Enhancement of systemic and CNS delivery of meptazinol hydrochloride by intranasal administration to rats

Yaoxue Xuebao

Volumn 40, Issue 8, 2005, Pages 754-757

  Shi, Zhen Qi ^a   Zhang, Qi Zhi ^a   Jiang, Xin Guo ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Cerebrospinal fluid; Intranasal administration; Meptazinol hydrochloride; Rats

Indexed keywords

MEPTAZINOL; NARCOTIC ANALGESIC AGENT;

ANIMAL; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; BLOOD; CEREBROSPINAL FLUID; COMPARATIVE STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRANASAL DRUG ADMINISTRATION; MALE; METHODOLOGY; ORAL DRUG ADMINISTRATION; RAT; SPRAGUE DAWLEY RAT;

ADMINISTRATION, INTRANASAL; ADMINISTRATION, ORAL; ANALGESICS, OPIOID; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MALE; MEPTAZINOL; RATS; RATS, SPRAGUE-DAWLEY;

EID: 26844507114     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Illum L. Transport of drugs from the nasal cavity to the central nervous system [J]. Eur J Pharm Sci, 2000, 11(1):1-18.
2. Ilium L. Nasal drug delivery - possibilities, problems and solutions [J]. J Control Release, 2003, 87(1-3):187-198.
3. Dahlin M, Jansson B, Björk E. Levels of dopamine in blood and brain following nasal administration to rats [J]. Eur J Pharm Sci, 2001, 14(1):75-80.
4. Wang F, Jiang XG, Lu W. Profiles of methotrexate in blood and CSF following intranasal and intravenous administration to rats [J]. Int J Pharm, 2003, 263(1-2):1-7.
5. Zhang QZ, Jiang XG, Wu CH. Distribution of nimodipine into brain following intranasal administration in rats [J]. Acta Pharmacol Sin, 2004, 25(4):522-527.
6. Holmes B, Ward A. Meptazinol. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy [J]. Drugs, 1985, 30(4):285-312.
7. Franklin RA. The clinical pharmacokinetics and metabolism of the analgesic meptazinol [J]. Xenobiotica, 1988, 18(1):105-112.
8. Van den Berg MP, Romeijn SG, Verhoef JC, et al. Serial cerebrospinal fluid sampling in a rat model to study drug uptake from the nasal cavity [J]. J Neurosci Methods, 2002, 116(1):99-107.
9. Hussain MA, Aungst BJ. Intranasal absorption of oxymorphone [J]. J Pharm Sci, 1997, 86(8):975-976.
10. McMartin C, Hurchinson LEF, Hyde R, et al. Analysis of structural requirements for the absorption of drugs and macromolecules from the nasal cavity [J]. J Pharm Sci, 1987, 76(7):535-540.
11. Jiang XG, Lu X, Cui JB, et al. Studies on octanol-water partition coefficient and nasal drug absorption [J]. Acta Pharm Sin, 1997, 32(6):458-461.
12. Van den Berg MP, Merkus P, Romeijn SG, et al. Hydroxocobalamin uptake into the cerebrospinal fluid after nasal and intravenous delivery in rats and humans [J]. J Drug Target, 2003, 11(6):325-331.
13. Kawakami J, Yamamoto K, Sawada Y, et al. Prediction of brain delivery of ofloxacin, a new quinolone, in the human from animal data [J]. J Pharmacokinet Biopharm, 1994, 22(3):207-227.
14. Xu SY, Bian RL, Chen X, et al. Pharmacology Experiment Methodology [M]. 3rd Ed. Beijing: People's Medical Publishing House, 2002. 166.