Advancement in the modeling of pressure-flow for the guidance of development and scale-up of commercial-scale biopharmaceutical chromatography

Journal of Chromatography A

Volumn 1190, Issue 1-2, 2008, Pages 127-140

  Keener III, Ronald N ^a   Fernandez, Erik J ^b   Maneval, James E ^c   Hart, Roger A ^a  

^a AMGEN INC   (United States)

^b University of Virginia   (United States)

^c BUCKNELL UNIVERSITY   (United States)

Author keywords

Column packing; Commercial scale chromatography; Modeling; Number of cycles; Pressure drop; Process time; Protein A; Protein purification; Scale up

Indexed keywords

CHROMATOGRAPHIC ANALYSIS; ELASTIC MODULI; POLYSACCHARIDES; POROSITY; PRESSURE DROP; PROTEINS;

COLUMN PACKING; COMMERCIAL SCALE CHROMATOGRAPHY; PACKED PRESSURE FLOW; PROCESS TIME; PROTEIN PURIFICATION;

DRUG PRODUCTS;

RESIN;

ARTICLE; CHROMATOGRAPHY; ELASTICITY; PARTICLE SIZE; POROSITY; PRESSURE; PRIORITY JOURNAL; PROTEIN PURIFICATION; SCALE UP; THEORETICAL MODEL;

CHEMISTRY, PHARMACEUTICAL; MODELS, THEORETICAL; PARTICLE SIZE;

EID: 42049121121     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2008.02.113     Document Type: Article

References (10)

1. Stickel J.J., and Fotopolous A. Biotechnol. Prog. 17 (2001) 744
2. Colby C.B., O'Neill B.K., and Middelberg A.P.J. Biotechnol. Prog. 12 (1996) 92
3. Östergren K.C.E., Trägårdh C., Enstad G.G., and Mosby J. AIChE J. 44 (1998) 2
4. Keener R.N., Maneval J.E., Östergren K.C.E., and Fernandez E.J. Biotechnol. Prog. 18 (2002) 587
5. Keener R.N., Maneval J.E., and Fernandez E.J. Biotechnol. Prog. 20 (2004) 1146
6. Keener R.N., Maneval J.E., and Fernandez E.J. Biotechnol. Prog. 20 (2004) 1159
7. Keener R.N., Hart R.A., and Fernandez E.J. Presented at the 230th American Chemical Society Meeting. Anaheim, CA, 28 March-1 April (2004)
8. McCue J.T., Cecchini D., Chu C., Liu W., and Spann A. J. Chromatogr. A 1145 (2007) 89
9. Nelder J.A., and Mead R. Comp. J. 7 308 (1965)
10. Packing Procedure for Fractogel EMD Resins in 5-20 cm I.D. columns, EMD Chemicals Gibbstown, NJ, 2007, http://www.emdchemicals.com/lifescience/literature/Process_Separations.asp.