Non-steroidal anti-inflammatory drugs suppress the ERK signaling pathway via block of Ras/c-Raf interaction and activation of MAP kinase phosphatases

Cellular Signalling

Volumn 20, Issue 6, 2008, Pages 1134-1141

  Pan, Mei Ren ^a   Chang, Hui Chiu ^a,b   Hung, Wen Chun ^b,c  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

c Raf; Cyclooxgenase 2; Extracellular signal regulated kinase; MAP kinase phosphatase 1; NS398; Phosphorylation

Indexed keywords

ACETYLSALICYLIC ACID; DUAL SPECIFICITY PHOSPHATASE 6; GELATINASE A; INDOMETACIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEIN; PROTEIN C RAF; RAS PROTEIN; SERINE; SULINDAC SULFIDE; UNCLASSIFIED DRUG; VANADATE SODIUM;

ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UPREGULATION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL MEMBRANE; DUAL SPECIFICITY PHOSPHATASE 1; DUAL SPECIFICITY PHOSPHATASE 6; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MAP KINASE KINASE 1; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASES; NITROBENZENES; PROTO-ONCOGENE PROTEINS C-RAF; PROTO-ONCOGENE PROTEINS P21(RAS); SERINE; SULFONAMIDES; VANADATES;

EID: 42249090354     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellsig.2008.02.004     Document Type: Article

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