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Volumn 24, Issue 3, 2008, Pages 269-277

Hepatobiliary pathology

Author keywords

Ductular reaction; Hemochromatosis; Hepatocellular carcinoma; Liver pathology; Viral hepatitis; Wilson disease

Indexed keywords

BETA CATENIN; GLUCOSE; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HEPCIDIN; IMMUNOGLOBULIN G4; INSULIN; IRON; STEROID;

EID: 42149108005     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOG.0b013e3282f8e28f     Document Type: Review
Times cited : (6)

References (63)
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    • Zen Y, Notsumata K, Tanaka N, Nakanuma Y. Hepatic centrilobular zonal necrosis with positive antinuclear antibody: a unique subtype or early disease of autoimmune hepatitis? Hum Pathol 2007; 38:1669-1675. Five patients (one male, four female) with centrizonal necroinflammation accompanied by minimal or mild portal inflammation and no interface hepatitis, with antinuclear antibodies of 1 : 40 to 1 : 1280 were reported. The authors review the several other series describing this phenomenon.
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    • Alvaro D, Mancino MG, Glaser S, et al. Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver. Gastroenterology 2007; 132:415-431. A masterful synthesis of the current milieu of cholangiocytes in the liver, including a discussion of primary cilia, mediators of cholangiocyte dormancy and proliferation and neuropeptide/ neurotransmitter actions on proliferating cholangiocytes. Four types of ductular proliferation are reviewed.
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    • Fabris L, Cadamuro M, Guido M, et al. Analysis of liver repair mechanisms in Alagille syndrome and biliary atresia reveals a role for Notch signaling. Am J Pathol 2007; 171:641-653. Multiple immunostains, including cytokeratin 7 and 19 and p21, were used to examine the distribution and degree of hepatic progenitor cells, intermediate hepatobiliary cells and reactive ductular cells in Alagille syndrome(AGS) and biliary atresia as well as to correlate the thick fibrous septa of biliary atresia (associated with ductules) and the thin septa with prominent pericellular fibrosis associated with AGS.
    • Fabris L, Cadamuro M, Guido M, et al. Analysis of liver repair mechanisms in Alagille syndrome and biliary atresia reveals a role for Notch signaling. Am J Pathol 2007; 171:641-653. Multiple immunostains, including cytokeratin 7 and 19 and p21, were used to examine the distribution and degree of hepatic progenitor cells, intermediate hepatobiliary cells and reactive ductular cells in Alagille syndrome(AGS) and biliary atresia as well as to correlate the thick fibrous septa of biliary atresia (associated with ductules) and the thin septa with prominent pericellular fibrosis associated with AGS.
  • 17
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    • IL-8 expression by biliary epithelial cells is associated with neutrophilic infiltration and reactive bile ductules
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    • Isse, K.1    Harada, K.2    Nakanuma, Y.3
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    • Mutations in bile salt export pump (ABCB11) in two children with progressive familial intrahepatic cholestasis and cholangiocarcinoma
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    • Immunoglobulin G4 associated cholangitis: Description of an emerging clinical entity based on review of the literature
    • The clinical, radiological and histopathological features of IgG4-associated cholangitis are described in this review, with a discussion of the interrelationship with autoimmune pancreatitis
    • Björnsson E, Chari ST, Smyrk TC, Lindor K. Immunoglobulin G4 associated cholangitis: description of an emerging clinical entity based on review of the literature. Hepatology 2007; 45:1547-1554. The clinical, radiological and histopathological features of IgG4-associated cholangitis are described in this review, with a discussion of the interrelationship with autoimmune pancreatitis.
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    • Björnsson, E.1    Chari, S.T.2    Smyrk, T.C.3    Lindor, K.4
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    • Pathological classification of hepatic inflammatory pseudotumor with respect to IgG4-related disease
    • Sixteen cases of hepatic inflammatory pseudotumor (11 men, five women) were reported with descriptions of two types: fibrohistocytic and lymphoplasmacytic
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    • Zen, Y.1    Fujii, T.2    Sato, Y.3
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    • Umemura T, Zen Y, Hamano H, et al. Immunoglobulin G4-hepatopathy: association of immunoglobulin G4-bearing plasma cells in liver with autoimmune pancreatitis. Hepatology 2007; 46:463-471. Liver biopsies from 17 patients with autoimmune pancreatitis were analyzed for features potentially related to this IgG4-plasma cell disease, and compared with biopsies from patients with autoimmune hepatitis, PBC, PSC and chronic viral hepatitis. Five patterns of liver pathology included portal inflammation with or without interface hepatitis; features of large bile duct obstruction; portal sclerosis; lobular hepatitis; and canalicular cholestasis.
    • Umemura T, Zen Y, Hamano H, et al. Immunoglobulin G4-hepatopathy: association of immunoglobulin G4-bearing plasma cells in liver with autoimmune pancreatitis. Hepatology 2007; 46:463-471. Liver biopsies from 17 patients with autoimmune pancreatitis were analyzed for features potentially related to this IgG4-plasma cell disease, and compared with biopsies from patients with autoimmune hepatitis, PBC, PSC and chronic viral hepatitis. Five patterns of liver pathology included portal inflammation with or without interface hepatitis; features of large bile duct obstruction; portal sclerosis; lobular hepatitis; and canalicular cholestasis.
  • 24
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    • Zen, Y.1    Fujii, T.2    Harada, K.3
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    • Hemochromatosis: An endocrine liver disease
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    • Pietrangelo A. Hemochromatosis: an endocrine liver disease. Hepatology 2007; 46:1291-1301. This extremely well synthesized look at iron homeostasis and overload examines hereditary forms of hemochromatosis, ferroportin disease, aceruloplasminemia and other conditions in the context of other defining features such as presence or absence of anemia, hepcidin expression and clinical modulators.
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    • Pietrangelo, A.1
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    • Xuan A, Bookman I, Cox DW, Heathcote J. Three atypical cases of Wilson disease: assessment of the Leipzig scoring system in making a diagnosis. J Hepatol 2007; 47:428-433. The three patients described were 51, 41 and 58 years old at first presentation and all had Leipzig scores of 6 (highly likely Wilson disease). The absence of neuropsychiatric symptoms in all three and Kaiser-Fleischer rings in one and their older age are discussed among the confounding diagnostic features of the cases.
    • Xuan A, Bookman I, Cox DW, Heathcote J. Three atypical cases of Wilson disease: assessment of the Leipzig scoring system in making a diagnosis. J Hepatol 2007; 47:428-433. The three patients described were 51, 41 and 58 years old at first presentation and all had Leipzig scores of 6 (highly likely Wilson disease). The absence of neuropsychiatric symptoms in all three and Kaiser-Fleischer rings in one and their older age are discussed among the confounding diagnostic features of the cases.
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    • Roberts EA. Pediatric nonalcoholic fatty liver disease (NAFLD): a 'growing' problem? J Hepatol 2007; 46:1133-1142. A comprehensive review of pediatric NAFLD discusses the settings in which fatty liver occurs in this group, including hypothalamic, genetic and metabolic disease as well as the clinical diagnosis and treatment. The author points out the salient histological differences between pediatric and adult NASH as well as their differing natural history.
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    • In vitro production of Malory bodies and intracellular hyaline bodies: The central role of sequestosome 1/p62
    • This in-vitro cell transfection study sorts out the various constituents (ubiquitin, p62, cytokeratins 8 and 18) which are required for formation of Mallory bodies types 1, 2 and 3 or of intracellular hyaline bodies
    • Stumpner C, Fuchsbichler A, Zatloukal K, Denk H. In vitro production of Malory bodies and intracellular hyaline bodies: the central role of sequestosome 1/p62. Hepatology 2007; 46:851-860. This in-vitro cell transfection study sorts out the various constituents (ubiquitin, p62, cytokeratins 8 and 18) which are required for formation of Mallory bodies types 1, 2 and 3 or of intracellular hyaline bodies.
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    • Stumpner, C.1    Fuchsbichler, A.2    Zatloukal, K.3    Denk, H.4
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    • Keratin 18 overexpression but not phosphorylation or filament organization blocks mouse Mallory body formation
    • Harada M, Strnad P, Resurreccion EZ, et al. Keratin 18 overexpression but not phosphorylation or filament organization blocks mouse Mallory body formation. Hepatology 2007; 45:88-96.
    • (2007) Hepatology , vol.45 , pp. 88-96
    • Harada, M.1    Strnad, P.2    Resurreccion, E.Z.3
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    • Transglutaminase 2 regulates Mallory body inclusion formation and injury-associated liver enlargement
    • Strnad P, Harada M, Siegel M, et al. Transglutaminase 2 regulates Mallory body inclusion formation and injury-associated liver enlargement. Gastroenterology 2007; 132:1515-1526.
    • (2007) Gastroenterology , vol.132 , pp. 1515-1526
    • Strnad, P.1    Harada, M.2    Siegel, M.3
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    • Hepatic abnormalities in patients with chronic granulomatous disease
    • A total of 194 patients with chronic granulomatous disease were evaluated for evidence of biochemical, clinical and histological liver disease. Eighty-eight liver specimens from 38 patients were available for review
    • Hussain N, Feld JJ, Kleiner DE, et al. Hepatic abnormalities in patients with chronic granulomatous disease. Hepatology 2007; 45:675-683. A total of 194 patients with chronic granulomatous disease were evaluated for evidence of biochemical, clinical and histological liver disease. Eighty-eight liver specimens from 38 patients were available for review.
    • (2007) Hepatology , vol.45 , pp. 675-683
    • Hussain, N.1    Feld, J.J.2    Kleiner, D.E.3
  • 34
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    • The liver in celiac disease
    • This interesting literature review cites the reported prevalence of celiac disease in PBC patients as 0-11, celiac disease in AIH patients as 4-6.4% and celiac disease in PSC patients as 1.6, The possible mechanisms of intestinal and liver injury are also discussed
    • Rubio-Tapia A, Murray JA. The liver in celiac disease. Hepatology 2007; 46:1650-1658. This interesting literature review cites the reported prevalence of celiac disease in PBC patients as 0-11%, celiac disease in AIH patients as 4-6.4% and celiac disease in PSC patients as 1.6%. The possible mechanisms of intestinal and liver injury are also discussed.
    • (2007) Hepatology , vol.46 , pp. 1650-1658
    • Rubio-Tapia, A.1    Murray, J.A.2
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    • Lee WS, Sokol RJ. Mitochondrial hepatopathies: advances in genetics and pathogenesis. Hepatology 2007; 45:1555-1565. This detailed summation of mitochondrial hepatopathies points out the clinical presentation, liver histology and genetic alterations in neonatal liver failure, mitochondrial DNA depletion syndrome (affecting respiratory chain components I, III, IV and V), delayed onset liver disease, Pearson syndrome and other disorders.
    • Lee WS, Sokol RJ. Mitochondrial hepatopathies: advances in genetics and pathogenesis. Hepatology 2007; 45:1555-1565. This detailed summation of mitochondrial hepatopathies points out the clinical presentation, liver histology and genetic alterations in neonatal liver failure, mitochondrial DNA depletion syndrome (affecting respiratory chain components I, III, IV and V), delayed onset liver disease, Pearson syndrome and other disorders.
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    • Pathological diagnosis of liver cell adenoma and focal nodular hyperplasia: Bordeaux update
    • An expert panel reviews the contemporary diagnostic criteria for adenoma and focal nodular hyperplasia
    • Bioulac-Sage P, Balabaud C, Bedossa P, et al. Pathological diagnosis of liver cell adenoma and focal nodular hyperplasia: Bordeaux update. J Hepatol 2007; 46:521-527. An expert panel reviews the contemporary diagnostic criteria for adenoma and focal nodular hyperplasia.
    • (2007) J Hepatol , vol.46 , pp. 521-527
    • Bioulac-Sage, P.1    Balabaud, C.2    Bedossa, P.3
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    • Paradis V, Champault A, Ronot M, et al. Telangiectatic adenoma: an entity associated with increased body mass index and inflammation. Hepatology 2007; 46:140-146. The authors describe the tumors and patient demographics of 32 telangiectatic adenomas from 27 patients of whom 92% were women.
    • Paradis V, Champault A, Ronot M, et al. Telangiectatic adenoma: an entity associated with increased body mass index and inflammation. Hepatology 2007; 46:140-146. The authors describe the tumors and patient demographics of 32 telangiectatic adenomas from 27 patients of whom 92% were women.
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    • Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry
    • An immunohistochemical and quantitative reverse transcription-PCR study differentiates between several subtypes of liver cell adenoma
    • Bioulac-Sage P, Rebouissou S, Thomas C, et al. Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry. Hepatology 2007; 46:740-748. An immunohistochemical and quantitative reverse transcription-PCR study differentiates between several subtypes of liver cell adenoma.
    • (2007) Hepatology , vol.46 , pp. 740-748
    • Bioulac-Sage, P.1    Rebouissou, S.2    Thomas, C.3
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    • Shaikh OS, Demetris AJ. Idiopathic posttransplantation hepatitis? Liver Transplant 2007; 13:943-946. The authors of this editorial take a critical look at the two series of patients with 'idiopathic' posttransplant chronic hepatitis and raise the possibility of exposure of the recipient's immune system to nonmajor histocompatibility determinants such as drug metabolizing enzymes produced by donor hepatocytes as a means of provoking a 'hepatitic' immune, nonclassical rejection injury after transplantation.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.