Na+/Ca2+ exchanger 2 is neuroprotective by exporting Ca2+ during a transient focal cerebral ischemia in the mouse

Cell Calcium

Volumn 43, Issue 5, 2008, Pages 482-491

  Jeon, Daejong ^a,b   Chu, Kon ^c   Jung, Keun Hwa ^c,d   Kim, Manho ^c   Yoon, Byung Woo ^c   Lee, C Justin ^a   Oh, Uhtaek ^b   Shin, Hee Sup ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Seoul National University   (South Korea)

^c Seoul National University Hospital   (South Korea)

^d Korea Centers for Disease Control and Prevention   (South Korea)

Author keywords

Cerebral ischemia; Membrane depolarization; Na+ Ca2+ exchanger; NCX2 deficient mice; Population spike; Ca2+ i

Indexed keywords

CALCIUM ION; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM CALCIUM EXCHANGE PROTEIN 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL PROTECTION; CONTROLLED STUDY; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; MEMBRANE DEPOLARIZATION; MOUSE; NERVE CELL MEMBRANE POTENTIAL; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPERFUSION; SPIKE WAVE; WILD TYPE;

MUS;

EID: 42149087628     PISSN: 01434160     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ceca.2007.08.003     Document Type: Article

References (22)

1. Lipton P. Ischemic cell death in brain neurons. Physiol. Rev. 79 (1999) 1431-1568
2. Blaustein M.P., and Lederer W.J. Sodium/calcium exchange: its physiological implications. Physiol. Rev. 79 (1999) 763-854
3. Philipson K.D., and Nicoll D.A. Sodium-calcium exchange: a molecular perspective. Annu. Rev. Physiol. 62 (2000) 111-133
4. 2+ exchanger: from molecular biology to therapeutic perspectives. Pharmacol. Rev. 56 (2004) 633-654
5. Tanaka E., Uchikado H., Niiyama S., Uematsu K., and Higashi H. Extrusion of intracellular calcium ion after in vitro ischemia in the rat hippocampal CA1 region. J. Neurophysiol. 88 (2002) 879-887
6. 2+ exchanger. Science 250 (1990) 562-565
7. 2+ exchanger. J. Biol. Chem. 269 (1994) 17434-17439
8. 2+ exchanger, NCX3. J. Biol. Chem. 271 (1996) 24914-24921
9. 2+ exchanger isoforms in rat brain. Brain Res. Mol. Brain Res. 50 (1997) 285-292
10. 2+ exchanger (NCX1, NCX2, NCX3). Am. J. Physiol. 274 (1998) C415-C423
11. 2+ exchanger transcripts and proteins in rat brain regions. J. Comp. Neurol. 461 (2003) 31-48
12. Pignataro G., Gala R., Cuomo O., Tortiglione A., Giaccio L., Castaldo P., Sirabella R., Matrone C., Canitano A., Amoroso S., Di Renzo G., and Annunziato L. Two sodium/calcium exchanger gene products, NCX1 and NCX3, play a major role in the development of permanent focal cerebral ischemia. Stroke 35 (2004) 2566-2570
13. 2+ exchanger gene expression in the ischemic core, periinfarct area, and intact brain regions. J. Cereb. Blood Flow Metab. 26 (2006) 502-517
14. 2+ exchanger in excitotoxicity. Cell 120 (2005) 275-285
15. 2+ exchanger isoforms after transient focal cerebral ischemia in rats. Neurosci. Lett. 404 (2006) 249-253
16. 2+ exchanger 2. Neuron 38 (2003) 965-976
17. 2+ channel-deficient mice. Genes Brain Behav. 6 (2007) 375-388
18. Lee S.H., Kim M., Yoon B.W., Kim Y.J., Ma S.J., Roh J.K., Lee J.S., and Seo J.S. Targeted hsp70.1 disruption increases infarction volume after focal cerebral ischemia in mice. Stroke 32 (2001) 2905-2912
19. Jung K.H., Chu K., Jeong S.W., Han S.Y., Lee S.T., Kim J.Y., Kim M., and Roh J.K. HMG-CoA reductase inhibitor, atorvastatin, promotes sensorimotor recovery, suppressing acute inflammatory reaction after experimental intracerebral hemorrhage. Stroke 35 (2004) 1744-1749
20. Secondo A., Staiano R.I., Scorziello A., Sirabella R., Boscia F., Adornetto A., Valsecchi V., Molinaro P., Canzoniero L.M., Di Renzo G., and Annunziato L. BHK cells transfected with NCX3 are more resistant to hypoxia followed by reoxygenation than those transfected with NCX1 and NCX2: possible relationship with mitochondrial membrane potential. Cell Calcium 42 (2007) 521-535
21. Tanaka E., Yamamoto S., Kudo Y., Mihara S., and Higashi H. Mechanisms underlying the rapid depolarization produced by deprivation of oxygen and glucose in rat hippocampal CA1 neurons in vitro. J. Neurophysiol. 78 (1997) 891-902
22. 2+ exchanger enhances depolarizations induced by oxygen/glucose deprivation but not responses to excitatory amino acids in rat striatal neurons. Stroke 30 (1999) 1687-1694