-
1
-
-
0015243872
-
Pharmacometrics of guinea pig's gall-bladder in vitro [in Chinese]
-
Lee WH, Fujiwara M. Pharmacometrics of guinea pig's gall-bladder in vitro [in Chinese]. Taiwan Yi Xue Hui Za Zhi. 1971 ; 70: 687-696.
-
(1971)
Taiwan Yi Xue Hui Za Zhi
, vol.70
, pp. 687-696
-
-
Lee, W.H.1
Fujiwara, M.2
-
2
-
-
0017194511
-
Neuromuscular sensitivity to tubocurarine. a comparison of 10 parameters
-
Lee C., Barnes A., Katz RL Neuromuscular sensitivity to tubocurarine. A comparison of 10 parameters. Br J Anaesth. 1976 ; 48: 1045-1051.
-
(1976)
Br J Anaesth
, vol.48
, pp. 1045-1051
-
-
Lee, C.1
Barnes, A.2
Katz, R.L.3
-
3
-
-
84889479950
-
Pharmacometrics: Impacting drug development and pharmacotherapy
-
EI Ette, PJ Williams, eds. Hoboken, NJ: John Wiley & Sons;
-
Williams PJ, Ette EI Pharmacometrics: impacting drug development and pharmacotherapy. In: Pharmacometrics: The Science of Quantitative Pharmacology. EI Ette, PJ Williams, eds. Hoboken, NJ: John Wiley & Sons ; 2007: 1-21.
-
(2007)
Pharmacometrics: The Science of Quantitative Pharmacology
, pp. 1-21
-
-
Williams, P.J.1
Ette, E.I.2
-
4
-
-
51249124443
-
Applying quantitative pharmacology in an academic translational research environment
-
Barrett JS Applying quantitative pharmacology in an academic translational research environment. AAPS J. In press.
-
AAPS J.
-
-
Barrett, J.S.1
-
5
-
-
0141642224
-
Medicine. the NIH roadmap
-
Zerhouni E., Medicine. The NIH roadmap. Science. 2003 ; 302: 63-72.
-
(2003)
Science
, vol.302
, pp. 63-72
-
-
Zerhouni, E.1
-
7
-
-
0030814837
-
Exploring clinical study design by computer simulation based on pharmacokinetic/ pharmacodynamic modelling
-
Gieschke R., Reigner BG, Steimer JL Exploring clinical study design by computer simulation based on pharmacokinetic/ pharmacodynamic modelling. Int J Clin Pharmacol Ther. 1997 ; 35: 469-474.
-
(1997)
Int J Clin Pharmacol Ther
, vol.35
, pp. 469-474
-
-
Gieschke, R.1
Reigner, B.G.2
Steimer, J.L.3
-
8
-
-
0037352930
-
Population pharmacokinetics and concentration-effect relationships of capecitabine metabolites in colorectal cancer patients
-
Gieschke R., Burger HU, Reigner B., et al. Population pharmacokinetics and concentration-effect relationships of capecitabine metabolites in colorectal cancer patients. Br J Clin Pharmacol. 2003 ; 55: 252-263.
-
(2003)
Br J Clin Pharmacol
, vol.55
, pp. 252-263
-
-
Gieschke, R.1
Burger, H.U.2
Reigner, B.3
-
9
-
-
0029783171
-
A population pharmacokinetic model for docetaxel (Taxotere): Model building and validation
-
Bruno R., Vivier N., Vergniol JC, et al. A population pharmacokinetic model for docetaxel (Taxotere): model building and validation. J Pharmacokinet Biopharm. 1996 ; 24: 153-172.
-
(1996)
J Pharmacokinet Biopharm
, vol.24
, pp. 153-172
-
-
Bruno, R.1
Vivier, N.2
Vergniol, J.C.3
-
10
-
-
0034520354
-
Clinical trial simulation of docetaxel in patients with cancer as a tool for dosage optimization
-
Veyrat-Follet C., Bruno R., Olivares R., et al. Clinical trial simulation of docetaxel in patients with cancer as a tool for dosage optimization. Clin Pharmacol Ther. 2000 ; 68: 677-687.
-
(2000)
Clin Pharmacol Ther
, vol.68
, pp. 677-687
-
-
Veyrat-Follet, C.1
Bruno, R.2
Olivares, R.3
-
11
-
-
33745779940
-
Model-based drug development: The road to quantitative pharmacology
-
Zhang L., Sinha V., Forgue ST, et al. Model-based drug development: the road to quantitative pharmacology. J Pharmacokinet Pharmacodyn. 2006 ; 33: 369-393.
-
(2006)
J Pharmacokinet Pharmacodyn
, vol.33
, pp. 369-393
-
-
Zhang, L.1
Sinha, V.2
Forgue, S.T.3
-
12
-
-
0036133350
-
Relationships between bone mineral density and incident vertebral fracture risk with raloxifene therapy
-
Sarkar S., Mitlak BH, Wong M., et al. Relationships between bone mineral density and incident vertebral fracture risk with raloxifene therapy. J Bone Miner Res. 2002 ; 17: 1-10.
-
(2002)
J Bone Miner Res
, vol.17
, pp. 1-10
-
-
Sarkar, S.1
Mitlak, B.H.2
Wong, M.3
-
13
-
-
18544381541
-
Efficacy of raloxifene on vertebral fracture risk reduction in postmenopausal women with osteoporosis: 4-year results from a randomized clinical trial
-
Delmas PD, Ensrud KE, Adachi JD, et al. Efficacy of raloxifene on vertebral fracture risk reduction in postmenopausal women with osteoporosis: 4-year results from a randomized clinical trial. J Clin Endocrinol Metab. 2002 ; 87: 3609-3617.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 3609-3617
-
-
Delmas, P.D.1
Ensrud, K.E.2
Adachi, J.D.3
-
14
-
-
0032783433
-
Biological simulations in drug discovery
-
Noble D., Levin J., Scott W. Biological simulations in drug discovery. Drug Discov Today. 1999 ; 4: 10-16.
-
(1999)
Drug Discov Today
, vol.4
, pp. 10-16
-
-
Noble, D.1
Levin, J.2
Scott, W.3
-
15
-
-
0034491130
-
Optimizing the science of drug development: Opportunities for better candidate selection and accelerated evaluation in humans
-
Lesko LJ, Rowland M., Peck CC, et al. Optimizing the science of drug development: opportunities for better candidate selection and accelerated evaluation in humans. Pharm Res. 2000 ; 17: 1335-1344.
-
(2000)
Pharm Res
, vol.17
, pp. 1335-1344
-
-
Lesko, L.J.1
Rowland, M.2
Peck, C.C.3
-
16
-
-
32044442986
-
The crisis of resistance: Identifying drug exposures to suppress amplification of resistant mutant subpopulations
-
Drusano GL, Louie A., Deziel M., et al. The crisis of resistance: identifying drug exposures to suppress amplification of resistant mutant subpopulations. Clin Infect Dis. 2006 ; 42: 525-532.
-
(2006)
Clin Infect Dis
, vol.42
, pp. 525-532
-
-
Drusano, G.L.1
Louie, A.2
Deziel, M.3
-
17
-
-
28444480672
-
Collapsing mechanistic models: An application to dose selection for proof of concept of a selective irreversible antagonist
-
Hutmacher MM, Mukherjee D., Kowalski KG, et al. Collapsing mechanistic models: an application to dose selection for proof of concept of a selective irreversible antagonist. J Pharmacokinet Pharmacodyn. 2005 ; 32: 501-520.
-
(2005)
J Pharmacokinet Pharmacodyn
, vol.32
, pp. 501-520
-
-
Hutmacher, M.M.1
Mukherjee, D.2
Kowalski, K.G.3
-
18
-
-
0033810574
-
Pharmacometrics: Modelling and simulation tools to improve decision making in clinical drug development
-
Gieschke R., Steimer JL Pharmacometrics: modelling and simulation tools to improve decision making in clinical drug development. Eur J Drug Metab Pharmacokinet. 2000 ; 25: 49-58.
-
(2000)
Eur J Drug Metab Pharmacokinet
, vol.25
, pp. 49-58
-
-
Gieschke, R.1
Steimer, J.L.2
-
19
-
-
33750690698
-
Model selection and mixed-effects modeling of HIV infection dynamics
-
Bortz DM, Nelson PW Model selection and mixed-effects modeling of HIV infection dynamics. Bull Math Biol. 2006 ; 68: 2005-2025.
-
(2006)
Bull Math Biol
, vol.68
, pp. 2005-2025
-
-
Bortz, D.M.1
Nelson, P.W.2
-
20
-
-
15044349288
-
Longitudinal progression of fracture prevalence through a population of postmenopausal women with osteoporosis
-
Lindsay R., Pack S., Li Z. Longitudinal progression of fracture prevalence through a population of postmenopausal women with osteoporosis. Osteoporos Int. 2005 ; 16: 306-312.
-
(2005)
Osteoporos Int
, vol.16
, pp. 306-312
-
-
Lindsay, R.1
Pack, S.2
Li, Z.3
-
21
-
-
34047185294
-
Predictive modeling of therapy response in multiple sclerosis using gene expression data
-
Mostafavi S., Baranzini S., Oksernberg J., et al. Predictive modeling of therapy response in multiple sclerosis using gene expression data. Conf Proc IEEE Eng Med Biol Soc. 2006 ; 1: 5519-5522.
-
(2006)
Conf Proc IEEE Eng Med Biol Soc
, vol.1
, pp. 5519-5522
-
-
Mostafavi, S.1
Baranzini, S.2
Oksernberg, J.3
-
22
-
-
33847009428
-
A prediction rule for disease outcome in patients with recent-onset undifferentiated arthritis: How to guide individual treatment decisions
-
van der Helm-van Mil AH, le Cessie, S., van Dongen H., et al. A prediction rule for disease outcome in patients with recent-onset undifferentiated arthritis: how to guide individual treatment decisions. Arthritis Rheum. 2007 ; 56: 433-440.
-
(2007)
Arthritis Rheum
, vol.56
, pp. 433-440
-
-
Van Der Helm-Van Mil, A.H.1
Le Cessie, S.2
Van Dongen, H.3
-
23
-
-
0242410490
-
Comparison of rheumatoid arthritis clinical trial outcome measures: A simulation study
-
Anderson JJ, Bolognese JA, Felson DT Comparison of rheumatoid arthritis clinical trial outcome measures: a simulation study. Arthritis Rheum. 2003 ; 48: 3031-3038.
-
(2003)
Arthritis Rheum
, vol.48
, pp. 3031-3038
-
-
Anderson, J.J.1
Bolognese, J.A.2
Felson, D.T.3
-
24
-
-
17344389740
-
The use of modelling to evaluate new drugs for patients with a chronic condition: The case of antibodies against tumor necrosis factor in rheumatoid arthritis
-
Barton P., Jobanputra P., Wilson J., et al. The use of modelling to evaluate new drugs for patients with a chronic condition: the case of antibodies against tumor necrosis factor in rheumatoid arthritis. Health Technol Assess. 2004 ; 8: iii, 1-91.
-
(2004)
Health Technol Assess
, vol.8
, Issue.3
, pp. 1-91
-
-
Barton, P.1
Jobanputra, P.2
Wilson, J.3
-
25
-
-
33644642980
-
Directors of pharmacology graduate programs: Pharm Phorum
-
Barnett J. Directors of pharmacology graduate programs: Pharm Phorum. Mol Interv. 2006 ; 6: 4-7.
-
(2006)
Mol Interv
, vol.6
, pp. 4-7
-
-
Barnett, J.1
-
27
-
-
30444434228
-
Challenges in the transition to model-based development
-
Grasela TH, Fiedler-Kelly J., Walawander CA, et al. Challenges in the transition to model-based development. AAPS J. 2005 ; 7: E488 - E495.
-
(2005)
AAPS J
, vol.7
-
-
Th, G.1
Fiedler-Kelly, J.2
Walawander, C.A.3
-
28
-
-
34447564991
-
Pharmacometrics and the transition to model-based development
-
Grasela TH, Dement CW, Kolterman OG, et al. Pharmacometrics and the transition to model-based development. Clin Pharmacol Ther. 2007 ; 82: 137-142.
-
(2007)
Clin Pharmacol Ther
, vol.82
, pp. 137-142
-
-
Th, G.1
Dement, C.W.2
Kolterman, O.G.3
-
29
-
-
34250632673
-
Introduction of quantitative methods in pharmacology and clinical pharmacology: A historical overview
-
Atkinson AJ Jr, Lalonde RL Introduction of quantitative methods in pharmacology and clinical pharmacology: a historical overview. Clin Pharmacol Ther. 2007 ; 82: 3-6.
-
(2007)
Clin Pharmacol Ther
, vol.82
, pp. 3-6
-
-
Atkinson Jr., A.J.1
Lalonde, R.L.2
-
30
-
-
34250638541
-
Pharmacometrics at FDA: Evolution and impact on decisions
-
Powell JR, Gobburu JV Pharmacometrics at FDA: evolution and impact on decisions. Clin Pharmacol Ther. 2007 ; 82: 97-102.
-
(2007)
Clin Pharmacol Ther
, vol.82
, pp. 97-102
-
-
Powell, J.R.1
Gobburu, J.V.2
-
31
-
-
0035693563
-
Utilization of pharmacokinetic-pharmacodynamic modelling and simulation in regulatory decision making
-
Gobburu JV, Marroum PJ Utilization of pharmacokinetic-pharmacodynamic modelling and simulation in regulatory decision making. Clin Pharmacokinet. 2001 ; 40: 883-892.
-
(2001)
Clin Pharmacokinet
, vol.40
, pp. 883-892
-
-
Gobburu, J.V.1
Marroum, P.J.2
-
32
-
-
26444505936
-
Translational and clinical science-time for a new vision
-
Zerhouni EA Translational and clinical science-time for a new vision. N Engl J Med. 2005 ; 353: 1621-1623.
-
(2005)
N Engl J Med
, vol.353
, pp. 1621-1623
-
-
Zerhouni, E.A.1
-
33
-
-
33748062359
-
Clinical and translational science awards: A framework for a national research agenda
-
Zerhouni EA, Alving B. Clinical and translational science awards: a framework for a national research agenda. Transl Res. 2006 ; 148: 4-5.
-
(2006)
Transl Res
, vol.148
, pp. 4-5
-
-
Zerhouni, E.A.1
Alving, B.2
-
34
-
-
33846806035
-
Facilitating compound progression of antiretroviral agents via modeling and simulation
-
Barrett JS Facilitating compound progression of antiretroviral agents via modeling and simulation. J Neuroimmune Pharmacol. 2007 ; 2: 58-71.
-
(2007)
J Neuroimmune Pharmacol
, vol.2
, pp. 58-71
-
-
Barrett, J.S.1
-
36
-
-
34250650802
-
Time for quantitative clinical pharmacology: A proposal for a pharmacometrics curriculum
-
Holford N., Karlsson MO Time for quantitative clinical pharmacology: a proposal for a pharmacometrics curriculum. Clin Pharmacol Ther. 2007 ; 82: 103-105.
-
(2007)
Clin Pharmacol Ther
, vol.82
, pp. 103-105
-
-
Holford, N.1
Karlsson, M.O.2
-
37
-
-
34249066786
-
Clinical pharmacology education and training at the National Institutes of Health
-
Lertora JJ, Atkinson AJ Jr. Clinical pharmacology education and training at the National Institutes of Health. Clin Pharmacol Ther. 2007 ; 81: 907-909.
-
(2007)
Clin Pharmacol Ther
, vol.81
, pp. 907-909
-
-
Lertora, J.J.1
Atkinson Jr., A.J.2
-
38
-
-
34447301266
-
The role of pharmacology in medical teaching
-
Collier AC The role of pharmacology in medical teaching. Hawaii Med J. 2007 ; 66: 135-136.
-
(2007)
Hawaii Med J
, vol.66
, pp. 135-136
-
-
Collier, A.C.1
-
39
-
-
0040623480
-
Development and application of an online module for teaching Bayesian forecasting principles in a clinical pharmacokinetics course
-
Mehvar R. Development and application of an online module for teaching Bayesian forecasting principles in a clinical pharmacokinetics course. Am J Pharm Educ. 2000 ; 64: 121-125.
-
(2000)
Am J Pharm Educ
, vol.64
, pp. 121-125
-
-
Mehvar, R.1
-
40
-
-
33750999634
-
EDrug: A dynamic interactive electronic drug formulary for medical students
-
Maxwell SR, McQueen DS, Ellaway R. eDrug: a dynamic interactive electronic drug formulary for medical students. Br J Clin Pharmacol. 2006 ; 62: 673-681.
-
(2006)
Br J Clin Pharmacol
, vol.62
, pp. 673-681
-
-
Maxwell, S.R.1
McQueen, D.S.2
Ellaway, R.3
-
41
-
-
0035203560
-
Economic evaluations during early (phase II) drug development: A role for clinical trial simulations
-
Hughes DA, Walley T. Economic evaluations during early (phase II) drug development: a role for clinical trial simulations ? Pharmacoeconomics. 2001 ; 19: 1069-1077.
-
(2001)
Pharmacoeconomics
, vol.19
, pp. 1069-1077
-
-
Hughes, D.A.1
Walley, T.2
-
42
-
-
0031003468
-
Learning versus confirming in clinical drug development
-
Sheiner LB Learning versus confirming in clinical drug development. Clin Pharmacol Ther. 1997 ; 61: 275-291.
-
(1997)
Clin Pharmacol Ther
, vol.61
, pp. 275-291
-
-
Sheiner, L.B.1
-
43
-
-
33646649531
-
Impact of pharmacometrics on drug approval and labeling decisions: A survey of 42 new drug applications
-
Bhattaram VA, Booth BP, Ramchandani RP, et al. Impact of pharmacometrics on drug approval and labeling decisions: a survey of 42 new drug applications. AAPS J. 2005 ; 7: E503 - E512.
-
(2005)
AAPS J
, vol.7
-
-
Bhattaram, V.A.1
Booth, B.P.2
Ramchandani, R.P.3
-
44
-
-
33846573411
-
Impact of pharmacometric reviews on new drug approval and labeling decisions-a survey of 31 new drug applications submitted between 2005 and 2006
-
Bhattaram VA, Bonapace C., Chilukuri DM, et al. Impact of pharmacometric reviews on new drug approval and labeling decisions-a survey of 31 new drug applications submitted between 2005 and 2006. Clin Pharmacol Ther. 2007 ; 81: 213-221.
-
(2007)
Clin Pharmacol Ther.
, vol.81
, pp. 213-221
-
-
Bhattaram, V.A.1
Bonapace, C.2
Chilukuri, D.M.3
|