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In our attempts involving reaction of diisopinocamphenylborane complex of pyridine with benzaldehyde, α-lithiation was observed but without asymmetric induction (ref 53). Extensive work on chiral auxiliary based C-C bond-forming reactions of secondary amine derived carbanions has been carried out: Meyer, A. I. in ref 69; p 45. Also use of chiral Lewis acid catalysts in asymmetric synthesis not involving basic conditions is well known, see ref 69 (p 37)
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In our attempts involving reaction of diisopinocamphenylborane complex of pyridine with benzaldehyde, α-lithiation was observed but without asymmetric induction (ref 53). Extensive work on chiral auxiliary based C-C bond-forming reactions of secondary amine derived carbanions has been carried out: Meyer, A. I. in ref 69; p 45. Also use of chiral Lewis acid catalysts in asymmetric synthesis not involving basic conditions is well known, see ref 69 (p 37).
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