Detection of ethyl glucuronide in dried human blood using LC-MS/MS

International Journal of Legal Medicine

Volumn 122, Issue 3, 2008, Pages 245-249

  Kaufmann, Eckhard ^a,b   Alt, Andreas ^a  

^a UNIVERSITY OF ULM   (Germany)

^b UNIVERSITY OF ULM MEDICAL SCHOOL   (Germany)

Author keywords

Ethanol; Ethyl glucuronide; Ion trap; LC MS

Indexed keywords

ALCOHOL; ETHYLGLUCURONIDE; GLUCURONIDE; UNCLASSIFIED DRUG;

ALCOHOL BLOOD LEVEL; ARTICLE; BLOOD ANALYSIS; DRINKING BEHAVIOR; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INFORMED CONSENT; MASS SPECTROMETER; METHODOLOGY; NORMAL HUMAN; PRIORITY JOURNAL; VOLUNTEER;

ALCOHOL DRINKING; BIOLOGICAL MARKERS; BLOOD CHEMICAL ANALYSIS; CHROMATOGRAPHY, LIQUID; FEMALE; FORENSIC TOXICOLOGY; GLUCURONATES; HUMANS; MALE; TANDEM MASS SPECTROMETRY;

EID: 42149126325     PISSN: 09379827     EISSN: 14371596     Source Type: Journal    
DOI: 10.1007/s00414-007-0219-x     Document Type: Article

References (18)

1. Alt A, Janda I, Seidl S et al (2000) Determination of ethyl glucuronide in hair samples. Alcohol Alcohol 35:313-314
2. Droenner P, Schmitt G, Aderjan R et al (2002) A kinetic model describing the pharmacokinetics of ethyl glucuronide in humans. Forensic Sci Int 126:24-29
3. Halter C, Dresen S, Auwaerter V et al (2007) Kinetics in serum and urinary excretion of ethyl sulfate and ethyl glucuronide after medium dose ethanol intake. Int J Legal Med (in press)
4. Hannuksela ML, Liisanantti MK, Nissinen AE et al (2007) Biochemical markers of alcoholism. Clin Chem Lab Med 45:953-961
5. Helander A (2003) Biological markers in alcoholism. J Neural Transm Suppl 66:15-32
6. Janda I, Alt A (2001) Improvement of ethyl glucuronide determination in human urine and serum samples by solid-phase extraction. J Chromatogr B Biomed Sci Appl 758:229-234
7. Janda I, Weinmann W, Kuehnle T et al (2002) Determination of ethyl glucuronide in human hair by SPE and LC-MS. Forensic Sci Int 128:59-65
8. Kaufmann E, Alt A (2007) Determination of GHB in urine and serum by LC/MS using a simple one-step derivative. Forensic Sci Int 168:133-137
9. Kugelberg FC, Jones AW (2007) Interpreting results of ethanol analysis in postmortem specimens: a review of the literature. Forensic Sci Int 165:10-29
10. Morini L, Politi L, Zucchella A et al (2007) Ethyl glucuronide and ethyl sulphate determination in serum by liquid chromatography-electrospray tandem mass spectrometry. Clin Chim Acta 376:213-219
11. Pragst F, Balikova MA (2006) State of the art in hair analysis for detection of drug and alcohol abuse. Clin Chim Acta 370:17-49
12. Schloegl H, Dresen S, Spaczynski K et al (2006) Stability of ethyl glucuronide in urine, post-mortem tissue and blood samples. Int J Legal Med 120:83-88
13. Schmidt G, Jerbold M, Peters F Qualitaetssicherung im forensisch-toxikologischen Labor und VALISTAT 1.0 Programm auf Excel-Basis zur Validierung nach den Richtlinien der GTFCh unter Berücksichtigung der ISO 5725. ISBN 3-9808734-0-4 ( http://www.pts-gtfch.de/s50880496b80aef407/index.html )
14. Seidl S, Wurst FM, Alt A (2001) Ethyl glucuronide-a biological marker for recent alcohol consumption. Addict Biol 6:205-212
15. Weinmann W, Schaefer P, Thierauf A et al (2004) Confirmatory analysis of ethylglucuronide in urine by liquid-chromatography/electrospray ionization/tandem mass spectrometry according to forensic guidelines. J Am Soc Mass Spectrom 15:188-193
16. Wojcik MH, Hawthorne JS (2007) Sensitivity of commercial ethyl glucuronide (EtG) testing in screening for alcohol abstinence. Alcohol Alcohol 42:317-320
17. Wurst FM, Skipper GE, Weinmann W (2003) Ethyl glucuronide-the direct ethanol metabolite on the threshold from science to routine use. Addiction 98(Suppl 2):51-61
18. Wurst FM, Vogel R, Jachau K et al (2003) Ethyl glucuronide discloses recent covert alcohol use not detected by standard testing in forensic psychiatric inpatients. Alcohol Clin Exp Res 27:471-476