Effects of Phytosterol Esters on Serum Lipids and Fecal Steroids Excretion in Hamsters

Journal of Oleo Science

Volumn 52, Issue 5, 2003, Pages 229-237

  Kojima, Keiichi ^a   Seki, Shinji ^a   Hidaka, Ichiro ^a   Yoshino, Hisako ^a   Noguchi, Osamu ^a   Sato, Chiemi ^a   Aoyama, Toshiaki ^a  

^a The Nisshin OilliO Group   (Japan)

Author keywords

blood cholesterol; fecal steroid; hamster; lipoprotein; phytosterol ester

Indexed keywords

EID: 42049099489     PISSN: 13458957     EISSN: 13473352     Source Type: Journal    
DOI: 10.5650/jos.52.229     Document Type: Article

References (46)

1. H. GYLLING, M. A. SIIMES and T. A. MIETTINEN, Sitosterol Ester Margarine in Dietary Treatment of Children with Familial Hypercholesterolemia, J. Lipid Res., Vol. 36, 1807-1812 (1995).
2. M. BECKER, D. STAAB and K. VON BERGMANN, Treatment of Severe Familial Hypercholesterolemia in Childhood with Sitosterol and Sitostanol, J. Pediatr., Vol. 122, 292-296 (1993).
3. M. SUGANO, F. KAMO, I. IKEDA and H. MORIOKA, Lipid Lowering Activity of Phytostanols in Rats, Atherosclerosis, Vol. 4, 301-309 (1976).
4. F. Y. NTANIOS, D. E. MACDOUGALL and P. J. H. JONES, Gen-der Effects of Tall Oil versus Soybean Phytosterols as Choles-terol-Lowering Agents in Hamsters, Can. J. Physiol. Pharma-col., Vol. 76, 780-787 (1998).
5. F. Y. NTANIOS and P. J. H. JONES, Effects of Variable Dietary Sitosterol Concentrations on Plasma Lipid Profile and Phytos-terol Metabolism in Hamsters, Biochim. Biophys. Acta, Vol. 1390, 237-244 (1998).
6. Y. SHIDOJI, M. WATANABE, T. OKU, Y. MUTO and N. HOSOYA, Inhibition of Beta-Sitosterol on Intestinal Cholesterol Absorption in Rats Using in vivo Dual Isotope Ratio Method, J. Nutr. Sci. Vitaminol., Vol. 26, 183-188 (1980).
7. I. IKEDA and M. SUGANO, Some Aspects of Mechanism of Inhibition of Cholesterol Absorption by β -sitosterol, Biochim. Biophys. Acta, Vol. 732, 651-658 (1983).
8. T. HEINEMANN, B. PIETRUCK, G. KULLAK-UBLICK and K. VON BERGMANN, Comparison of Sitosterol and Sitostanol on Inhibition of Intestinal Cholesterol Absorption, Agents Actions, Vol. 26, S117-S122 (1988).
9. Food and Drug Administration (USA), Food Labeling: Health Claims; Plant Sterol/Stanol Esters and Coronary Heart Disease; Interim Final Rule, Federal Register, Vol. 65, 21 (2000).
10. R. J. JANDACEK, M. R. WEBB and F. H. MATTSON, The Effect of an Aqueous Phase on the Solubility of Cholesterol in an Oil Phase, J. Lipid Res., Vol. 18, 203-210 (1977).
11. M. LAW, Plant Sterol and Stanol Margarines and Health, Br. Med. J., Vol. 320, 861-864 (2000).
12. J. A. WESTSTRATE and G. W. MEIJER, Plant Sterol-Enriched Margarines and Reduction of Plasma Total and LDL-Cholesterol Concentrations in Normocholesterolemic and Mildly Hyperc-holesterolemic Subjects, Eur. J. Clin. Nutr., Vol. 52, 334-343 (1998).
13. M. H. MOGHADASIAN and J. J. FROHLICK, Effect of Dietary Phytosterols on Cholesterol Metabolism and Atherosclerosis: Clinical and Experimental Evidence, Am. J. Med., Vol. 107, 588-594 (1999).
14. H. F. HENDRIKS, J. A. WESTSTRATE, T. VAN VLIET and G. W. MEIJER, Spreads Enriched Three Different Levels of Vegetable Oil Sterol and Degree of Cholesterol Lowering in Normocholes-terolemic Subjects, Eur. J. Clin. Nutr., Vol. 53, 319-327 (1999).
15. F. H. MATTSON, R. A. VOLPENHEIN and B. A. ERICKSON, Effect of Plant Sterol Ester on the Absorption of Dietary Choles-terol, J. Nutr., Vol. 107, 1139-1146 (1977).
16. National Research Council, Guide for the Care and Use of Lab-oratory Animals, Publication No. 85-23 (rev.), National Institute of Health, Bethesda, MD (1985).
17. K. C. HAYES, Z. F. STEPHAN, A. PRONCZUK, S. LINDSEY and C. VERDON, Lactose Protects against Estrogen-Induced Pigment Gallstones in Hamsters Fed Nutritionally Adequate Purified Diets, J. Nutr., Vol. 119, 1726-1736 (1989).
18. J. FOLCH, M. LEES and G. H. SLOANE-STANLEY, A Simple Method for the Isolation and Purification of Total Lipids from Animal Tissue, J. Biol. Chem., Vol. 226, 497-509 (1956).
19. C. C. ALLAIN, L. S. POON, C. S. CHAN, W. RICHMOND and P. C. FU, Enzymatic Determination of Total Serum Cholesterol, Clin. Chem., Vol. 20, 470-475 (1974).
20. R. W. SPAYD, B. BRUSCHI, B. A. BURDICK, G. M. DAPPEN, J. N. EIKENBERRY, T. W. ESDERS, J. FIGUERAS, C. T. GOODHUE, D. D. LAROSSA, R. W. NELSON, R. N. RAND and T. W. WU, Multilayer Film Elements for Clinical Analysis: Applications to Representative Chemical Determinations, Clin. Chem., Vol. 24, 1343-1350 (1978).
21. R. W. KEENAN, G. SCHMIDT and T. TANAKA, Quantitative Determination of Phosphatidal Ethanolamine and Other Phos-phatides in Various Tissues of the Rat, Anal. Biochem., Vol. 23, 555-566 (1968).
22. T. A. MIETTINEN, E. H. AHRENS Jr. and S. M. GRUNDY, Quantitative Isolation and Gas-Liquid Chromatographic Analy-sis of Total Dietary and Fecal Neutral Steroids, J. Lipid Res., Vol. 6, 411-424 (1965).
23. M. SCOTT, E. H. GRUNDY, E. H. AHRENS Jr. and T. A. MIET-TINEN, Quantitative Isolation and Gas-Liquid Chromatographic Analysis of Total Fecal Bile Acids, J. Lipid Res., Vol. 6, 397-410 (1965).
24. D. B. DUNCAN, Multiple Range Test for Correlated and Het- eroscedatic Means, Biometrics, Vol. 13, 164-176 (1957).
25. S. L. SHEFER, B. NGUYEN, G. SALEN, C. NESS, I. R. CHOWDHARY, S. LERNER, A. K. BATTA and G. S. TINT, Dif-fering Effects of Cholesterol and Taurocholate on Steady State Hepatic HMG-CoA Reductase and Cholesterol 7α-Hydroxylase Activities and mRNA Levels in the Rat, J. Lipid Res., Vol. 33, 1193-1200 (1992).
26. L. A. WOOLLETT, D. K. SPADY and J. M. DIETSCHY, Saturat-ed and Unsaturated Fatty Acids Independently Regulate Low Density Lipoprotein Receptor Activity and Production Rate, J. Lipid Res., Vol. 33, 77-88 (1992).
27. H. TOMOTAKE, I. SHIMAOKA, J. KAYASHITA, F. YOKOYAMA, M. NAKAJOH and N. KATO, A Buckwheat Protein Product Suppresses Gallstone Formation and Plasma Cholesterol More Strongly than Soy Protein Isolate in Hamsters, J. Nutr., Vol. 130, 1670-1674 (2000).
28. T. A. WILSON, C. M. MESERVEY and R. J. NICOLOSI, Soy Lecithin Reduces Plasma Lipoprotein Cholesterol and Early Atherogenesis in Hypercholesterolemic Monkeys and Hamsters: Beyond Linoleate, Atherosclerosis, Vol. 140, 147-153 (1998).
29. F. BALMIR, R. STAACK, E. JEFFREY, M. D. B. JIMENEZ, L. WANG and S. M. POTTER, An Extract of Soy Flour Influences Serum Cholesterol and Thyroid Hormones in Rats and Ham-sters, J. Nutr., Vol. 126, 3046-3053 (1996).
30. S. KUROKI, T. NAITO, K. CHIJIIWA and M. TANAKA, Effects of Cholestyramine on Hepatic Cholesterol 7α-Hydroxy-lase and Serum 7α-Hydroxylcholesterol in the Hamster, Lipids, Vol. 34, 817-823 (1999).
31. J. OTTO, J. M. ORDOVAS, D. SMITH, D. VAN DONGEN, R. J. NICOLOSI and E. J. SCHAEFER, Lovastatin Inhibits Diet Induced Atherosclerosis in F1B Golden Syrian Hamsters, Atherosclerosis, Vol. 114, 19-28 (1995).
32. A. YASUI and T. KANEDA, The Synergistic Effectiveness of Tocopherols on Plasma Cholesterol Lowering Effect by Veg-etable Sterols, J. Jpn. Soc. Food and Nutr., Vol. 21, 27-32 (1973).
33. R. D. SHARMA and C. RUKMINI, Rice Bran Oil and Hypoc- holesterolemia in Rats, Lipids, Vol. 21, 715-717 (1986).
34. M. SUGANO, K. KOBA and E. TSUJI, Health Benefits of Rice Bran Oil, Anticancer Res., Vol. 19, 3651-3658 (1999).
35. K. EINARSSON, J. E. AKERLUND and I. BJORKHEIM, The Pool of Free Cholesterol is not of Major Importance for Regula-tion of the Cholesterol 7α-Hydroxylase Activity in Rat Liver Microsomes, J. Lipid Res., Vol. 28, 253-256 (1987).
36. K. A. MITROPOULOS, S. BALASUBRAMANIAM and N. B. MYANT, The Effect of Interruption of Enterohepatic Circulation of Bile Acids and Cholesterol Feeding on Cholesterol 7α-Hydroxylase in Relation on the Diurnal Rhythm in Its Activity, Biochim. Biophys. Acta, Vol. 326, 428-438 (1973).
37. D. K. SPADY, S. D. TURLEY and J. M. DIETSCHY, Rates of Low Density Lipoprotein Uptake and Cholesterol Synthesis are Regulated Independently in the Liver, J. Lipid Res., Vol. 26, 465-472 (1985).
38. E. REIHNER, B. ANGELIN, M. RUDLING, S. EWERTH, I. BJORKHEM and K. EINARSSON, Regulation of Hepatic Cholesterol Metabolism in Humans: Stimulatory Effects of Cholestyramine on HMG-CoA Reductase Activity and Low Density Lipoprotein Receptor Expression in Gallstone Patients, J. Lipid Res., Vol. 31, 2219-2226 (1990).
39. S. SAITO, I. IKEDA and M. SUGANO, Effect of Plant Sterols and Stanols on Blood Cholesterol Level: Clinical Evidence of Minimum Effective Dose, J. Jpn. Soc. Nutr. Food Sci., Vol. 55, 177-189 (2002).
40. N. GOTO, H. MORI, Y. KATSURAGI, T. TOI, T. YASUKAWA and H. SHIMASAKI, Effect of Diacylglycerol Containing Phy- tosterol on Reducing Blood Cholesterol Level, J. Jpn. Oil Chem. Soc., Vol. 48, 47-52 (1999).
41. M. SUGANO, H. MORITA and I. IKEDA, A Comparison of Hypocholesterolemic Activity of b-Sitosterol and β -Sitostanol in Rats, J. Nutr., Vol. 107, 2011-2019 (1977).
42. M. SHINOMIYA, N. MORISAKI, Y. FUJIYAMA, K. SHIRAI, Y. SAITO, A. KUMAGAI, N. MATSUOKA, S. MURANO, K. MITANI and S. MORITA, Effect of γ-Oryzanol on the Lipid Metabolism of High Cholesterol Diet-Administered Rats, J. Jpn. Atheroscler. Soc., Vol. 10, 1069-1075 (1983).
43. K. MITANI, Y. KIDO, S. SHIMIZU and S. MORITA, Effect of γ-Oryzanol (Hi-z) on the Metabolism of Cholesterol in Hyperc-holesterolemic Rats, J. Jpn. Atheroscler. Soc., Vol. 11, 411-416 (1983).
44. G. S. SEETHARAMAIAH and N. CHANDRASEKHARA, Studies on Hypocholesterolemic Activity of Rice Bran Oil, Atherosclerosis, Vol. 78, 219-223 (1989).
45. K. C. HAYES, A. PRONCZUK, V. WIJENDRAN and M. BEER, Free Phytosterols Effectively Reduce Plasma and Liver Choles-terol in Gerbils Fed Cholesterol, J. Nutr., Vol. 32, 1983-1988 (2002).
46. A. K. SINGHAL, B. I. COHEN, J. FINVER-SADOWSKY, C. K. MCSHERRY and E. H. MOSBACH, Role of Hydrophilic Bile Acids and of Sterols on Cholelithiasis in the Hamster, J. Lipid Res., Vol. 25, 564-570 (1984).