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Zucchini S, Wasniewska M, Cisternino M, Salerno M, Iughetti L, Maghnie M, Street ME, Caruso-Nicoletti M, Cianfarani S: Adult height in children with short stature and idiopathic delayed puberty after different management. Eur J Pediatr (2007) [Epub ahead of print]. • In this study, subjects with short stature and idiopathic delayed puberty (particularly girls) do not reach a better adult height when treated with GH.
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Ranke MB, Lindberg A, Chatelain P, Wilton P, Cutfield W, Albertsson-Wikland K, Price DA: Derivation and validation of a mathematical model for predicting the response to exogenous recombinant human growth hormone (GH) in prepubertal children with idiopathic GH deficiency. KIGS International Board. Kabi Pharmacia International Growth Study. J Clin Endocrinol Metab (1999) 84(4):1174-1183.
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Blum WF, Crowe BJ, Quigley CA, Jung H, Cao D, Ross JL, Braun L, Rappold G, SHOX Study Group: Growth hormone is effective in treatment of short stature associated with short stature homeobox-containing gene deficiency: Two-year results of a randomized, controlled, multicenter trial. J Clin Endocrinol Metab (2007) 92(1):219-228.
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Argente J, Gracia R, Ibáñez L, Oliver A, Borrajo E, Vela A, López-Siguero JP, Moreno ML, Rodríguez-Hierro F, Spanish SGA Working Group: Improvement in growth after two years of growth hormone therapy in very young children born small for gestational age and without spontaneous catch-up growth: Results of a multicenter, controlled, randomized, open clinical trial. J Clin Endocrinol Metab (2007) 92(8):3095-3101. • In this study, children aged two to five years, who were small for gestational age, showed a 2.1 SDS height gain after 2 years of GH treatment, with the children under four years of age having the greatest gain in growth velocity.
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Argente J, Gracia R, Ibáñez L, Oliver A, Borrajo E, Vela A, López-Siguero JP, Moreno ML, Rodríguez-Hierro F, Spanish SGA Working Group: Improvement in growth after two years of growth hormone therapy in very young children born small for gestational age and without spontaneous catch-up growth: Results of a multicenter, controlled, randomized, open clinical trial. J Clin Endocrinol Metab (2007) 92(8):3095-3101. • In this study, children aged two to five years, who were small for gestational age, showed a 2.1 SDS height gain after 2 years of GH treatment, with the children under four years of age having the greatest gain in growth velocity.
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Davenport ML, Crowe BJ, Travers SH, Rubin K, Ross JL, Fechner PY, Gunther DF, Liu C, Geffner ME, Thrailkill K, Huseman C, Zagar AJ, Quigley CA: Growth hormone treatment of early growth failure in toddlers with Turner syndrome: A randomized, controlled, multicenter trial. J Clin Endocrinol Metab (2007) 92(9):3406-3416. • This study showed that after two years of GH treatment, 9-month to four-year old toddlers with Turner syndrome showed a 1.6 SDS height gain compared to untreated subjects.
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Davenport ML, Crowe BJ, Travers SH, Rubin K, Ross JL, Fechner PY, Gunther DF, Liu C, Geffner ME, Thrailkill K, Huseman C, Zagar AJ, Quigley CA: Growth hormone treatment of early growth failure in toddlers with Turner syndrome: A randomized, controlled, multicenter trial. J Clin Endocrinol Metab (2007) 92(9):3406-3416. • This study showed that after two years of GH treatment, 9-month to four-year old toddlers with Turner syndrome showed a 1.6 SDS height gain compared to untreated subjects.
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Carel JC: Can we increase adolescent growth? Eur J Endocrinol (2004) 151(Suppl 3):U101-U108. • This review observed that current therapies used to increase pubertal growth (GH, LHRH analogue in particular) have so far obtained only modest or dubiously significant clinical results.
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Carel JC: Can we increase adolescent growth? Eur J Endocrinol (2004) 151(Suppl 3):U101-U108. • This review observed that current therapies used to increase pubertal growth (GH, LHRH analogue in particular) have so far obtained only modest or dubiously significant clinical results.
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Kamp GA, Waelkens JJ, de Muinck Keizer-Schrama SM, Delemarre-Van de Waal HA, Verhoeven-Wind L, Zwinderman AH, Wit JM: High dose growth hormone treatment induces acceleration of skeletal maturation and an earlier onset of puberty in children with idiopathic short stature. Arch Dis Child (2002) 87(3):215-220.
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Cohen P, Rogol AD, Howard CP, Bright GM, Kappelgaard AM, Rosenfeld RG, American Norditropin Study Group: Insulin growth factor-based dosing of growth hormone therapy in children: A randomized, controlled study. J Clin Endocrinol Metab (2007) 92(7):2480-2486. •• This study provides robust evidence that titrating GH dose to achieve higher IGF-1 targets results in improved growth responses, although at higher average GH doses. Furthermore, there was up to 10 times variability of GH dose between subjects to maintain a similar IGF-1 level.
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Cohen P, Rogol AD, Howard CP, Bright GM, Kappelgaard AM, Rosenfeld RG, American Norditropin Study Group: Insulin growth factor-based dosing of growth hormone therapy in children: A randomized, controlled study. J Clin Endocrinol Metab (2007) 92(7):2480-2486. •• This study provides robust evidence that titrating GH dose to achieve higher IGF-1 targets results in improved growth responses, although at higher average GH doses. Furthermore, there was up to 10 times variability of GH dose between subjects to maintain a similar IGF-1 level.
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