Type 2 deiodinase Thr92Ala polymorphism is not associated with arterial hypertension in type 2 diabetes mellitus patients [11]

Hypertension

Volumn 49, Issue 6, 2007, Pages

  Canani, Luís Henrique ^a   Leie, Murilo A ^a   Machado, Walter Escouto ^a   Capp, Clarissa ^a   Mai, Ana Luiza ^a  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ENZYME; THREONINE; TYPE 2 DEIODINASE; UNCLASSIFIED DRUG;

BLOOD PRESSURE MEASUREMENT; CARDIOVASCULAR RISK; DIASTOLIC BLOOD PRESSURE; DNA DETERMINATION; GENE FREQUENCY; GENOTYPE; HOMOZYGOSITY; HUMAN; HYPERTENSION; INSULIN RESISTANCE; LABORATORY TEST; LETTER; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYSICAL EXAMINATION; PREVALENCE; PRIORITY JOURNAL; QUESTIONNAIRE; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE;

ALANINE; DIABETES MELLITUS, TYPE 2; FEMALE; GENOTYPE; HUMANS; HYPERTENSION; INSULIN RESISTANCE; IODIDE PEROXIDASE; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; REPRODUCIBILITY OF RESULTS; RISK FACTORS; THREONINE;

EID: 34249279855     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.107.088278     Document Type: Letter

References (5)

1. Canani LH, Capp C, Dora JM, Meyer EL, Wagner MS, Harney JW, Larsen PR, Gross JL, Bianco AC, Maia AL. The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab. 2005;90:3472-3478.
2. Mentuccia D, Proietti-Pannunzi L, Tanner K, Bacci V, Pollin TI, Poehlman ET, Shuldiner AR, Celi FS. Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor. Diabetes. 2002;51:880-883.
3. Grarup N, Andersen MK, Andreasen CH, Albrechtsen A, Borch-Johnsen K, Jorgensen T, Auwerx J, Schmitz O, Hansen T, Pedersen O. Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects. J Clin Endocrinol Metab. 2007;92:363-366.
4. Maia AL, Dupuis J, Manning A, Liu C, Meigs JB, Cupples LA, Larsen PR, Fox CS. The type 2 deiodinase (DIO2) A/G polymorphism is not associated with glycemic traits: the Framingham Heart Study. Thyroid. 2007;In press.
5. Gumieniak O, Perlstein TS, Williams JS, Hopkins PN, Brown NJ, Raby BA, Williams GH. Ala92 Type 2 deiodinase allele increases risk for the development of hypertension. Hypertension. 2007;49:461-466.