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Volumn 9, Issue 4, 2008, Pages 396-401

Growth hormone use in the treatment of idiopathic short stature

Author keywords

Child; Growth hormone; Growth hormone therapy; Idiopathic short stature; Insulin growth factor 1; Puberty

Indexed keywords

GROWTH HORMONE RECEPTOR; GROWTH HORMONE SECRETAGOGUE; HUMAN GROWTH HORMONE; SOMATOMEDIN; STEROID;

EID: 41949087910     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (7)

References (52)
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    • Argente J, Gracia R, Ibáñez L, Oliver A, Borrajo E, Vela A, López-Siguero JP, Moreno ML, Rodríguez-Hierro F, Spanish SGA Working Group: Improvement in growth after two years of growth hormone therapy in very young children born small for gestational age and without spontaneous catch-up growth: Results of a multicenter, controlled, randomized, open clinical trial. J Clin Endocrinol Metab (2007) 92(8):3095-3101. • In this study, children aged two to five years, who were small for gestational age, showed a 2.1 SDS height gain after 2 years of GH treatment, with the children under four years of age having the greatest gain in growth velocity.
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    • Davenport ML, Crowe BJ, Travers SH, Rubin K, Ross JL, Fechner PY, Gunther DF, Liu C, Geffner ME, Thrailkill K, Huseman C, Zagar AJ, Quigley CA: Growth hormone treatment of early growth failure in toddlers with Turner syndrome: A randomized, controlled, multicenter trial. J Clin Endocrinol Metab (2007) 92(9):3406-3416. • This study showed that after two years of GH treatment, 9-month to four-year old toddlers with Turner syndrome showed a 1.6 SDS height gain compared to untreated subjects.
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    • Carel JC: Can we increase adolescent growth? Eur J Endocrinol (2004) 151(Suppl 3):U101-U108. • This review observed that current therapies used to increase pubertal growth (GH, LHRH analogue in particular) have so far obtained only modest or dubiously significant clinical results.
    • Carel JC: Can we increase adolescent growth? Eur J Endocrinol (2004) 151(Suppl 3):U101-U108. • This review observed that current therapies used to increase pubertal growth (GH, LHRH analogue in particular) have so far obtained only modest or dubiously significant clinical results.
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    • Cohen P, Rogol AD, Howard CP, Bright GM, Kappelgaard AM, Rosenfeld RG, American Norditropin Study Group: Insulin growth factor-based dosing of growth hormone therapy in children: A randomized, controlled study. J Clin Endocrinol Metab (2007) 92(7):2480-2486. •• This study provides robust evidence that titrating GH dose to achieve higher IGF-1 targets results in improved growth responses, although at higher average GH doses. Furthermore, there was up to 10 times variability of GH dose between subjects to maintain a similar IGF-1 level.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.