Micronutrient needs of malnourished children

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 11, Issue 3, 2008, Pages 309-314

  Bhutta, Zulfiqar A ^a  

^a AGA KHAN UNIVERSITY   (Pakistan)

Author keywords

Fortification; Multiple micronutrients; Supplementation; Vitamin A; Zinc

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; FOLIC ACID; IODINE; IRON; NICOTINIC ACID; PANTOTHENATE CALCIUM; PYRIDOXINE; RETINOL; RIBOFLAVIN; THIAMINE; TRACE ELEMENT; VITAMIN D; VITAMIN K GROUP; ZINC;

DISEASE SEVERITY; EVIDENCE BASED MEDICINE; FOLIC ACID DEFICIENCY; HEALTH CARE NEED; HEALTH CARE PLANNING; HEALTH CARE SYSTEM; HEALTH SURVEY; HUMAN; INFORMATION RETRIEVAL; IODINE DEFICIENCY; IRON DEFICIENCY; MALNUTRITION; PREVALENCE; RETINOL DEFICIENCY; REVIEW; RISK FACTOR; STUNTING SYNDROME; TREATMENT DURATION; WASTING SYNDROME; ZINC DEFICIENCY;

CHILD; CHILD NUTRITION DISORDERS; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; MALE; MICRONUTRIENTS; NUTRITIONAL REQUIREMENTS; PROTEIN-ENERGY MALNUTRITION; RISK FACTORS;

EID: 42149128236     PISSN: 13631950     EISSN: 15353885     Source Type: Journal    
DOI: 10.1097/MCO.0b013e3282fbf5a0     Document Type: Review

References (41)

1. Black RE, Allen L, Bhutta ZA. Maternal and child undernutrition: global and regional exposures and health consequences. Lancet 2008; 371:243-260. This is the most recent assessment of the global burden of maternal and child undernutrition and presents data on attributable deaths and disability adjusted life years (DALYs). Taking into account joint distributions and effects of these risk factors the total attributable burden is 35% of deaths in children less than 5 years of age and 11% of the total disease burden.
2. Bhutta ZA. Effect of infections and environmental factors on growth and nutritional status in developing countries. J Pediatr Gastroenterol Nutr 2006; 43 (Suppl 3):S13-S21.
3. Tienboon P, Wangpakapattanawong P. Vitamin A status of the minority ethnic group of Karen hill tribe children aged 1-6 years in Northern Thailand. Asia Pac J Clin Nutr 2007; 16:158-162. Thailand has made enormous strides in child survival and nutrition interventions. This survey underscores the wide variations in vitamin A status in a population of children in hill tribes in the north of the country with biochemical vitamin A deficiency ranging from 0-63%.
4. Ma G, Li Y, Jin Y, et al. Assessment of intake inadequacy and food sources of zinc of people in China. Public Health Nutr 2007; 10:848-854.
5. Griffin IJ, Lynch MF, Hawthorne KM, et al. Zinc homeostasis in 1-4 year olds consuming diets typical of US children. Br J Nutr 2007; 98:358-363. A small but important study of the relationships among Zn intake, absorption, endogenous faecal excretion and retention in a group of healthy children using stable-isotope techniques. Thirty children, aged 15-48 months, were studied on a diet representative of their usual daily mineral intake.
6. Dewey KG, Chaparro CM. Session 4: mineral metabolism and body composition iron status of breast-fed infants. Proc Nutr Soc 2007; 66:412-422.
7. Hopkins D, Emmett P, Steer C, et al. Infant feeding in the second 6 months of life related to iron status: an observational study. Arch Dis Child 2007; 92:850-854.
8. Thorsdottir I, Gunnarsson BS. Dietary quality and adequacy of micronutrient intakes in children. Proc Nutr Soc 2006; 65:366-375.
9. Lynch MF, Griffin IJ, Hawthorne KM, et al. Iron absorption is more closely related to iron status than to daily iron intake in 12- to 48-mo-old children. J Nutr 2007; 137:88-92.
10. Sarkar S, Mohanty B, Basu S. Iodine deficiency in school going children of Pondicherry. Indian J Pediatr 2007; 74:731-734.
11. 12, magnesium, folate, calcium and zinc in comparison with Adequate Intake estimates (for vitamin D and calcium) or the Estimated Average Requirement (EAR) (all other micronutrients).
12. Roth DE. Bones and beyond: an update on the role of vitamin D in child and adolescent health in Canada. Appl Physiol Nutr Metab 2007; 32:770-777.
13. Siddiqui AM, Kamfar HZ. Prevalence of vitamin D deficiency rickets in adolescent school girls in Western region, Saudi Arabia. Saudi Med J 2007; 28:441-444.
14. Dahifar H, Faraji A, Yassobi S, Ghorbani A. Asymptomatic rickets in adolescent girls. Indian J Pediatr 2007; 74:571-575.
15. Chen KJ, Shaw NS, Pan WH, Lin BF. Evaluation of folate status by serum and erythrocyte folate levels and dietary folate intake in Taiwanese schoolchildren. Asia Pac J Clin Nutr 2007; 16 (Suppl 2):572-578.
16. Shaw NS, Wang JL, Pan WH, et al. Thiamin and riboflavin status of Taiwanese elementary schoolchildren. Asia Pac J Clin Nutr 2007; 16 (Suppl 2):564-571.
17. Strand TA, Taneja S, Bhandari N, et al. Folate, but not vitamin B-12 status, predicts respiratory morbidity in north Indian children. Am J Clin Nutr 2007; 86:139-144.
18. 12, folate, alpha-tocopherol, ferritin and zinc are common in South African breastfeeding mothers. HIV-positive mothers had lower mean serum concentrations of albumin, prealbumin, folate, retinol and hemoglobin than did HIV-negative mothers.
19. The Supplementation with Multiple Micronutrients Intervention Trial (SUMMIT) Study Group. Effect of maternal multiple micronutrient supplementation on fetal loss and infant death in Indonesia: a double-blind cluster-randomised trial. Lancet 2008; 371:215-227. A large cluster randomized trial of maternal micronutrient supplementation during pregnancy indicating 18% reduction in mortality in infancy in the intervention group.
20. Bhutta ZA, Ahmed T, Black RE, et al. What works? Interventions for maternal and child undernutrition and survival. Lancet 2008; 371:417-440. [Epub ahead of print] An extensive review of 45 nutrition and related disease burden reduction interventions to evaluate impact on maternal and childhood deaths and DALYs. The model showed that these existing interventions could reduce stunting at 36 months by 36%; mortality between birth and 36 months by about 25%; and DALYs associated with stunting, severe wasting, intrauterine growth restriction and micronutrient deficiencies by about 25%.
21. Fischer Walker CL, Black RE. Micronutrients and diarrheal disease. Clin Infect Dis 2007; 45 (Suppl 1):S73-S77.
22. Olney DK, Pollitt E, Kariger PK, et al. Combined iron and folic acid supplementation with or without zinc reduces time to walking unassisted among Zanzibari infants 5- to 11-mo old. J Nutr 2006; 136:2427-2434.
23. Olney DK, Pollitt E, Kariger PK, et al. Young Zanzibari children with iron deficiency, iron deficiency anemia, stunting, or malaria have lower motor activity scores and spend less time in locomotion. J Nutr 2007; 137:2756-2762.
24. Sachdev H, Gera T, Nestel P. Effect of iron supplementation on mental and motor development in children: systematic review of randomised controlled trials. Public Health Nutr 2005; 8:117-132.
25. Lozoff B, Jimenez E, Smith JB. Double burden of iron deficiency in infancy and low socioeconomic status: a longitudinal analysis of cognitive test scores to age 19 years. Arch Pediatr Adolesc Med 2006; 160:1108-1113.
26. Leaf AA, RCPCH Standing Committee on Nutrition. Vitamins for babies and young children. Arch Dis Child 2007; 92:160-164. Review of daily vitamin requirements for children and dietary sources.
27. Dalmiya N, Palmer A, Darnton-Hill I. Sustaining vitamin A supplementation requires a new vision. Lancet 2006; 368:1052-1054.
28. Bryce J, Terreri N, Victora CG, et al. Countdown to 2015: tracking intervention coverage for child survival. Lancet 2006; 368:1067-1076.
29. Zimmermann MB, Hurrell RF. Nutritional iron deficiency. Lancet 2007; 370: 511-520. Review of iron deficiency including the molecular basis for absorption.
30. Domellöf M. Iron requirements, absorption and metabolism in infancy and childhood. Curr Opin Clin Nutr Metab Care 2007; 10:329-335. Review of recent developments in iron absorption and metabolism and its regulation in response to changing iron status by upregulation or downregulation of key intestinal and hepatic proteins.
31. Hutton EK, Hassan ES. Late vs early clamping of the umbilical cord in full-term neonates: systematic review and meta-analysis of controlled trials. JAMA 2007; 297:1241-1252.
32. Thi Le H, Brouwer ID, Burema J, et al. Efficacy of iron fortification compared to iron supplementation among Vietnamese schoolchildren. Nutr J 2006; 5:32.
33. Sazawal S, Dhingra U, Dhingra P, et al. Effects of fortified milk on morbidity in young children in north India: community based, randomised, double masked placebo controlled trial. BMJ 2007; 334:140.
34. Sazawal S, Black RE, Ramsan M, et al. Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial. Lancet 2006; 367:133-143.
35. Fischer Walker CL, Aboubaker S, Van de Weerdt R, Black RE. Zinc for diarrhoea management in Sub-Saharan Africa: a review. East Afr Med J 2007; 84:441-449.
36. Roy SK, Hossain MJ, Khatun W, et al. Zinc supplementation in children with cholera in Bangladesh: randomized controlled trial. BMJ 2008; 336:266-268. [Epub ahead of print].
37. Aggarwal R, Sentz J, Miller MA. Role of zinc administration in prevention of childhood diarrhea and respiratory illnesses: a meta-analysis. Pediatrics 2007; 119:1120-1130. A meta-analysis of 17 rather heterogeneous studies of zinc supplementation in children were pooled by using random-effects and fixed-effects models. While impact was demonstrated, the quality of studies varied greatly. The need for better large-scale robust studies was underscored.
38. Tielsch JM, Khatry SK, Stoltzfus RJ, et al. Effect of daily zinc supplementation on child mortality in southern Nepal: a community-based, cluster randomised, placebo-controlled trial. Lancet 2007; 370:1230-1239.
39. Sazawal S, Black RE, Ramsan M, et al. Effect of zinc supplementation on mortality in children aged 1-48 months: a community-based randomised placebo-controlled trial. Lancet 2007; 369:927-934.
40. Bhandari N, Taneja S, Mazumder S, et al., Zinc Study Group. Adding zinc to supplemental iron and folic acid does not affect mortality and severe morbidity in young children. J Nutr 2007; 137:112-117.
41. Brown KH, Peerson JM, Rivera J, Allen LH. Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials. Am J Clin Nutr 2002; 75:1062-1071.