Genes associated with the tumour microenvironment are differentially expressed in cured versus primary chemotherapy-refractory diffuse large B-cell lymphoma

British Journal of Haematology

Volumn 141, Issue 4, 2008, Pages 423-432

  Linderoth, Johan ^a   Edén, Patrik ^b   Ehinger, Mats ^a   Valcich, Jeanette ^a   Jerkeman, Mats ^a   Bendahl, Pär Ola ^a   Berglund, Mattias ^c   Enblad, Gunilla ^c   Erlanson, Martin ^d   Roos, Göran ^d   Cavallin Ståhl, Eva ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

^d UMEÅ UNIVERSITY   (Sweden)

Author keywords

Chemotherapy; Diffuse large B cell lymphoma; Gene expression; Microenvironment

Indexed keywords

BLEOMYCIN; CATHEPSIN B; CATHEPSIN D; CD3 ANTIGEN; CD68 ANTIGEN; CHEMOKINE RECEPTOR CCR1; CYCLOPHOSPHAMIDE; CYTOKINE; DIPEPTIDYL PEPTIDASE I; DNA DIRECTED DNA POLYMERASE EPSILON; DOXORUBICIN; ENDOTHELIAL CELL GROWTH FACTOR; ETOPOSIDE; GALECTIN 3; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 32; LYSOZYME; MACROPHAGE ELASTASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MITOXANTRONE; PREDNISONE; PROSAPOSIN; RITUXIMAB; STAT1 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VINCRISTINE; VINCRISTINE SULFATE;

ADULT; AGED; ARTICLE; B CELL LYMPHOMA; CANCER REGRESSION; CANCER RESISTANCE; CANCER STAGING; CLINICAL ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DNA MICROARRAY; EXTRACELLULAR MATRIX; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE OVEREXPRESSION; HUMAN; IMMUNOHISTOCHEMISTRY; MICROENVIRONMENT; MULTIPLE CYCLE TREATMENT; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DEGRADATION; REFRACTORY PERIOD; TISSUE MICROARRAY;

AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; DISEASE PROGRESSION; DRUG RESISTANCE, NEOPLASM; FOLLOW-UP STUDIES; GENE EXPRESSION PROFILING; GENES, NEOPLASM; HUMANS; IMMUNOENZYME TECHNIQUES; LYMPHOMA, LARGE B-CELL, DIFFUSE; MIDDLE AGED; PROGNOSIS; RNA, NEOPLASM; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 42249094550     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2008.07037.x     Document Type: Article

References (45)

1. Alizadeh, A.A., Eisen, M.B., Davis, R.E., Ma, C., Lossos, I.S., Rosenwald, A., Boldrick, J.C., Sabet, H., Tran, T., Yu, X., Powell, J.I., Yang, L., Marti, G.E., Moore, T., Hudson, J. Jr., Lu, L., Lewis, D.B., Tibshirani, R., Sherlock, G., Chan, W.C., Greiner, T.C., Weisenburger, D.D., Armitage, J.O., Warnke, R., Levy, R., Wilson, W., Grever, M.R., Byrd, J.C., Botstein, D., Brown, P.O. Staudt, L.M. (2000) Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature, 403, 503 511.
2. Alvaro, T., Lejeune, M., Camacho, F.I., Salvado, M.T., Sanchez, L., Garcia, J.F., Lopez, C., Jaen, J., Bosch, R., Pons, L.E., Bellas, C. Piris, M.A. (2006a) The presence of STAT1-positive tumor-associated macrophages and their relation to outcome in patients with follicular lymphoma. Haematologica, 91, 1605 1612.
3. Alvaro, T., Lejeune, M., Salvado, M.T., Lopez, C., Jaen, J., Bosch, R. Pons, L.E. (2006b) Immunohistochemical patterns of reactive microenvironment are associated with clinicobiologic behavior in follicular lymphoma patients. Journal of Clinical Oncology, 24, 5350 5357.
4. Andersson, A., Eden, P., Lindgren, D., Nilsson, J., Lassen, C., Heldrup, J., Fontes, M., Borg, A., Mitelman, F., Johansson, B., Hoglund, M. Fioretos, T. (2005) Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations. Leukemia, 19, 1042 1050.
5. Ansell, S.M., Stenson, M., Habermann, T.M., Jelinek, D.F. Witzig, T.E. (2001) Cd4+ T-cell immune response to large B-cell non-Hodgkin's lymphoma predicts patient outcome. Journal of Clinical Oncology, 19, 720 726.
6. Ben-Baruch, A. (2006) The multifaceted roles of chemokines in malignancy. Cancer and Metastasis Reviews, 25, 357 371.
7. Benjamini, Y. Hochberg, Y. (1995) Controlling the False Discovery Rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society, 00, 289 300.
8. Berchem, G., Glondu, M., Gleizes, M., Brouillet, J.P., Vignon, F., Garcia, M. Liaudet-Coopman, E. (2002) Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosis. Oncogene, 21, 5951 5955.
9. Dave, S.S., Wright, G., Tan, B., Rosenwald, A., Gascoyne, R.D., Chan, W.C., Fisher, R.I., Braziel, R.M., Rimsza, L.M., Grogan, T.M., Miller, T.P., LeBlanc, M., Greiner, T.C., Weisenburger, D.D., Lynch, J.C., Vose, J., Armitage, J.O., Smeland, E.B., Kvaloy, S., Holte, H., Delabie, J., Connors, J.M., Lansdorp, P.M., Ouyang, Q., Lister, T.A., Davies, A.J., Norton, A.J., Muller-Hermelink, H.K., Ott, G., Campo, E., Montserrat, E., Wilson, W.H., Jaffe, E.S., Simon, R., Yang, L., Powell, J., Zhao, H., Goldschmidt, N., Chiorazzi, M. Staudt, L.M. (2004) Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. New England Journal of Medicine, 351, 2159 2169.
10. Farinha, P., Masoudi, H., Skinnider, B.F., Shumansky, K., Spinelli, J.J., Gill, K., Klasa, R., Voss, N., Connors, J.M. Gascoyne, R.D. (2005) Analysis of multiple biomarkers shows that lymphoma-associated macrophage (LAM) content is an independent predictor of survival in follicular lymphoma (FL). Blood, 106, 2169 2174.
11. Fernebro, J., Francis, P., Eden, P., Borg, A., Panagopoulos, I., Mertens, F., Vallon-Christersson, J., Akerman, M., Rydholm, A., Bauer, H.C., Mandahl, N. Nilbert, M. (2006) Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma. International Journal of Cancer, 118, 1165 1172.
12. Forssell, J., Oberg, A., Henriksson, M.L., Stenling, R., Jung, A. Palmqvist, R. (2007) High macrophage infiltration along the tumor front correlates with improved survival in colon cancer. Clinical Cancer Research, 13, 1472 1479.
13. Glas, A.M., Knoops, L., Delahaye, L., Kersten, M.J., Kibbelaar, R.E., Wessels, L.A., van Laar, R., van Krieken, J.H., Baars, J.W., Raemaekers, J., Kluin, P.M., van't Veer, L.J. de Jong, D. (2007) Gene-expression and immunohistochemical study of specific T-cell subsets and accessory cell types in the transformation and prognosis of follicular lymphoma. Journal of Clinical Oncology, 25, 390 398.
14. Imort, M., Zuhlsdorf, M., Feige, U., Hasilik, A. von Figura, K. (1983) Biosynthesis and transport of lysosomal enzymes in human monocytes and macrophages. Effects of ammonium chloride, zymosan and tunicamycin. Biochemical Journal, 214, 671 678.
15. Jerkeman, M., Anderson, H., Cavallin-Stahl, E., Dictor, M., Hagberg, H., Johnson, A., Kaasa, S., Kvaloy, S., Sundstrom, C. Akerman, M. (1999) CHOP versus MACOP-B in aggressive lymphoma-a Nordic Lymphoma Group randomised trial. Annals of Oncology, 10, 1079 1086.
16. Kallakury, B.V., Karikehalli, S., Haholu, A., Sheehan, C.E., Azumi, N. Ross, J.S. (2001) Increased expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinases 1 and 2 correlate with poor prognostic variables in renal cell carcinoma. Clinical Cancer Research, 7, 3113 3119.
17. Kaneko, T., Konno, H., Baba, M., Tanaka, T. Nakamura, S. (2003) Urokinase-type plasminogen activator expression correlates with tumor angiogenesis and poor outcome in gastric cancer. Cancer Science, 94, 43 49.
18. Lackner, M.R., Kindt, R.M., Carroll, P.M., Brown, K., Cancilla, M.R., Chen, C., de Silva, H., Franke, Y., Guan, B., Heuer, T., Hung, T., Keegan, K., Lee, J.M., Manne, V., O'Brien, C., Parry, D., Perez-Villar, J.J., Reddy, R.K., Xiao, H., Zhan, H., Cockett, M., Plowman, G., Fitzgerald, K., Costa, M. Ross-Macdonald, P. (2005) Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors. Cancer Cell, 7, 325 336.
19. Lee, A.H., Happerfield, L.C., Bobrow, L.G. Millis, R.R. (1997) Angiogenesis and inflammation in ductal carcinoma in situ of the breast. Journal of Pathology, 181, 200 206.
20. Leek, R.D., Landers, R.J., Harris, A.L. Lewis, C.E. (1999) Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast. British Journal of Cancer, 79, 991 995.
21. Linderoth, J., Ehinger, M., Jerkeman, M., Bendahl, P.O., Akerman, M., Berglund, M., Enblad, G., Erlanson, M., Roos, G. Cavallin-Stahl, E. (2007) CD40 expression identifies a prognostically favourable subgroup of diffuse large B-cell lymphoma. Leukaemia & Lymphoma, 48, 1774 1779.
22. Lippman, S.M., Spier, C.M., Miller, T.P., Slymen, D.J., Rybski, J.A. Grogan, T.M. (1990) Tumor-infiltrating T-lymphocytes in B-cell diffuse large cell lymphoma related to disease course. Modern Pathology, 3, 361 367.
23. Mantovani, A., Allavena, P., Sozzani, S., Vecchi, A., Locati, M. Sica, A. (2004) Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors. Seminars in Cancer Biology, 14, 155 160.
24. Miura, S. Izuta, S. (2004) DNA polymerases as targets of anticancer nucleosides. Current Drug Targets, 5, 191 195.
25. Miyauchi, J., Sasadaira, H., Watanabe, K. Watanabe, Y. (1985) Ultrastructural immunocytochemical localization of lysozyme in human monocytes and macrophages. Cell and Tissue Research, 242, 269 277.
26. Monti, S., Savage, K.J., Kutok, J.L., Feuerhake, F., Kurtin, P., Mihm, M., Wu, B., Pasqualucci, L., Neuberg, D., Aguiar, R.C., Dal Cin, P., Ladd, C., Pinkus, G.S., Salles, G., Harris, N.L., Dalla-Favera, R., Habermann, T.M., Aster, J.C., Golub, T.R. Shipp, M.A. (2005) Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response. Blood, 105, 1851 1861.
27. van Netten, J.P., Ashmed, B.J., Cavers, D., Fletcher, C., Thornton, I.G., Antonsen, B.L., Coy, P. Brigden, M.L. (1992) 'Macrophages' and their putative significance in human breast cancer. British Journal of Cancer, 66, 220 221.
28. Ohsawa, M., Ikura, Y., Fukushima, H., Shirai, N., Sugama, Y., Suekane, T., Hirayama, M., Hino, M. Ueda, M. (2005) Immunohistochemical expression of multidrug resistance proteins as a predictor of poor response to chemotherapy and prognosis in patients with nodal diffuse large B-cell lymphoma. Oncology, 68, 422 431.
29. Pawelec, G. (2006) Immunity and ageing in man. Experimental Gerontology, 41, 1239 1242.
30. Pyke, C., Graem, N., Ralfkiaer, E., Ronne, E., Hoyer-Hansen, G., Brunner, N. Dano, K. (1993) Receptor for urokinase is present in tumor-associated macrophages in ductal breast carcinoma. Cancer Research, 53, 1911 1915.
31. Rimsza, L.M., Roberts, R.A., Miller, T.P., Unger, J.M., LeBlanc, M., Braziel, R.M., Weisenburger, D.D., Chan, W.C., Greiner, T.C., Muller-Hermelink, H.K., Jaffe, E.S., Gascoyne, R.D., Campo, E., Fuchs, D.A., Spier, C.M., Fisher, R.I., Delabie, J., Rosenwald, A., Staudt, L.M. Grogan, T.M. (2004) Loss of MHC class II gene and protein expression in diffuse large B cell lymphoma is related to decreased tumor immunosurveillance and poor patient survival irrespective of other prognostic factors: a follow-up study from the leukemia and lymphoma molecular profiling project. Blood, 103, 4251 4258.
32. Roelofs, A.J., Hulley, P.A., Meijer, A., Ebetino, F.H., Russell, R.G. Shipman, C.M. (2006) Selective inhibition of Rab prenylation by a phosphonocarboxylate analogue of risedronate induces apoptosis, but not S-phase arrest, in human myeloma cells. International Journal of Cancer, 119, 1254 1261.
33. Rosenwald, A., Wright, G., Chan, W.C., Connors, J.M., Campo, E., Fisher, R.I., Gascoyne, R.D., Muller-Hermelink, H.K., Smeland, E.B., Giltnane, J.M., Hurt, E.M., Zhao, H., Averett, L., Yang, L., Wilson, W.H., Jaffe, E.S., Simon, R., Klausner, R.D., Powell, J., Duffey, P.L., Longo, D.L., Greiner, T.C., Weisenburger, D.D., Sanger, W.G., Dave, B.J., Lynch, J.C., Vose, J., Armitage, J.O., Montserrat, E., Lopez-Guillermo, A., Grogan, T.M., Miller, T.P., LeBlanc, M., Ott, G., Kvaloy, S., Delabie, J., Holte, H., Krajci, P., Stokke, T. Staudt, L.M. (2002) The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. New England Journal of Medicine, 346, 1937 1947.
34. Rytkonen, A.K., Hillukkala, T., Vaara, M., Sokka, M., Jokela, M., Sormunen, R., Nasheuer, H.P., Nethanel, T., Kaufmann, G., Pospiech, H. Syvaoja, J.E. (2006) DNA polymerase epsilon associates with the elongating form of RNA polymerase II and nascent transcripts. FEBS Journal, 273, 5535 5549.
35. Saal, L.H., Troein, C., Vallon-Christersson, J., Gruvberger, S., Borg, A. Peterson, C. (2002) BioArray Software Environment (BASE): a platform for comprehensive management and analysis of microarray data. Genome Biology, 3, SOFTWARE0003.
36. Sano, H., Hsu, D.K., Apgar, J.R., Yu, L., Sharma, B.B., Kuwabara, I., Izui, S. Liu, F.T. (2003) Critical role of galectin-3 in phagocytosis by macrophages. Journal of Clinical Investigation, 112, 389 397.
37. Schroeijers, A.B., Reurs, A.W., Scheffer, G.L., Stam, A.G., de Jong, M.C., Rustemeyer, T., Wiemer, E.A., de Gruijl, T.D. Scheper, R.J. (2002) Up-regulation of drug resistance-related vaults during dendritic cell development. Journal of Immunology, 168, 1572 1578.
38. Shipp, M.A., Anderson, J.R., Armitage, J.O., Bonnadonna, G. Brittinger, G. (1993) A predictive model for aggressive NHL. The International Non-Hodgin′s Lymphoma Prognostic Factors Project. New England Journal of Medicine, 329, 987 994.
39. Shipp, M.A., Ross, K.N., Tamayo, P., Weng, A.P., Kutok, J.L., Aguiar, R.C., Gaasenbeek, M., Angelo, M., Reich, M., Pinkus, G.S., Ray, T.S., Koval, M.A., Last, K.W., Norton, A., Lister, T.A., Mesirov, J., Neuberg, D.S., Lander, E.S., Aster, J.C. Golub, T.R. (2002) Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning. Nature Medicine, 8, 68 74.
40. Shurin, M.R., Shurin, G.V., Lokshin, A., Yurkovetsky, Z.R., Gutkin, D.W., Chatta, G., Zhong, H., Han, B. Ferris, R.L. (2006) Intratumoral cytokines/chemokines/growth factors and tumor infiltrating dendritic cells: friends or enemies? Cancer and Metastasis Reviews, 25, 333 356.
41. Stopeck, A.T., Gessner, A., Miller, T.P., Hersh, E.M., Johnson, C.S., Cui, H., Frutiger, Y. Grogan, T.M. (2000) Loss of B7.2 (CD86) and intracellular adhesion molecule 1 (CD54) expression is associated with decreased tumor-infiltrating T lymphocytes in diffuse B-cell large-cell lymphoma. Clinical Cancer Research, 6, 3904 3909.
42. Terol, M.J., Lopez-Guillermo, A., Bosch, F., Villamor, N., Cid, M.C., Rozman, C., Campo, E. Montserrat, E. (1998) Expression of the adhesion molecule ICAM-1 in non-Hodgkin's lymphoma: relationship with tumor dissemination and prognostic importance. Journal of Clinical Oncology, 16, 35 40.
43. Wright, G., Tan, B., Rosenwald, A., Hurt, E.H., Wiestner, A. Staudt, L.M. (2003) A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma. Proceedings of the National Academy of Sciences of the United States of America, 100, 9991 9996.
44. Xu, Y., Kroft, S.H., McKenna, R.W. Aquino, D.B. (2001) Prognostic significance of tumour-infiltrating T lymphocytes and T-cell subsets in de novo diffuse large B-cell lymphoma: a multiparameter flow cytometry study. British Journal Haematology, 112, 945 949.
45. Yang, Y.H., Dudoit, S., Luu, P., Lin, D.M., Peng, V., Ngai, J. Speed, T.P. (2002) Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Research, 30, e15.