The pharmacokinetic profiles of dexamethasone and methylprednisolone concentration in perilymph and plasma following systemic and local administration

Acta Oto-Laryngologica

Volumn 128, Issue 5, 2008, Pages 496-504

  Yang, Jun ^a   Wu, Hao ^a,c   Zhang, Ping ^a   Hou, Dong Ming ^a   Chen, Jie ^a   Zhang, Shun Guo ^b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Dexamethasone; Methylprednisolone; Otocyst infusion; Perilymph; Pharmacokinetic; Round window membrane topical application

Indexed keywords

DEXAMETHASONE; GELFOAM; METHYLPREDNISOLONE; STEROID;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; COCHLEA; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DISTRIBUTION; GUINEA PIG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INNER EAR; NONHUMAN; PERILYMPH; PRIORITY JOURNAL;

ADMINISTRATION, TOPICAL; ANIMALS; CAPILLARY PERMEABILITY; DEXAMETHASONE; GUINEA PIGS; HEART; INJECTIONS; METABOLIC CLEARANCE RATE; METHYLPREDNISOLONE; OTOLITHIC MEMBRANE; PERILYMPH; ROUND WINDOW, EAR;

EID: 42249089875     PISSN: 00016489     EISSN: 16512553     Source Type: Journal    
DOI: 10.1080/00016480701558906     Document Type: Article

References (36)

1. Yang GSY, Song HT, Keithley EM, Harris JP. Intratympanic immunosuppressive for prevention of immune-mediated sensorineural hearing loss. Am J Otol 2000;21:499-504.
2. Harris J, Ryan A. Immunobiology of the inner ear. Am J Otolaryngol 1984;5:418-25.
3. Gloddek B, Arnold W. Clinical and experimental studies of autoimmune inner ear disease. Acta Otolaryngol Suppl 2002;548:10-4.
4. Stone JH, Francis HW. Immune-mediated inner ear disease. Curr Opin Rheumatol 2000;12:32-40.
5. Rahman MU, Poe DS, Choi HK. Autoimmune vestibulocochlear disorders. Curr Opin Rheumatol 2001;13:184-9.
6. Bovo R, Aimoni C, Martini A. Immune-mediated inner ear disease. Acta Otolaryngol (Stockh) 2006;126:1012-21.
7. Moskowitz D, Lee KJ, Smith HW. Steroid use in idiopathic sudden sensorineural hearing loss. Laryngoscope 1984;94:664-6.
8. Kanzaki J, O-uchi T, Tsuchihashi N. Steroid-responsive sensorineural hearing loss: combination therapy with prednisolone and Sairei-to. ORL J Otorhinolaryngol Relat Spec 1993;55:24-9.
9. Haynes BF, Pikus A, Kaiser-Kupfer M, Fauci AS. Successful treatment of sudden hearing loss in Cogan's syndrome with corticosteroids. Arthritis Rheum 1981;24:501-3.
10. McCabe BF. Autoimmune inner ear disease: therapy. Am J Otol 1989;10:196-7.
11. Shea JJ. Autoimmune sensorineural hearing loss as an aggravating factor in Meniere's disease. Adv Otorhinolaryngol 1983;30:254-7.
12. Shea JJ Jr, Ge X. Dexamethasone perfusion of the labyrinth plus intravenous dexamethasone for Meniere's disease. Otolaryngol Clin North Am 1996;29:353-8.
13. Ariyasu L, Byl FM, Sprague MS, Adour KK. The beneficial effect of methylprednisolone in acute vestibular vertigo. Arch Otolaryngol Head Neck Surg 1990;116:700-3.
14. Sakata E, Itoh A, Itoh Y. Treatment of cochlear tinnitus with dexamethasone infusion into the tympanic cavity. Int Tinnitus J 1996;2:129-35.
15. Takemura K, Komeda M, Yagi M, Himeno C, Izumikawa M, Doi T, et al. Direct inner ear infusion of dexamethasone attenuates noise-induced trauma in guinea pig. Hear Res 2004;196:58-.
16. El-Hennawi DM, El-Deen MH, Abou-Halawa AS, Nadeem HS, Ahmed MR. Efficacy of intratympanic methylprednisolone acetate in treatment of drill-induced sensorineural hearing loss in guinea pigs. J Laryngol Otol 2005;119:2-7.
17. Karlidag T, Yalcin S, Ozturk A, Ustundag B, Gok U, Kaygusuz I, et al. The role of free oxygen radicals in noise induced hearing loss: effects of melatonin and methylprednisolone. Auris Nasus Larynx 2002;29:147-52.
18. Parnes LS, Sun AH, Freeman DJ. Corticosteroid pharmacokinetics in the inner ear fluids: an animal study followed by clinical application. Laryngoscope 1999;109:1-17.
19. Brown JN, Miller JM, Altschuler RA, Nuttall AL. Osmotic pump implant for chronic infusion of drugs into the inner ear. Hear Res 1993;70:67-72.
20. Prieskorn DM, Miller JM. Technical report: chronic and acute intracochlear infusion in rodents. Hear Res 2000;140:212-5.
21. Chandrasekhar SS, Rubinstein RY, Kwartler JA, Gatz M, Connelly PE, Huang E, et al. Dexamethasone pharmacokinetics in the inner ear: comparison of route of administration and use of facilitating agents. Otolaryngol Head Neck Surg 2000;122:521-8.
22. Liu HJ, Dong MM, Chi FL. Dexamethasone pharmacokinetics in Guinea pig inner ear perilymph. ORL J Otorhinolaryngol Relat Spec 2006;68:93-8.
23. Carpenter AM, Muchow D, Goycoolea MV. Ultrastructural studies of the human round window membrane. Arch Otolaryngol Head Neck Surg 1989;115:585-90.
24. Schachern PA, Paparella MM, Duvall AJ III, Choo YB. The human round window membrane. An electron microscopic study. Arch Otolaryngol 1984;110:15-21.
25. Goycoolea MV. Clinical aspects of round window membrane permeability under normal and pathological conditions. Acta Otolaryngol (Stockh) 2001;121:437-47.
26. Goycoolea MV, Paparella MM, Juhn SK. Oval and round window changes in otitis media. Potential pathways between middle and inner ear. Laryngoscope 1980;90:1387-91.
27. Goycooolea MV, Muchow D, Schachern P. Experimental studies on round window structure: function and permeability. Laryngoscope 1988;98:1-20.
28. Lundman L, Santi PA, Morizono T, Harada T, Juhn SK, Bagger- Sjöbäck D. Inner ear damage and passage through the round window membrane of Pseudomonas aeruginosa exotoxin A in a chinchilla model. Ann Otol Rhinol Laryngol 1992;101:437-44.
29. Spandow O, Anniko M, Moller AR. The round window as access route for agents injurious to the inner ear. Am J Otolaryngol 1988;9:327-35.
30. Oshiro EM, Shelton C, Lusted HS. Role of perilymphatic fistula in sudden hearing loss: an animal model. Ann Otol Rhinol Laryngol 1989;98:491-5.
31. Alles MJ, der Gaag MA, Stokroos RJ. Intratympanic steroid therapy for inner ear diseases, a review of the literature. Eur Arch Otorhinolaryngol 2006;263:791-7.
32. Chelikh L, Teixeira M, Martin C, Sterkers O, Ferrary E, Couloigner V. High variability of perilymphatic entry of neutral molecules through the round window. Acta Otolaryngol (Stockh) 2003;123:199-202.
33. Goycoolea MV, Lundman L. Round window membrane. Structure function and permeability: a review. Microsc Res Tech 1997;36:201-11.
34. Naci Ozluoglu L, Yilmaz I, Akkuzu B, Haberal A. Buffered papaverine facilitates passage of intratympanic dexamethasone to the inner ear. Acta Otolaryngol 2006;126:1260-5.
35. Scheibe F, Haupt H, Bergmann K. On sources of error in the biochemical study of perilymph (guinea-pig). Arch Otolaryngol 1984;240:43-8.
36. Salt AN, Kellner C, Hale S. Contamination of perilymph sampled from the basal cochlear turn with cerebrospinal fluid. Hear Res 2003;182:24-33.