Local environmental influences on uveal melanoma: Vitreous humor promotes uveal melanoma invasion, whereas the aqueous can be inhibitory

Cancer

Volumn 112, Issue 8, 2008, Pages 1787-1794

  Canovas, David ^a   Rennie, Ian G ^a   Nichols, Carmel E ^a   Sisley, Karen ^a,b  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Aqueous; Invasion; Metastasis; Uveal melanoma; Vitreous

Indexed keywords

TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TRANSFORMING GROWTH FACTOR BETA2;

ADULT; AGED; AQUEOUS HUMOR; ARTICLE; CANCER INVASION; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR LOCALIZATION; UVEA MELANOMA; VITREOUS BODY;

ADULT; AGED; ANTICARCINOGENIC AGENTS; AQUEOUS HUMOR; CARCINOGENS; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMOTAXIS; CHOROID NEOPLASMS; CILIARY BODY; CYTOKINES; FEMALE; FOLLOW-UP STUDIES; HUMANS; IRIS NEOPLASMS; MALE; MELANOMA; MIDDLE AGED; NEOPLASM INVASIVENESS; TISSUE CULTURE TECHNIQUES; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TISSUE INHIBITOR OF METALLOPROTEINASE-3; TRANSFORMING GROWTH FACTOR BETA2; UVEAL NEOPLASMS; VITREOUS BODY;

EID: 42149179213     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.23358     Document Type: Article

References (24)

1. Fidler IJ. Critical determinants of metastasis. Semin Cancer Biol. 2002;12:89-96.
2. Gragoudas ES, Egan KM. Uveal melanoma: a rare malignancy. Ophthalmology. 2000;107:1441-1442.
3. Kujala E, Makitie T, Kivela T. Very long-term prognosis of patients with malignant uveal melanoma. Invest Ophthalmol Vis Sci. 2003;44:4651-4659.
4. Conway RM, Chua WC, Qureshi C, Billson FA. Primary iris melanoma: diagnostic features and outcome of conservative surgical treatment. Br J Ophthalmol. 2001;85:848-854.
5. Shields CL, Shields JA, Materin M, Gershenbaum E, Singh AD, Smith A. Iris melanoma: risk factors in 169 consecutive patients. Ophthalmology. 2001;108:172-178.
6. Patel JI, Tombran-Tink J, Hykin PG, Gregor ZJ, Cree IA. Vitreous and aqueous concentrations of proangiogenic, antiangiogenic factors and other cytokines in diabetic retinopathy patients with macular edema: implications for structural differences in macular profiles. Exp Eye Res. 2006;82:798-806.
7. Nishimura M, Ikeda T, Ushiyama M, Nanbu A, Kinoshita S, Yoshimura M. Increased vitreous concentrations of human hepatocyte growth factor in proliferative diabetic retinopathy. J Clin Endocrinol Metab. 1999;84:659-662.
8. de Boer JH, Limpens J, Orengo-Nania S, de Jong PT, La Heij E, Kijlstra A. Low mature TGF-beta 2 levels in aqueous humor during uveitis. Invest Ophthalmol Vis Sci. 1994;35:3702-3710.
9. Ozean AA, Ozdemir N, Canataroglu A. The aqueous levels of TGF-beta 2 in patients with glaucoma. Int Ophthamol. 2004;25:19-22.
10. Hendrix MJ, Seftor EA, Sefter RE, et al. Regulation of uveal melanoma interconverted phenotype by hepatocyte growth factor/scatter factor (HGF/SF). Am J Pathol. 1998;152:855-863.
11. Woodward JKL, Elshaw SR, Murray AK, et al. Stimulation and inhibition of uveal melanoma invasion by HGF, GRO, IL-1alpha and TGF-beta. Invest Ophthalmol Vis Sci. 2002;43:3144-3152.
12. Hu DN, McCormick SA, Lin AY, Lin JY. TGF-beta 2 inhibits growth of uveal melanocytes at physiological concentrations. Exp Eye Res. 1998;67:143-150.
13. Myatt N, Aristodemon P, Neale MH, et al. Abnormalities of the transforming growth factor-beta pathway in ocular melanoma. J Pathol. 2000;192:511-518.
14. Boyd SR, Tan D, Bunce C, et al. Vascular endothelial growth factor is elevated in ocular fluids of eyes harbouring uveal melanoma: identification of a potential therapeutic window. Br J Ophthalmol. 2002;86:448-452.
15. Canton I, Eves PC, Szabo M, et al. Tumor necrosis factor alpha increases and alpha melanocyte-stimulating hormone reduces uveal melanoma invasion through fibronectin. J Invest Dermatol. 2003;121:557-563.
16. Elshaw SR, Sisley K, Cross NA, et al. A comparison of ocular melanocyte and uveal melanoma cell invasion and the implication of α1β1, α4 β1 and α6 β1 integrins. Br J Ophthalmol. 2001;85:732-738.
17. Tschentscher F, Husing J, Hoher T, et al. Tumor classification based on gene expression profiling shows that uveal melanomas with and without monosomy 3 represent two distinct entities. Cancer Res. 2003;63:2578-2584.
18. van der Velden PA, Zuidervaart W, Hurks MH, et al. Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development. Int J Cancer. 2003;106:472-479.
19. Nareyeck G, Zeschnigk M, von der Haar D, Schilling H, Bornfeld N, Anastassiou G. Differential expression of tissue inhibitor of matrix metalloproteinases 3 in uveal melanoma. Ophthalmic Res. 2005;37:23-28.
20. El-Shabrawi Y, Ardjomand N, Radner H, Ardjomand N. MMP-9 is predominantly expressed in epithelioid and not spindle cell uveal melanoma. J Pathol. 2001;194:201-206.
21. Klisovic DD, Klisovic MI, Effron D, Liu S, Marcucci G, Katz SE. Depsipeptide inhibitis migration of primary and metastatic uveal melanoma cell lines in vitro: a potential stratedy for uveal melanoma. Melanoma Res. 2005;15:147-153.
22. Woodward JKL, Rennie IG, Elshaw SR, Burn JL, Sisley K. Invasive and non-invasive uveal melanomas have different adhesive properties. Eye. 2005;19:342-348.
23. Missotten GS, Notting IC, Schlingemann RO, et al. Vascular endothelial growth factor α in eyes with uveal melanoma. Arch Ophthalmol. 2006;124:1428-1434.
24. Folberg R, Arbieva Z, Moses J, et al. Tumor cell plasticity in uveal melanoma: microenvironment directed dampening of the invasive and metastatic genotype and phenotype accompanies the generation of vasculogenic mimicry patterns. Am J Pathol. 2006;169:1376-1389.