Toward a robust model of packing and scale-up for chromatographic beds. 2. Flow packing

Biotechnology Progress

Volumn 20, Issue 4, 2004, Pages 1159-1168

  Keener, Ronald N ^a   Maneval, James E ^a   Fernandez, Erik J ^a  

^a University of Virginia   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPACTION; ELASTIC MODULI; ELASTICITY; MATHEMATICAL MODELS; RIGIDITY;

CHROMATOGRAPHIC BEDS; CHROMATOGRAPHIC RESINS; MECHANICAL COMPRESSION;

CHROMATOGRAPHIC ANALYSIS;

ARTICLE; PARTICLE SIZE; PERMEABILITY; PILOT STUDY; SENSITIVITY AND SPECIFICITY; THEORETICAL MODEL;

MODELS, THEORETICAL; PARTICLE SIZE; PERMEABILITY; PILOT PROJECTS; SENSITIVITY AND SPECIFICITY;

EID: 4043104041     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp0342809     Document Type: Article

References (6)

1. ) Keener, R. N.; Maneval, J. E.; Fernandez, E. J. Toward a Robust Model of Packing and Scale-Up of Chromatographic Beds. 1. Mechanical compression. Biotechnol. Prog. 2004, 20, 1146-1158.
2. Stickel, J. J.; Fotopoulos A. Pressure-Flow relationships for Packed Beds of Compressible Chromatography Media at Laboratory and Production Scale. Biotechnol. Prog. 2001, 17, 744-751.
3. Östergren, K. C. E.; Trägårdh, A. C.; Enstad, G. G.; Mosby, J. Deformation of a Chromatographic Bed During Steady-State Liquid Flow AIChE J. 1998, 44, 2-12.
4. Bird, R. B.; Stewart, W. E.; Lightfoot, E. N. Transport Phenomena; John Wiley and Sons: New York, 1960.
5. Hamilton, R. T. Darcy Constant for Multisized Spheres with No Arbitrary Constant. AIChE J. 1997, 43, 835-836.
6. Colby, C. B.; O,Neill, B. K.; Middelberg, A. P. J. A Modified Version of the Volume-Averaged Continuum Theory to Predict Pressure Drop Across Compressible Packed Beds of Sepharose Big-Beads SP. Biotechnol. Prog. 1996, 12, 92-99.