Immunosuppressive drug therapy and subclinical acute renal allograft rejection: Impact and effect

Transplantation

Volumn 85, Issue 7 SUPPL., 2008, Pages

  Kuypers, Dirk R J ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Immunosuppressive drugs; Protocol biopsies; Renal transplantation; Subclinical acute rejection; Surveillance biopsies; Treatment

Indexed keywords

AZATHIOPRINE; CALCINEURIN INHIBITOR; CORTICOSTEROID; CYCLOSPORIN; CYCLOSPORIN A; CYTOKINE; INTERLEUKIN 2 RECEPTOR ANTIBODY; MESSENGER RNA; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; OKT 3; PREDNISOLONE; RAPAMYCIN; STEROID; TACROLIMUS; THYMOCYTE ANTIBODY;

ACUTE GRAFT REJECTION; ATROPHY; CELL ACTIVATION; CELL INFILTRATION; CLINICAL PROTOCOL; CLINICAL TRIAL; DRUG DOSE REDUCTION; DRUG EFFECT; FIBROSING ALVEOLITIS; GENE EXPRESSION; HUMAN; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; INCIDENCE; INFLAMMATORY CELL; KIDNEY BIOPSY; KIDNEY GRAFT REJECTION; KIDNEY TUBULE DISORDER; MAINTENANCE THERAPY; MICROARRAY ANALYSIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOGENESIS; PATIENT SAFETY; PRIORITY JOURNAL; PROGNOSIS; PROTEOMICS; REVIEW; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT;

GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; PROGNOSIS; TRANSPLANTATION, HOMOLOGOUS;

EID: 42049084906     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e318169c48d     Document Type: Review

References (62)

1. Isoniemi HM, Krogerus L, von Willebrand E, et al. Histopathological findings in well-functioning, long-term renal allografts. Kidney Int 1992; 41: 155.
2. Solez K, Colvin RB, Racusen LC, et al. Banff '05 meeting report: Differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ("CAN"). Am J Transplant 2007; 7: 518.
3. Meier-Kriesche HU, Schold JD, Kaplan B. Long-term renal allograft survival: Have we made significant progress or is it time to rethink our analytic and therapeutic strategies? Am J Transplant 2004; 4: 1289.
4. Nickerson P, Jeffery J, Gough J, et al. Effect of increasing baseline immunosuppression on the prevalence of clinical and subclinical rejection, a pilot study. J Am Soc Nephrol 1999; 10: 1801.
5. Nankivell B, Borrows R, Fung C, et al. Natural history, risk factors, and impact of subclinical rejection in kidney transplantation. Transplantation 2004; 78: 242.
6. Racusen LC, Halloran PF, Solez K. Banff 2003 meeting report: New diagnostic insights and standards. Am J Transplant 2004; 4: 1562.
7. Nankivell B, Fenton-Lee C, Kuypers D, et al. Effect of histological damage on long-term kidney transplant outcome. Transplantation 2001; 71: 515.
8. Stehlik J, Starling RC, Movsesian MA, et al. Utility of long-term surveillance endomyocardial biopsy: A multi-institutional analysis. J Heart Lung Transplant 2006; 25: 1402.
9. Mansfield E, Sarwal M. Arraying the orchestration of allograft pathology. Am J Transplant 2004; 4: 853.
10. Wittke S, Haubitz M, Walden M, et al. Detection of acute tubulointerstitial rejection by proteomic analysis of urinary samples in renal transplant recipients. Am J Transplant 2005; 5: 2749.
11. Ibernon M, Goma M, Moreso F, et al. Subclinical rejection impairs glomerular adaptation after renal transplantation. Kidney Int 2006; 70: 557.
12. Miyagi M, Ishikawa Y, Mizuiri S, et al. Significance of subclinical rejection in early renal allograft biopsies for chronic allograft dysfunction. Clin Transplant 2005; 19: 456.
13. Moreso F, Ibernon M, Goma M, et al. Subclinical rejection associated with chronic allograft nephropathy in protocol biopsies as a risk factor for late graft loss. Am J Transplant 2006; 6: 747.
14. Grimm P, McKenna R, Nickerson P, et al. Clinical rejection is distinguished from subclinical rejection by increased infiltration by a population of activated macrophages. J Am Soc Nephrol 1999; 10: 1582.
15. Veronese F, Noronha I, Manfro R, et al. Prevalence and immunohistochemical findings of subclinical kidney allograft rejection and its association with graft outcome. Clin Transplant 2004; 18: 1.
16. Lipman M, Shen Y, Jeffery J, et al. Immune-activation gene expression in clinically stable renal allograft biopsies: Molecular evidence for subclinical rejection. Transplantation 1998; 66: 1673.
17. Dias E, Veronese F, Gonçalves L, et al. Molecular markers in subclinical acute rejection of renal transplants. Clin Transplant 2004; 18: 281.
18. Tinckam K, Rush D, Hutchinson I, et al. The relative importance of cytokine gene polymorphisms in the development of early and late acute rejection and six-month renal allograft pathology. Transplantation 2005; 79: 836.
19. 1 levels. Transplantation 2006; 81: 1463.
20. Brabcova I, Petrasek J, Hribova P, et al. Genetic variability of major inflammatory mediators has no impact on the outcome of kidney transplantation. Transplantation 2007; 84: 1037.
21. Rowshani A, Florquin S, Bemelman F, et al. Hyperexpression of the granzyme B inhibitor PI-9 in human renal allografts: A potential mechanism for stable renal function in patients with subclinical rejection. Kidney Int 2004; 66: 1417.
22. Rosenberger C, Pratschke J, Rudolph B, et al. Immunohistochemical detection of hypoxia-inducible factor-1(alpha) in human renal allograft biopsies. J Am Soc Nephrol 2006; e-pub ahead of print.
23. Choi BS, Shin MJ, Shin SJ, et al. Clinical significance of an early protocol biopsy in living-donor renal transplantation: Ten-year experience at a single center. Am J Transplant, 2005; 5: 1354.
24. Kumar A, Moritz M, Saaed M, et al. Avoidance of chronic steroid therapy in African American kidney transplant recipients monitored by surveillance biopsy: 1-year results. Am J Transplant 2005; 5: 1976.
25. Nankivell B, Richard J, Borrows R, et al. The natural history of chronic allograft nephropathy. N Engl J Med 2003; 349: 2326.
26. Rush D, Nickerson P, Gough J, et al. Beneficial effects of treatment of early subclinical rejection: A randomized study. J Am Soc Nephrol 1998; 9: 2129.
27. Seron D, Moreso F, Bover J, et al. Early protocol renal allograft biopsies and graft outcome. Kidney Int 1997; 51: 310.
28. Kee T, Chapman J, O'Connell PJ, et al. Treatment of subclinical rejection diagnosed by protocol biopsy of kidney transplants. Transplantation 2006; 82: 36.
29. Gloor J, Cohen A, Lager D, et al. Subclinical rejection in tacrolimustreated renal transplant recipients. Transplantation 2002; 73: 1965.
30. Scholten E, Rowshani A, Cremers S, et al. Untreated rejection in 6-month protocol biopsies is not associated with fibrosis in serial biopsies or with loss of graft function. J Am Soc Nephrol 2006; 17: 2622.
31. Rush D, Arlen D, Boucher A, et al. Lack of benefit of early protocol biopsies in renal transplant patients receiving TAC and MMF: A randomized study. Am J Transplant 2007; 7: 2538.
32. Naesens M, Lerut E, van Damme B, et al. Tacrolimus exposure and evolution of renal allograft histology in the first year after transplantation. Am J Transplant 2007; 7: 2114.
33. Kumar M, Heifets M, Fyfe B, et al. Comparison of steroid avoidance in tacrolimus/mycophenolate mofetil and tacrolimus/sirolimus combination in kidney transplantation monitored by surveillance biopsy. Transplantation 2005; 80: 807.
34. Vincenti F, Larsen C, Durrbach A, et al. Costimulation blockade with belatacept in renal transplantation. N Engl J Med 2005; 353: 770.
35. Solez K, Vincenti F, Filo R. Histopathologic findings from 2-year protocol biopsies from a U.S. multicenter kidney transplant trial comparing tacrolimus versus cyclosporine: A report of the FK506 Kidney Transplant Study Group. Transplantation 1998; 66: 1736.
36. Jurewicz WA. Tacrolimus versus cyclosporin immunosuppression: Long-term outcome in renal transplantation. Nephrol Dial Transplant 2003; 18: 7.
37. Laftavi M, Stephan R, Stefanick B, et al. Randomized prospective trial of early steroid withdrawal compared with low-dose steroids in renal transplant recipients using serial protocol biopsies to assess efficacy and safety. Surgery 2005; 137: 364.
38. Kanetsuna Y, Yamaguchi Y, Toma H, et al. Histological evaluation of renal allograft protocol biopsies in the early period and 1 year after transplantation. Clin Transplant 2003; 17: 25.
39. Kumar M, Xiao S, Fyfe B, et al. Steroid avoidance in renal transplantation using basiliximab induction, cyclosporine-based immunosuppression and protocol biopsies. Clin Transplant 2005; 19: 61.
40. Rush D, Somorjai R, Deslauriers R, et al. Subclinical rejection - a potential surrogate marker for chronic rejection - may be diagnosed by protocol biopsy or urine spectroscopy. Ann Transplant 2000; 5: 44.
41. Simon T, Opelz G, Wiesel M, et al. Serial peripheral blood perforin and granzyme B gene expression measurements for prediction of acute rejection in kidney graft recipients. Am J Transplant 2003; 3: 1121.
42. Kotsch M, Mashreghi M, Bold G, et al. Enhanced granulysin mRNA expression in urinary sediment in early and delayed acute renal allograft rejection. Transplantation 2004; 77: 1866.
43. Li B, Hartono C, Ding R, et al. Noninasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine. N Engl J Med 2001; 344: 947.
44. Tatapudi R, Mathukumar T, Dadhania D, et al. Noninvasive detection of renal allograft inflammation by measurements of mRNA for IP-10 and CXCR3 in urine. Kidney Int 2004; 65: 2390.
45. Ding R, Li B, Muthukumar T, et al. CD103 mRNA levels in urinary cells predict acute rejection of renal allografts. Transplantation 2003; 75: 1307.
46. Muthukumar T, Dadhania D, Ding R, et al. Messenger RNA for FOXP3 in the urine of renal-allograft recipients. N Engl J Med 2005; 353: 2342.
47. Schaub S, Rush D, Wilkins J, et al. Proteomic-based detection of urine proteins associated with acute renal allograft rejection. J Am Soc Nephrol 2004; 15: 219.
48. Schaub S, Mayr M, Hönger G, et al. Detection of subclinical tubular injury after renal transplantation: Comparison of urine protein analysis with allograft histopathology. Transplantation 2007; 84: 104.
49. Brandacher G, Cakar F, Winkler C, et al. Non-invasive monitoring of kidney allograft rejection through IDO metabolism evaluation. Kidney Int 2007; 71: 60.
50. Mueller TF, Einecke G, Reeve J, et al. Microarray analysis of rejection in human kidney transplants using pathogenesis-based transcripts sets. Am J Transplant 2007; 7: 2712.
51. Mengel M, Gwinner W, Schwarz A, et al. Infiltrates in protocol biopsies from renal allografts. Am J Transplant 2007; 7: 356.
52. Roberts I, Reddy S, Russell C, et al. Subclinical rejection and borderline changes in early protocol biopsy specimens after renal transplantation. Transplantation 2004; 77: 1194.
53. Shishido S, Asanuma H, Nakai H, et al. The impact of repeated subclinical acute rejection on the progression of chronic allograft nephropathy. J Am Soc Nephrol 2003; 14: 1046.
54. Schweitzer EJ, Drachenberg CB, Anderson L, et al. Significance of the Banff borderline biopsy. Am J Kidney Dis 1996; 28: 585.
55. Meehan SN, Siegel CT, Aronson AJ, et al. The relationship of untreated borderline infiltrates by the Banff criteria to acute rejection in renal allograft biopsies. J Am Soc Nephrol 1999; 10: 1806.
56. Dahan K, Audard V, Roudot-Thoraval F, et al. Renal allograft biopsies with borderline changes: Predictive factors of clinical outcome. Am J Transplant 2006; 6: 1725.
57. Kuypers DR, Chapman JR, O'Connell PJ, et al. Predictors of renal transplant histology at three months. Transplantation 1999; 67: 1222.
58. Kirk A, Jacobson L, Heisey D, et al. Clinically stable human renal allografts contain histological and RNA-based findings that correlate with deteriorating graft function. Transplantation 1999; 68: 1578.
59. Furness PN, Philpott CM, Chorbadjian MT, et al. Protocol biopsy of the stable renal transplant: A multicenter study of methods and complication rates. Transplantation 2003; 76: 969.
60. Hergesell O, Felten H, Andrassy K, et al. Safety of ultrasound-guided percutaneous renal biopsy-retrospective analysis of 1090 consecutive cases. Nephrol Dial Transplant 1998; 13: 975.
61. Wilczek HE. Percutaneous needle biopsy of the renal allograft. A clinical safety evaluation of 1129 biopsies. Transplantation 1990; 50: 790.
62. Kim D, Kim H, Shin G, et al. A randomized, prospective, comparative study of manual and automated renal biopsies. Am J Kidney Dis 1998; 32: 426.