Transcriptional profiling uncovers a network of cholesterol-responsive atherosclerosis target genes

PLoS Genetics

Volumn 4, Issue 3, 2008, Pages

  Skogsberg, Josefin ^a   Lundström, Jesper ^a   Kovacs, Alexander ^a   Nilsson, Roland ^a,b   Noori, Peri ^a   Maleki, Shohreh ^a   Köhler, Marina ^a   Hamsten, Anders ^a   Tegnér, Jesper ^a,b   Björkegren, Johan ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b LINKÖPING UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; SMALL INTERFERING RNA; APOLIPOPROTEIN B100; CARRIER PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; GENE SWITCHING; GENE TARGETING; GENETIC TRANSCRIPTION; HYPERCHOLESTEROLEMIA; LIPOPROTEIN BLOOD LEVEL; MACROPHAGE; MOUSE; NONHUMAN; ANIMAL; DNA MICROARRAY; FOAM CELL; GENE EXPRESSION PROFILING; GENETICS; HUMAN; METABOLISM; MOUSE MUTANT; PATHOLOGY;

MUS;

ANIMALS; APOLIPOPROTEIN B-100; ATHEROSCLEROSIS; CARRIER PROTEINS; CHOLESTEROL; FOAM CELLS; GENE EXPRESSION PROFILING; HUMANS; MACROPHAGES; MICE; MICE, KNOCKOUT; MICE, MUTANT STRAINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, LDL; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 41949107824     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1000036     Document Type: Article

References (22)

1. Ong HT (2005) The statin studies: from targeting hypercholesterolaemia to targeting the high risk patient. Qjm 98: 599-614.
2. Grines CL (2006) The role of statins in reversing atherosclerosis: What the latest regression studies show. J Interv Cardiol 19: 3-9.
3. Tuomisto TT, Binder BR, Yla-Herttuala S (2005) Genetics, genomics and proteomics in atherosclerosis research. Ann Med 37: 323-332.
4. Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, et al. (2001) The sequence of the human genome. Science 291: 1304-1351.
5. Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, et al. (2001) Initial sequencing and analysis of the human genome. Nature 409: 860-921.
6. Waterston RH, Lindblad-Toh K, Birney E, Rogers J, Abril JF, et al. (2002) Initial sequencing and comparative analysis of the mouse genome. Nature 420: 520-562.
7. Lieu HD, Withycombe SK, Walker Q, Rong JX, Walzem RL, et al. (2003) Eliminating atherogenesis in mice by switching off hepatic lipoprotein secretion. Circulation 107: 1315-1321.
8. Efron B, Tibshirani R, Storey J, Tusher V (2001) Empirical Bayes analysis of a microarray experiment. J Am Stat Assoc 96: 1151-1160.
9. Tegner J, Yeung MK, Hasty J, Collins JJ (2003) Reverse engineering gene networks: integrating genetic perturbations with dynamical modeling. Proc Natl Acad Sci U S A 100: 5944-5949.
10. Nicholson AC, Han J, Febbraio M, Silversterin RL, Hajjar DP (2001) Role of CD36, the macrophage class B scavenger receptor, in atherosclerosis. Ann N Y Acad Sci 947: 224-228.
11. Hennuyer N, Tailleux A, Torpier G, Mezdour H, Fruchart JC, et al. (2005) PPARalpha, but not PPARgamma, activators decrease macrophage-laden atherosclerotic lesions in a nondiabetic mouse model of mixed dyslipidemia. Arterioscler Thromb Vasc Biol 25: 1897-1902.
12. Libby P, Geng YJ, Aikawa M, Schoenbeck U, Mach F, et al. (1996) Macrophages and atherosclerotic plaque stability. Curr Opin Lipidol 7: 330-335.
13. Schmidt S, Pericak-Vance MA, Sawcer S, Barcellos LF, Hart J, et al. (2006) Allelic association of sequence variants in the herpes virus entry mediator-B gene (PVRL2) with the severity of multiple sclerosis. 7: 384-392.
14. Edqvist J, Blomqvist K (2006) Fusion and fission, the evolution of sterol carrier protein-2. J Mol Evol 62: 292-306.
15. Tegner J, Skogsberg J, Bjorkegren J (2007) Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Multi-organ whole-genome measurements and reverse engineering to uncover gene networks underlying complex traits. J Lipid Res 48: 267-277.
16. Veniant MM, Sullivan MA, Kim SK, Ambroziak P, Chu A, et al. (2000) Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100. J Clin Invest 106: 1501-1510.
17. Stotz E, Schenk EA, Churukian C, Willis C (1986) Oil red O: Comparison of staining quality and chemical components as determined by thin layer chromatography. Stain Technol 61: 187-190.
18. Basu SK, Goldstein JL, Anderson GW, Brown MS (1976) Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts. Proc Natl Acad Sci U S A 73: 3178-3182.
19. Redgrave TG, Carlson LA (1979) Changes in plasma very low density and low density lipoprotein content, composition, and size after a fatty meal in normoand hypertriglyceridemic man. J Lipid Res 20: 217-229.
20. Christoffersen C, Nielsen LB, Axler O, Andersson A, Johnsen AH, et al. (2006) Isolation and characterization of human apolipoprotein M-containing lipoproteins. J Lipid Res 47: 1833-11843.
21. Cleveland W (1979) Robust locally weighted regression and smoothing scatterplots. J Am Statist Assoc 74: 829-836.
22. Hosack DA, Dennis G Jr, Sherman BT, Lane HC, Lempicki RA (2003) Identifying biological themes within lists of genes with EASE. Genome Biol 4: R70.