEROL; BUTHIONINE SULFOXIMINE; CYCLIC AMP; CYTOCHROME P450C17; GLUTATHIONE; GLUTATHIONE ETHYL ESTER; LUTEINIZING HORMONE; N TERT BUTYL ALPHA PHENYLNITRONE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TESTOSTERONE; TROLOX C;

EID: 42449098527     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-1245     Document Type: Article
Times cited : (48)

References (35)
  • 1
    • 0028979570 scopus 로고
    • Ageing of the hypothalamo-pituitary- testicular axis in men
    • Vermeulen A, Kaufman JM 1995 Ageing of the hypothalamo-pituitary- testicular axis in men. Horm Res 43:25-28
    • (1995) Horm Res , vol.43 , pp. 25-28
    • Vermeulen, A.1    Kaufman, J.M.2
  • 2
    • 0033796721 scopus 로고    scopus 로고
    • Regulation of Leydig cell steroidogenic function during aging
    • Zirkin BR, Chen H 2000 Regulation of Leydig cell steroidogenic function during aging. Biol Reprod 63:977-981
    • (2000) Biol Reprod , vol.63 , pp. 977-981
    • Zirkin, B.R.1    Chen, H.2
  • 3
    • 0028558510 scopus 로고
    • Age-related decreased Leydig cell testosterone production in the brown Norway rat
    • Chen H, Hardy MP, Huhtaniemi I, Zirkin BR 1994 Age-related decreased Leydig cell testosterone production in the brown Norway rat. J Androl 15:551-557
    • (1994) J Androl , vol.15 , pp. 551-557
    • Chen, H.1    Hardy, M.P.2    Huhtaniemi, I.3    Zirkin, B.R.4
  • 4
    • 0029980067 scopus 로고    scopus 로고
    • Depletion and repopulation of Leydig cells in the testes of aging brown Norway rats
    • Chen H, Huhtaniemi I, Zirkin BR 1996 Depletion and repopulation of Leydig cells in the testes of aging brown Norway rats. Endocrinology 137:3447-3452
    • (1996) Endocrinology , vol.137 , pp. 3447-3452
    • Chen, H.1    Huhtaniemi, I.2    Zirkin, B.R.3
  • 5
    • 4644300593 scopus 로고    scopus 로고
    • Dibutyryl cyclic adenosine monophosphate restores the ability of aged Leydig cells to produce testosterone at the high levels characteristic of young cells
    • Chen H, Liu J, Luo L, Zirkin BR 2004 Dibutyryl cyclic adenosine monophosphate restores the ability of aged Leydig cells to produce testosterone at the high levels characteristic of young cells. Endocrinology 145:4441-4446
    • (2004) Endocrinology , vol.145 , pp. 4441-4446
    • Chen, H.1    Liu, J.2    Luo, L.3    Zirkin, B.R.4
  • 6
    • 0029827114 scopus 로고    scopus 로고
    • Are Leydig cell steroidogenic enzymes differentially regulated with aging?
    • Luo L, Chen H, Zirkin BR 1996 Are Leydig cell steroidogenic enzymes differentially regulated with aging? J Androl 17:509-515
    • (1996) J Androl , vol.17 , pp. 509-515
    • Luo, L.1    Chen, H.2    Zirkin, B.R.3
  • 7
    • 0035189247 scopus 로고    scopus 로고
    • Leydig cell aging: Steroidogenic acute regulatory protein (StAR) and cholesterol side-chain cleavage enzyme
    • Luo L, Chen H, Zirkin BR 2001 Leydig cell aging: steroidogenic acute regulatory protein (StAR) and cholesterol side-chain cleavage enzyme. J Androl 22:149-156
    • (2001) J Androl , vol.22 , pp. 149-156
    • Luo, L.1    Chen, H.2    Zirkin, B.R.3
  • 8
    • 0036220150 scopus 로고    scopus 로고
    • Cholesterol transport, peripheral benzodiazepine receptor, and steroidogenesis in aging Leydig cells
    • Culty M, Luo L, Yao ZX, Chen H, Papadopoulos V, Zirkin BR 2002 Cholesterol transport, peripheral benzodiazepine receptor, and steroidogenesis in aging Leydig cells. J Androl 23:439-447
    • (2002) J Androl , vol.23 , pp. 439-447
    • Culty, M.1    Luo, L.2    Yao, Z.X.3    Chen, H.4    Papadopoulos, V.5    Zirkin, B.R.6
  • 9
  • 10
    • 1542329063 scopus 로고    scopus 로고
    • Aging alters the functional expression of enzymatic and non-enzymatic anti-oxidant defense systems in testicular rat Leydig cells
    • Cao L, Leers-Sucheta S, Azhar S 2004 Aging alters the functional expression of enzymatic and non-enzymatic anti-oxidant defense systems in testicular rat Leydig cells. J Steroid Biochem Mol Biol 88:61-67
    • (2004) J Steroid Biochem Mol Biol , vol.88 , pp. 61-67
    • Cao, L.1    Leers-Sucheta, S.2    Azhar, S.3
  • 11
    • 0034899370 scopus 로고    scopus 로고
    • Age-related increase in mitochondrial superoxide generation in the testosterone-producing cells of Brown Norway rat testes: Relationship to reduced steroidogenic function?
    • Chen H, Cangello D, Benson S, Folmer J, Zhu H, Trush MA, Zirkin BR 2001 Age-related increase in mitochondrial superoxide generation in the testosterone-producing cells of Brown Norway rat testes: relationship to reduced steroidogenic function? Exp Gerontol 36:1361-1373
    • (2001) Exp Gerontol , vol.36 , pp. 1361-1373
    • Chen, H.1    Cangello, D.2    Benson, S.3    Folmer, J.4    Zhu, H.5    Trush, M.A.6    Zirkin, B.R.7
  • 13
    • 0036804710 scopus 로고    scopus 로고
    • Free radicals, antioxidants, and nutrition
    • Fang YZ, Yang S, Wu G 2002 Free radicals, antioxidants, and nutrition. Nutrition 18:872-879
    • (2002) Nutrition , vol.18 , pp. 872-879
    • Fang, Y.Z.1    Yang, S.2    Wu, G.3
  • 14
    • 0033231162 scopus 로고    scopus 로고
    • Biologic and pharmacologic regulation of mammalian glutathione synthesis
    • Griffith OW 1999 Biologic and pharmacologic regulation of mammalian glutathione synthesis. Free Radic Biol Med 27:922-935
    • (1999) Free Radic Biol Med , vol.27 , pp. 922-935
    • Griffith, O.W.1
  • 15
    • 3042802690 scopus 로고    scopus 로고
    • Glutathione: An overview of biosynthesis and modulation
    • Anderson ME 1998 Glutathione: an overview of biosynthesis and modulation. Chem Biol Interact 111-112:1-14
    • (1998) Chem Biol Interact , vol.111-112 , pp. 1-14
    • Anderson, M.E.1
  • 16
    • 0018666729 scopus 로고
    • Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine)
    • Griffith OW, Meister A 1979 Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). J Biol Chem 254:7558-7560
    • (1979) J Biol Chem , vol.254 , pp. 7558-7560
    • Griffith, O.W.1    Meister, A.2
  • 17
    • 0021718674 scopus 로고
    • Effects of luteinizing hormone withdrawal on Leydig cell smooth endoplasmic reticulum and steroidogenic reactions which convert pregnenolone to testosterone
    • Wing TY, Ewing LL, Zirkin BR 1984 Effects of luteinizing hormone withdrawal on Leydig cell smooth endoplasmic reticulum and steroidogenic reactions which convert pregnenolone to testosterone. Endocrinology 115:2290-2296
    • (1984) Endocrinology , vol.115 , pp. 2290-2296
    • Wing, T.Y.1    Ewing, L.L.2    Zirkin, B.R.3
  • 18
    • 0023222052 scopus 로고
    • Effect of luteinizing hormone deprivation in situ on steroidogenesis of rat Leydig cells purified by a multistep procedure
    • Klinefelter GR, Hall PF, Ewing LL 1987 Effect of luteinizing hormone deprivation in situ on steroidogenesis of rat Leydig cells purified by a multistep procedure. Biol Reprod 36:769-783
    • (1987) Biol Reprod , vol.36 , pp. 769-783
    • Klinefelter, G.R.1    Hall, P.F.2    Ewing, L.L.3
  • 19
    • 0018870772 scopus 로고
    • Luteinizing hormone receptor and testosterone synthesis in two distinct populations of Leydig cells
    • Payne AH, Downing JR, Wong KL 1980 Luteinizing hormone receptor and testosterone synthesis in two distinct populations of Leydig cells. Endocrinology 106:1424-1429
    • (1980) Endocrinology , vol.106 , pp. 1424-1429
    • Payne, A.H.1    Downing, J.R.2    Wong, K.L.3
  • 20
    • 0017064979 scopus 로고
    • A fluorometric method for determination of oxidized and reduced glutathione in tissues
    • Hissin PJ, Hilf R 1976 A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem 74:214-226
    • (1976) Anal Biochem , vol.74 , pp. 214-226
    • Hissin, P.J.1    Hilf, R.2
  • 21
    • 0000402821 scopus 로고    scopus 로고
    • Cytotoxicity and viability assays
    • Masters JRW, ed, 3rd ed. Oxford, UK: Oxford University Press;
    • Wilson AP 2000 Cytotoxicity and viability assays. In: Masters JRW, ed. Animal cell culture: a practical approach. 3rd ed. Oxford, UK: Oxford University Press; 175-219
    • (2000) Animal cell culture: A practical approach , pp. 175-219
    • Wilson, A.P.1
  • 22
    • 0034626735 scopus 로고    scopus 로고
    • Oxidants, oxidative stress and the biology of ageing
    • Finkel T, Holbrook NJ 2000 Oxidants, oxidative stress and the biology of ageing. Nature 408:239-247
    • (2000) Nature , vol.408 , pp. 239-247
    • Finkel, T.1    Holbrook, N.J.2
  • 23
    • 0036236271 scopus 로고    scopus 로고
    • Aging and the role of reactive nitrogen species
    • Drew B, Leeuwenburgh C 2002 Aging and the role of reactive nitrogen species. Ann NY Acad Sci 959:66-81
    • (2002) Ann NY Acad Sci , vol.959 , pp. 66-81
    • Drew, B.1    Leeuwenburgh, C.2
  • 24
    • 0030024408 scopus 로고    scopus 로고
    • Induction of lipid peroxidation during steroidogenesis in the rat testis
    • Peltola V, Huhtaniemi I, Metsa-Ketela T, Ahotupa M 1996 Induction of lipid peroxidation during steroidogenesis in the rat testis. Endocrinology 137:105-112
    • (1996) Endocrinology , vol.137 , pp. 105-112
    • Peltola, V.1    Huhtaniemi, I.2    Metsa-Ketela, T.3    Ahotupa, M.4
  • 25
    • 0024576968 scopus 로고
    • Steroid and xenobiotic effects on the adrenal cortex: Mediation by oxidative and other mechanisms
    • Hornsby PJ 1989 Steroid and xenobiotic effects on the adrenal cortex: mediation by oxidative and other mechanisms. Free Radic Biol Med 6:103-115
    • (1989) Free Radic Biol Med , vol.6 , pp. 103-115
    • Hornsby, P.J.1
  • 26
    • 0021361841 scopus 로고
    • Oxygen-mediated damage of microsomal cytochrome P-450 enzymes in cultured Leydig cells. Role in steroidogenic desensitization
    • Quinn PG, Payne AH 1984 Oxygen-mediated damage of microsomal cytochrome P-450 enzymes in cultured Leydig cells. Role in steroidogenic desensitization. J Biol Chem 259:4130-4135
    • (1984) J Biol Chem , vol.259 , pp. 4130-4135
    • Quinn, P.G.1    Payne, A.H.2
  • 27
    • 0021999583 scopus 로고
    • Steroid product-induced, oxygen-mediated damage of microsomal cytochrome P-450 enzymes in Leydig cell cultures. Relationship to desensitization
    • Quinn PG, Payne AH 1985 Steroid product-induced, oxygen-mediated damage of microsomal cytochrome P-450 enzymes in Leydig cell cultures. Relationship to desensitization. J Biol Chem 260:2092-2099
    • (1985) J Biol Chem , vol.260 , pp. 2092-2099
    • Quinn, P.G.1    Payne, A.H.2
  • 28
    • 0023637369 scopus 로고
    • Steroid synthesis-dependent, oxygen-mediated damage of mitochondrial and microsomal cytochrome P-450 enzymes in rat Leydig cell cultures
    • Georgiou M, Perkins LM, Payne AH 1987 Steroid synthesis-dependent, oxygen-mediated damage of mitochondrial and microsomal cytochrome P-450 enzymes in rat Leydig cell cultures. Endocrinology 121:1390-1399
    • (1987) Endocrinology , vol.121 , pp. 1390-1399
    • Georgiou, M.1    Perkins, L.M.2    Payne, A.H.3
  • 29
    • 0037661090 scopus 로고    scopus 로고
    • Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis
    • Diemer T, Allen JA, Hales KH, Hales DB 2003 Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis. Endocrinology 144:2882-2891
    • (2003) Endocrinology , vol.144 , pp. 2882-2891
    • Diemer, T.1    Allen, J.A.2    Hales, K.H.3    Hales, D.B.4
  • 30
    • 0029125737 scopus 로고
    • Alteration of the adrenal antioxidant defense system during aging in rats
    • Azhar S, Cao L, Reaven E 1995 Alteration of the adrenal antioxidant defense system during aging in rats. J Clin Invest 96:1414-1424
    • (1995) J Clin Invest , vol.96 , pp. 1414-1424
    • Azhar, S.1    Cao, L.2    Reaven, E.3
  • 31
    • 0036829579 scopus 로고    scopus 로고
    • Redox analysis of human plasma allows separation of pro-oxidant events of aging from decline in antioxidant defenses
    • Jones DP, Mody Jr VC, Carlson JL, Lynn MJ, Sternberg Jr P 2002 Redox analysis of human plasma allows separation of pro-oxidant events of aging from decline in antioxidant defenses. Free Radic Biol Med 33:1290-1300
    • (2002) Free Radic Biol Med , vol.33 , pp. 1290-1300
    • Jones, D.P.1    Mody Jr, V.C.2    Carlson, J.L.3    Lynn, M.J.4    Sternberg Jr, P.5
  • 32
    • 0036082232 scopus 로고    scopus 로고
    • Alterations in oxidative stress scavenger system in aging rat brain and lymphocytes
    • Sandhu SK, Kaur G 2002 Alterations in oxidative stress scavenger system in aging rat brain and lymphocytes. Biogerontology 3:161-173
    • (2002) Biogerontology , vol.3 , pp. 161-173
    • Sandhu, S.K.1    Kaur, G.2
  • 33
    • 3242686012 scopus 로고    scopus 로고
    • Glutathione metabolism during aging and in Alzheimer disease
    • Liu H, Wang H, Shenvi S, Hagen TM, Liu RM 2004 Glutathione metabolism during aging and in Alzheimer disease. Ann NY Acad Sci 1019:346-349
    • (2004) Ann NY Acad Sci , vol.1019 , pp. 346-349
    • Liu, H.1    Wang, H.2    Shenvi, S.3    Hagen, T.M.4    Liu, R.M.5
  • 34
    • 0036570038 scopus 로고    scopus 로고
    • Down-regulation of γ-glutamylcysteine synthetase regulatory subunit gene expression in rat brain tissue during aging
    • Liu RM 2002 Down-regulation of γ-glutamylcysteine synthetase regulatory subunit gene expression in rat brain tissue during aging. J Neurosci Res 68:344-351
    • (2002) J Neurosci Res , vol.68 , pp. 344-351
    • Liu, R.M.1
  • 35
    • 4344644670 scopus 로고    scopus 로고
    • Effect of glutathione depletion on antioxidant enzymes in the epididymis, seminal vesicles, and liver and on spermatozoa motility in the aging brown Norway rat
    • Zubkova EV, Robaire B 2004 Effect of glutathione depletion on antioxidant enzymes in the epididymis, seminal vesicles, and liver and on spermatozoa motility in the aging brown Norway rat. Biol Reprod 71:1002-1008
    • (2004) Biol Reprod , vol.71 , pp. 1002-1008
    • Zubkova, E.V.1    Robaire, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.