Reversible inactivation of cytochrome P450 by alkaline earth metal ions: Auxiliary metal ion induced conformation change and formation of inactive P420 species in CYP101

Journal of Inorganic Biochemistry

Volumn 102, Issue 5-6, 2008, Pages 1312-1321

  Manna, Soumen K ^a   Mazumdar, Shyamalava ^a  

^a TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

Author keywords

Alkaline earth metal ion; Auxiliary metal ion; Circular dichroism; Conformational change; Cytochrome P450cam; Heme; P420; Site directed mutagenesis

Indexed keywords

ALKALINE EARTH METAL; CALCIUM; CAMPHOR; CYTOCHROME; CYTOCHROME P420; CYTOCHROME P450; HEME; MAGNESIUM; METAL ION; MONOVALENT CATION; POTASSIUM; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CIRCULAR DICHROISM; ENZYME INACTIVATION; GENE MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; SPECTROSCOPY; ULTRAVIOLET RADIATION; WILD TYPE;

CALCIUM; CAMPHOR; CAMPHOR 5-MONOOXYGENASE; CATIONS, DIVALENT; CIRCULAR DICHROISM; CYTOCHROME P-450 ENZYME SYSTEM; MAGNESIUM; POTASSIUM CHLORIDE; SPECTROPHOTOMETRY, ULTRAVIOLET;

MAMMALIA;

EID: 41949088824     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2008.01.013     Document Type: Article

References (37)

1. Williams R.J.P. Biosci. Reports 8 (1988) 653-668
2. Morishima I., Kurono M., and Shiro Y. J. Biol. Chem. 261 (1986) 9391-9399
3. Nowak T., and Suelter C. Mol. Cell Biochem. 35 (1981) 65-75
4. Peterson J.A. Arch. Biochem. Biophys. 144 (1971) 678-693
5. Sligar S.G. Biochemistry 15 (1976) 5399-5406
6. Sligar S.G., and Gunsalus I.C. Proc. Natl. Acad. Sci. USA 73 (1976) 1078-1082
7. Lange R., Bonfils C., and Debey P. Eur. J. Biochem. 79 (1977) 623-628
8. Deprez E., Di Primo C., Hoa G.H., and Douzou P. FEBS Lett. 347 (1994) 207-210
9. Deprez E., Gill E., Helms V., Wade R.C., and Hui Bon Hoa G. J. Inorg. Biochem. 91 (2002) 597-606
10. Hui Bon Hoa G., and Marden M.C. Eur. J. Biochem. 124 (1982) 311-315
11. Schlichting I., Berendzen J., Chu K., Stock A.M., Maves S.A., Benson D.E., Sweet R.M., Ringe D., Petsko G.A., and Sligar S.G. Science 287 (2000) 1615-1622
12. Poulos T.L., Finzel B.C., and Howard A.J. J. Mol. Biol. 195 (1987) 687-700
13. Hui Bon Hoa G., Di Primo C., Dondaine I., Sligar S.G., Gunsalus I.C., and Douzou P. Biochemistry 28 (1989) 651-656
14. OuYang B., Pochapsky S.S., Pagani G.M., and Pochapsky T.C. Biochemistry 45 (2006) 14379-14388
15. Sanghvi A., Grassi E., and Diven W. Proc. Natl. Acad. Sci. USA 80 (1983) 2175-2178
16. Butterworth M., Lau S.S., and Monks T.J. Drug Metab. Dispos. 24 (1996) 588-594
17. Kinoshita Y., Higashi Y., Oshima H., and Troen P. J. Steroid Biochem. 23 (1985) 491-495
18. Bjorkhem I., and Karlmar K.E. J. Lipid Res. 18 (1977) 592-603
19. Kwok C.T., Burnett W., and Hardie I.R. J. Lipid Res. 22 (1981) 580-589
20. Atkins W.M., and Sligar S.G. J. Biol. Chem. 263 (1988) 18842-18849
21. Di Primo C., Hui Bon Hoa G., Douzou P., and Sligar S. J. Biol. Chem. 265 (1990) 5361-5363
22. Westlake A.C., Harford-Cross C.F., Donovan J., and Wong L.L. Eur. J. Biochem. 265 (1999) 929-935
23. Manna S.K., and Mazumdar S. Biochemistry 45 (2006) 12715-12722
24. Gunsalus I.C., and Wagner G.C. In: Fleischer S., and Packer L. (Eds). Methods Enzymology (1978), Academic Press, New York 166-188
25. Mouro C., Jung C., Bondon A., and Simonneaux G. Biochemistry 36 (1997) 8125-8134
26. Fisher M.T., and Sligar S.G. Biochemistry 26 (1987) 4797-4803
27. Di Primo C., Hui Bon Hoa G., Douzou P., and Sligar S. Eur. J. Biochem. 193 (1990) 383-386
28. Murugan R., and Mazumdar S. J. Biol. Inorg. Chem. 9 (2004) 477-488
29. Poulos T.L., Finzel B.C., and Howard A.J. Biochemistry 25 (1986) 5314-5322
30. Martinis S.A., Blanke S.R., Hager L.P., Sligar S.G., Hoa G.H., Rux J.J., and Dawson J.H. Biochemistry 35 (1996) 14530-14536
31. Wells A.V., Li P., Champion P.M., Martinis S.A., and Sligar S.G. Biochemistry 31 (1992) 4384-4393
32. Hui Bon Hoa G., Di Primo C., Geze M., Douzou P., Kornblatt J.A., and Sligar S.G. Biochemistry 29 (1990) 6810-6815
33. Shannon R.D. Acta Crystal. A32 (1976) 751-767
34. Strynadka N.C., and James M.N. Annu. Rev. Biochem. 58 (1989) 951-998
35. Yu C., and Gunsalus I.C. J. Biol. Chem. 249 (1974) 102-106
36. Sato B., Huseby R.A., and Samuels L.T. Endocrinology 103 (1978) 805-816
37. Tsoulis C.J., and Hobkirk R. Can. J. Biochem. 59 (1981) 454-460