-
1
-
-
34548456509
-
Beyond unfractionated heparin and warfarin: Current and future advances
-
Hirsh J, O'Donnell M, Eikelboom JW. Beyond unfractionated heparin and warfarin: current and future advances. Circulation 116, 552-560 (2007).
-
(2007)
Circulation
, vol.116
, pp. 552-560
-
-
Hirsh, J.1
O'Donnell, M.2
Eikelboom, J.W.3
-
2
-
-
33744779960
-
The status of new anticoagulants
-
Bates SM, Weitz JI: The status of new anticoagulants. Br. J. Haematol. 134, 3-19 (2006).
-
(2006)
Br. J. Haematol
, vol.134
, pp. 3-19
-
-
Bates, S.M.1
Weitz, J.I.2
-
3
-
-
34447338638
-
A replacement for warfarin: The search continues
-
Eikelboom JW, Weitz JI: A replacement for warfarin: the search continues. Circulation 116, 131-133 (2007)
-
(2007)
Circulation
, vol.116
, pp. 131-133
-
-
Eikelboom, J.W.1
Weitz, J.I.2
-
4
-
-
33645053521
-
Small molecule coagulation cascade inhibitors in the clinic
-
Saiah E, Soares C: Small molecule coagulation cascade inhibitors in the clinic. Curr. Top. Med. Chem. 5, 1677-1695 (2005).
-
(2005)
Curr. Top. Med. Chem
, vol.5
, pp. 1677-1695
-
-
Saiah, E.1
Soares, C.2
-
6
-
-
34249310268
-
Oral, direct factor Xa inhibitors in development for the prevention and treatment of thromboembolic diseases
-
Turpie AGG: Oral, direct factor Xa inhibitors in development for the prevention and treatment of thromboembolic diseases. Arterioscler. Thromb Vasc. Biol. 27, 1238-1247 (2007).
-
(2007)
Arterioscler. Thromb Vasc. Biol
, vol.27
, pp. 1238-1247
-
-
Turpie, A.G.G.1
-
7
-
-
9944251352
-
Idraparinux sodium. Sanofi-Aventis
-
Ma Q, Fareed J: Idraparinux sodium. Sanofi-Aventis. IDrugs 7, 1028-1034 (2004).
-
(2004)
IDrugs
, vol.7
, pp. 1028-1034
-
-
Ma, Q.1
Fareed, J.2
-
8
-
-
2642617786
-
Biochemical and pharmacological properties of SANORG 34006, a potent and long-acting pentasaccharide
-
Herbert JM, Herault JP, Bernal A et al.: Biochemical and pharmacological properties of SANORG 34006, a potent and long-acting pentasaccharide. Blood 91, 4197-4205 (1998).
-
(1998)
Blood
, vol.91
, pp. 4197-4205
-
-
Herbert, J.M.1
Herault, J.P.2
Bernal, A.3
-
9
-
-
1542359508
-
Recombinant factor VIIa reverses the anticoagulant effect of the long-acting pentasaccharide ldraparinux in healthy volunteers
-
Bijsterveld NR, Vink R, Van Arken BE et al.: Recombinant factor VIIa reverses the anticoagulant effect of the long-acting pentasaccharide ldraparinux in healthy volunteers. Br. J. Haematol. 124, 653-658 (2004)
-
(2004)
Br. J. Haematol
, vol.124
, pp. 653-658
-
-
Bijsterveld, N.R.1
Vink, R.2
Van Arken, B.E.3
-
10
-
-
19944432311
-
A novel long-acting synthetic factor Xa inhibitor (SanOrg34006) to replace warfarin for secondary prevention in deep vein thrombosis: A Phase II evaluation
-
The PERSIST Investigators
-
The PERSIST Investigators: A novel long-acting synthetic factor Xa inhibitor (SanOrg34006) to replace warfarin for secondary prevention in deep vein thrombosis: a Phase II evaluation. J. Thromb. Haemost. 2, 47-53 (2004).
-
(2004)
J. Thromb. Haemost
, vol.2
, pp. 47-53
-
-
-
11
-
-
34548768174
-
Idraparinux versus standard therapy for venous thromboembolic disease
-
The van Gogh Investigators
-
The van Gogh Investigators. Idraparinux versus standard therapy for venous thromboembolic disease. N. Engl. J. Med. 357, 1094-1104 (2007).
-
(2007)
N. Engl. J. Med
, vol.357
, pp. 1094-1104
-
-
-
12
-
-
34548712332
-
Extended prophylaxis of venous thromboembolism with idraparinux
-
The van Gogh Investigators
-
The van Gogh Investigators: Extended prophylaxis of venous thromboembolism with idraparinux. N. Engl. J. Med. 357, 1105-1112 (2007).
-
(2007)
N. Engl. J. Med
, vol.357
, pp. 1105-1112
-
-
-
13
-
-
42549097091
-
Anticoagulant effects of idraparinux after termination of therapy for prevention of recurrent venous thromboembolism: Observations from the van Gogh trials
-
In press
-
Harenberg J, Joerg I, Vukojevic Y, Weiss C, Mikus G: Anticoagulant effects of idraparinux after termination of therapy for prevention of recurrent venous thromboembolism: observations from the van Gogh trials. Eur. J. Clin. Pharmacol. (2008) (In press).
-
(2008)
Eur. J. Clin. Pharmacol
-
-
Harenberg, J.1
Joerg, I.2
Vukojevic, Y.3
Weiss, C.4
Mikus, G.5
-
14
-
-
42049099988
-
Long elimination half-life of idraparinux after termination of therapy explains bleeding in the van Gogh trials
-
In press
-
Harenberg J, Weiss C, Mikus G, Joerg I, Vukojevic Y: Long elimination half-life of idraparinux after termination of therapy explains bleeding in the van Gogh trials. J. Thromb. Haemost. (2008) (In press).
-
(2008)
J. Thromb. Haemost
-
-
Harenberg, J.1
Weiss, C.2
Mikus, G.3
Joerg, I.4
Vukojevic, Y.5
-
15
-
-
42549168221
-
Reversible biotinylated oligosaccharides, a new approach for a better management of the anticoagulant therapy
-
Abstract P-W-645
-
Savi F, Herault JP, Duchaussoy P et al.: Reversible biotinylated oligosaccharides, a new approach for a better management of the anticoagulant therapy. J. Thromb. Haemost. (Suppl.), Abstract P-W-645 (2007).
-
(2007)
J. Thromb. Haemost
, Issue.SUPPL.
-
-
Savi, F.1
Herault, J.P.2
Duchaussoy, P.3
-
16
-
-
44349157456
-
AV5026, a new anticoagulant for prevention of venous thromboembolism in total knee replacement surgery - TREK: A dose ranging study
-
Abstract 311
-
Lassen MR, Dahl OF, Mismetti P, Destrèe D: AV5026, a new anticoagulant for prevention of venous thromboembolism in total knee replacement surgery - TREK: a dose ranging study. Blood 110, Abstract 311 (2007).
-
(2007)
Blood
, pp. 110
-
-
Lassen, M.R.1
Dahl, O.F.2
Mismetti, P.3
Destrèe, D.4
-
17
-
-
34250700118
-
Factor Xa or thrombin: Is factor Xa a better target?
-
Ansell J: Factor Xa or thrombin: is factor Xa a better target? J. Thromb. Haemost. 5(Suppl. 1), 60-64 (2007).
-
(2007)
J. Thromb. Haemost
, vol.5
, Issue.SUPPL. 1
, pp. 60-64
-
-
Ansell, J.1
-
18
-
-
29644437323
-
Pharmacokinetics of otamixaban, a direct factor Xa inhibitor, in healthy male subjects: Pharmacokinetic model development for Phase 2/3 simulation of exposure
-
Paccaly A, Frick A, Rohatagi S et al.: Pharmacokinetics of otamixaban, a direct factor Xa inhibitor, in healthy male subjects: pharmacokinetic model development for Phase 2/3 simulation of exposure. J. Clin. Pharmacol. 46, 37-44 (2006).
-
(2006)
J. Clin. Pharmacol
, vol.46
, pp. 37-44
-
-
Paccaly, A.1
Frick, A.2
Rohatagi, S.3
-
19
-
-
34249025394
-
-
Cohen M, Deepak L. Bhatt DL et al.; on behalf of the SEPIA-PCI Trial Investigators: Randomized, double-blind, dose-ranging study of otamixaban, a novel, parenteral, short-acting direct factor Xa Inhibitor, in percutaneous coronary intervention: The SEPIA-PCI Trial. Circulation 115, 2642-2651 (2007).
-
Cohen M, Deepak L. Bhatt DL et al.; on behalf of the SEPIA-PCI Trial Investigators: Randomized, double-blind, dose-ranging study of otamixaban, a novel, parenteral, short-acting direct factor Xa Inhibitor, in percutaneous coronary intervention: The SEPIA-PCI Trial. Circulation 115, 2642-2651 (2007).
-
-
-
-
20
-
-
0037250429
-
DX-9065a inhibition of factor Xa and the prothrombinase complex: Mechanism of inhibition and comparison with therapeutic heparins
-
Rezaie AR: DX-9065a inhibition of factor Xa and the prothrombinase complex: mechanism of inhibition and comparison with therapeutic heparins. Thromb. Haemost. 89, 112-121 (2003).
-
(2003)
Thromb. Haemost
, vol.89
, pp. 112-121
-
-
Rezaie, A.R.1
-
21
-
-
0037150191
-
First experience with direct factor Xa inhibition in patients with stable coronary disease: A pharmacokinetic and pharmacodynamic evaluation
-
Dyke CK, Becker RC, Kleiman NS et al.: First experience with direct factor Xa inhibition in patients with stable coronary disease: a pharmacokinetic and pharmacodynamic evaluation. Circulation 105, 2385-2391 (2002).
-
(2002)
Circulation
, vol.105
, pp. 2385-2391
-
-
Dyke, C.K.1
Becker, R.C.2
Kleiman, N.S.3
-
22
-
-
23944460642
-
on behalf of the XANADU-ACS Investigators: First experience with direct, selective factor Xa inhibition in patients with non-ST-elevation acute coronary syndromes: results of the XANADU-ACS trial
-
Alexander JH, Yang H, Becker RC et al.; on behalf of the XANADU-ACS Investigators: First experience with direct, selective factor Xa inhibition in patients with non-ST-elevation acute coronary syndromes: results of the XANADU-ACS trial. J. Thromb. Haemost. 3, 439-447 (2005).
-
(2005)
J. Thromb. Haemost
, vol.3
, pp. 439-447
-
-
Alexander, J.H.1
Yang, H.2
Becker, R.C.3
-
23
-
-
33746805812
-
Novel factor Xa inhibitors for prevention and treatment of thromboembolic diseases
-
Kubitza D, Haas S: Novel factor Xa inhibitors for prevention and treatment of thromboembolic diseases. Expert Opin. Investig. Drugs 15, 843-855 (2006).
-
(2006)
Expert Opin. Investig. Drugs
, vol.15
, pp. 843-855
-
-
Kubitza, D.1
Haas, S.2
-
24
-
-
33751559902
-
A once-daily, oral, direct factor Xa inhibitor, rivaroxaban (BAY 59-7939), for thromboprophylaxis after total hip replacement
-
for the ODIXa-HIP Study Investigators
-
Eriksson BI, Lars C, Borris LC et al.; for the ODIXa-HIP Study Investigators: A once-daily, oral, direct factor Xa inhibitor, rivaroxaban (BAY 59-7939), for thromboprophylaxis after total hip replacement. Circulation 114, 2374-2381 (2006).
-
(2006)
Circulation
, vol.114
, pp. 2374-2381
-
-
Eriksson, B.I.1
Lars, C.2
Borris, L.C.3
-
25
-
-
42049091531
-
Rivaroxaban - an oral, direct factor Xa inhibitor - for thromboprophylaxis after total knee arthroplasty: The RECORD3 trial
-
Abstract 308
-
Lassen MR, Turpie AG, Rosencher N et al.: Rivaroxaban - an oral, direct factor Xa inhibitor - for thromboprophylaxis after total knee arthroplasty: the RECORD3 trial. Blood 110, Abstract 308 (2007)
-
(2007)
Blood
, pp. 110
-
-
Lassen, M.R.1
Turpie, A.G.2
Rosencher, N.3
-
26
-
-
40849131491
-
Extended thromboprophylaxis with rivaroxaban compared with short-term thromboprophylaxis with enoxaparin after total hip arthroplasty: The RECORD2
-
Abstract 307
-
Kakkar AK, Brenner B, Dahl OE et al.: Extended thromboprophylaxis with rivaroxaban compared with short-term thromboprophylaxis with enoxaparin after total hip arthroplasty: the RECORD2. Blood 110, Abstract 307 (2007).
-
(2007)
Blood
, pp. 110
-
-
Kakkar, A.K.1
Brenner, B.2
Dahl, O.E.3
-
27
-
-
45749104552
-
Oral rivaroxaban compared with subcutaneous enoxaparin for extended thromboprophylaxis after total hip arthroplasty: The RECORD1
-
Abstract 6
-
Eriksson BI, Borris LC, Friedman RJ et al.: Oral rivaroxaban compared with subcutaneous enoxaparin for extended thromboprophylaxis after total hip arthroplasty: the RECORD1. Blood 110, Abstract 6 (2007).
-
(2007)
Blood
, pp. 110
-
-
Eriksson, B.I.1
Borris, L.C.2
Friedman, R.J.3
-
28
-
-
51349100177
-
Rivaroxaban has predictable pharmacokinetics (PK) and pharmacodynamics (PD) when given once or twice daily for the treatment of acute, proximal deep vein thrombosis (DVT)
-
Abstract 1880
-
Mueck W, Agnelli G, Buller H: Rivaroxaban has predictable pharmacokinetics (PK) and pharmacodynamics (PD) when given once or twice daily for the treatment of acute, proximal deep vein thrombosis (DVT). Blood 110, Abstract 1880 (2007).
-
(2007)
Blood
, pp. 110
-
-
Mueck, W.1
Agnelli, G.2
Buller, H.3
-
29
-
-
34447317298
-
Treatment of proximal deep-vein thrombosis with the oral direct factor Xa inhibitor rivaroxaban (BAY 59-7939). The ODIXa-DVT Study
-
for the ODIXa-DVT Study Investigators
-
Agnelli G, Gallus A, Goldhaber SZ et al.; for the ODIXa-DVT Study Investigators: Treatment of proximal deep-vein thrombosis with the oral direct factor Xa inhibitor rivaroxaban (BAY 59-7939). The ODIXa-DVT Study. Circulation 116, 180-187 (2007).
-
(2007)
Circulation
, vol.116
, pp. 180-187
-
-
Agnelli, G.1
Gallus, A.2
Goldhaber, S.Z.3
-
30
-
-
34147181108
-
Once-daily treatment with an oral, direct factor Xa inhibitor - rivaroxaban (BAY 59-7939) - in patients with acute, symptomatic deep vein thrombosis: The EINSTEIN-DVT dose-finding study
-
Abstract
-
Buller HR: Once-daily treatment with an oral, direct factor Xa inhibitor - rivaroxaban (BAY 59-7939) - in patients with acute, symptomatic deep vein thrombosis: the EINSTEIN-DVT dose-finding study. Eur. Heart J. 27, 761 Abstract (2006).
-
(2006)
Eur. Heart J
, vol.27
, pp. 761
-
-
Buller, H.R.1
-
31
-
-
35848929515
-
-
Pinto DJ, Orwat MJ, Koch S et al.: Discovery of 1-(4-Methoxyphenyl) -7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1H- pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa. J. Med. Chem. 50, 5339-5356 (2007).
-
Pinto DJ, Orwat MJ, Koch S et al.: Discovery of 1-(4-Methoxyphenyl) -7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1H- pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa. J. Med. Chem. 50, 5339-5356 (2007).
-
-
-
-
32
-
-
36348978071
-
The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement
-
Lassen MR, Davidson BL, Gallus A, Pineo G, Ansell J, Deitchman D: The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement. J. Thromb. Haemost. 5, 2368-2375 (2007).
-
(2007)
J. Thromb. Haemost
, vol.5
, pp. 2368-2375
-
-
Lassen, M.R.1
Davidson, B.L.2
Gallus, A.3
Pineo, G.4
Ansell, J.5
Deitchman, D.6
-
33
-
-
42049103306
-
A dose finding study of the oral direct factor Xa inhibitor apixaban in the treatment of patients with acute symptomatic deep vein thrombosis - the Botticelli investigators
-
Abstract O-S-003
-
Buller HR: A dose finding study of the oral direct factor Xa inhibitor apixaban in the treatment of patients with acute symptomatic deep vein thrombosis - the Botticelli investigators. J. Thromb. Haemost. (Suppl.), Abstract O-S-003 (2007).
-
(2007)
J. Thromb. Haemost
, Issue.SUPPL.
-
-
Buller, H.R.1
-
34
-
-
34249337290
-
Biochemical and pharmacological profiles of YM150, an oral direct Factor Xa inhibitor
-
Abstract 911
-
Iwatsuki Y, Shigenaga T, Moritani Y et al.: Biochemical and pharmacological profiles of YM150, an oral direct Factor Xa inhibitor. Blood 108, Abstract 911 (2006).
-
(2006)
Blood
, pp. 108
-
-
Iwatsuki, Y.1
Shigenaga, T.2
Moritani, Y.3
-
35
-
-
34447639584
-
A dose escalation study of YM150, an oral direct factor Xa inhibitor, in the prevention of venous thromboembolism in elective primary hip replacement surgery
-
for the Onyx Study Group
-
Eriksson BI, Turpie AGG, Lassen MR et al.; for the Onyx Study Group: A dose escalation study of YM150, an oral direct factor Xa inhibitor, in the prevention of venous thromboembolism in elective primary hip replacement surgery. J. Thromb. Haemost. 5, 1660-1665 (2007).
-
(2007)
J. Thromb. Haemost
, vol.5
, pp. 1660-1665
-
-
Eriksson, B.I.1
Turpie, A.G.G.2
Lassen, M.R.3
-
36
-
-
68549127691
-
Once daily YM150, an oral direct factor Xa inhibitor, for prevention of venous thromboembolism in patients undergoing elective primary hip relpacement
-
Abstract 309
-
Eriksson BI, Turpie AGG, Lassen MR et al.: Once daily YM150, an oral direct factor Xa inhibitor, for prevention of venous thromboembolism in patients undergoing elective primary hip relpacement. Blood 110, Abstract 309 (2007).
-
(2007)
Blood
, pp. 110
-
-
Eriksson, B.I.1
Turpie, A.G.G.2
Lassen, M.R.3
-
37
-
-
33748654160
-
Medicinal Chemistry - 12th RSC-SCI Symposium (Part I), Enzyme Inhibitors
-
Cambridge, UK
-
Norman P: Medicinal Chemistry - 12th RSC-SCI Symposium (Part I), Enzyme Inhibitors. IDdb Meeting Report, Cambridge, UK (2003).
-
(2003)
IDdb Meeting Report
-
-
Norman, P.1
-
38
-
-
34147141000
-
A Phase II study of the safety and efficacy of a novel oral fXa inhibitor (LY517717) for the prevention of venous thromboembolism following TKR or THR
-
Agnelli G, Haas SK, Krueger KA, Ginsberg JS, Dmitrienko A, Brandt JT: A Phase II study of the safety and efficacy of a novel oral fXa inhibitor (LY517717) for the prevention of venous thromboembolism following TKR or THR. J. Thromb. Haemost. 5, 746-753 (2007).
-
(2007)
J. Thromb. Haemost
, vol.5
, pp. 746-753
-
-
Agnelli, G.1
Haas, S.K.2
Krueger, K.A.3
Ginsberg, J.S.4
Dmitrienko, A.5
Brandt, J.T.6
-
39
-
-
35048854973
-
Antithrombotic effects of factor Xa inhibition with DU-176b: Phase-I study of an oral, direct factor Xa inhibitor using an ex-vivo flow chamber
-
Zafar MU, Vorchheimer DA, Gaztanaga J et al.: Antithrombotic effects of factor Xa inhibition with DU-176b: Phase-I study of an oral, direct factor Xa inhibitor using an ex-vivo flow chamber. Thromb. Haemost. 98, 883-888 (2007).
-
(2007)
Thromb. Haemost
, vol.98
, pp. 883-888
-
-
Zafar, M.U.1
Vorchheimer, D.A.2
Gaztanaga, J.3
-
40
-
-
34249303314
-
Animal models of thrombosis help predict the human therapeutic concentration of PRT54021, a potent oral Factor Xa inhibitor
-
Abstract 901
-
Abe K, Siu G, Edwards S et al.: Animal models of thrombosis help predict the human therapeutic concentration of PRT54021, a potent oral Factor Xa inhibitor. Blood. 108, Abstract 901 (2006).
-
(2006)
Blood
, pp. 108
-
-
Abe, K.1
Siu, G.2
Edwards, S.3
|