Effects of cholestyramine on hepatic cholesterol 7α-hydroxylase and serum 7α-hydroxycholesterol in the hamster

Lipids

Volumn 34, Issue 8, 1999, Pages 817-823

  Kuroki, Syoji ^a   Naito, Tokio ^a   Chijiiwa, Kazuo ^a   Tanaka, Masao ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

7ALPHA HYDROXYCHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; COLESTYRAMINE; TRIACYLGLYCEROL;

ANIMAL CELL; ARTICLE; CHOLESTEROL LIVER LEVEL; ENZYME ACTIVITY; FEMALE; LIPID ABSORPTION; LIPID METABOLISM; NONHUMAN; SYRIAN HAMSTER;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BODY WEIGHT; CHOLESTEROL; CHOLESTYRAMINE; CRICETINAE; CYTOCHROME P-450 ENZYME SYSTEM; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HYDROXYCHOLESTEROLS; KIDNEY; MESOCRICETUS; STEROID HYDROXYLASES; TIME FACTORS;

EID: 0032863506     PISSN: 00244201     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11745-999-0428-y     Document Type: Article

References (37)

1. Myant, N.B., and Mitropoulos, K.A. (1977) Cholesterol 7α-Hydroxylase, J. Lipid Res. 18, 135-153.
2. Shefer, S., Hauser, S., Bekersky, I., and Mosbach, E.H. (1970) Biochemical Site of Regulation of Bile Acid Biosynthesis in the Rat, J. Lipid Res. 11, 404-411.
3. Davis, R.A., Highsmith, W.E., McNeal, M.M., Schexnayder, J.A., and Kuan, J.C. (1983) Bile Acid Synthesis by Cultured Hepatocytes. Inhibition by Mevinolin, but Not by Bile Acids, J. Biol. Chem. 258, 4079-4082.
4. Danielsson, H. (1973) Effect of Biliary Obstruction on Formation and Metabolism of Bile Acids in Rats, Steroids 22, 567-579.
5. Horton, J.D., Cuthbert, J.A., and Spady, D.K. (1994) Regulation of Hepatic 7α-Hydroxylase Expression by Dietary Psyllium in the Hamster, J. Clin. Invest. 93, 2084-2092.
6. Spady, D.K., and Cuthbert, J.A. (1992) Regulation of Hepatic Cholesterol Metabolism in the Rat. Parallel Regulation of Activity and mRNA for 7α-Hydroxylase but Not 3-Hydroxy-3-methylglutaryl CoA Reductase or Low Density Lipoprotein Receptor, J. Biol. Chem. 267, 5584-5591.
7. Shefer, S., Nguyen, L.B., Salen, G., Ness, G.C., Chowdhary, I.R., Lerner, S., Batta, A.K., and Tint, G.S. (1992) Differing Effects of Cholesterol and Taurocholate on Steady State Hepatic HMG-CoA Reductase and Cholesterol 7α-Hydroxylase Activities and mRNA Levels in the Rat, J. Lipid Res. 33, 1193-1200.
8. Åkerlund, J.E., and Björkhem, I. (1990) Studies on the Regulation of Cholesterol 7α-Hydroxylase and HMG-CoA Reductase in Rat Liver. Effects of Lymphatic Drainage and Ligation of the Lymph Duct, J. Lipid Res. 31, 2159-2166.
9. Shefer, S., Hauser, S., and Mosbach, E.H. (1968) 7α-Hydroxylation of Cholestanol by Rat Liver Microsomes, J. Lipid Res. 9, 328-333.
10. Yamashita, H., Kuroki, S., and Nakayama, F. (1989) Assay of Cholesterol 7α-Hydroxylase Utilizing a Silica Cartridge Column and 5α-Cholestane-3β,7β-diol as an Internal Standard, J. Chromatogr. 496, 255-268.
11. Ogishima, T., and Okuda, K. (1986) An Improved Method for Assay of Cholesterol 7α-Hydroxylase Activity, Anal. Biochem. 158, 228-232.
12. Kuroki, S., Okamoto, S., Naito, T., Oda, H., Nagase, S., Sakai, H., Nawata, H., Yamashita, H., Chijiiwa, K., and Tanaka, M. (1995) Serum 7α-Hydroxycholesterol as a New Parameter of Liver Function in Patients with Chronic Liver Diseases, Hepatology 22, 1182-1187.
13. Oda, H., Yamashita, H., Kosahara, K., Kuroki, S., and Nakayama, F. (1990) Esterified and Total 7α-Hydroxycholesterol in Human Serum as an Indicator for Hepatic Bile Acid Synthesis, J. Lipid Res. 31, 2209-2218.
14. Okamoto, S., Fukushima, K., Higashijima, H., Makino, I., Kishinaka, M., Oda, H., Yamashita, H., Ichimiya, H., Chijiiwa, K., and Kuroki, S. (1994) Serum 7α-Hydroxycholesterol Reflects Hepatic Bile Acid Synthesis in Patients with Obstructive Jaundice After External Biliary Drainage, Hepatology 20, 95-100.
15. Fukushima, K., Ichimiya, H., Higashijima, H., Yamashita, H., Kuroki, S., Chijiiwa, K., and Tanaka, M. (1995) Regulation of Bile Acid Synthesis in the Rat: Relationship Between Hepatic Cholesterol 7α-Hydroxylase Activity and Portal Bile Acids, J. Lipid Res. 36, 315-321.
16. Nakano, K., Chijiiwa, K., Okamoto, S., Yamashita, H., Kuroki, S., and Tanaka, M. (1995) Hepatic Cholesterol 7α-Hydroxylase Activity and Serum 7α-Hydroxycholesterol Level During Liver Regeneration after Partial Hepatectomy in Rats, Eur. Surg. Res. 27, 389-395.
17. Naito, T., Kuroki, S., Chijiiwa, K., and Tanaka, M. (1996) Bile Acid Synthesis and Biliary Hydrophobicity During Obstructive Jaundice in Rats, J. Surg. Res. 65, 70-76.
18. Björkhem, I., Reihner, E., Angelin, B., Ewerth, S., Åkerlund, J.E., and Einarsson, K. (1987) On the Possible Use of the Serum Level of 7α-Hydroxycholesterol as a Marker for Increased Activity of the Cholesterol 7α-Hydroxylase in Humans, J. Lipid Res. 28, 889-894.
19. Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J. (1951) Protein Measurement with the Folin Phenol Reagent, J. Biol. Chem. 193, 265-275.
20. Cohen, B.I., Raicht, R.F., and Mosbach, E.H. (1977) Sterol Metabolism Studies in the Rat. Effects of Primary Bile Acids (sodium taurochenodeoxycholate and sodium taurocholate) on Sterol Metabolism, J. Lipid Res. 18, 223-231.
21. Chijiiwa, K., and Linscheer, W.G. (1987) Distribution and Monomer Activity of Cholesterol in Micellar Bile Salt: Effect of Cholesterol Level, Am. J. Physiol. 252, G309-G314.
22. Cronholm, T., and Sjovall, J. (1967) Bile Acids in Portal Blood of Rats Fed Different Diets and Cholestyramine. Bile Acids and Steroids 189, Eur. J. Biochem. 2, 375-383.
23. Myant, N.B., and Eder, H.A. (1961) The Effect of Drainage upon the Synthesis of Cholesterol in the Liver, J. Lipid Res. 2, 363-368.
24. Heuman, D.M., Hernandez, C.R., Hylemon, P.B., Kubaska, W.M., Hartman, C., and Vlahcevic, Z.R. (1988) Regulation of Bile Acid Synthesis. I. Effects of Conjugated Ursodeoxycholate and Cholate on Bile Acid Synthesis in Chronic Bile Fistula Rat, Hepatology 8, 358-365.
25. Einarsson, K., Åkerlund, J.E., and Björkhem, I. (1987) The Pool of Free Cholesterol Is Not of Major Importance for Regulation of the Cholesterol 7α-Hydroxylase Activity in Rat Liver Microsomes, J. Lipid Res. 28, 253-256.
26. Shefer, S., Hauser, S., Lapar, V., and Mosbach, E.H. (1973) Regulatory Effects of Sterols and Bile Acids on Hepatic 3-Hydroxy-3-methylglutaryl CoA Reductase and Cholesterol 7α-Hydroxylase in the Rat, J. Lipid Res. 14, 573-580.
27. Mitropoulos, K.A., Balasubramaniam, S., and Myant, N.B. (1973) The Effect of Interruption of the Enterohepatic Circulation of Bile Acids and of Cholesterol Feeding on Cholesterol 7α-Hydroxylase in Relation to the Diurnal Rhythm in Its Activity, Biochim. Biophys. Acta 326, 428-438.
28. Kovanen, P.T., Bilheimer, D.W., Goldstein, J.L. Jaramillo, J.J., and Brown, M.S. (1981) Regulatory Role for Hepatic Low Density Lipoprotein Receptors in vivo in the Dog, Proc. Natl. Acad. Sci. USA 78, 1194-1198.
29. Spady, D.K., Turley, S.D., and Dietschy, J.M. (1985) Rates of Low Density Lipoprotein Uptake and Cholesterol Synthesis Are Regulated Independently in the Liver, J. Lipid Res. 26, 465-472.
30. Reihner, E., Angelin, B., Rudling, M., Ewerth, S. Björkhem, I., and Einarsson, K. (1990) Regulation of Hepatic Cholesterol Metabolism in Humans: Stimulatory Effects of Cholestyramine on HMG-CoA Reductase Activity and Low Density Lipoprotein Receptor Expression in Gallstone Patients, J. Lipid Res. 31, 2219-2226.
31. Turley, S.D., Spady, D.K., and Dietschy, J.M. (1983) Alternation of the Degree of Biliary Cholesterol Saturation in the Hamster and Rat by Manipulation of the Pools of Preformed and Newly Synthesized Cholesterol, Gastroenterology 84, 253-264.
32. Shepherd, J., Packard, C.J., Bicker, S., Lawrie, T.D., and Morgan, H.G. (1980) Cholestyramine Promotes Receptor-Mediated Low-Density-Lipoprotein Catabolism, N. Engl. J. Med. 302, 1219-1222.
33. Kishinaka, M., Kuroki, S., Shimura, H., Chijiiwa, K., and Tanaka, M. (1998) Modulation of Cholesterol Metabolism Affects Tumor Growth in Hamsters, Fukuoka Acta Med. 89, 11-19.
34. Lin, D.S., and Connor, W.E. (1980) The Long-Term Effects of Dietary Cholesterol upon the Plasma Lipids, Lipoproteins, Cholesterol Absorption, and the Sterol Balance in Man: The Demonstration of Feedback Inhibition of Cholesterol Biosynthesis and Increased Bile Acid Excretion, J. Lipid Res. 21, 1042-1052.
35. Kuroki, S., Naito, T., Okamoto, S., Sakai, H., Yamashita, H., Chijiiwa, K., and Tanaka, M. (1997) Cholestyramine Loading Test to Assess Hepatic Reserve for Bile Acid Synthesis in Patients with Chronic Liver Diseases, Gastroenterology 112, 1277-1283.
36. Chao, Y., Yamin, T.T., and Alberts, A.W. (1982) Effects of Cholestyramine on Low Density Lipoprotein Binding Sites on Liver Membranes from Rabbits with Endogenous Hypercholesterolemia Induced by a Wheat Starch-Casein Diet, J. Biol. Chem. 257, 3623-3627.
37. Bascoul, J., Goze, C., Domergue, N., and Crastes de Paulet, A. (1990) Serum Level of 7α-Hydroxycholesterol in Hypercholesterolemic Patients Treated with Cholestyramine, Biochim. Biophys. Acta 1044, 357-360.