Viral inactivation

Blood Safety and Surveillance

Volumn , Issue , 2016, Pages 479-495

  Horowitz, Bernard ^a   Ben Hur, Ehud ^b  

^a VI Technologies Inc   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 4243756285     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (79)

1. Schreiber GB, Busch MP, Kleinman SH, Korelitz JJ. The risk of transfusiontransmitted viral infections. N Engl J Med 1996; 334:1685-1690.
2. Goedert JJ, Kessler CM, Aldort LM, Biggar RJ, Andes WA, White GC, Drummond JE, Vaidya K, Mann DL, Eyster ME, Ragni MV, Lederman MM, Cohen AR, Bray GL, Rosenberg PS, Friedman RM, Hilgartner MW, Blattner WA, Kroner B, Gail MH. A prospective study of human immunodeficiency infection and the development of AIDS in subjects with hemophilia. N Engl J Med 1989; 321:1141-1148.
3. Brettler DB, Alter HJ, Dienstag JL, Frosberg AD, Levine PH. The prevalence of antibody to hepatitis C in a cohort of hemophilic patients. Blood 1990; 76:254.
4. Troisi CL, Hollinger FB, Hoots WK, Contant C, Gill J, Ragni M, Parmley R, Sexauer C, Gomperts E, Buchanan G, Schwartz B, Adair S, Fields H. A multi-center study of viral hepatitis in a United States hemophilic population. Blood 1993; 81:412-428.
5. Oliphant JW, Hollander A. Homologous serum jaundice: experimental inactivation of etiologic agent in serum by ultraviolet irradiation. Public Health Rep 1946; 61:598-600.
6. Murray R, Oliphant JW, Tripp JT, Hampi B, Ratner F, Diefenbach WCL. Effect of ultraviolet irradiation on the infectivity of ictrogenic plasma. J Am Med Assoc 1955; 157:8-14.
7. Hilfenhaus J, Herrman A, Mauler R, Prince AM. Inactivation of the AIDS-causing retrovirus and other human viruses in antihemophilic plasma protein preparations by pasteurization. Vox Sang 1986; 50:208-211.
8. Hilfenhaus J, Weidmann E. Pasteurization as an efficient method to inactivate blood borne viruses in factor VIII concentrates. Arzneimittelforschung 1986; 36:621-625.
9. Horowitz B, Weibe ME, Lippin A, Vandersand J, Stryker MH. Inactivation of viruses in labile blood derivatives. II. Physical methods. Transfusion 1985; 25:523-527.
10. Levy JA, Mitra GA, Wong MF, Mozen MM. Inactivation by wet and dry heat of AIDS-associated retroviruses during factor VIII purification from plasma. Lancet 1985; 1:1456-1457.
11. Hollinger B, Dolana G, Thomas W, Gyorkey F. Reduction in risk of hepatitis transmission by heat treatment of a factor VIII concentrate. J Infect Dis 1984; 150:250-262.
12. Winkelman L, Owen NE, Evans DR, Evans H, Haddan ME, Smith JK, Prince PJ, Williams JD, Lane RS. Severely heated therapeutic factor VIII concentrate of high specific activity. Vox Sang 1989; 57:97-103.
13. Mannucci PM. Clinical evaluation of viral safety of coagulation factor VIII and IX concentrates. Vox Sang 1993; 64:197-203.
14. Horowitz B, Wiebe ME, Lippin A, Stryker MH. Inactivation of viruses in labile blood derivatives. I. Disruption of lipid-enveloped viruses by tri(n-butyl) phosphate detergent combinations. Transfusion 1985; 25:516-522.
15. Horowitz B, Prince AM, Hamman J, Watklevicz C. Viral safety of solvent/detergenttreated blood products. Blood Coagul Fibrinol 1994; 5(suppl):S21-S28.
16. Prince AM, Horowitz B, Baker L, Shulman RW, Ralph H, Valinsky J, Cundell A, Brotman B, Boehle W, Rey F, Piet M, Reesink H, Lelie N, Tersmette M, Miedema F, Barbosa L, Nemo G, Nastala CL, Allan JS, Lee DR, Eichberg JW. Failure of human immunodeficiency virus (HIV) immune globulin to protect against experimental challenge with HIV. Proc Natl Acad Sci USA 1988; 85:6944-6948.
17. Horowitz B. Inactivation of viruses found with plasma proteins: In: Goldstein J, ed. Biotechnology of Blood. Stoneham: Butterworth-Heinemann, 1991:417-430.
18. Horowitz B, Bonomo R, Prince AM, Chin SN, Brotman B, Shulman RW. Solvent/ detergent-treated plasma: a virus inactivated substitute for fresh frozen plasma. Blood 1992; 79:826-831.
19. Lemon SM, Murphy PC, Smith A, Zou J, Hamman J, Horowitz B. Removal/neutralization of hepatitis A virus during manufacture of high purity, solvent/detergent treated plasma. Blood 1992; 79:826-831.
20. Piquet Y, Janvier G, Selosse P, Doutremepuich C, Journeau J, Nicolle G, Platel D, Vezon G. Virus inactivation of fresh frozen plasma by a solvent-detergent procedure: biological results. Vox Sang 1992; 63:251-256.
21. Hellstern P, Sachse H, Schwinn H, Overfrank K. Manufacture and in vitro characterization of solvent/detergent-treated human plasma. Vox Sang 1992; 63:178-185.
22. Solheim BG, Svennevig JL, Mohr B, et al. The use of Octasplas in patients undergoing open heart surgery. In: Muller-Berghanns G, et al., eds. DIS: Pathogenesis, Diagnosis and Therapy of Disseminated Intravascular Fibrin Formation. Amsterdam: Elsevier Science Publishers, 1993:253-262.
23. Moake J, Chintagumpala M, Turner J, McPherson P, Nolasco L, Steuber C, Santiago-Borrero P, Horowitz M, Pehta J. Solvent/detergent-treated plasma suppresses shearinduced platelet aggregation and prevents episodes of thrombotic thrombocytopenic purpura. Blood 1994; 84:490-497.
24. Pehta JC. Clinical studies with solvent-detergent-treated products. Transfusion Med Rev 1996; 10:303-311.
25. Piszkeiwicz D, Sun CS, Tondreau SC. Inactivation and removal of human immunodeficiency virus in monoclonal purified antihemophilic factor (human) (Hemophil M). Thromb Res 1989; 55:627-634.
26. Hamamoto Y, Harada S, Kobayashi S, Yamaguchi K, Iijima H, Manabe S, Tsurumi T, Aizawa H, Yamamoto N. A novel method for removal of human immunodeficiency virus: filtration with porous polymeric membranes. Vox Sang 1989; 56:230-236.
27. Burnouf-Radosevich M, Appourchaux P, Huart JJ, Burnouf T. Nanofiltration, a new specific virus elimination method applied to high purity factor IV and factor XI concentrates. Vox Sang 1994; 67:132-138.
28. Horowitz B, Zou J, Hamman J, Gottlieb P, Chin S, Marx G, Golyakhovsky V. Elimination of small, heat and solvent/detergent (S/D)-resistant viruses in factor VIII concentrate and fibrin sealant. Throm Haemost 1995; 73:1460.
29. Patrick MH, Rahn RO. Photochemistry of DNA and polynucleotides: photoproducts. In: Wang SY, ed. Photochemistry and Photobiology of Nucleic Acids, Vol. 2. New York: Academic Press, 1976:35-95.
30. Rauth AM. The physical state of viral nucleic acid and the sensitivity of viruses to ultraviolet light. Biophys J 1965; 5:257-273.
31. Chin S, Williams B, Gottlieb P, Margolis-Nunno H, Ben-Hur E, Hamman J, Jin R, Dubovi E, Horowitz B. Virucidal UVC treatment of plasma and factor VIII concentrate: protection of proteins by antioxidants. Blood 1995; 86:4331-4336.
32. Marx G, Mou X, Freed R, Ben-Hur E, Yang C, Horowitz B. Protecting fibrinogen with rutin during UVC irradiation for viral inactivation. Photochem Photobiol 1996; 63:541-546.
33. Chin S, Jin R, Wang XL, Hamman J, Marx G, Mou X, Andersson I, Lindquist LO, Horowitz B. Virucidal treatment of blood protein products with UVC. Photochem Photobiol 1997; 65:432-435.
34. Highsmith FA, Caple M, Walthall B, Shanbron E, Drohan WN. Viral inactivation of vesicular stomatitis virus in normal human serum by crosslinked polyvinylpyrrolidone. J Infect Dis 1993; 167:1027-1033.
35. Highsmith FA, Xue H, Caple M, Walthall B, Drohan WN, Shanbrom E. Inactivation of lipid-enveloped and non-lipid-enveloped model viruses in normal human plasma by crosslinked starch-iodine. Transfusion 1994; 34:322-327.
36. Wallis C, Melnick JL. Photodynamic inactivation of animal viruses: a review. Photochem Photobiol 1965; 4:159-170.
37. Specht K. The role of DNA damage in PM2 viral inactivation by methylene blue photosensitization. Photochem Photobiol 1994; 59:506-514.
38. Abe H, Wagner SJ. Analysis of viral DNA, protein and envelope damage after methylene blue, phthalocyanine derivative or merocyanine 540 photosensitization. Photochem Photobiol 1995; 61:402-409.
39. Lambrecht B, Mohr H, Knuver-Hopf J, Schmitt H. Photoinactivation of viruses in human fresh plasma by phenothiazine dyes in combination with visible light. Vox Sang 1991; 60:207-213.
40. Wagner SJ, Robinette D, Storry J, Chen XY, Shumaker J, Benade L. Differential sensitivities of viruses in red cells suspensions to methylene blue photosensitization. Transfusion 1994; 34:521-526.
41. Mohr H, Lambrecht B, Selz A. Photodynamic virus inactivation of blood components. Immunol Invest 1995; 24:73-85.
42. Wieding JU, Neumeyer H. Erste Erfahrungen mit Methylenblau-virus inaktiviertem Fresh-frozen-plasma: Ergebnisse einer klinischen und einer in vitro Studie. Infusion Ther 1992; 19:84-90.
43. Mohr H, Knuver-Hopf J, Lambrecht B, Scheidecker H, Schmitt H. No evidence for neoantigens in human plasma after photochemical virus inactivation. Ann Hematol 1992; 65:224-228.
44. Zeiler T, Riess H, Wittman G, Hintz G, Zimmerman R, Muller C, Geuft HG, Huhn D. The effect of methylene blue phototreatment on plasma proteins and in vitro coagulation capability of single-donor fresh-frozen plasma. Transfusion 1994; 34:685-689.
45. Wagner SJ, Cifone MA, Murli H, Dodd RY, Myhr B. Mammalian genotoxicity assessment of methylene blue in plasma: implications for virus inactivation. Transfusion 1995; 35:407-413.
46. Murphy S, Rebulla P, Bertolini F, Holme S, Moroff G, Snyder E, Stromberg R. In vitro assessment of the quality of stored platelet concentrates. Transfusion Med Rev 1994; 8:29-36.
47. Ben-Hur E, Song PS. Photochemistry and photobiology of furocoumarins (psoralens). Adv Radiat Biol 1984; 11:131-171.
48. Kao KJ. Effects of leukocyte depletion and UVB irradiation on allogenicity of major histocompatibility antigens in platelet concentrates: a comparative study. Blood 1992; 80:2931-2937.
49. Heddle NM, Klama L, Singer J, Richards C, Fedak P, Walker I, Kelton JG. The role of plasma from platelet concentrates in transfusion reactions. N Engl J Med 1994; 331:625-628.
50. Lehmann PV, Shumm G, Moon D, Hurtenbach U, Falcioni F, Muller S, Zagy ZA. Acute lethal graft-versus-host reaction induced by major histocompatibility complex class II reactive T helper cell clone. J Exp Med 1990; 171:1485-1496.
51. Margolis-Nunno H, Robinson R, Ben-Hur E, Horowitz B. Quencher enhanced specificity of psoralens photosensitized viral inactivation in platelet concentrates. Transfusion 1994; 34:802-810.
52. Lin L, Cook DN, Wiesehahn GP, Alfonso R, Behrman B, Cimino GD, Corten L, Damonte PB, Dikeman R, Dupuis K, Fang YM, Hanson CV, Hearst JE, Lin CY, Londe HF, Metchette K, Nerio AT, Pu JT, Reames AA, Rheinschmidt M, Tessman J, Isaacs ST, Wollowitz S, Corash L. Photochemical inactivation of viruses and bacteria in platelet concentrates by use of a novel psoralen and long wavelength ultraviolet light. Transfusion 1997; 37:423-435.
53. Margolis-Nunno H, Robinson R, Ben-Hur E, Chin S, Orme T, Horowitz B. Elimination of potential mutagenicity in platelet concentrates that are virally inactivated with psoralens and ultraviolet A light. Transfusion 1995; 35:855-862.
54. Margolis-Nunno H, Robinson R, Horowitz B, Geacintov NE and Ben-Hur E. Psoralen-mediated virus photoinactivation in platelet concentrates: enhanced specificity of virus kill in the absence of shorter UVA wavelengths. Photochem Photobiol 1995; 62:917-922.
55. Gottlieb P, Marolis-Nunno H, Robinson R, Shen LG, Chimezie E, Horowitz B, Ben-Hur E. Inactivation of Trypanosoma cruzi trypomastigote forms in blood components with a psoralen and ultraviolet A light. Photochem Photobiol 1996; 63:562-565.
56. Lin L, Londe H, Janda JM, Hanson CV, Corash L. Photochemical inactivation of pathogenic bacteria in human platelet concentrates. Blood 1994; 83:2698-2706.
57. Benade L, Shumaker J, Xu Y, Shen X, Dodd RY. Inactivation of free and cellassociated human immunodeficiency virus in platelet suspensions by aminomethyl psoralen and ultraviolet light. Transfusion 1994; 34:680-684.
58. Margolis-Nunno H, Bardossy L, Robinson R, Ben-Hur E, Horowitz B, Blajchman MA. Psoralen-mediated photodecontamination of platelet concentrates: inactivation of cell-free and cell associated forms of human immunodeficiency virus and assessment of platelet function in vivo. Transfusion 1997;.
59. Goodrich RP, Yerram NR, Tay-Goodrich BH, Forster P, Platz MS, Kasturi C, Park SC, Aebischer JN, Rai S, Kulaga L. Selective inactivation of viruses in the presence of human platelets: UV sensitization with psoralen derivatives. Proc Natl Acad Sci USA 1994; 91:5552-5556.
60. Piet B, Legrand-Poels S, Sappety C, Piette J. NF-KB transcription factor and human immunodeficiency virus type 1 (HIV-1) activation by methylene blue photosensitization. Eur J Biochem. 1995; 228:447-455.
61. Wagner SJ, Storry JR, Mallory DA, Stromber RR, Benade LE, Friedman LI. Red cell alterations associated with virucidal methylene blue phototreatment. Transfusion 1993; 33:30-36.
62. Skripchenko A, Robinette D, Wagner SJ. Comparison of methylene blue and methylene violet for photoinactivation of intracellular and extracellular virus in red cell suspension. Photochem Photobiol 1997;.
63. North J, Coombs R, Levy J. Photodynamic inactivation of free and cell-associated HIV-1 using the photosensitizer benzoporphyrin derivative. J AIDS 1994; 7:891-898.
64. Meruelo D, Lavie G, Lavie D. Therapeutic agents with dramatic antiretroviral activity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin. Proc Natl Acad Sci USA 1988; 85:5230-5234.
65. Carpenter S, Kraus GA. Photosensitization is required for inactivation of equine infectious anemia virus by hypericin. Photochem Photobiol 1991; 53:169-174.
66. Lavie G, Mazur Y, Lavie D, Prince AM, Pascual D, Liebes L, Levin B, Meruelo D. Hypericin as an inactivator of infectious virus in blood products. Transfusion 1995; 35:392-400.
67. Horowitz B, Williams B, Rywkin S, Prince AM, Pascual D, Geacintov N, Valinsky J. Inactivation of viruses in blood with aluminum phthalocyanine derivatives. Transfusion 1991; 31:102-108.
68. Gaspard S, Tempete C, Werner GH. Studies on photoinactivation by various phthalocyanines of a free or replicating non-enveloped viruses. J Photochem Photobiol B:Biol 1995; 31:159-162.
69. Rywkin S, Lenny L, Goldstein J, Geacintov NE, Margolis-Nunno H, Horowitz B. Importance of type I and type II mechanisms in the photodynamic inactivation of viruses in blood with aluminum phthalocyanine derivatives. Photochem Photobiol 1995; 56:463-469.
70. Rywkin S, Ben-Hur E, Reid ME, Oyen R, Ralph H, Horowitz B. Selective protection against IgG binding to red cells treated with phthalocyanines and red light for virus inactivation. Transfusion 1995; 35:414-420.
71. Ben-Hur E, Rywkin S, Rosenthal I, Geacintov NE, Horowitz B. Virus inactivation in red cell concentrates by photosensitization with phthalocyanines: protection of red cells but not of vesicular stomatitis virus with a water-soluble analog of vitamin E. Transfusion 1995; 35:401-406.
72. Ben-Hur E, Geacintov NE, Studamire B, Kenney ME, Horowitz B. The effect of irradiance on virus sterilization and photodynamic damage in red blood cells sensitized by phthalocyanines. Photochem Photobiol 1995; 61:190-195.
73. Ben-Hur E, Zuk MM, Kenney ME, Oleinick NL, Mulvihill J, Horowitz B. Action spectra (660-700 nm) for virus inactivation and red cell damage photosensitized by the silicon phthalocyanine Pc 4. Lasers Med Sci 1996; 11:221-225.
74. Ben-Hur E, Zuk MM, Chin S, Banerjee D, Kenney ME, Horowitz B. Biodistribution and virus inactivation efficacy of the silicon phthalocyanine Pc 4 in red blood cell concentrates as a function of delivery vehicle. Photochem Photobiol 1995; 62:575-579.
75. Margolis-Nunno H, Ben-Hur E, Gottlieb P, Robinson R, Oetjen J, Horowitz B. Inactivation of multiple forms of human immunodeficiency virus in red cell concentrates by phthalocyanine photosensitization. Transfusion 1996; 36:743-750.
76. Gottlieb P, Shen LG, Chimezie E, Bhang S, Kenney ME, Horowitz B, Ben-Hur E. Inactivation of Trypanosoma cruzi trypomastigote forms in blood components by photodynamic treatment with phthalocyanines. Photochem Photobiol 1995; 62:869-874.
77. Lustigman S, Ben-Hur E. Photosensitized inactivation of Plasmodium falciparum in human erythrocytes by phthalocyanines. Transfusion 1995; 36:562-565.
78. Ben-Hur E, Oetjen J, Zuk MM, Chan WS, Horowitz B. Photochemical decontamination of red cell concentrates with silicon phthalocyanine (Pc 4) and red light. Transfusion 1996; 36(suppl):64S.
79. Zhang Q-X, Edson C, Budowsky E, Purmal A. Inactine: a method for viral inactivation in red blood cell concentrate. Transfusion 1998; 38(suppl):75S.