Clinical outcomes after treatment of intra-bony defects with an EMD/synthetic bone graft or EMD alone: A multicentre randomized-controlled clinical trial

Journal of Clinical Periodontology

Volumn 35, Issue 5, 2008, Pages 420-428

  Jepsen, S ^a   Topoll, H ^b   Rengers, H ^b   Heinz, B ^c   Teich, M ^c   Hoffmann, T ^d   Al Machot, E ^d   Meyle, J ^e   Jervoe Storm P M ^a  

^a UNIVERSITY OF BONN   (Germany)

^b Private Practice   (Germany)

^c Private Practice   (Germany)

^d DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^e JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Bone replacement graft; Enamel matrix derivative; Intra bony defects; Periodontal regeneration; Randomized clinical trial

Indexed keywords

BETA-TRICALCIUM PHOSPHATE; CALCIUM PHOSPHATE; ENAMEL MATRIX PROTEINS; ENAMEL PROTEIN; HYDROXYAPATITE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BONE PROSTHESIS; BONE REGENERATION; CHRONIC DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; MALE; MIDDLE AGED; MULTICENTER STUDY; OSTEOLYSIS; PERIODONTITIS; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADULT; AGED; ALVEOLAR BONE LOSS; BONE REGENERATION; BONE SUBSTITUTES; CALCIUM PHOSPHATES; CHRONIC DISEASE; DENTAL ENAMEL PROTEINS; DURAPATITE; FEMALE; HUMANS; MALE; MIDDLE AGED; PERIODONTITIS; TREATMENT OUTCOME;

EID: 42149118424     PISSN: 03036979     EISSN: 1600051X     Source Type: Journal    
DOI: 10.1111/j.1600-051X.2008.01217.x     Document Type: Article

References (39)

1. Blomlöf, J. Lindskog, S. (1995) Root surface texture and cell colonization after different etching modalities. European Journal of Oral Sciences 103, 17 24.
2. Blomlöf, J. P. S., Blomlöf, L. B. Lindskog, S. F. (1996) Smear removal and collagen exposure after non-surgical root-planing followed by etching with EDTA gel preparation. Journal of Clinical Periodontology 67, 841 845.
3. Bokan, I., Bill, J. S. Schlagenhauf, U. (2006) Primary flap closure combined with Emdogain alone or Emdogain and Cerasorb in the treatment of intra-bony defects. Journal of Clinical Periodontology 33, 885 893.
4. Cortellini, P., Pini-Prato, G. Tonetti, M. (1995) The modified papilla preservation technique. A new surgical approach for interproximal regenerative procedures. Journal of Periodontology 66, 261 266.
5. Cortellini, P., Pini-Prato, G. Tonetti, M. (1999) The simplified papilla preservation technique. A novel surgical approach for the management of soft tissues in regenerative procedures. The International Journal of Periodontics & Restorative Dentistry 66, 589 599.
6. Daculsi, G., Weiss, P., Bouler, J. M., Gauthier, O., Millot, F. Aguado, E. (1999) Biphasic calcium phosphate/hydrosoluble polymer composites: a new concept for bone and dental substitution biomaterials. Bone 25, 59S 61S.
7. Döri, F., Arweiler, N., Gera, I. Sculean, A. (2005) Clinical evaluation of an enamel matrix protein derivative combined with either a natural bone mineral or ß-tricalcium phosphate. Journal of Periodontology 76, 2236 2243.
8. ®) for periodontal tissue regeneration in intrabony defects. Cochrane Database of Systematic Reviews 4, CD003875.
9. Froum, S. J., Weinberg, M. A., Rosenberg, E. Tarnow, D. (2001) A comparative study utilizing open flap debridement with and without enamel matrix derivative in the treatment of periodontal intrabony defects: a 12-month re-entry. Journal of Periodontology 72, 25 34.
10. Gestrelius, S., Andersson, C., Johansson, A.-C., Persson, E., Brodin, A., Rydhag, L. Hammarström, L. (1997) Formulation of enamel matrix derivative for surface coating. Kinetics and cell colonization. Journal of Clinical Periodontology 24, 678 684.
11. Giannobile, W. V. Somerman, M. J. (2003) Growth and amelogenin-like factors in periodontal wound healing. A systematic review. Annals of Periodontology 8, 193 204.
12. Guida, L., Annunziata, M., Belardo, S., Farina, R., Scabbia, A. Trombelli, L. (2007) Effect of autogenous cortical bone particulate in conjunction with enamel matrix derivative in the treatment of periodontal intraosseous defects. Journal of Periodontology 78, 231 238.
13. Gurinsky, B. S., Mills, M. P. Mellonig, J. T. (2004) Clinical evaluation of demineralized freeze-dried bone allograft and enamel matrix derivative versus enamel matrix derivative alone for the treatment of periodontal osseous defects in humans. Journal of Periodontology 75, 1309 1318.
14. Hammarström, L., Heijl, L. Gestrelius, S. (1997) Periodontal regeneration in a buccal dehiscence model in monkeys after application of enamel matrix proteins. Journal of Clinical Periodontology 24, 669 677.
15. Heijl, L. (1997) Periodontal regeneration with enamel matrix derivative in one human experimental defect. A case report. Journal of Clinical Periodontology 24, 693 696.
16. Heijl, L., Heden, G., Svärdström, G. Ostgren, A. (1997) Enamel matrix derivative (Emdogain) in the treatment of intrabony periodontal defects. Journal of Clinical Periodontology 24, 705 714.
17. Jepsen, S., Heinz, B., Jepsen, K., Arjomand, M., Hoffmann, T., Richter, S., Reich, E., Sculean, A., Gonzales, J. R., Bödeker, R. H. Meyle, J. (2004) A randomized clinical trial comparing enamel matrix derivative and membrane treatment of buccal class II furcation involvement in mandibular molars. Part I: study design and results for primary outcomes. Journal of Periodontology 75, 1150 1160.
18. Lekovic, V., Camargo, P. M., Weinlaender, M., Nedic, M., Aleksic, Z. Kenney, E. B. (2000) A comparison between enamel matrix proteins used alone or in combination with bovine porous bone mineral in the treatment of intrabony periodontal defects in humans. Journal of Periodontology 71, 1110 1116.
19. Lindhe, J. Palmer, R. (2002) Group C summary. Journal of Clinical Periodontology 29, 160 162.
20. Machtei, E. E. (1997) Outcome variables in the study of periodontal regeneration. Annals of Periodontology 2, 229 239.
21. Mellonig, J. (1999) Enamel matrix derivative for periodontal reconstructive surgery: technique and clinical and histologic case report. The International Journal of Periodontics & Restorative Dentistry 19, 9 19.
22. Mirastschijski, U., Konrad, D., Lundberg, E., Lyngstadaas, S., Jorgensen, L. Agren, M. (2004) Effects of a topical enamel matrix derivative on skin wound healing. Wound Repair and Regeneration 12, 100 108.
23. Nery, B. E., LeGeros, R. Z., Lynch, K. L. Lee, K. (1992) Tissue response to biphasic calcium phosphate ceramic with different ratios of HA/ßTCP in periodontal osseous defects. Journal of Periodontology 63, 729 735.
24. Okuda, K., Miyazaki, A., Momose, M., Murata, M., Nomura, T., Kubota, T., Wolff, L. F. Yoshie, H. (2001) Levels of tissue inhibitor of metalloproteinases-1 and matrix metalloproteinases-1 and -8 in gingival crevicular fluid following treatment with enamel matrix derivative (EMDOGAIN). Journal of Periodontal Research 36, 309 316.
25. O'Leary, T. J., Drake, R. B. Naylor, J. E. (1972) The plaque control record. Journal of Periodontology 43, 38 40.
26. Polson, A. (1997) The research team, calibration and quantity assurance. Annals of Periodontology 2, 75 82.
27. Polson, A. M., Frederick, G. T., Ladenheim, S. Hanes, P. J. (1984) The production of a root surface smear-layer by instrumentation and its removal by citric acid. Journal of Periodontology 55, 443 446.
28. Polson, A. M. Proye, M. P. (1982) Effect of root surface alterations on periodontal healing. II. Citric acid treatment of the denuded root. Journal of Clinical Periodontology 9, 441 454.
29. Sculean, A., Chiantella, G. C., Windisch, P. Donos, N. (2000) Clinical and histologic evaluation of human intrabony defects treated with an enamel matrix protein derivative (Emdogain). The International Journal of Periodontics & Restorative Dentistry 20, 375 381.
30. Sculean, A., Pietruska, M., Arweiler, N. B., Auschill, T. M. Nemcovsky, C. (2007) Four-year results of a prospective-controlled clinical study evaluating healing of intra-bony defects following treatment with an enamel matrix protein derivative alone or combined with a bioactive glass. Journal of Clinical Periodontology 34, 507 513.
31. Sculean, A., Windisch, P., Kegelvich, T., Fabi, B., Lundgran, E. Lyngstadaas, P. S. (2002) Presence of an enamel matrix protein derivative on human teeth following periodontal surgery. Clinical Oral Investigations 6, 183 187.
32. Tonetti, M., Fourmousis, I., Suvan, J., Cortellini, P., Brägger, U. Lang, N. (2004) Healing, post-operative morbidity and patient perception of outcomes following regenerative therapy of deep intrabony defects. Journal of Clinical Periodontology 31, 1092 1098.
33. Tonetti, M. S., Lang, N. P., Cortellini, P., Suvan, J. E., Adriaens, P., Dubravec, D., Fonzar, A., Fourmousis, I., Mayfield, L., Rossi, R., Silvestri, M., Tiedemann, C., Topoll, H., Vangsted, T. Wallkamm, B. (2002) Enamel matrix proteins in the regenerative therapy of deep intrabony defects. Journal of Clinical Periodontology 29, 317 325.
34. Trombelli, L. (2005) Which reconstructive procedures are effective for treating the periodontal intraosseous defect? Periodontology 2000 37, 88 105.
35. Venezia, E., Goldstein, M., Boyan, B. D. Schwartz, Z. (2004) The use of enamel matrix derivative in the treatment of periodontal defects: a literature review and meta-analysis. Critical Reviews in Oral Biology and Medicine 15, 382 402.
36. Wachtel, H., Schenk, G., Böhm, S., Weng, D., Zuhr, O. Hürzeler, M. B. (2003) Microsurgical access flap and enamel matrix derivative for the treatment of periodontal intrabony defects: a controlled clinical study. Journal of Clinical Periodontology 30, 496 504.
37. Wennström, J. L. Lindhe, J. (2002) Some effects of enamel matrix proteins on wound healing in the dentogingival region. Journal of Clinical Periodontology 29, 9 14.
38. Zafiropoulos, G. G., Hoffmann, O., Kasaj, A., Willershausen, B., Weiss, O. Van Dyke, T. E. (2007) Treatment of intrabony defects using guided tissue regeneration and autogenous spongiosa alone or combined with hydroxyapatite/beta-tricalcium phosphate bone substitute or bovine-derived xenograft. Journal of Periodontology 78, 2216 2225.
39. Zucchelli, G., Amore, C., Montebugnoli, L. De Sanctis, M. (2003) Enamel matrix proteins and bovine porous bone mineral in the treatment of intrabony defects: a comparative controlled clinical trial. Journal of Periodontology 74, 1725 1735.