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1
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34447521675
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The histology of acute autochthonous hepatitis E virus infection
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Liver biopsy histopathology of three patients with meat-acquired acute HEV infection, and one patient who had returned from China with the disease, showed differences in the intensity of portal and lobular necroinflammation
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Malcolm P, Dalton H, Hussaini HS, Mathew J. The histology of acute autochthonous hepatitis E virus infection. Histopathology 2007; 51:190-194. Liver biopsy histopathology of three patients with meat-acquired acute HEV infection, and one patient who had returned from China with the disease, showed differences in the intensity of portal and lobular necroinflammation.
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(2007)
Histopathology
, vol.51
, pp. 190-194
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Malcolm, P.1
Dalton, H.2
Hussaini, H.S.3
Mathew, J.4
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3
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33947507817
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Hepatitis Cvirus replication in transfected and serum-infected cultured human fetal hepatocytes
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HCV genotype 1a was transfected to and infected human fetal hepatocytes in culture, resulting in detectable virus in themediumfor at least 2 months with a cyclical pattern of HCV titers, Virions were shown by transmission electron microscopy
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Lázaro CA, Chang M, Tang W, et al. Hepatitis Cvirus replication in transfected and serum-infected cultured human fetal hepatocytes. Am J Pathol 2007; 170:478-489. HCV genotype 1a was transfected to and infected human fetal hepatocytes in culture, resulting in detectable virus in themediumfor at least 2 months (with a cyclical pattern of HCV titers). Virions were shown by transmission electron microscopy.
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(2007)
Am J Pathol
, vol.170
, pp. 478-489
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Lázaro, C.A.1
Chang, M.2
Tang, W.3
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4
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34247636126
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Hepatitis C virus: The viral way to fatty liver
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The potential steatogenic effects of HCV core protein are described in this editorial commentary
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Clément S, Negro F. Hepatitis C virus: the viral way to fatty liver. J Hepatol 2007; 46:985-987. The potential steatogenic effects of HCV core protein are described in this editorial commentary.
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(2007)
J Hepatol
, vol.46
, pp. 985-987
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Clément, S.1
Negro, F.2
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5
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34247636649
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Jackel-Cram C, Babiuk LA, Liu Q. Up-regulation of fatty acid synthase promoter by hepatitis C virus core protein: genotype-3a core has a stronger effect than genotype-1b core. J Hepatol 2007; 46:999-1008. A stronger effect of HCV-3a core protein than of HCV-1b core on fatty acid synthase upregulation was found in this cell culture study using Huh-7 cells.
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Jackel-Cram C, Babiuk LA, Liu Q. Up-regulation of fatty acid synthase promoter by hepatitis C virus core protein: genotype-3a core has a stronger effect than genotype-1b core. J Hepatol 2007; 46:999-1008. A stronger effect of HCV-3a core protein than of HCV-1b core on fatty acid synthase upregulation was found in this cell culture study using Huh-7 cells.
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6
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34347205995
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Björnsson E, Angulo P. Hepatitis C and steatosis. Arch Med Res 2007; 38:621-627. A review of the metabolic syndrome and associated steatosis and nonalcoholic fatty liver disease (NAFLD) in patients with HCV infection versus the mechanisms of fat accumulation in genotype 3 infection.
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Björnsson E, Angulo P. Hepatitis C and steatosis. Arch Med Res 2007; 38:621-627. A review of the metabolic syndrome and associated steatosis and nonalcoholic fatty liver disease (NAFLD) in patients with HCV infection versus the mechanisms of fat accumulation in genotype 3 infection.
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7
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34548304725
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Evidence for a role of nonalcoholic steatohepatitis in hepatitis C: A prospective study
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A total of 278 consecutive patients with chronic hepatitis C were investigated prospectively for the copresence of steatosis or NASH. One hundred and sixty cases (57, had chronic hepatitis C alone, 94 (34, had chronic hepatitis C with steatosis and 24 9, had chronic hepatitis C with NASH
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Bedossa P, Moucari R, Chelbi E, et al. Evidence for a role of nonalcoholic steatohepatitis in hepatitis C: a prospective study. Hepatology 2007; 46:380-387. A total of 278 consecutive patients with chronic hepatitis C were investigated prospectively for the copresence of steatosis or NASH. One hundred and sixty cases (57%) had chronic hepatitis C alone, 94 (34%) had chronic hepatitis C with steatosis and 24 (9%) had chronic hepatitis C with NASH.
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(2007)
Hepatology
, vol.46
, pp. 380-387
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Bedossa, P.1
Moucari, R.2
Chelbi, E.3
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8
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35348813082
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Zen Y, Notsumata K, Tanaka N, Nakanuma Y. Hepatic centrilobular zonal necrosis with positive antinuclear antibody: a unique subtype or early disease of autoimmune hepatitis? Hum Pathol 2007; 38:1669-1675. Five patients (one male, four female) with centrizonal necroinflammation accompanied by minimal or mild portal inflammation and no interface hepatitis, with antinuclear antibodies of 1 : 40 to 1 : 1280 were reported. The authors review the several other series describing this phenomenon.
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Zen Y, Notsumata K, Tanaka N, Nakanuma Y. Hepatic centrilobular zonal necrosis with positive antinuclear antibody: a unique subtype or early disease of autoimmune hepatitis? Hum Pathol 2007; 38:1669-1675. Five patients (one male, four female) with centrizonal necroinflammation accompanied by minimal or mild portal inflammation and no interface hepatitis, with antinuclear antibodies of 1 : 40 to 1 : 1280 were reported. The authors review the several other series describing this phenomenon.
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9
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33947231201
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Black pigments in the liver related to gold and titanium deposits: A report of four cases
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The differential diagnosis of black pigment particles in the liver includes gold salt therapy, titanium from prosthetic hip or knee prostheses, injected drug use and inhaled particles. Chronically increased alkaline phosphatase and γ-glutamyl peptidase are described in four patients
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Brenard R, Dumortier P, Del Natale M, et al. Black pigments in the liver related to gold and titanium deposits: a report of four cases. Liver Int 2007; 27:408-413. The differential diagnosis of black pigment particles in the liver includes gold salt therapy, titanium from prosthetic hip or knee prostheses, injected drug use and inhaled particles. Chronically increased alkaline phosphatase and γ-glutamyl peptidase are described in four patients.
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(2007)
Liver Int
, vol.27
, pp. 408-413
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Brenard, R.1
Dumortier, P.2
Del Natale, M.3
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10
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33846403788
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Cat scratch disease causing hepatic masses after liver transplant
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Thudi KR, Kreikemeier JT, Phillips NJ, et al. Cat scratch disease causing hepatic masses after liver transplant. Liver Int 2007; 27:145-148.
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(2007)
Liver Int
, vol.27
, pp. 145-148
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Thudi, K.R.1
Kreikemeier, J.T.2
Phillips, N.J.3
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11
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33846205222
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Alvaro D, Mancino MG, Glaser S, et al. Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver. Gastroenterology 2007; 132:415-431. A masterful synthesis of the current milieu of cholangiocytes in the liver, including a discussion of primary cilia, mediators of cholangiocyte dormancy and proliferation and neuropeptide/ neurotransmitter actions on proliferating cholangiocytes. Four types of ductular proliferation are reviewed.
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Alvaro D, Mancino MG, Glaser S, et al. Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver. Gastroenterology 2007; 132:415-431. A masterful synthesis of the current milieu of cholangiocytes in the liver, including a discussion of primary cilia, mediators of cholangiocyte dormancy and proliferation and neuropeptide/ neurotransmitter actions on proliferating cholangiocytes. Four types of ductular proliferation are reviewed.
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12
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33947196926
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Cassiman D, Sinelli N, Bockx I, et al. Human hepatic progenitor cells express vasoactive intestinal peptide receptor type 2 and receive nerve endings. Liver Int 2007; 27:323-328. Immunohistochemical staining for vasoactive intestinal peptide receptor (VIPR) 1 and 2 on normal and diseased liver and reverse transcription PCR on rat liver for VIPR1 and 2 were performed. Progenitor cells and bile ductules were stained. Staining of ductules with cytokeratin 7 antibodies and for nerve endings (using β-III tubulin) showed the endings abuting on reactive ductules.
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Cassiman D, Sinelli N, Bockx I, et al. Human hepatic progenitor cells express vasoactive intestinal peptide receptor type 2 and receive nerve endings. Liver Int 2007; 27:323-328. Immunohistochemical staining for vasoactive intestinal peptide receptor (VIPR) 1 and 2 on normal and diseased liver and reverse transcription PCR on rat liver for VIPR1 and 2 were performed. Progenitor cells and bile ductules were stained. Staining of ductules with cytokeratin 7 antibodies and for nerve endings (using β-III tubulin) showed the endings abuting on reactive ductules.
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13
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33947409989
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Identification of hepatocytic and bile ductular cell lineages and candidate stem cells in bipolar ductular reactions in cirrhotic human liver
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Single, double and triple immunostaining of ductular structures for NCAM, cytokeratin 19 and Hep Par 1 showed the bipolar nature of the ductular reactions in cirrhosis of various etiologies
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Zhou H, Rogler LE, Teperman L, et al. Identification of hepatocytic and bile ductular cell lineages and candidate stem cells in bipolar ductular reactions in cirrhotic human liver. Hepatology 2007; 45:716-724. Single, double and triple immunostaining of ductular structures for NCAM, cytokeratin 19 and Hep Par 1 showed the bipolar nature of the ductular reactions in cirrhosis of various etiologies.
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(2007)
Hepatology
, vol.45
, pp. 716-724
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Zhou, H.1
Rogler, L.E.2
Teperman, L.3
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14
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34447100647
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Progressive fibrosis in nonalcoholic steatohepatitis: Association with altered regeneration and a ductular reaction
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An immunohistochemical study examining ductular reaction and hepatic progenitor cell outgrowth and hepatocellular replicative arrest as assessed by cytokeratin 7 and p21 immunostaining, respectively
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Richardson MM, Jonsson JR, Powell EE, et al. Progressive fibrosis in nonalcoholic steatohepatitis: association with altered regeneration and a ductular reaction. Gastroenterology 2007; 133:80-90. An immunohistochemical study examining ductular reaction and hepatic progenitor cell outgrowth and hepatocellular replicative arrest as assessed by cytokeratin 7 and p21 immunostaining, respectively.
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(2007)
Gastroenterology
, vol.133
, pp. 80-90
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Richardson, M.M.1
Jonsson, J.R.2
Powell, E.E.3
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15
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34447099725
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Theise ND, Kuwahara R. The tissue biology of ductular reactions in human chronic liver disease. Gastroenterology 2007; 133:350-352. An editorial examining the milieu around stem/progenitor cells and the ductular reaction, including vascular supply, nerves, patrix proteins and bile.
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Theise ND, Kuwahara R. The tissue biology of ductular reactions in human chronic liver disease. Gastroenterology 2007; 133:350-352. An editorial examining the milieu around stem/progenitor cells and the ductular reaction, including vascular supply, nerves, patrix proteins and bile.
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16
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34548324268
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Fabris L, Cadamuro M, Guido M, et al. Analysis of liver repair mechanisms in Alagille syndrome and biliary atresia reveals a role for Notch signaling. Am J Pathol 2007; 171:641-653. Multiple immunostains, including cytokeratin 7 and 19 and p21, were used to examine the distribution and degree of hepatic progenitor cells, intermediate hepatobiliary cells and reactive ductular cells in Alagille syndrome(AGS) and biliary atresia as well as to correlate the thick fibrous septa of biliary atresia (associated with ductules) and the thin septa with prominent pericellular fibrosis associated with AGS.
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Fabris L, Cadamuro M, Guido M, et al. Analysis of liver repair mechanisms in Alagille syndrome and biliary atresia reveals a role for Notch signaling. Am J Pathol 2007; 171:641-653. Multiple immunostains, including cytokeratin 7 and 19 and p21, were used to examine the distribution and degree of hepatic progenitor cells, intermediate hepatobiliary cells and reactive ductular cells in Alagille syndrome(AGS) and biliary atresia as well as to correlate the thick fibrous septa of biliary atresia (associated with ductules) and the thin septa with prominent pericellular fibrosis associated with AGS.
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17
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34547667392
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The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis
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Photomicrographs and extensive detailed discussion of the abnormalities in intrahepatic and extrahepatic bile ducts which may arise when there is altered expression of the Hhex gene
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Hunter MP, Wilson CM, Jiang X, et al. The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis. Dev Biol 2007; 308:355-367. Photomicrographs and extensive detailed discussion of the abnormalities in intrahepatic and extrahepatic bile ducts which may arise when there is altered expression of the Hhex gene.
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(2007)
Dev Biol
, vol.308
, pp. 355-367
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Hunter, M.P.1
Wilson, C.M.2
Jiang, X.3
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18
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34547118328
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IL-8 expression by biliary epithelial cells is associated with neutrophilic infiltration and reactive bile ductules
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An immunohistochemical and cell culture study examining the mechanism of neutrophil localization near bile ductules in several forms of liver disease
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Isse K, Harada K, Nakanuma Y. IL-8 expression by biliary epithelial cells is associated with neutrophilic infiltration and reactive bile ductules. Liver Int 2007; 27:672-680. An immunohistochemical and cell culture study examining the mechanism of neutrophil localization near bile ductules in several forms of liver disease.
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(2007)
Liver Int
, vol.27
, pp. 672-680
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Isse, K.1
Harada, K.2
Nakanuma, Y.3
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19
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34247354077
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Bile acid treatment alters hepatic disease and bile acid transport in peroxisome-deficient PEX2 Zellweger mice
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Zellweger peroxisome-deficient mice show a mixed picture of bile acid disturbances, light microscopic and ultrastructural cholestatic damage and steatosis, and with bile acid administration, altered expression of bile acid transporters
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Keane MH, Overmars H, Wikander TM, et al. Bile acid treatment alters hepatic disease and bile acid transport in peroxisome-deficient PEX2 Zellweger mice. Hepatology 2007; 45:982-997. Zellweger peroxisome-deficient mice show a mixed picture of bile acid disturbances, light microscopic and ultrastructural cholestatic damage and steatosis, and with bile acid administration, altered expression of bile acid transporters.
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(2007)
Hepatology
, vol.45
, pp. 982-997
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Keane, M.H.1
Overmars, H.2
Wikander, T.M.3
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20
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34247177532
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Mutations in bile salt export pump (ABCB11) in two children with progressive familial intrahepatic cholestasis and cholangiocarcinoma
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Scheimann AO, Strautnieks SS, Knisely AS, et al. Mutations in bile salt export pump (ABCB11) in two children with progressive familial intrahepatic cholestasis and cholangiocarcinoma. J Pediatr 2007; 150:556-559.
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(2007)
J Pediatr
, vol.150
, pp. 556-559
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Scheimann, A.O.1
Strautnieks, S.S.2
Knisely, A.S.3
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21
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34250318195
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Immunoglobulin G4 associated cholangitis: Description of an emerging clinical entity based on review of the literature
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The clinical, radiological and histopathological features of IgG4-associated cholangitis are described in this review, with a discussion of the interrelationship with autoimmune pancreatitis
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Björnsson E, Chari ST, Smyrk TC, Lindor K. Immunoglobulin G4 associated cholangitis: description of an emerging clinical entity based on review of the literature. Hepatology 2007; 45:1547-1554. The clinical, radiological and histopathological features of IgG4-associated cholangitis are described in this review, with a discussion of the interrelationship with autoimmune pancreatitis.
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(2007)
Hepatology
, vol.45
, pp. 1547-1554
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Björnsson, E.1
Chari, S.T.2
Smyrk, T.C.3
Lindor, K.4
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22
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34447555784
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Pathological classification of hepatic inflammatory pseudotumor with respect to IgG4-related disease
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Sixteen cases of hepatic inflammatory pseudotumor (11 men, five women) were reported with descriptions of two types: fibrohistocytic and lymphoplasmacytic
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Zen Y, Fujii T, Sato Y, et al. Pathological classification of hepatic inflammatory pseudotumor with respect to IgG4-related disease. Modern Pathol 2007; 20:884-894. Sixteen cases of hepatic inflammatory pseudotumor (11 men, five women) were reported with descriptions of two types: fibrohistocytic and lymphoplasmacytic.
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(2007)
Modern Pathol
, vol.20
, pp. 884-894
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Zen, Y.1
Fujii, T.2
Sato, Y.3
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23
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Umemura T, Zen Y, Hamano H, et al. Immunoglobulin G4-hepatopathy: association of immunoglobulin G4-bearing plasma cells in liver with autoimmune pancreatitis. Hepatology 2007; 46:463-471. Liver biopsies from 17 patients with autoimmune pancreatitis were analyzed for features potentially related to this IgG4-plasma cell disease, and compared with biopsies from patients with autoimmune hepatitis, PBC, PSC and chronic viral hepatitis. Five patterns of liver pathology included portal inflammation with or without interface hepatitis; features of large bile duct obstruction; portal sclerosis; lobular hepatitis; and canalicular cholestasis.
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Umemura T, Zen Y, Hamano H, et al. Immunoglobulin G4-hepatopathy: association of immunoglobulin G4-bearing plasma cells in liver with autoimmune pancreatitis. Hepatology 2007; 46:463-471. Liver biopsies from 17 patients with autoimmune pancreatitis were analyzed for features potentially related to this IgG4-plasma cell disease, and compared with biopsies from patients with autoimmune hepatitis, PBC, PSC and chronic viral hepatitis. Five patterns of liver pathology included portal inflammation with or without interface hepatitis; features of large bile duct obstruction; portal sclerosis; lobular hepatitis; and canalicular cholestasis.
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24
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34250373327
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Th2 and regulatory immune reactions are increased in immunoglobulin G4-related sclerosing pancreatitis and cholangitis
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Zen Y, Fujii T, Harada K, et al. Th2 and regulatory immune reactions are increased in immunoglobulin G4-related sclerosing pancreatitis and cholangitis. Hepatology 2007; 45:1538-1546.
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(2007)
Hepatology
, vol.45
, pp. 1538-1546
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Zen, Y.1
Fujii, T.2
Harada, K.3
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25
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36349028180
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Hemochromatosis: An endocrine liver disease
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This extremely well synthesized look at iron homeostasis and overload examines hereditary forms of hemochromatosis, ferroportin disease, aceruloplasminemia and other conditions in the context of other defining features such as presence or absence of anemia, hepcidin expression and clinical modulators
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Pietrangelo A. Hemochromatosis: an endocrine liver disease. Hepatology 2007; 46:1291-1301. This extremely well synthesized look at iron homeostasis and overload examines hereditary forms of hemochromatosis, ferroportin disease, aceruloplasminemia and other conditions in the context of other defining features such as presence or absence of anemia, hepcidin expression and clinical modulators.
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(2007)
Hepatology
, vol.46
, pp. 1291-1301
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Pietrangelo, A.1
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Xuan A, Bookman I, Cox DW, Heathcote J. Three atypical cases of Wilson disease: assessment of the Leipzig scoring system in making a diagnosis. J Hepatol 2007; 47:428-433. The three patients described were 51, 41 and 58 years old at first presentation and all had Leipzig scores of 6 (highly likely Wilson disease). The absence of neuropsychiatric symptoms in all three and Kaiser-Fleischer rings in one and their older age are discussed among the confounding diagnostic features of the cases.
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Xuan A, Bookman I, Cox DW, Heathcote J. Three atypical cases of Wilson disease: assessment of the Leipzig scoring system in making a diagnosis. J Hepatol 2007; 47:428-433. The three patients described were 51, 41 and 58 years old at first presentation and all had Leipzig scores of 6 (highly likely Wilson disease). The absence of neuropsychiatric symptoms in all three and Kaiser-Fleischer rings in one and their older age are discussed among the confounding diagnostic features of the cases.
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28
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0142029450
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Diagnosis and phenotypic classification of Wilson disease
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Ferenci P, Caca K, Loudianos G, et al. Diagnosis and phenotypic classification of Wilson disease. Liver Int 2003; 23:139-142.
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(2003)
Liver Int
, vol.23
, pp. 139-142
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Ferenci, P.1
Caca, K.2
Loudianos, G.3
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29
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34247643846
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A comprehensive review of pediatric NAFLD discusses the settings in which fatty liver occurs in this group, including hypothalamic, genetic and metabolic disease as well as the clinical diagnosis and treatment. The author points out the salient histological differences between pediatric and adult NASH as well as their differing natural history
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Roberts EA. Pediatric nonalcoholic fatty liver disease (NAFLD): a 'growing' problem? J Hepatol 2007; 46:1133-1142. A comprehensive review of pediatric NAFLD discusses the settings in which fatty liver occurs in this group, including hypothalamic, genetic and metabolic disease as well as the clinical diagnosis and treatment. The author points out the salient histological differences between pediatric and adult NASH as well as their differing natural history.
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(2007)
Pediatric nonalcoholic fatty liver disease (NAFLD): A 'growing' problem? J Hepatol
, vol.46
, pp. 1133-1142
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Roberts, E.A.1
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30
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34548817868
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In vitro production of Malory bodies and intracellular hyaline bodies: The central role of sequestosome 1/p62
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This in-vitro cell transfection study sorts out the various constituents (ubiquitin, p62, cytokeratins 8 and 18) which are required for formation of Mallory bodies types 1, 2 and 3 or of intracellular hyaline bodies
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Stumpner C, Fuchsbichler A, Zatloukal K, Denk H. In vitro production of Malory bodies and intracellular hyaline bodies: the central role of sequestosome 1/p62. Hepatology 2007; 46:851-860. This in-vitro cell transfection study sorts out the various constituents (ubiquitin, p62, cytokeratins 8 and 18) which are required for formation of Mallory bodies types 1, 2 and 3 or of intracellular hyaline bodies.
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(2007)
Hepatology
, vol.46
, pp. 851-860
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Stumpner, C.1
Fuchsbichler, A.2
Zatloukal, K.3
Denk, H.4
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31
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Keratin 18 overexpression but not phosphorylation or filament organization blocks mouse Mallory body formation
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Harada M, Strnad P, Resurreccion EZ, et al. Keratin 18 overexpression but not phosphorylation or filament organization blocks mouse Mallory body formation. Hepatology 2007; 45:88-96.
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(2007)
Hepatology
, vol.45
, pp. 88-96
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Harada, M.1
Strnad, P.2
Resurreccion, E.Z.3
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Transglutaminase 2 regulates Mallory body inclusion formation and injury-associated liver enlargement
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Strnad P, Harada M, Siegel M, et al. Transglutaminase 2 regulates Mallory body inclusion formation and injury-associated liver enlargement. Gastroenterology 2007; 132:1515-1526.
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(2007)
Gastroenterology
, vol.132
, pp. 1515-1526
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Strnad, P.1
Harada, M.2
Siegel, M.3
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33947364434
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Hepatic abnormalities in patients with chronic granulomatous disease
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A total of 194 patients with chronic granulomatous disease were evaluated for evidence of biochemical, clinical and histological liver disease. Eighty-eight liver specimens from 38 patients were available for review
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Hussain N, Feld JJ, Kleiner DE, et al. Hepatic abnormalities in patients with chronic granulomatous disease. Hepatology 2007; 45:675-683. A total of 194 patients with chronic granulomatous disease were evaluated for evidence of biochemical, clinical and histological liver disease. Eighty-eight liver specimens from 38 patients were available for review.
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(2007)
Hepatology
, vol.45
, pp. 675-683
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Hussain, N.1
Feld, J.J.2
Kleiner, D.E.3
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36348944560
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The liver in celiac disease
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This interesting literature review cites the reported prevalence of celiac disease in PBC patients as 0-11, celiac disease in AIH patients as 4-6.4% and celiac disease in PSC patients as 1.6, The possible mechanisms of intestinal and liver injury are also discussed
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Rubio-Tapia A, Murray JA. The liver in celiac disease. Hepatology 2007; 46:1650-1658. This interesting literature review cites the reported prevalence of celiac disease in PBC patients as 0-11%, celiac disease in AIH patients as 4-6.4% and celiac disease in PSC patients as 1.6%. The possible mechanisms of intestinal and liver injury are also discussed.
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(2007)
Hepatology
, vol.46
, pp. 1650-1658
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Rubio-Tapia, A.1
Murray, J.A.2
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Lee WS, Sokol RJ. Mitochondrial hepatopathies: advances in genetics and pathogenesis. Hepatology 2007; 45:1555-1565. This detailed summation of mitochondrial hepatopathies points out the clinical presentation, liver histology and genetic alterations in neonatal liver failure, mitochondrial DNA depletion syndrome (affecting respiratory chain components I, III, IV and V), delayed onset liver disease, Pearson syndrome and other disorders.
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Lee WS, Sokol RJ. Mitochondrial hepatopathies: advances in genetics and pathogenesis. Hepatology 2007; 45:1555-1565. This detailed summation of mitochondrial hepatopathies points out the clinical presentation, liver histology and genetic alterations in neonatal liver failure, mitochondrial DNA depletion syndrome (affecting respiratory chain components I, III, IV and V), delayed onset liver disease, Pearson syndrome and other disorders.
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36
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33846811365
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Pathological diagnosis of liver cell adenoma and focal nodular hyperplasia: Bordeaux update
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An expert panel reviews the contemporary diagnostic criteria for adenoma and focal nodular hyperplasia
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Bioulac-Sage P, Balabaud C, Bedossa P, et al. Pathological diagnosis of liver cell adenoma and focal nodular hyperplasia: Bordeaux update. J Hepatol 2007; 46:521-527. An expert panel reviews the contemporary diagnostic criteria for adenoma and focal nodular hyperplasia.
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(2007)
J Hepatol
, vol.46
, pp. 521-527
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Bioulac-Sage, P.1
Balabaud, C.2
Bedossa, P.3
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Paradis V, Champault A, Ronot M, et al. Telangiectatic adenoma: an entity associated with increased body mass index and inflammation. Hepatology 2007; 46:140-146. The authors describe the tumors and patient demographics of 32 telangiectatic adenomas from 27 patients of whom 92% were women.
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Paradis V, Champault A, Ronot M, et al. Telangiectatic adenoma: an entity associated with increased body mass index and inflammation. Hepatology 2007; 46:140-146. The authors describe the tumors and patient demographics of 32 telangiectatic adenomas from 27 patients of whom 92% were women.
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38
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34250763945
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Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry
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An immunohistochemical and quantitative reverse transcription-PCR study differentiates between several subtypes of liver cell adenoma
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Bioulac-Sage P, Rebouissou S, Thomas C, et al. Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry. Hepatology 2007; 46:740-748. An immunohistochemical and quantitative reverse transcription-PCR study differentiates between several subtypes of liver cell adenoma.
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(2007)
Hepatology
, vol.46
, pp. 740-748
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Bioulac-Sage, P.1
Rebouissou, S.2
Thomas, C.3
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Hubert C, Sempoux C, Horsmans Y, et al. Nodular regenerative hyperplasia: a deleterious consequence of chemotherapy for colorectal liver metastases? Liver Int 2007; 27:938-943. Three cases of nodular regenerative hyperplasia after 5-fluorouracil and oxaliplatin are described, with a discussion of nodular regenerative hyperplasia pathogenesis and the incidence of veno-occlusive disease (sinusoidal obstruction syndrome).
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Hubert C, Sempoux C, Horsmans Y, et al. Nodular regenerative hyperplasia: a deleterious consequence of chemotherapy for colorectal liver metastases? Liver Int 2007; 27:938-943. Three cases of nodular regenerative hyperplasia after 5-fluorouracil and oxaliplatin are described, with a discussion of nodular regenerative hyperplasia pathogenesis and the incidence of veno-occlusive disease (sinusoidal obstruction syndrome).
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40
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34250020201
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El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007; 132:2557-2576. This superb and comprehensive review includes detailed discussion of the molecular roles of telomere shortening (leading to fusion of abnormal chromosomes with resultant gains, losses and translocations), loss of cell cycle checkpoints, p53, retinoblastoma, p16, insulin resistance growth factor 2 receptors and oncogenic pathways.
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El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007; 132:2557-2576. This superb and comprehensive review includes detailed discussion of the molecular roles of telomere shortening (leading to fusion of abnormal chromosomes with resultant gains, losses and translocations), loss of cell cycle checkpoints, p53, retinoblastoma, p16, insulin resistance growth factor 2 receptors and oncogenic pathways.
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41
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Glycogen storage disease type III: Hepatocellular carcinoma a long-term complication?
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Demo E, Frush D, Gottfried M, et al. Glycogen storage disease type III: hepatocellular carcinoma a long-term complication? J Hepatol 2007; 46:492-498.
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(2007)
J Hepatol
, vol.46
, pp. 492-498
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Demo, E.1
Frush, D.2
Gottfried, M.3
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42
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35948984059
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Hepatocellular carcinoma versus metastatic neoplasms
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The various immunostains in distinguishing HCC from other tumors are reviewed, with detailed descriptions of their advantages and disadvantages
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Kakar S, Gown AM, Goodman ZD, Ferrell LD. Hepatocellular carcinoma versus metastatic neoplasms. Arch Pathol Lab Med 2007; 133:1648-1654. The various immunostains in distinguishing HCC from other tumors are reviewed, with detailed descriptions of their advantages and disadvantages.
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(2007)
Arch Pathol Lab Med
, vol.133
, pp. 1648-1654
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Kakar, S.1
Gown, A.M.2
Goodman, Z.D.3
Ferrell, L.D.4
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43
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38449095281
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Glypican-3 immunocytochemistry in liver fine-needle aspirates: A novel stain to assist in the differentiation of benign and malignant liver lesions
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Kandil D, Leiman G, Allegretta M, et al. Glypican-3 immunocytochemistry in liver fine-needle aspirates: a novel stain to assist in the differentiation of benign and malignant liver lesions. Cancer Cytopathol 2007; 111:316-322.
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(2007)
Cancer Cytopathol
, vol.111
, pp. 316-322
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Kandil, D.1
Leiman, G.2
Allegretta, M.3
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44
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33947396135
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Di Tommaso L, Franchi G, Park YN, et al. Diagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosis. Hepatology 2007; 45:725-734. Fifty-two surgically resected nonmalignant nodules (including large regenerative nodules, high and low-grade dysplastic nodules, and early HCC grade 1) were studied with three immunostains for heat shock protein 70, glypican 3 and glutamine synthetase.
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Di Tommaso L, Franchi G, Park YN, et al. Diagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosis. Hepatology 2007; 45:725-734. Fifty-two surgically resected nonmalignant nodules (including large regenerative nodules, high and low-grade dysplastic nodules, and early HCC grade 1) were studied with three immunostains for heat shock protein 70, glypican 3 and glutamine synthetase.
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45
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33845922311
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Hepatoid carcinoma of the pancreas: A case report and literature review of a heterogeneous group of tumors
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Hameed O, Xu H, Saddeghi S, Maluf H. Hepatoid carcinoma of the pancreas: a case report and literature review of a heterogeneous group of tumors. Am J Surg Pathol 2007; 31:146-152.
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(2007)
Am J Surg Pathol
, vol.31
, pp. 146-152
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Hameed, O.1
Xu, H.2
Saddeghi, S.3
Maluf, H.4
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46
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34249980343
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Identification and characterization of tumorigenic liver cancer stem/progenitor cells
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The search for cancer stem cells (CSCs) which provide continued growth expansion in liver tumors was examined by isolating such cells from mice treated by partial hepatectomy and from hepatocellular and hepatoblastoma cell lines
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Ma S, Chan K-W, Hu L, et al. Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology 2007; 132:2542-2556. The search for cancer stem cells (CSCs) which provide continued growth expansion in liver tumors was examined by isolating such cells from mice treated by partial hepatectomy and from hepatocellular and hepatoblastoma cell lines.
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(2007)
Gastroenterology
, vol.132
, pp. 2542-2556
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Ma, S.1
Chan, K.-W.2
Hu, L.3
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47
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33846422330
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Novel hepatic progenitor cell surface markers in the adult rat liver
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Gene array chips, reverse transcription PCR, immunofluorescence, immunohistochemistry and in-situ hybrization analyses were used to examine rat oval cells in 2-acetylaminofluorene treated and partially hepatectomized rats to look at expression of surface and adhesion markers
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Yovchev MI, Grozdanov PN, Joseph B, et al. Novel hepatic progenitor cell surface markers in the adult rat liver. Hepatology 2007; 45:139-149. Gene array chips, reverse transcription PCR, immunofluorescence, immunohistochemistry and in-situ hybrization analyses were used to examine rat oval cells in 2-acetylaminofluorene treated and partially hepatectomized rats to look at expression of surface and adhesion markers.
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(2007)
Hepatology
, vol.45
, pp. 139-149
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Yovchev, M.I.1
Grozdanov, P.N.2
Joseph, B.3
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48
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34247549347
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Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma
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A gene microarray study examined profiles of 75 tissue samples from chronic HCV patients with cirrhosis, dysplasia and hepatocellular carcinoma for distinctive gene signatures
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Wurmbach E, Chen Y, Khitrov G, et al. Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma. Hepatology 2007; 45:938-947. A gene microarray study examined profiles of 75 tissue samples from chronic HCV patients with cirrhosis, dysplasia and hepatocellular carcinoma for distinctive gene signatures.
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(2007)
Hepatology
, vol.45
, pp. 938-947
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Wurmbach, E.1
Chen, Y.2
Khitrov, G.3
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49
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A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis
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A quantitative real-time reverse transcription PCR study of 17 dysplastic nodules (10mm diameter) and 20 early hepatocellular carcinomas (18mm diameter) from HCV cirrhosis patients to determine whether a significant diagnostic profile of gene transcripts exists which differentiates the two categories
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Llovet JM, Chen Y, Wurmbach E, et al. A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis. Gastroenterology 2007; 131:1758-1767. A quantitative real-time reverse transcription PCR study of 17 dysplastic nodules (10mm diameter) and 20 early hepatocellular carcinomas (18mm diameter) from HCV cirrhosis patients to determine whether a significant diagnostic profile of gene transcripts exists which differentiates the two categories.
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(2007)
Gastroenterology
, vol.131
, pp. 1758-1767
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Llovet, J.M.1
Chen, Y.2
Wurmbach, E.3
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50
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Telomere shortening and inactivation of cell cycle checkpoints characterize human hepatocarcinogenesis
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An immunohistochemical and fluorescence in-situ hybridization study comparing telomere length and p21 and p16 expression in small and large cell change, cirrhosis and hepatocellular carcinoma
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Plentz RR, Park YN, Lechel A, et al. Telomere shortening and inactivation of cell cycle checkpoints characterize human hepatocarcinogenesis. Hepatology 2007; 45:968-976. An immunohistochemical and fluorescence in-situ hybridization study comparing telomere length and p21 and p16 expression in small and large cell change, cirrhosis and hepatocellular carcinoma.
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(2007)
Hepatology
, vol.45
, pp. 968-976
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Plentz, R.R.1
Park, Y.N.2
Lechel, A.3
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51
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FOXG 1 is overexpressed in hepatoblastoma
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Bacterial artificial chromosome array comparative genomic hybridization analysis was used to determine that FOXG1 gain in the region immediately telomeric to the deleted locus 14q12 is commonly found in a series of hepatoblastomas
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Adesina AM, Nguyen Y, Guanaratne P, et al. FOXG 1 is overexpressed in hepatoblastoma. Hum Pathol 2007; 38:400-409. Bacterial artificial chromosome array comparative genomic hybridization analysis was used to determine that FOXG1 gain in the region immediately telomeric to the deleted locus 14q12 is commonly found in a series of hepatoblastomas.
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(2007)
Hum Pathol
, vol.38
, pp. 400-409
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Adesina, A.M.1
Nguyen, Y.2
Guanaratne, P.3
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52
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Zen Y, Adsay NV, Bardadin K, et al. Biliary intraepithelial neoplasia: an international interobserver agreement study and proposal for diagnostic criteria. Modern Pathol 2007; 20:701-709. Seventeen pathologists from the US, Europe and Asia used a digital file with 30 foci of noninvasive biliary mucosal neoplastic lesions to reach agreement on the criteria for biliary intraepithelial neoplasia types 1, 2 and 3.
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Zen Y, Adsay NV, Bardadin K, et al. Biliary intraepithelial neoplasia: an international interobserver agreement study and proposal for diagnostic criteria. Modern Pathol 2007; 20:701-709. Seventeen pathologists from the US, Europe and Asia used a digital file with 30 foci of noninvasive biliary mucosal neoplastic lesions to reach agreement on the criteria for biliary intraepithelial neoplasia types 1, 2 and 3.
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Kozaka K, Sasaki M, Fujii T, et al. A subgroup of intrahepatic cholangiocarcinoma with an infiltrating replacement growth pattern and a resemblance to reactive proliferating bile ductules: 'bile ductular carcinoma'. Histopathology 2007; 51:390-400. A study comparing the routine histopathology and immunohistochemical staining of 24 cases of peripheral cholangiocarcinoma, 27 cases of hepatocellular carcinoma and 24 cases of metastatic colorectal carcinoma, stressing different histologic growth patterns.
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Kozaka K, Sasaki M, Fujii T, et al. A subgroup of intrahepatic cholangiocarcinoma with an infiltrating replacement growth pattern and a resemblance to reactive proliferating bile ductules: 'bile ductular carcinoma'. Histopathology 2007; 51:390-400. A study comparing the routine histopathology and immunohistochemical staining of 24 cases of peripheral cholangiocarcinoma, 27 cases of hepatocellular carcinoma and 24 cases of metastatic colorectal carcinoma, stressing different histologic growth patterns.
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54
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Intrahepatic clear cell cholangiocarcinoma: Immunohistochemical aspects in a very rare type of cholangiocarcinoma
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Haas S, Gütgemann I, Wolff M, Fischer H-P. Intrahepatic clear cell cholangiocarcinoma: immunohistochemical aspects in a very rare type of cholangiocarcinoma. Am J Surg Pathol 2007; 31:902-906.
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(2007)
Am J Surg Pathol
, vol.31
, pp. 902-906
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Haas, S.1
Gütgemann, I.2
Wolff, M.3
Fischer, H.-P.4
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55
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Primary and recurrent embryonal sarcoma of the liver: Clinicopathological and immunohistochemical analysis
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Zheng J-M, Xu A-M, Chen X-F, et al. Primary and recurrent embryonal sarcoma of the liver: clinicopathological and immunohistochemical analysis. Histopathology 2007; 51:195-203.
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(2007)
Histopathology
, vol.51
, pp. 195-203
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Zheng, J.-M.1
Xu, A.-M.2
Chen, X.-F.3
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56
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Primary carcinosarcoma of the liver: Clinicopathologic features of 5 cases and a review of the literature
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Lao X-M, Chen D-Y, Zhang Y-Q, et al. Primary carcinosarcoma of the liver: clinicopathologic features of 5 cases and a review of the literature. Am J Surg Pathol 2007; 31:817-826.
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(2007)
Am J Surg Pathol
, vol.31
, pp. 817-826
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Lao, X.-M.1
Chen, D.-Y.2
Zhang, Y.-Q.3
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57
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Histopathology of graft versus host disease of the liver
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Quaglia A, Duarte R, Patch D, et al. Histopathology of graft versus host disease of the liver. Histopathology 2007; 50:727-738.
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(2007)
Histopathology
, vol.50
, pp. 727-738
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Quaglia, A.1
Duarte, R.2
Patch, D.3
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58
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Rapidly progressive recurrent hepatitis C virus infection starting 9 days after liver transplantation
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Saraf N, Fiel MI, DeBoccardo G, et al. Rapidly progressive recurrent hepatitis C virus infection starting 9 days after liver transplantation. Liver Transplant 2007; 13:913-917.
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(2007)
Liver Transplant
, vol.13
, pp. 913-917
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Saraf, N.1
Fiel, M.I.2
DeBoccardo, G.3
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59
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Khettry U, Huang W-Y, Simpson MA, et al. Patterns of recurrent hepatitis C after liver transplantation in a recent cohort of patients. Hum Pathol 2007; 38:443-452. This study of 92 HCV patients transplanted between 1999 and 2003 was subdivided into categories of: no histologic recurrence, typical recurrent HCV, nonprogressive (≤stage 1) and progressive HCV (≥stage 2). Inflammation grade greater than 2 and plasma cell-rich interface hepatitis were predictors of progressive fibrosis.
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Khettry U, Huang W-Y, Simpson MA, et al. Patterns of recurrent hepatitis C after liver transplantation in a recent cohort of patients. Hum Pathol 2007; 38:443-452. This study of 92 HCV patients transplanted between 1999 and 2003 was subdivided into categories of: no histologic recurrence, typical recurrent HCV, nonprogressive (≤stage 1) and progressive HCV (≥stage 2). Inflammation grade greater than 2 and plasma cell-rich interface hepatitis were predictors of progressive fibrosis.
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60
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Early histologic changes in fibrosing cholestatic hepatitis C
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Dixon LR, Crawford JM. Early histologic changes in fibrosing cholestatic hepatitis C. Liver Transplant 2007; 13:219-226.
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(2007)
Liver Transplant
, vol.13
, pp. 219-226
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Dixon, L.R.1
Crawford, J.M.2
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Seyam M, Neuberger JM, Gunson BK, Hübscher SG. Cirrhosis after orthotopic liver transplantation in the absence of primary disease recurrence. Liver Transplant 2007; 13:966-974. Of 1287 patients transplanted between 1982 and 2002 in Birmingham, UK, 48 (3.7%) developed cirrhosis. In this group, 29 patients had cirrhosis due to recurrent disease and in nine patients another etiology such as de-novo AIH was found. In 10 cases no cause was discerned, the biopsies having shown chronic hepatitis of unknown etiology. The prevalence was greatest in patients transplanted for fulminant seronegative hepatitis.
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Seyam M, Neuberger JM, Gunson BK, Hübscher SG. Cirrhosis after orthotopic liver transplantation in the absence of primary disease recurrence. Liver Transplant 2007; 13:966-974. Of 1287 patients transplanted between 1982 and 2002 in Birmingham, UK, 48 (3.7%) developed cirrhosis. In this group, 29 patients had cirrhosis due to recurrent disease and in nine patients another etiology such as de-novo AIH was found. In 10 cases no cause was discerned, the biopsies having shown chronic hepatitis of unknown etiology. The prevalence was greatest in patients transplanted for fulminant seronegative hepatitis.
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Syn W-K, Nightingale P, Gunson B, et al. Natural history of unexplained chronic hepatitis after liver transplantation. Liver Transplant 2007; 13:984-989. Of 288 patients transplanted for alcoholic liver disease or fulminant hepatic failure, 30 with unknown cause of chronic hepatitis also had at least two biopsies and exclusion of recurrent disease. The biopsy features of portal plasma cells in conjunction with high titer of antinuclear antibody of greater than 1 : 1600, female gender and serum alkaline phosphatase level were associated with progressive fibrosis.
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Syn W-K, Nightingale P, Gunson B, et al. Natural history of unexplained chronic hepatitis after liver transplantation. Liver Transplant 2007; 13:984-989. Of 288 patients transplanted for alcoholic liver disease or fulminant hepatic failure, 30 with unknown cause of chronic hepatitis also had at least two biopsies and exclusion of recurrent disease. The biopsy features of portal plasma cells in conjunction with high titer of antinuclear antibody of greater than 1 : 1600, female gender and serum alkaline phosphatase level were associated with progressive fibrosis.
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Shaikh OS, Demetris AJ. Idiopathic posttransplantation hepatitis? Liver Transplant 2007; 13:943-946. The authors of this editorial take a critical look at the two series of patients with 'idiopathic' posttransplant chronic hepatitis and raise the possibility of exposure of the recipient's immune system to nonmajor histocompatibility determinants such as drug metabolizing enzymes produced by donor hepatocytes as a means of provoking a 'hepatitic' immune, nonclassical rejection injury after transplantation.
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Shaikh OS, Demetris AJ. Idiopathic posttransplantation hepatitis? Liver Transplant 2007; 13:943-946. The authors of this editorial take a critical look at the two series of patients with 'idiopathic' posttransplant chronic hepatitis and raise the possibility of exposure of the recipient's immune system to nonmajor histocompatibility determinants such as drug metabolizing enzymes produced by donor hepatocytes as a means of provoking a 'hepatitic' immune, nonclassical rejection injury after transplantation.
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