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Volumn 86, Issue 3, 2008, Pages 122-130

Overexpression of Gsα compensates for myocyte loss in diabetic cardiomyopathy

Author keywords

adrenergic receptors; Diabetes mellitus; Gs overexpression; Hyperglycemia; Oxidative stress; Reactive oxygen species (ROS)

Indexed keywords

BETA ADRENERGIC RECEPTOR; CATALASE; DNA; GUANINE NUCLEOTIDE BINDING PROTEIN; MALONALDEHYDE; PHOSPHOLAMBAN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN SUBUNIT; REACTIVE OXYGEN METABOLITE; SERINE; STREPTOZOCIN; SUPEROXIDE DISMUTASE; APOPTOSIS REGULATORY PROTEIN; CALCIUM BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

EID: 42149126053     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y08-015     Document Type: Article
Times cited : (3)

References (33)
  • 1
    • 0032699668 scopus 로고    scopus 로고
    • Beta-adrenergic receptor blockade arrests myocyte damage, and preserves cardiac function in the transgenic Gs (alpha) mouse
    • PMID:10487769
    • Asai, K., Yang, G.P., Geng, Y.J., Takagi, G., Bishop, S., Ishikawa, Y., et al. 1999. Beta-adrenergic receptor blockade arrests myocyte damage, and preserves cardiac function in the transgenic Gs (alpha) mouse. J. Clin. Invest. 104: 551-558. PMID:10487769.
    • (1999) J. Clin. Invest , vol.104 , pp. 551-558
    • Asai, K.1    Yang, G.P.2    Geng, Y.J.3    Takagi, G.4    Bishop, S.5    Ishikawa, Y.6
  • 2
    • 0021928415 scopus 로고
    • β-Adrenergic receptors, adenylate cyclase activity, and cardiac dysfunction in diabetic rat
    • PMID:2580153, doi:10.1097/00005344-198501000-00011
    • Atkins, F.L., Dowell, R.T., and Love, S. 1985. β-Adrenergic receptors, adenylate cyclase activity, and cardiac dysfunction in diabetic rat. J. Cardiovasc. Pharmacol. 7: 66-70. doi:10.1097/00005344-198501000-00011. PMID:2580153.
    • (1985) J. Cardiovasc. Pharmacol , vol.7 , pp. 66-70
    • Atkins, F.L.1    Dowell, R.T.2    Love, S.3
  • 3
    • 0032913309 scopus 로고    scopus 로고
    • Role of oxidative stress in diabetic complications: A new perspective on an old paradigm
    • PMID:9892215, doi:10.2337/diabetes.48.1.1
    • Baynes, J.W., and Thorpe, S.R. 1999. Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes, 48: 1-9. doi:10.2337/diabetes.48.1.1. PMID:9892215.
    • (1999) Diabetes , vol.48 , pp. 1-9
    • Baynes, J.W.1    Thorpe, S.R.2
  • 4
    • 0029060453 scopus 로고
    • Diabetic cardiomyopathy: A unique entity or a complication of coronary artery disease?
    • PMID:8586013, doi:10.2337/diacare.18.5.708
    • Bell, D.S.H. 1995. Diabetic cardiomyopathy: a unique entity or a complication of coronary artery disease? Diabetes Care, 18: 708-714. doi:10.2337/diacare.18.5.708. PMID:8586013.
    • (1995) Diabetes Care , vol.18 , pp. 708-714
    • Bell, D.S.H.1
  • 5
    • 33846870605 scopus 로고    scopus 로고
    • Inhibition of wild-type p66ShcA in mesangial cells prevents glycooxidant-dependent FOXO3a regulation and promotes the survival phenotype
    • PMID:17077388, doi:10.1152/ajprenal.00215.2006
    • Chintapalli, J., Yang, S., Opawumi, D., Goyal, S.R., Shamsuddin, N., Malhotra, A., et al. 2007. Inhibition of wild-type p66ShcA in mesangial cells prevents glycooxidant-dependent FOXO3a regulation and promotes the survival phenotype. Am. J. Physiol. Renal Physiol. 292: F523-F530. doi:10.1152/ajprenal.00215.2006. PMID:17077388.
    • (2007) Am. J. Physiol. Renal Physiol , vol.292
    • Chintapalli, J.1    Yang, S.2    Opawumi, D.3    Goyal, S.R.4    Shamsuddin, N.5    Malhotra, A.6
  • 6
    • 0034623718 scopus 로고    scopus 로고
    • A single site (Ser16) phosphorylation in phospholamban is sufficient in mediating its maximal cardiac responses to beta -agonists
    • PMID:10988285, doi:10.1074/jbc.M004079200
    • Chu, G., Lester, J.W., Young, K.B., Luo, W., Zhai, J., and Kranias, E.G. 2000. A single site (Ser16) phosphorylation in phospholamban is sufficient in mediating its maximal cardiac responses to beta -agonists. J. Biol. Chem. 275: 38938-38943. doi:10.1074/jbc.M004079200. PMID:10988285.
    • (2000) J. Biol. Chem , vol.275 , pp. 38938-38943
    • Chu, G.1    Lester, J.W.2    Young, K.B.3    Luo, W.4    Zhai, J.5    Kranias, E.G.6
  • 9
    • 0028510483 scopus 로고
    • Pharmacological studies on alterations in myocardial beta-adrenoceptors and their intracellular signal transduction in experimental diabetic rats
    • PMID:7868054
    • Gando, S. 1994. Pharmacological studies on alterations in myocardial beta-adrenoceptors and their intracellular signal transduction in experimental diabetic rats. Hokkaido Igaku Zasshi, 69: 1140-1153. PMID:7868054.
    • (1994) Hokkaido Igaku Zasshi , vol.69 , pp. 1140-1153
    • Gando, S.1
  • 10
    • 0030770245 scopus 로고    scopus 로고
    • Impaired contractile response to beta AR stimulation in diabetic rat hearts: Alternations in beta ARs-G protein-adenylate cyclase system and phospholamban phosphorylation
    • PMID:9223590
    • Gando, S., Hattori, Y., Akaishi, Y., Nishihira, J., and Kanno, M. 1997. Impaired contractile response to beta AR stimulation in diabetic rat hearts: alternations in beta ARs-G protein-adenylate cyclase system and phospholamban phosphorylation. J. Pharmacol. Exp. Ther. 282: 475-484. PMID:9223590.
    • (1997) J. Pharmacol. Exp. Ther , vol.282 , pp. 475-484
    • Gando, S.1    Hattori, Y.2    Akaishi, Y.3    Nishihira, J.4    Kanno, M.5
  • 11
    • 0037022232 scopus 로고    scopus 로고
    • Accelerated cardiomyopathy in mice with overexpression of cardiac G(s)alpha and a missense mutation in the alpha-myosin heavy chain
    • PMID:11827928, doi:10.1161/hc0502.103012
    • Hardt, S.E., Geng, Y.J., Montagne, O., Asai, K., Hong, C., Yang, G.P., et al. 2002. Accelerated cardiomyopathy in mice with overexpression of cardiac G(s)alpha and a missense mutation in the alpha-myosin heavy chain. Circulation, 105: 614-620. doi:10.1161/hc0502.103012. PMID:11827928.
    • (2002) Circulation , vol.105 , pp. 614-620
    • Hardt, S.E.1    Geng, Y.J.2    Montagne, O.3    Asai, K.4    Hong, C.5    Yang, G.P.6
  • 12
    • 10344255610 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy: Mechanisms, diagnosis and treatment
    • PMID:15341511
    • Hayat, S.A., Patel, B., Khattar, R.S., and Malik, R.A. 2004. Diabetic cardiomyopathy: mechanisms, diagnosis and treatment. Clin. Sci. (Lond.), 107: 539-557. PMID:15341511.
    • (2004) Clin. Sci. (Lond.) , vol.107 , pp. 539-557
    • Hayat, S.A.1    Patel, B.2    Khattar, R.S.3    Malik, R.A.4
  • 13
    • 0027034519 scopus 로고
    • The bcl-2 oncogene and apoptosis
    • PMID:1286168
    • Hockenbery, D.M. 1992. The bcl-2 oncogene and apoptosis. Semin. Immunol. 4: 413-420. PMID:1286168.
    • (1992) Semin. Immunol , vol.4 , pp. 413-420
    • Hockenbery, D.M.1
  • 14
    • 0026067040 scopus 로고
    • Beta-adrenergic receptor regulation in the heart in pathophysiologic states: Abnormal adrenergic responsiveness in cardiac disease
    • PMID:1645945, doi:10.1146/annurev.ph.53.030191.001033
    • Homcy, C.J., Vatner, S.F., and Vatner, D.E. 1991. Beta-adrenergic receptor regulation in the heart in pathophysiologic states: abnormal adrenergic responsiveness in cardiac disease. Annu. Rev. Physiol. 53: 137-159. doi:10.1146/annurev.ph.53.030191.001033. PMID:1645945.
    • (1991) Annu. Rev. Physiol , vol.53 , pp. 137-159
    • Homcy, C.J.1    Vatner, S.F.2    Vatner, D.E.3
  • 15
    • 34249686103 scopus 로고    scopus 로고
    • Recipes for creating animal models of diabetic cardiovascular disease
    • PMID:17525381, doi:10.1161/01.RES.0000266449.37396. 1f
    • Hsueh, W., Abel, E.D., Breslow, J.L., Maeda, N., Davis, R.C., Fisher, E.A., et al. 2007. Recipes for creating animal models of diabetic cardiovascular disease. Circ. Res. 100: 1415-1427. doi:10.1161/01.RES.0000266449.37396. 1f. PMID:17525381.
    • (2007) Circ. Res , vol.100 , pp. 1415-1427
    • Hsueh, W.1    Abel, E.D.2    Breslow, J.L.3    Maeda, N.4    Davis, R.C.5    Fisher, E.A.6
  • 16
    • 0029912925 scopus 로고    scopus 로고
    • Adverse effects of chronic endogenous sympathetic drive induced by cardiac Gs overexpression
    • PMID:8635208
    • Iwase, M., Bishop, S.P., Uechi, M., Vatner, D.E., Shannon, R.P., Kudej, R.K., et al. 1996. Adverse effects of chronic endogenous sympathetic drive induced by cardiac Gs overexpression. Circ. Res. 78: 517-524. PMID:8635208.
    • (1996) Circ. Res , vol.78 , pp. 517-524
    • Iwase, M.1    Bishop, S.P.2    Uechi, M.3    Vatner, D.E.4    Shannon, R.P.5    Kudej, R.K.6
  • 18
    • 0018764335 scopus 로고
    • Diabetes and cardiovascular disease. The Framingham Heart Study
    • PMID:430798, doi:10.1001/jama.241. 19.2035
    • Kannel, W.B., and McGee, D.L. 1979. Diabetes and cardiovascular disease. The Framingham Heart Study. JAMA, 241: 2035-2038. doi:10.1001/jama.241. 19.2035. PMID:430798.
    • (1979) JAMA , vol.241 , pp. 2035-2038
    • Kannel, W.B.1    McGee, D.L.2
  • 19
    • 0032899328 scopus 로고    scopus 로고
    • Differential regulation of inotropy and lusitropy in overexpressed Gsalpha myocytes through cAMP and Ca2+ channel pathways
    • PMID:10194482, doi:10.1172/JCI4848
    • Kim, S.J., Yatani, A., Vatner, D.E., Yamamoto, S., Ishikawa, Y., Wagner, T.E., et al. 1999. Differential regulation of inotropy and lusitropy in overexpressed Gsalpha myocytes through cAMP and Ca2+ channel pathways. J. Clin. Invest. 103: 1089-1097. doi:10.1172/JCI4848. PMID:10194482.
    • (1999) J. Clin. Invest , vol.103 , pp. 1089-1097
    • Kim, S.J.1    Yatani, A.2    Vatner, D.E.3    Yamamoto, S.4    Ishikawa, Y.5    Wagner, T.E.6
  • 20
    • 0021179862 scopus 로고
    • Cardiac autonomic receptors: Effect of long-term experimental diabetes
    • PMID:6086879
    • Latifpour, J., and McNeill, J.H. 1984. Cardiac autonomic receptors: effect of long-term experimental diabetes. J. Pharmacol. Exp. Ther. 230: 242-249. PMID:6086879.
    • (1984) J. Pharmacol. Exp. Ther , vol.230 , pp. 242-249
    • Latifpour, J.1    McNeill, J.H.2
  • 21
    • 25444486073 scopus 로고    scopus 로고
    • PKC- {epsilon}-dependent survival signals in diabetic hearts
    • PMID:15894568, doi:10.1152/ajpheart. 01200.2004
    • Malhotra, A., Begley, R., Kang, B.P., Rana, I., Liu, J., Yang, G., et al. 2005. PKC- {epsilon}-dependent survival signals in diabetic hearts. Am. J. Physiol. Heart Circ. Physiol. 289: H1343-H1350. doi:10.1152/ajpheart. 01200.2004. PMID:15894568.
    • (2005) Am. J. Physiol. Heart Circ. Physiol , vol.289
    • Malhotra, A.1    Begley, R.2    Kang, B.P.3    Rana, I.4    Liu, J.5    Yang, G.6
  • 22
    • 0024203534 scopus 로고
    • Deficiency of cardiac beta-adrenergic receptor in streptozocin-induced diabetic rats
    • PMID:2842211, doi:10.2337/diabetes.37.9.1181
    • Nishio, Y., Kashiwagi, A., Kida, Y., Kodama, M., Abe, N., Saeki, Y., and Shigeta, Y. 1988. Deficiency of cardiac beta-adrenergic receptor in streptozocin-induced diabetic rats. Diabetes, 37: 1181-1187. doi:10.2337/diabetes.37.9.1181. PMID:2842211.
    • (1988) Diabetes , vol.37 , pp. 1181-1187
    • Nishio, Y.1    Kashiwagi, A.2    Kida, Y.3    Kodama, M.4    Abe, N.5    Saeki, Y.6    Shigeta, Y.7
  • 23
    • 0027325097 scopus 로고
    • Pro-oxidants and mitochondrial Ca2+: Their relationship to apoptosis and oncogenesis
    • doi:10.1016/0014-5793(93)81423-W
    • Richter, C. 1993. Pro-oxidants and mitochondrial Ca2+: their relationship to apoptosis and oncogenesis. FEBS Lett. 325: 104-107. doi:10.1016/0014-5793(93)81423-W.
    • (1993) FEBS Lett , vol.325 , pp. 104-107
    • Richter, C.1
  • 24
    • 85047677635 scopus 로고
    • The diabetic heart: Metabolic causes for the development of a cardiomyopathy
    • PMID:1486584
    • Rodrigues, B., and McNeill, J.H. 1992. The diabetic heart: metabolic causes for the development of a cardiomyopathy. Cardiovasc. Res. 26: 913-922. PMID:1486584.
    • (1992) Cardiovasc. Res , vol.26 , pp. 913-922
    • Rodrigues, B.1    McNeill, J.H.2
  • 25
    • 33746207801 scopus 로고    scopus 로고
    • Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene
    • PMID:16763167, doi:10.1161/01.RES.0000231289.63468.08
    • Rota, M., LeCapitaine, N., Hosoda, T., Boni, A., De Angelis, A., Padin-Iruegas, M.E., et al. 2006. Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene. Circ. Res. 99: 42-52. doi:10.1161/01.RES.0000231289.63468.08. PMID:16763167.
    • (2006) Circ. Res , vol.99 , pp. 42-52
    • Rota, M.1    LeCapitaine, N.2    Hosoda, T.3    Boni, A.4    De Angelis, A.5    Padin-Iruegas, M.E.6
  • 26
    • 0018599277 scopus 로고
    • β-adrenergic receptor decrease in diabetic rat hearts
    • PMID:231718, doi:10.1016/0024-3205(79)90200-5
    • Savarese, J.J., and Berkowitz, B.A. 1979. β-adrenergic receptor decrease in diabetic rat hearts. Life Sci. 25: 2075-2078. doi:10.1016/0024-3205(79)90200-5. PMID:231718.
    • (1979) Life Sci , vol.25 , pp. 2075-2078
    • Savarese, J.J.1    Berkowitz, B.A.2
  • 27
    • 0037222391 scopus 로고    scopus 로고
    • Oxidative injury and apoptosis of dorsal root ganglion neurons in chronic experimental diabetic neuropathy
    • PMID:12502508, doi:10.2337/diabetes.52.1.165
    • Schmeichel, A.M., Schmelzer, J.D., and Low, P.A. 2003. Oxidative injury and apoptosis of dorsal root ganglion neurons in chronic experimental diabetic neuropathy. Diabetes, 52: 165-171. doi:10.2337/diabetes.52.1.165. PMID:12502508.
    • (2003) Diabetes , vol.52 , pp. 165-171
    • Schmeichel, A.M.1    Schmelzer, J.D.2    Low, P.A.3
  • 28
    • 0021278833 scopus 로고
    • Decreased beta-adrenergic receptors in rat heart in streptozotocin-induced diabetes: Role of thyroid hormones
    • PMID:6323144
    • Sundaresan, P.R., Sharma, V.K., Gingold, S.L., and Banerjee, P.S. 1984. Decreased beta-adrenergic receptors in rat heart in streptozotocin-induced diabetes: role of thyroid hormones. Endocrinology, 114: 1358-1363. PMID:6323144.
    • (1984) Endocrinology , vol.114 , pp. 1358-1363
    • Sundaresan, P.R.1    Sharma, V.K.2    Gingold, S.L.3    Banerjee, P.S.4
  • 29
    • 33644783770 scopus 로고    scopus 로고
    • Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy
    • PMID:16380497, doi:10.2337/diabetes.55.01.06.db05-0894
    • Susztak, K., Raff, A.C., Schiffer, M., and Bottinger, E.P. 2006. Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes, 55: 225-233. doi:10.2337/diabetes.55.01.06.db05-0894. PMID:16380497.
    • (2006) Diabetes , vol.55 , pp. 225-233
    • Susztak, K.1    Raff, A.C.2    Schiffer, M.3    Bottinger, E.P.4
  • 30
    • 20944445197 scopus 로고    scopus 로고
    • Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load
    • PMID:15841206, doi:10.1172/JCI200521968
    • Takimoto, E., Champion, H.C., Li, M., Ren, S., Rodriguez, E.R., Tavazzi, B., et al. 2005. Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load. J. Clin. Invest. 115: 1221-1231. doi:10.1172/JCI200521968. PMID:15841206.
    • (2005) J. Clin. Invest , vol.115 , pp. 1221-1231
    • Takimoto, E.1    Champion, H.C.2    Li, M.3    Ren, S.4    Rodriguez, E.R.5    Tavazzi, B.6
  • 31
    • 34447339953 scopus 로고    scopus 로고
    • For the Primary Coronary Angioplasty vs. Thrombolysis-2 Trialists Collaborators Group. Primary Percutaneous Coronary Intervention Compared With Fibrinolysis for Myocardial Infarction in Diabetes Mellitus: Results From the Primary Coronary Angioplasty vs. Thrombolysis-2 Trial
    • PMID:17620527, doi:10.1001/archinte.167.13. 1353
    • Timmer, J.R., Ottervanger, J.P., de Boer, M.J., Boersma, E., Grines, C.L., Westerhout, C.M., et al. 2007. For the Primary Coronary Angioplasty vs. Thrombolysis-2 Trialists Collaborators Group. Primary Percutaneous Coronary Intervention Compared With Fibrinolysis for Myocardial Infarction in Diabetes Mellitus: Results From the Primary Coronary Angioplasty vs. Thrombolysis-2 Trial. Arch. Intern. Med. 167: 1353-1359. doi:10.1001/archinte.167.13. 1353. PMID:17620527.
    • (2007) Arch. Intern. Med , vol.167 , pp. 1353-1359
    • Timmer, J.R.1    Ottervanger, J.P.2    de Boer, M.J.3    Boersma, E.4    Grines, C.L.5    Westerhout, C.M.6
  • 32
    • 0027427492 scopus 로고
    • Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair
    • PMID:8402909, doi:10.1016/0092- 8674(93)80065-M
    • Veis, D.J., Sorenson, C.M., Shutter, J.R., and Korsmeyer, S.J. 1993. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell, 75: 229-240. doi:10.1016/0092- 8674(93)80065-M. PMID:8402909.
    • (1993) Cell , vol.75 , pp. 229-240
    • Veis, D.J.1    Sorenson, C.M.2    Shutter, J.R.3    Korsmeyer, S.J.4
  • 33
    • 0018969926 scopus 로고
    • Some statistical methods useful in circulation research
    • PMID:7379260
    • Wallenstein, S., Zucker, C.L., and Fleiss, J.L. 1980. Some statistical methods useful in circulation research. Circ. Res. 47: 1-9. PMID:7379260.
    • (1980) Circ. Res , vol.47 , pp. 1-9
    • Wallenstein, S.1    Zucker, C.L.2    Fleiss, J.L.3


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