Baggs ewes adapt to maternal undernutrition and maintain conceptus growth by maintaining fetal plasma concentrations of amino acids

Journal of Animal Science

Volumn 86, Issue 4, 2008, Pages 820-826

  Jobgen, W S ^a   Ford, S P ^b   Jobgen, S C ^a   Feng, C P ^a,c   Hess, B W ^b   Nathanielsz, P W ^d   Li, P ^a   Wu, G ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b UNIVERSITY OF WYOMING   (United States)

^c CHINA JAPAN FRIENDSHIP HOSPITAL   (China)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Fetal growth; Fetal intrauterine growth restriction; Fetal programming; Nutrition; Pregnancy

Indexed keywords

AMINO ACID; POLYAMINE;

ADAPTATION; ANIMAL; ANIMAL DISEASE; ANIMAL FOOD; ARTICLE; BLOOD; BREEDING; FEMALE; FETAL MALNUTRITION; FETOMATERNAL TRANSFUSION; FETUS; FETUS BLOOD; FETUS DEVELOPMENT; INTRAUTERINE GROWTH RETARDATION; MATERNAL NUTRITION; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PLACENTA; PREGNANCY; RANDOMIZATION; SHEEP; STARVATION;

ADAPTATION, PHYSIOLOGICAL; AMINO ACIDS; ANIMAL NUTRITION PHYSIOLOGY; ANIMALS; FEMALE; FETAL BLOOD; FETAL DEVELOPMENT; FETAL GROWTH RETARDATION; FETAL NUTRITION DISORDERS; FETUS; MATERNAL NUTRITION PHYSIOLOGY; MATERNAL-FETAL EXCHANGE; PLACENTA; POLYAMINES; PREGNANCY; PREGNANCY, ANIMAL; RANDOM ALLOCATION; SHEEP; STARVATION;

EID: 42149196162     PISSN: 00218812     EISSN: None     Source Type: Journal    
DOI: 10.2527/jas.2007-0624     Document Type: Article

References (44)

1. Barker, D. J. P., and P. M. Clark. 1997. Fetal undernutrition and disease in later life. Rev. Reprod. 2:105-112.
2. Bell, A. W., C. L. Ferrell, and H. C. Freetly. 2005. Pregnancy and fetal metabolism. Pages 523-550 in Quantitative Aspects of Ruminant Digestion and Metabolism. J. Dijkstra, J. M. Forbes, and J. France, ed. CABI Publ., Wallingford, UK.
3. Bell, A. W., J. M. Kennaugh, F. C. Battaglia, and G. Meschia. 1987. Uptake of amino acids and ammonia at mid-gestation by the fetal lamb. Q. J. Exp. Physiol. 74:635-643.
4. Ehrhardt, R. A., and A. W. Bell. 1995. Growth and metabolism of the ovine placenta during mid-gestation. Placenta 16:727-741.
5. Flynn, N. E., C. J. Meininger, T. E. Haynes, and G. Wu. 2002. The metabolic basis of arginine nutrition and pharmacotherapy. Biomed. Pharmacother. 56:427-438.
6. Ford, S. P. 1995. Control of blood flow to the gravid uterus of domestic livestock species. J. Anim. Sci. 73:1852-1860.
7. Ford, S. P., M. J. Nijland, M. M. Miller, B. W. Hess, and P. W. Nathanielsz. 2006. Maternal undernutrition advanced placentomal type, in association with increased placentomal size and cotyledonary (cot) blood flow. J. Soc. Gynecol. Invest. 12(Sup-pl.):212A. (Abstr.)
8. Ford, S. P., K. A. Vonnahme, M. C. Drumhiller, L. P. Reynolds, M. J. Nijland, and P. W. Nathanielsz. 2004. Arteriolar density and capillary volume increase as placentomes advance from type A through type D developmental stages. Biol. Reprod. 71(Suppl.):509. (Abstr.)
9. Hess, B. W., L. J. Krysl, M. B. Judkins, D. W. Holcombe, J. D. Hess, D. R. Hanks, and S. A. Huber. 1996. Supplemental cracked corn or wheat bran for steers grazing endophyte-free fescue pasture: Effects on live weight gain, nutrient quality, forage intake, particulate and fluid kinetics, ruminal fermentation, and digestion. J. Anim. Sci. 74:1116-1125.
10. Hoet, J. J., and M. A. Hanson. 1999. Intrauterine nutrition: Its importance during critical periods for cardiovascular and endocrine development. J. Physiol. 514:617-627.
11. Jobgen, W. S., S. K. Fried, W. J. Fu, C. J. Meininger, and G. Wu. 2006. Regulatory role for the arginine-nitric oxide pathway in energy-substrate metabolism. J. Nutr. Biochem. 17:571-588.
12. Jones, H. N., T. L. Powell, and T. Jansson. 2007. Regulation of placental nutrient transport - A review. Placenta 28:763-774.
13. Kwon, H., S. P. Ford, F. W. Bazer, T. E. Spencer, P. W. Nathanielsz, M. J. Nijland, B. W. Hess, and G. Wu. 2004a. Maternal undernutrition reduces concentrations of amino acids and polyamines in ovine maternal and fetal plasma and fetal fluids. Biol. Reprod. 71:901-908.
14. Kwon, H., T. E. Spencer, F. W. Bazer, and G. Wu. 2003a. Developmental changes of amino acids in ovine fetal fluids. Biol. Reprod. 68:1813-1820.
15. Kwon, H., G. Wu, F. W. Bazer, and T. E. Spencer. 2003b. Developmental changes in polyamine levels and synthesis in the ovine conceptus. Biol. Reprod. 69:1626-1634.
16. Kwon, H., G. Wu, C. J. Meininger, F. W. Bazer, and T. E. Spencer. 2004b. Developmental changes in nitric oxide synthesis in the ovine placenta. Biol. Reprod. 70:679-686.
17. Li, P., Y. L. Yin, D. F. Li, S. W. Kim, and G. Wu. 2007. Amino acids and immune function. Br. J. Nutr. 98:237-252.
18. Mellor, D. J. 1983. Nutritional and placental determinants of fetal growth rate in sheep and consequences for the newborn lamb. Br. Vet. J. 139:307-324.
19. NRC. 1985. Nutrient Requirements of Sheep. Natl. Acad. Press, Washington, DC.
20. Osgerby, J. C., D. C. Wathes, D. Howard, and T. S. Gadd. 2002. The effect of maternal undernutrition on ovine fetal growth. J. Endocrinol. 173:131-141.
21. Osgerby, J. C., D. C. Wathes, D. Howard, and T. S. Gadd. 2004. The effect of maternal undernutrition on the placental growth trajectory and the uterine insulin-like growth factor axis in the pregnant ewe. J. Endocrinol. 182:89-103.
22. Ostle, B. 1963. Statistics in Research. Iowa State Univ. Press, Ames.
23. Redmer, D. A., J. M. Wallace, and L. P. Reynolds. 2004. Effect of nutrient intake during pregnancy on fetal and placental growth and vascular development. Domest. Anim. Endocrinol. 27:199-217.
24. Regnault, T. R. H., J. E. Friedman, R. B. Wilkening, R. V. Anthony, and W. W. Hay Jr. 2005. Fetoplacental transport and utilization of amino acids in IUGR - A review. Placenta 26(Suppl. A):S52-S62.
25. Reynolds, L. P., P. P. Borowicz, K. A. Vonnahme, M. L. Johnson, A. T. Grazul-Bilska, D. A. Redmer, and J. S. Caton. 2005a. Placental angiogenesis in sheep models of compromised pregnancy. J. Physiol. 565:43-58.
26. Reynolds, L. P., P. Borowicz, K. A. Vonnahme, M. L. Johnson, A. T. Grazul-Bilska, J. M. Wallace, J. S. Caton, and D. A. Redmer. 2005b. Animal models of placental angiogenesis. Placenta 26:689-708.
27. Reynolds, L. P., J. S. Caton, D. A. Redmer, A. T. Grazul-Bilska, K. A. Vonnahme, P. B. Borowicz, J. S. Luther, J. M. Wallace, G. Wu, and T. E. Spencer. 2006. Evidence for altered placental blood flow and vascularity in compromised pregnancies. J. Physiol. 572:51-58.
28. Reynolds, L. P., and D. A. Redmer. 2001. Angiogenesis in the placenta. Biol. Reprod. 64:1033-1040.
29. Shi, W., C. J. Meininger, T. E. Haynes, K. Hatakeyama, and G. Wu. 2004. Regulation of tetrahydrobiopterin synthesis and bioavailability in endothelial cells. Cell Biochem. Biophys. 41:415-433.
30. Spencer, T. E., O. Sandra, and E. Wolf. 2008. Genes involved in conceptus-endometrial interactions in ruminants: Insights from reductionism and thoughts on holistic approaches. Reproduction 135:165-179.
31. Thomas, V. M., and R. W. Kott. 1995. A review of Montana winter range ewe nutrition research. Sheep Goat Res. J. 11:17-24.
32. Vonnahme, K. A., B. W. Hess, T. R. Hansen, R. J. McCormick, D. C. Rule, G. E. Moss, W. J. Murdoch, M. J. Nijland, D. C. Skinner, P. W. Nathanielsz, and S. P. Ford. 2003. Maternal undernutrition from early to mid gestation leads to growth retardation, cardiac ventricular hypertrophy and increased liver weight in the fetal sheep. Biol. Reprod. 69:133-140.
33. Vonnahme, K. A., B. W. Hess, M. J. Nijland, P. W. Nathanielsz, and S. P. Ford. 2006. Placentomal differentiation may compensate for maternal nutrient restriction in ewes adapted to harsh range conditions. J. Anim. Sci. 84:3451-3459.
34. Ward, J. W., A. J. Forhead, F. B. P. Wooding, and A. L. Fowden. 2006. Functional significance and cortisol dependence of the gross morphology of ovine placentomes during late gestation. Biol. Reprod. 74:137-145.
35. Wu, G. 1995. Urea synthesis in enterocytes of developing pigs. Biochem. J. 312:717-723.
36. Wu, G. 1998. Intestinal mucosal amino acid catabolism. J. Nutr. 128:1249-1252.
37. Wu, G., F. W. Bazer, T. A. Cudd, C. J. Meininger, and T. E. Spencer. 2004. Maternal nutrition and fetal development. J. Nutr. 134:2169-2172.
38. Wu, G., F. W. Bazer, J. M. Wallace, and T. E. Spencer. 2006. Board-invited review: Intrauterine growth retardation: Implications for the animal sciences. J. Anim. Sci. 84:2316-2337.
39. Wu, G., P. K. Devis, N. E. Flynn, D. A. Knabe, and J. T. Davidson. 1997. Endogenous synthesis of arginine plays an important role in maintaining arginine homeostasis in postweaning growing pigs. J. Nutr. 127:2342-2349.
40. Wu, G., Y. Z. Fang, S. Yang, J. R. Lupton, and N. D. Turner. 2004. Glutathione metabolism and its implications for health. J. Nutr. 134:489-492.
41. Wu, G., and S. W. Kin. 2007. Functional amino acids in animal production. Pages 1:1,1-3 in Encyclopedia of Animal Science. W. G. Pond and A. W. Bell, ed. Marcel Dekker Inc., New York, NY.
42. Wu, G., and S. M. Morris Jr. 1998. Arginine metabolism: Nitric oxide and beyond. Biochem. J. 336:1-17.
43. Wu, G., W. G. Pond, S. P. Flynn, T. Ott, and F. W. Bazer. 1998. Maternal dietary protein deficiency decreases nitric oxide synthase and ornithine decarboxylase activities in placenta and endometrium of pigs during early gestation. J. Nutr. 128:2395-2402.
44. Wu, G., and J. T. Self. 2005. Amino acids: Metabolism and functions. Pages 9-12 in Encyclopedia of Animal Science. W. G. Pond and A. W. Bell, ed. Marcel Dekker Inc., New York, NY.