Dexamethasone pharmacokinetics in guinea pig inner ear perilymph

ORL

Volumn 68, Issue 2, 2006, Pages 93-98

  Liu, Hong Jian ^a   Dong, Ming Min ^b   Chi, Fang Lu ^a,c  

^a FUDAN UNIVERSITY   (China)

^b ZHENGZHOU UNIVERSITY   (China)

^c EYE AND ENT HOSPITAL OF FUDAN UNIVERSITY   (China)

Author keywords

Chromatography, high pressure liquid; Dexamethasone pharmacokinetics; Guinea pig labyrinth; Perilymph

Indexed keywords

DEXAMETHASONE;

AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; GUINEA PIG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INNER EAR; NONHUMAN; PERILYMPH; PRIORITY JOURNAL;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEXAMETHASONE; EAR, INNER; GUINEA PIGS; PERILYMPH; RANDOM ALLOCATION;

EID: 33644886891     PISSN: 03011569     EISSN: None     Source Type: Journal    
DOI: 10.1159/000091210     Document Type: Article

References (14)

1. Ayllon L, Silva M, Perez-Bendito D: Improved automatic kinetic method for the determination of various corticosteroids. J Pharm Sci 1994;83:1135-1141.
2. Zignani M, Einmahl S, Baeyens V, Varesio E, Veuthey JL, Anderson J, Heller J, Tabatabay C, Gurny R: A poly(ortho ester) designed for combined ocular delivery of dexamethasone sodium phosphate and S-fluorouracil: subconjunctival tolerance and in vitro release. Eur J Pharm Biopharm 2000;50:251-255.
3. Hendrix C, Yongxin Z, Pijcke M, Roets E, Hoogmartens J: A comparative study of LC methods for analysis of cefradine. J Pharm Biomed Anal 1993;11:595-599.
4. Milojevic Z, Agbaba D, Eric S, Boberic-Borojevic D, Ristic P, Solujic M: High-pressure liquid chromatographic method for the assay of dexamethasone and xylometazoline in nasal drops containing methyl p-hydroxybenzoate. J Chromatogr A 2002;949:79-82.
5. Ryan AF, Harris JP, Keithley EM: Immune-mediated hearing loss: basic mechanisms and options for therapy. Acta Otolaryngol Suppl 2002;548:38-43.
6. Lasak JM, Sataloff RT, Hawkshaw M, Carey TE, Lyons KM, Spiegel JR: Autoimmune inner ear disease: steroid and cytotoxic drug therapy. Ear Nose Throat J 2001;80:808-811, 815-816, 818.
7. Sennaroglu L, Dini FM, Sennaroglu G, Gursel B, Ozkan S: Transtympanic dexamethasone application in Ménière's disease: an alternative treatment for intractable vertigo. J Laryngol Otol 1999;113:217-221.
8. Sennaroglu L, Sennaroglu G, Gursel B, Dini FM: Intratympanic dexamethasone, intratympanic gentamicin, and endolymphatic sac-surgery for intractable vertigo in Ménière's disease. Otolaryngol Head Neck Surg 2001;125:537-543.
9. Chandrasekhar SS: Intratympanic dexamethasone for sudden sensorineural hearing loss: clinical and laboratory evaluation. Otol Neurotol 2001;22:18-23.
10. Parnes LS, Sun AH, Freeman DJ: Corticosteroid pharmacokinetics in the inner ear fluids: an animal study followed by clinical application. Laryngoscope 1999;109:1-17.
11. Salt AN, Kellner C, Hale S: Contamination of perilymph sampled from the basal cochlear turn with cerebrospinal fluid. Hear Res 2003;182:24-33.
12. Salt AN, Ma Y: Quantification of solute entry into cochlear perilymph through the round window membrane. Hear Res 2001;154:88-97.
13. Stover T, Yagi M, Raphael Y: Cochlear gene transfer: round window versus cochleostomy inoculation. Hear Res 1999;136:124-130.
14. Plontke SKR, Salt AN: Quantitative interpretation of corticosteroid pharmacokinetics in inner fluids using computer simulations. Hear Res 2003;182:34-42.