Blockade of androgen receptors is sufficient to alter the sexual differentiation of the substantia nigra pars reticulata seizure-controlling network

Epileptic Disorders

Volumn 10, Issue 1, 2008, Pages 8-12

  Heida, James G ^a   Velíšková, Jana ^a   Moshé, Solomon L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Development; Flutamide; GABA; Rat; Substantia nigra

Indexed keywords

ANDROGEN RECEPTOR; FLUTAMIDE; MUSCIMOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; FEMALE; MALE; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SEIZURE; SEIZURE THRESHOLD; SEX DIFFERENCE; SUBSTANTIA NIGRA;

ANIMALS; CONVULSANTS; FEMALE; GABA AGONISTS; MALE; MUSCIMOL; NERVE NET; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ANDROGEN; SEIZURES; SEX DIFFERENTIATION; SUBSTANTIA NIGRA;

EID: 41949111926     PISSN: 12949361     EISSN: None     Source Type: Journal    
DOI: 10.1684/epd.2008.0160     Document Type: Article

References (30)

1. Andersen SL, Teicher MH. Delayed effects of early stress on hippocampal development. Neuropsychopharmacology 2004; 29: 1988-93.
2. Bernardi F, Pluchino N, Stomati M, et al. CNS: sex steroids and SERMs. Ann N Y Acad Sci 2003; 997: 378-88.
3. Breedlove SM, Arnold AP. Hormonal control of a developing neuromuscular system. II. Sensitive periods for the androgen-induced masculinization of the rat spinal nucleus of the bulb-ocavernosus. J Neurosci 1983; 3: 424-32.
4. Card JP, Levitt P, Gluhovsky M, et al. Early experience modifies the postnatal assembly of autonomic emotional motor circuits in rats. J Neurosci 2005; 25: 9102-11.
5. Cooke BM, Tabibnia G, Breedlove SM. A brain sexual dimorphism controlled by adult circulating androgens. Proc Natl Acad Sci USA 1999; 96: 7538-40.
6. Galanopoulou AS, Moshé SL. Role of sex hormones in the sexually dimorphic expression of KCC2 in rat substantia nigra. Exp Neurol 2003; 184: 1003-9.
7. Galanopoulou AS, Kyrozis A, Claudio OI, et al. Sex-specific KCC2 expression and GABA(A) receptor function in rat substantia nigra. Exp Neurol 2003; 183: 628-37.
8. Garant DS, Xu SG, Sperber EF, et al. Age-related differences in the effects of GABAA agonists microinjected into rat substantia nigra: Pro- and anticonvulsant actions. Epilepsia 1995; 36: 960-5.
9. Giorgi FS, Velíšková J, Chudomel O, et al. The role of substantia nigra pars reticulata in modulating clonic seizures is determined by testosterone levels during the immediate postnatal period. Neurobiol Dis 2007; 25: 73-9.
10. Grisham W, Lee J, McCormick ME, Yang-Stayner K, Arnold AP. Antiandrogen blocks estrogen-induced masculinization of the song system in female zebra finches. J Neurobiol 2002; 51: 1-8.
11. Hauser WA, Annegers JF, Kurland LT. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia 1993; 34: 453-68.
12. Hsu FC, Zhang GJ, Raol YS, et al. Repeated neonatal handling with maternal separation permanently alters hippocampal GABAA receptors and behavioral stress responses. Proc Natl Acad Sci USA 2003; 100: 12213-8.
13. Iadarola MJ, Gale K. Cellular compartments of GABA in brain and their relationship to anticonvulsant activity. Mol Cell Biochem 1981; 39: 305-30.
14. ILAE. International league against epilepsy. Task force on epilepsy classification and terminology. 2006 URL: http://ilae.org/Visitors/Centre/ctf/ index.cfm.
15. Kyrozis A, Chudomel O, Moshé SL, et al. Sex-dependent maturation of GABAA receptor-mediated synaptic events in rat substantia nigra reticulata. Neurosci Lett 2006; 398: 1-5.
16. Lieberburg I, MacLusky N, McEwen BS. Androgen receptors in the perinatal rat brain. Brain Res 1980; 196: 125-38.
17. Lu S, Simon NG, Wang Y, et al. Neural androgen receptor regulation: effects of androgen and antiandrogen. J Neurobiol 1999; 41: 505-12.
18. Lund TD, Salyer DL, Fleming DE, et al. Pre- or postnatal testosterone and flutamide effects on sexually dimorphic nuclei of the rat hypothalamus. Brain Res Dev Brain Res 2000; 120: 261-6.
19. O'Connor JC, Cook JC, Slone TW, et al. An ongoing validation of a Tier I screening battery for detecting endocrine-active compounds (EACs). Toxicol Sci 1998; 46: 45-60.
20. Ravizza T, Friedman LK, Moshé SL, et al. Sex differences in GABA(A)ergic system in rat substantia nigra pars reticulata. Int J Dev Neurosci 2003; 21: 245-54.
21. Seale JV, Wood SA, Atkinson HC, et al. Organizational role for testosterone and estrogen on adult hypothalamic-pituitary-adrenal axis activity in the male rat. Endocrinology 2005; 146: 1973-82.
22. Sperber EF, Wong BY, Wurpel JN, et al. Nigral infusions of muscimol or bicuculline facilitate seizures in developing rats. Brain Res 1987; 465: 243-50.
23. Staudt J, Dorner G. Structural changes in the medial and central amygdala of the male rat, following neonatal castration and androgen treatment. Endokrinologie 1976; 67: 296-300.
24. Steyn FJ, Anderson GM, Grattan DR. Differential effects of centrally-administered oestrogen antagonist ICI-182,780 on oestrogen-sensitive functions in the hypothalamus. J Neuroendocrinol 2007; 19: 26-33.
25. Velíšková J, Moshé SL. Update on the role of substantia nigra pars reticulata in the regulation of seizures. Epilepsy Curr 2006; 6: 83-7.
26. Velíšková J, Moshé SL. Sexual dimorphism and developmental regulation of substantia nigra function. Ann Neurol 2001; 50: 596-601.
27. Velíšková J, Löscher W, Moshé SL. Regional and age specific effects of zolpidem microinfusions in the substantia nigra on seizures. Epilepsy Res 1998; 30: 107-14.
28. A receptor subunits in the substantia nigra is developmentally regulated and region-specific. Ital J Neurol Sci 1998; 19: 205-10.
29. Weisz J, Ward IL. Plasma testosterone and progesterone titers of pregnant rats, their male and female fetuses, and neonatal offspring. Endocrinology 1980; 106: 306-16.
30. Zhao L, O'Neill K, Brinton RD. Estrogenic agonist activity of ICI 182,780 (Faslodex) in hippocampal neurons: implications for basic science understanding of estrogen signaling and development of estrogen modulators with a dual therapeutic profile. J Pharmacol Exp Ther 2006; 319: 1124-32.