Cytosine arabinoside affects the heat and capsaicin receptor TRPV1 localisation and sensitivity in human sensory neurons

Journal of Neuro-Oncology

Volumn 89, Issue 1, 2008, Pages 1-7

  Anand, Uma ^a,b   Otto, William R ^b   Bountra, Chas ^c   Chessell, Iain ^c   Sinisi, Marco ^d   Birch, Rolfe ^d   Anand, Praveen ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c GLAXOSMITHKLINE   (United Kingdom)

^d ROYAL NATIONAL ORTHOPAEDIC HOSPITAL   (United Kingdom)

Author keywords

Calcium homeostasis; Chemotherapy; Chronic pain; Cytosine arabinoside; Neuropathy; Sensory neurons; TRPV1

Indexed keywords

CALCIUM; CAPSAICIN; CYTARABINE; IONOMYCIN; NEUROMODULIN; VANILLOID RECEPTOR 1;

ADULT; ARTICLE; CELL VIABILITY; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOPLASM; DRUG EXPOSURE; HEAT SENSITIVITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MOLECULAR IMAGING; NERVE CELL CULTURE; NERVE CELL MEMBRANE; NOCICEPTIVE STIMULATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SENSORY NERVE CELL; SPINAL CORD NERVE CELL; SPINAL GANGLION; STATISTICAL SIGNIFICANCE; STIMULUS RESPONSE; STUDENT T TEST;

ADULT; ANTIMETABOLITES, ANTINEOPLASTIC; CALCIUM; CAPSAICIN; CELL DIVISION; CELL MEMBRANE; CELL SURVIVAL; CELLS, CULTURED; CYTARABINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GANGLIA, SPINAL; GAP-43 PROTEIN; HUMANS; IONOMYCIN; NEURONS, AFFERENT; PERIPHERAL NERVOUS SYSTEM DISEASES; SENSORY SYSTEM AGENTS; TIME FACTORS; TRPV CATION CHANNELS;

EID: 41949133429     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-008-9585-6     Document Type: Article

References (31)

1. Foley K, (2000) Controlling cancer pain. Hosp Pract (Off Ed) 35:101-108, 111-112
2. Portenoy RK, Forbes K, Lussier D, Hanaks G (2003) Difficult pain problems: An integrated approach. In: Doyle D, Hanks G, Cherney N, Calman K (eds) Oxford textbook of palliative medicine. Oxford University Press, New York, pp 438-458
3. Peters L, Sellick K (2006) Quality of life of cancer patients receiving inpatient and home-based palliative care. J Adv Nurs 53(5):524-533
4. Cata JP, Weng HR, Lee BN, Reuben JM, Dougherty PM (2006) Clinical and experimental findings in humans and animals with chemotherapy-induced peripheral neuropathy. Minerva Anaestesiol 72:151-169
5. Dougherty PM, Cata JP, Cordella JV, Burton A, Wreng HR (2004) Taxol-induced sensory disturbance is characterised by preferential impairment of myelinated fibre function in cancer patients. Pain 109:132-142
6. Verstappen CCP, Postma TJ, Hoekman K, Heimans JJ (2003) Peripheral neuropathy due to therapy with paclitaxel, gemcitabine, and cisplatin in patients with advanced ovarian cancer. J Neuro-Oncol 63:201-205
7. Anand U (2007) Mechanisms and management of cancer pain, Chapter 98. In: Alison M (ed) Handbook of cancer, 2nd edn. Wiley
8. Powell BL, Capizzi RL, Lyerly S, Cooper RM (1986) Peripheral neuropathy after high-dose cytosine arabinoside, Daunorubicin, and asparaginase consolidation for acute nonlymphocytic leukaemia. J Clin Oncol 4:95-97
9. Neville TJ, Benstead TJ, McCormick CW, Hayne OA (1989) Horner's syndrome and demyelinating peripheral neuropathy caused by high-dose cytosine arabinoside. Am J Haematol 32:314-315
10. Openshaw H, Slatkin NE, Stein AS, Hinton DR, Forman SJ (1996) Acute polyneuropathy after high dose Cytosine Arabinoside in patients with Leukemia. Cancer 78(9):1899-1905
11. Johnson NT, Crawford SW, Sargur M (1987) Acute aquired demyelinating polyneuropathy with respiratory failure following high-dose systemic cytosine arabinoside and marrow transplantation. Bone Marrow Transplant 2:203-207
12. Kornblau SM, Cortes-Franco J, Estey E (1993) Neurotoxicity associated with fludarabine and cytosine arabinoside chemotherapy for acute leukaemia and myelodysplasia. Leukemia 7(3):378-383
13. Cavaliere R, Schiff D (2006) Neurologic toxicities of cancer therapies. Curr Neurol Neurosci Rep 6:218-226
14. Saito T, Asai O, Dobashi N, Yano S, Osawa H, Takei Y, Takahara S, Ogasawara Y, Yamaguchi Y, Minami J, Usui N (2006) Peripheral neuropathy caused by high-dose cytosine arabinoside treatment in a patient with acute myeloid leukaemia. J Infect Chemother 12:148-151
15. Yee KWL, Cortes J, Ferrajoli A, Garcia-Manero G, Verstovsek S, Wierda W, Thomas D, Faderl S, King I, O'Brien SM, Jeha S, Andreef M, Cahill A, Sznol M, Giles FJ (2006) Triapine and cytarabine is an active combination in patients with acute leukaemia or myelodisplastic syndrome. Leuk Res 30:813-822
16. Russell JA, Powles RL (1974) Neuropathy due to cytosine arabinoside. Br Med J 4(5945):652-653
17. Duffy TP (1985) How much is too much high-dose cytosine Arabinoside? J Clin Oncol 3(5):601-603
18. Anand U, Otto WR, Casula MA, Day NC, Davis JB, Bountra C, Birch R, Anand P (2006) The effect of neurotrophic factors on morphology, TRPV1 expression and capsaicin responses of cultured human DRG sensory neurons. Neurosci Lett 399:51-56
19. Benham CD, Davis JB, Randall AD (2002) Vanilloid and TRP channels: A family of lipid-gated cation channels. Neuropharmacology 42:873-888
20. Smith GD, Gunthorpe MJ, Kelsell RE, Hayes PD, Reilly P, Facer P, Wright JE, Jerman JC, Walhin JP, Ooi L, Egerton J, Charles KJ, Smart D, Randall AD, Anand P, Davis J (2002) TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature 418:186-190
21. Chan CLH, Facer P, Davis JB, Smith GD, Egerton J, Bountra C, Williams NS, Anand P (2003) Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency. Lancet 361:385-391
22. Planells-Cases R, Garcia-Sanz N, Morenill-Palao C, Ferrer-Montiel A (2005) Functional aspects and mechanisms of TRPV1 involvement in neurogenic inflammation that leads to thermal hyperalgesia. Pflugers Arch - Eur J Physiol 451:151-159
23. Bernardini N, Neuhuber W, Reeh PW, Sauer SK (2004) Morphological evidence for functional capsaicin receptor exression and calcitonin gene-related peptide exocytosis in isolated peripheral nerve axons of the mouse. Neuroscience 126:585-590
24. Morenilla-Palao C, Planells-Caases R, Garcia-Sanz N, Ferrer-Montiel A (2004) Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity. J Biol Chem 279:25665-25672
25. Berridge MJ, Lipp P, Bootman MD (2000) The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol 1(1):11-21
26. Chang DTW, Reynolds IJ (2006) Mitochondrial trafficking and morphology in healthy and injured neurons. Prog Neurobiol 80:241-268
27. Hilaire C, Inquimbert P, Al-Jumaily M, Greuet D, Valmier J, Scamps F (2005) Calcium dependence of axotomised sensory neurons excitability. Neurosci Lett 380:330-334
28. 2+ efflux mechanisms following depolarisation evoked calcium transients in cultured rat sensory neurons. J Physiol 455:567-583
29. Greene DA, Lattimer S, Ulbrecht J, Carroll P (1985) Glucose induced alterations in nerve metabolism: Current perspectives on the pathogenesis of diabetic neuropathy and future directions for research and therapy. Diabetes Care 8:290-299
30. 2+-ATPase activity in rats with streptozotocin-induced diabetes: Association with reduced anaesthetic requirements. Life Sci 55:L359-L364
31. Siau C, Bennett G (2006) Dysregulation of clellular calcium homeostasis in chemotherapy-evoked peripheral neuropathy. Anaesth Analg 102(5):1484-1490