Randomized prospective trial of early steroid withdrawal compared with low-dose steroids in renal transplant recipients using serial protocol biopsies to assess efficacy and safety

Surgery

Volumn 137, Issue 3, 2005, Pages 364-371

  Laftavi, Mark R ^a   Stephan, Rabie ^a   Stefanick, Barbara ^a   Kohli, Romesh ^a   Dagher, Fadi ^a   Applegate, Mary ^a   O'Keefe, John ^a   Pierce, Drew ^a   Rubino, Andrea ^b   Guzowski, Haley ^a   Leca, Nicolae ^a   Dayton, Merril ^a   Pankewycz, Oleh ^a,c  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c BUFFALO GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; CLOTRIMAZOLE; COTRIMOXAZOLE; LYMPHOCYTE ANTIBODY; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; STEROID; TACROLIMUS; VALGANCICLOVIR;

ACUTE GRAFT REJECTION; ACUTE TOXICITY; ADULT; ARTICLE; CHRONIC ALLOGRAFT NEPHROPATHY; CLINICAL ARTICLE; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; HEALTH HAZARD; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY ALLOGRAFT; KIDNEY BIOPSY; KIDNEY FAILURE; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY GRAFT REJECTION; LOW DRUG DOSE; MALE; POSTOPERATIVE COMPLICATION; POSTOPERATIVE INFECTION; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RECIPIENT; TREATMENT OUTCOME;

EID: 20044372324     PISSN: 00396060     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.surg.2004.10.013     Document Type: Article

References (26)

1. A. Tarantino, G. Montagnino, and C. Ponticelli Corticosteroids in kidney transplant recipients: safety issues and timing of discontinuation Drug Safety 13 1995 145 156
2. M.N. Hill, R.A. Grossman, H.I. Feldman, S. Hurwitz, and D.C. Dafoe Changes in causes of death after renal transplantation, 1966-87 Am J Kid Dis 17 1991 512 518
3. M.T. Sartori, P. Rigotti, F. Marchini, L. Spiezia, N. Baldan, and L. Furian Plasma fibrinolytic capacity in renal transplant recipients: effect of steroid-free immunosuppression therapy Transpl 75 2003 994 998
4. G.V. Prasad, M.M. Nash, P.A. McFarlane, and J.S. Zaltzman Renal transplant recipient attitudes toward steroid use and steroid withdrawal Clin Transplant 17 2003 135 139
5. D.Y. Kim, and M.D. Stegall Steroid-sparing regimens in organ transplantation Cur Opinion Organ Transpl 6 2001 313 319
6. B.L. Kasiske, H.A. Chakkera, T.A. Louis, and J.Z. Ma A meta-analysis of immunosuppression withdrawal trials in renal transplantation J Am Soc Nephrol 11 2000 1910 1917
7. Steroid Withdrawal Study Group Prednisone withdrawal in kidney transplant recipients on cyclosporin and mycophenolate mofetil - a prospective randomized study Transpl 68 1999 1865 1874
8. Y. Vanrenterghem, Y. Lebranchu, R. Hene, F. Oppenheimer, H. Ekberg for the Steroid Dosing Study Group Double-blind comparison of two corticosteroid regimens plus mycophenolate mofetil and cyclosporin for prevention of acute renal allograft rejection Transpl 9 2000 1352 1359
9. F. Vincenti, A. Monaco, J. Grinyo, M. Kinkhabwala, and A. Roza Multicenter randomized prospective trial of steroid withdrawal in renal transplant recipients receiving basiliximab, cyclosporin microemulsion and mycophenolate mofetil Am J Transpl 3 2003 306 311
10. E. Cole, D. Landsberg, D. Russell, J. Zaltzman, B. Kiberd, and C. Caravaggio A pilot study of steroid-free immunosuppression in the prevention of acute rejection in renal allograft recipients Transpl 5 2001 845 850
11. S.A. Birkeland Steroid-free immunosuppression in renal transplantation: a long-term follow-up of 100 patients Transpl 8 2001 1089 1090
12. E.S. Woodle Corticosteroid withdrawal in renal transplantation Transpl Proc 31 1999 247 248
13. J.M.M. Boots, M.H.L. Christiaans, E.M. van Duijnhoven, R.-J. van Suylen, and J.P. van Hooff Early steroid withdrawal in renal transplantation with tacrolimus dual therapy: a pilot study Transpl 74 2002 1703 1709
14. P. Chakrabarti, H.Y. Wong, A. Toyofuku, V.P. Scantlebury, M.L. Jordan, and C. Vivas Outcome after steroid withdrawal in adult renal transplant patients receiving tacrolimus-based immunosuppression Transpl Proc 33 2001 1235 1236
15. F.Z. Ghandour, T.C. Knauss, D.C. Mulligan, J.A. Schulak, and D.E. Hricik Influence of steroid withdrawal on proteinuria in renal allograft recipients Clin Transpl 11 1997 395 398
16. L.C. Racusen, K. Solez, R.B. Colvin, S.M. Bonsib, M.C. Castro, and T. Cavallo The Banff 97 working classification of renal allograft pathology Kidney Int 55 1999 713 723
17. Nankivell BJ, Borrows RJ, Fung C L-S, O'Connell PJ, Allen RDM, Chapman JR. The natural history of chronic allograft nephropathy. NEJM 2003;349:2326-33.
18. S. Shishido, H. Asanuma, H. Nakai, Y. Mori, H. Satoh, and I. Kamimaki The impact of subclinical acute rejection on the progression of chronic allograft nephropathy J Am Soc Nephrol 14 2003 1046 1052
19. P. Nickerson, J. Jeffery, J. Gough, R. McKenna, P. Grimm, and M. Cheang Identification of clinical and histopathologic risk factors for diminished renal function 2 years posttransplant J Am Soc Nephrol 9 1998 482 487
20. R. Shapiro, P. Randhawa, M.L. Jordan, V.P. Scantlebury, C. Vivas, and A. Jain An analysis of early renal transplant protocol biopsies - the high incidence of subclinical tubulitis Am J Transpl 1 2001 47 50
21. P. Nickerson, J. Jeffery, J. Gough, P. Grimm, R. McKenna, and P. Birk Effect of increasing baseline immunosuppression on the prevalence of clinical and subclinical rejection: a pilot study J Am Soc Nephrol 10 1999 1801 1805
22. J.M. Gloor, A.J. Cohen, D.J. Lager, J.P. Grande, M.E. Fidler, and J.A. Velosa Subclinical rejection in tacrolimus-treated renal transplant recipients Transpl 73 2002 1965 1968
23. K. Khwaja, M. Asolati, J. Harmon, J.K. Melancon, T. Dunn, and K. Gillingham Outcome at 3 years with a prednisone-free maintenance regimen: a single-center experience with 349 kidney transplant recipients Am J Transpl 4 2004 980 987
24. S. Yilmaz, S. Tomlanovich, T. Mathew, E. Taskinen, T. Paavonen, and M. Navarro Protocol core needle biopsy and histologic Chronic Allograft Damage Index (CADI) as surrogate end point for long-term graft survival in multicenter studies J Am Soc Nephrol 14 2003 773 779
25. S.R.K. Lehtonen, E.I. Taskinen, and H.M. Isoniemi Histological alterations in implant and one-year protocol biopsy specimens of renal allografts Transpl 72 2001 1138 1144
26. W.S. Cherikh, H.M. Kauffman, M.A. McBride, J. Maghirang, L.J. Swinnen, and D.W. Hanto Association of the type of induction immunosuppression with posttransplant lymphoproliferative disorder, graft survival and patient survival after primary kidney transplantation Transpl 76 2003 1289 1293