Plasma proteome changes in subjects with Type 2 diabetes mellitus with a low or high early insulin response

Clinical Science

Volumn 114, Issue 7-8, 2008, Pages 499-507

  Sundsten, Tea ^a   Zethelius, Björn ^a   Berne, Christian ^a   Bergsten, Peter ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Early insulin response; Plasma protein; Proteomics; Surface enhanced laser desorption ionization time of flight MS (SELDI TOF MS); Type 2 diabetes mellitus; ULSAM (Uppsala Longitudinal Study of Adult Men)

Indexed keywords

BETA2 GLYCOPROTEIN 1; GLUCOSE; HEMOGLOBIN ALPHA CHAIN; HEMOGLOBIN BETA CHAIN; INSULIN; PREALBUMIN; PROTEOME; PLASMA PROTEIN; PROINSULIN;

AGED; ANALYSIS OF VARIANCE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; GLUCOSE TOLERANCE; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN RESPONSE; LONGITUDINAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; SURFACE ENHANCED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; BIOSYNTHESIS; BLOOD; CROSS-SECTIONAL STUDY; FOLLOW UP; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; INSULIN RESISTANCE; MALE; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

AGED; BLOOD GLUCOSE; BLOOD PROTEINS; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; FOLLOW-UP STUDIES; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MALE; PROINSULIN; PROTEOME; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 41949110827     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20070323     Document Type: Article

References (43)

1. Kahn, S. E., Montgomery, B., Howell, W. et al. (2001) Importance of early phase insulin secretion to intravenous glucose tolerance in subjects with type 2 diabetes mellitus. J. Clin. Endocrinol. Metab. 86, 5824-5829
2. Zethelius, B., Byberg, L., Hales, C. N., Lithell, H. and Berne, C. (2003) Proinsulin and acute insulin response independently predict Type 2 diabetes mellitus in men-report from 27 years of follow-up study. Diabetologia 46, 20-26
3. Vozarova, B., Weyer, C., Hanson, K., Tataranni, P. A., Bogardus, C. and Pratley, R. E. (2001) Circulating interieukin-6 in relation to adiposity, insulin action, and insulin secretion. Obes. Res. 9, 414-417
4. Norata, G. D., Ongari, M., Garlaschelli, K., Raselli, S., Grigore, L. and Catapano, A. L. (2007) Plasma resistin levels correlate with determinants of the metabolic syndrome. Eur. J. Endocrinol. 156, 279-284
5. Considine, R. V., Sinha, M. K., Heiman, M. L. et al. (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 334, 292-295
6. Hotta, K., Funahashi, T., Arita, Y. et al. (2000) Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler. Thromb. Vasc. Biol. 20, 1595-1599
7. Berndt, J., Kloting, N., Kralisch, S. et al. (2005) Plasma visfatin concentrations and fat depot-specific mRNA expression in humans. Diabetes 54, 2911-2916
8. Festa, A., D'Agostino, Jr, R., Tracy, R. P. and Haffner, S. M. (2002) Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study. Diabetes 51, 1131-1137
9. Pickup, J. C. (2004) Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care 27, 813-823
10. Sjoholm, A. and Nystrom, T. (2006) Inflammation and the etiology of type 2 diabetes. Diabetes Metab. Res. Rev. 22, 4-10
11. Wang, J., Li, D., Dangott, L. J. and Wu, G. (2006) Proteomics and its role in nutrition research. J. Nutr. 136, 1759-1762
12. Korc, M. (2003) Diabetes mellitus in the era of proteomics. Mol. Cell. Proteomics 2, 399-404
13. Issaq, H. J., Veenstra, T. D., Conrads, T. P. and Felschow, D. (2002) The SELDI-TOF MS approach to proteomics: protein profiling and biomarker identification. Biochem. Biophys. Res. Commun. 292, 587-592
14. Nyblom, H. K., Thorn, K., Ahmed, M. and Bergsten, P. (2006) Mitochondrial protein patterns correlating with impaired insulin secretion from INS-1E cells exposed to elevated glucose concentrations. Proteomics 6, 5193-5198
15. Ortsater, H., Sundsten, T., Lin, J. M. and Bergsten, P. (2007) Evaluation of the SELDI-TOF MS technique for protein profiling of pancreatic islets exposed to glucose and oleate. Proteomics 7, 3105-3115
16. Cho, W. C., Yip, T. T., Chung, W. S., Leung, A. W., Cheng, C. H. and Yue, K. K. (2006) Differential expression of proteins in kidney, eye, aorta, and serum of diabetic and non-diabetic rats. J. Cell. Biochem. 99, 256-268
17. Purohit, S., Podolsky, R., Schatz, D. et al. (2006) Assessing the utility of SELDI-TOF and model averaging for serum proteomic biomarker discovery. Proteomics 6, 6405-6415
18. Sundsten, T., Eberhardson, M., Goransson, M. and Bergsten, P. (2006) The use of proteomics in identifying differentially expressed serum proteins in humans with type 2 diabetes. Proteome Sci. 4, 22
19. Hedstrand, H. (1975) A study of middle-aged men with particular reference to risk factors for cardiovascular disease. Ups. J. Med. Sci. Suppl. 19, 1-61
20. Lithell, H., Sundstrom, J., Arnlov, J. et al. (2000) Epidemiological and clinical studies on insulin resistance and diabetes. Ups. J. Med. Sci. 105, 135-150
21. Kozak, K. R., Su, F., Whitelegge, J. P., Faull, K., Reddy, S. and Farias-Eisner, R. (2005) Characterization of serum biomarkers for detection of early stage ovarian cancer. Proteomics 5, 4589-4596
22. Qu, Y., Adam, B. L., Yasui, Y. et al. (2002) Boosted decision tree analysis of surface-enhanced laser desorption/ionization mass spectral serum profiles discriminates prostate cancer from noncancer patients. Clin. Chem. 48, 1835-1843
23. Laronga, C., Becker, S., Watson, P. et al. (2003) SELDI-TOF serum profiling for prognostic and diagnostic classification of breast cancers. Dis. Markers 19, 229-238
24. Diamandis, E. P. (2004) Mass spectrometry as a diagnostic and a cancer biomarker discovery tool: opportunities and potential limitations. Mol. Cell. Proteomics 3, 367-378
25. Rai, A. J., Stemmer, P. M., Zhang, Z. et al. (2005) Analysis of Human Proteome Organization Plasma Proteome Project (HUPO PPP) reference specimens using surface enhanced laser desorption/ionization-time of flight (SELDI-TOF) mass spectrometry: multi-institution correlation of spectra and identification of biomarkers. Proteomics 5, 3467-3474
26. Timms, J. F., Arslan-Low, E., Gentry-Maharaj, A. et al. (2007) Preanalytic influence of sample handling on SELDI-TOF serum protein profiles. Clin. Chem. 53, 645-656
27. Terazaki, H., Ando, Y., Suhr, O. et al. (1998) Post-translational modification of transthyretin in plasma. Biochem. Biophys. Res. Commun. 249, 26-30
28. Kiernan, U. A., Tubbs, K. A., Gruber, K. et al. (2002) High-throughput protein characterization using mass spectrometric immunoassay. Anal. Biochem. 301, 49-56
29. Schweigen, F. J., Wirth, K. and Raila, J. (2004) Characterization of the microheterogeneity of transthyretin in plasma and urine using SELDI-TOF-MS immunoassay. Proteome Sci. 2, 5
30. Jacobsson, B., Collins, V. P., Grimelius, L., Pettersson, T., Sandstedt, B. and Carlstrom, A. (1989) Transthyretin immunoreactivity in human and porcine liver, choroid plexus, and pancreatic islets. J. Histochem. Cytochem. 37, 31-37
31. Refai, E., Dekki, N., Yang, S. N. et al. (2005) Transthyretin constitutes a functional component in pancreatic beta-cell stimulus-secretion coupling. Proc. Natl. Acad. Sci. U.S.A. 102, 17020-17025
32. Myron Johnson, A., Merlini, G., Sheldon, J. and Ichihara, K. (2007) Clinical indications for plasma protein assays: transthyretin (prealbumin) in inflammation and malnutrition. Clin. Chem. Lab. Med. 45, 419-426
33. Itoh, N., Hanafusa, T., Miyagawa, J. et al. (1992) Transthyretin (prealbumin) in the pancreas and sera of newly diagnosed type I (insulin-dependent) diabetic patients. J. Clin. Endocrinol. Metab. 74, 1372-1377
34. Yang, Q., Yamagata, K., Yamamoto, K. et al. (1999) Structure/function studies of hepatocyte nuclear factor-1α, a diabetes-associated transcription factor. Biochem. Biophys. Res. Commun. 266, 196-202
35. Day, J. R., O'Hara, P. J., Grant, F. J. et al. (1992) Molecular cloning and sequence analysis of the cDNA encoding human apolipoprotein H (β2-glycoprotein I). Int. J. Clin. Lab. Res. 21, 256-263
36. Polz, E. and Kostner, G. M. (1979) The binding of β2-glycoprotein-I to human serum lipoproteins: distribution among density fractions. FEBS Lett. 102, 183-186
37. Cassader, M., Ruiu, G., Gambino, R. et al. (1994) Influence of apolipoprotein H polymorphism on levels of triglycerides. Atherosclerosis 110, 45-51
38. Roubey, R. A. (1994) Autoantibodies to phospholipid-binding plasma proteins: a new view of lupus anticoagulants and other 'antiphospholipid' autoantibodies. Blood 84, 2854-2867
39. Cassader, M., Ruiu, G., Gambino, R., Veglia, F. and Pagano, G. (1997) Apolipoprotein H levels in diabetic subjects: correlation with cholesterol levels. Metab. Clin. Exp. 46, 522-525
40. Mehdi, H., Nunn, M., Steel, D. M. et al. (1991) Nucleotide sequence and expression of the human gene encoding apolipoprotein H (β2-glycoprotein I). Gene 108, 293-298
41. Schmidt, M. I., Duncan, B. B., Sharrett, A. R. et al. (1999) Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. Lancet 353, 1649-1652
42. Gerich, J. E. (1998) The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity. Endocr. Rev. 19, 491-503
43. Sundsten, T., Östenson, C.-G. and Bergsten, P. (2008) Serum protein patterns in newly diagnosed type 2 diabetes mellitus: influence of diabetic environment and family history of diabetes., Diabetes Metab. Res. Rev. 24, 148-154