Intensified postgrafting immunosuppression failed to assure long-term engraftment of dog leukocyte antigen-identical canine marrow grafts after 1 gray total body irradiation

Transplantation

Volumn 85, Issue 7, 2008, Pages 1023-1029

  Sorror, Mohamed L ^a   Leisenring, Wendy ^a,b   Mielcarek, Marco ^a,b   Baron, Frederic ^a,e   Diaconescu, Razvan ^a,c   Hogan, William J ^a,d   Graves, Scott S ^a   Storb, Rainer ^a,b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c HÔPITAL DU SACRÉ COEUR DE MONTRÉAL   (Canada)

^d MAYO CLINIC   (United States)

^e UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

1 Gy TBI; DLA identical canine marrow grafts; Triple postgrafting immunosuppression

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CYCLOSPORIN; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; LEUKOCYTE ANTIGEN; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DOG; DRUG DOSE REDUCTION; GRAFT REJECTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOLOGICAL TOLERANCE; IMMUNOSUPPRESSIVE TREATMENT; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TREATMENT OUTCOME; WHOLE BODY RADIATION;

ANIMALS; ANTIBODY FORMATION; BLOOD TRANSFUSION; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; DOGS; GRAFT REJECTION; GRAFT SURVIVAL; HISTOCOMPATIBILITY ANTIGENS; IMMUNOSUPPRESSION; LYMPH NODES; LYMPHOCYTE COUNT; SHEEP; TRANSPLANTATION CHIMERA; TRANSPLANTATION, HOMOLOGOUS; WHOLE-BODY IRRADIATION;

EID: 42149166051     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e318169be24     Document Type: Article

References (19)

1. Storb R, Yu C, Wagner JL, et al. Stable mixed hematopoietic chimerism in DLA-identical littermate dogs given sublethal total body irradiation before and pharmacological immunosuppression after marrow transplantation. Blood 1997; 89: 3048.
2. Hogan WJ, Little M-T, Zellmer E, et al. Postgrafting immunosuppression with sirolimus and cyclosporine facilitates stable mixed hematopoietic chimerism in dogs given sublethal total body irradiation before marrow transplantation from DLA-identical littermates. Biol Blood Marrow Transplant 2003; 9: 489.
3. McSweeney PA, Niederwieser D, Shizuru JA, et al. Hematopoietic cell transplantation in older patients with hematologic malignancies: Replacing high-dose cytotoxic therapy with graft-versus-tumor effects. Blood 2001; 97: 3390.
4. Maris MB, Niederwieser D, Sandmaier BM, et al. HLA-matched unrelated donor hematopoietic cell transplantation after nonmyeloablative conditioning for patients with hematologic malignancies. Blood 2003; 102: 2021.
5. Burroughs L, Storb RF, Leisenring W, et al. Postgrafting immune suppression combined with nonmyeloablative conditioning for transplantation of HLA-identical hematopoietic cell grafts: Results of a phase I study for treatment of immunodeficiency disorders [abstract]. Blood 2005; 106(pt 1): 134a, #327.
6. Storb R, Yu C, Barnett T, et al. Stable mixed hematopoietic chimerism in dog leukocyte antigen-identical littermate dogs given lymph node irradiation before and pharmacologic immunosuppression after marrow transplantation. Blood 1999; 94: 1131.
7. Storb R, Yu C, Zaucha JM, et al. Stable mixed hematopoietic chimerism in dogs given donor antigen, CTLA4Ig, and 100 cGy total body irradiation before and pharmacologic immunosuppression after marrow transplant. Blood 1999; 94: 2523.
8. Jochum C, Beste M, Zellmer E, et al. CD154 blockade and donor-specific transfusions in DLA-identical marrow transplantation in dogs conditioned with 1-Gy total body irradiation. Biol Blood Marrow Transplant 2007; 13: 164.
9. Wagner JL, Burnett RC, DeRose SA, et al. Histocompatibility testing of dog families with highly polymorphic microsatellite markers. Transplantation 1996; 62: 876.
10. Wagner JL, Burnett RC, Works JD, et al. Molecular analysis of DLA-DRBB1 polymorphism. Tissue Antigens 1996; 48: 554.
11. n polymorphisms to determine the origin of blood cells after allogeneic canine marrow grafting. Transplantation 1994; 58: 701.
12. Hilgendorf I, Weirich V, Zeng L, et al. Canine haematopoietic chimerism analyses by semiquantitative fluorescence detection of variable number of tandem repeat polymorphism. Vet Res Commun 2005; 29: 103.
13. Georges GE, Storb R, Thompson JD, et al. Adoptive immunotherapy in canine mixed chimeras after nonmyeloablative hematopoietic cell transplantation. Blood 2000; 95: 3262.
14. Abbas AK, Lichtman AH. Humoral immune responses: Activation of B lymphocytes and production antibodies. In: Abbas AK, Lichtman AH, eds. Basic immunology: Functions and disorders of the immune system. Philadelphia, PA, Saunders, 2004, p 123.
15. Diaconescu R, Little M-T, Leisenring W, et al. What role is there for antithymocyte globulin in allogeneic nonmyeloablative canine hematopoietic cell transplantation? Biol Blood Marrow Transplant 2005; 11: 335.
16. Temple L, Kawabata TT, Munson AE, et al. Comparison of ELISA and plaque-forming cell assays for measuring the humoral immune response to SRBC in rats and mice treated with benzo[a]pyrene or cyclophosphamide. Fundamental Appl Toxicol 1993; 21: 412.
17. Raff RF, Storb R, Ladiges WC, et al. Recognition of target cell determinants associated with DLA-D-locus-encoded antigens by canine cytotoxic lymphocytes. Transplantation 1985; 40: 323.
18. + regulatory T cells (Treg) block alloreactive host anti-donor T cells in canine mixed hematopoietic chimeras [abstract]. Blood 2005; 106(pt 1): 867a, #3101.
19. Zaucha JM, Zellmer E, Georges G, et al. G-CSF-mobilized peripheral blood mononuclear cells added to marrow facilitates engraftment in nonmyeloablated canine recipients: CD3 cells are required. Biol Blood Marrow Transplant 2001; 7: 613.