Lack of association between the type 2 deiodinase A/G polymorphism and hypertensive traits: The Framingham heart study

Hypertension

Volumn 51, Issue 4, 2008, Pages

  Maia, Ana Luiza ^a   Hwang, Shih Jen ^b,c   Levy, Daniel ^b,c   Larson, Martin G ^d   Larsen, P Reed ^e   Fox, Caroline S ^b,c,e  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^b FRAMINGHAM HEART STUDY   (United States)

^c NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THYROXINE DEIODINASE; IODIDE PEROXIDASE; IODOTHYRONINE DEIODINASE TYPE II; UNCLASSIFIED DRUG;

ADULT; DIASTOLIC BLOOD PRESSURE; FEMALE; GENOTYPE; HUMAN; HYPERTENSION; LETTER; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; GENETIC POLYMORPHISM; GENETICS; NOTE; UNITED STATES;

HUMANS; HYPERTENSION; IODIDE PEROXIDASE; MASSACHUSETTS; POLYMORPHISM, GENETIC;

EID: 42049103714     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.107.109454     Document Type: Letter

References (6)

1. Canani LH, Capp C, Dora JM, Meyer EL, Wagner MS, Harney JW, Larsen PR, Gross JL, Bianco AC, Maia AL. The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab. 2005;90:3472-3478.
2. Maia AL, Dupuis J, Manning A, Liu C, Meigs JB, Cupples LA, Larsen PR, Fox CS. The type 2 deiodinase (DIO2) A/G polymorphism is not associated with glycemic traits: the Framingham Heart Study. Thyroid. 2007;17:199-202.
3. Gumieniak O, Perlstein TS, Williams JS, Hopkins PN, Brown NJ, Raby BA, Williams GH. Ala92 type 2 deiodinase allele increases risk for the development of hypertension. Hypertension. 2007;49:461-466.
4. Gumieniak O, Hurwitz S, Perlstein TS, Ngumezi UC, Hopkins PN, Jeunemaitre X, Williams GH. Aggregation of high-normal thyroid-stimulating hormone in hypertensive families. J Clin Endocrinol Metab. 2005;90:5985-5990.
5. Canani LH, Leie MA, Machado WE, Capp C, Maia AL. Type 2 deiodinase Thr92Ala polymorphism is not associated with arterial hypertension in type 2 diabetes mellitus patients. Hypertension. 2007;49:e47.
6. Gumieniak O, Williams GH. Response to type 2 deiodinase Thr92Ala polymorphism is not associated with arterial hypertension in type 2 diabetes mellitus patients. Hypertension. 2007;49:e48