Fatty acid-induced mitochondrial uncoupling in adipocytes as a key protective factor against insulin resistance and beta cell dysfunction: Do adipocytes consume sufficient amounts of oxygen to oxidise fatty acids?

Diabetologia

Volumn 51, Issue 5, 2008, Pages 907-908

  Maassen, J A ^a,b   Romijn, J A ^a   Heine, R J ^b,c  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

Adipocytes; Fatty acids; HAART; Mitochondria; Type 2 diabetes mellitus

Indexed keywords

ANTIRETROVIRUS AGENT; FATTY ACID; MITOCHONDRIAL DNA; OXIDOREDUCTASE; TRIACYLGLYCEROL;

ADIPOCYTE; ADIPOSE TISSUE; BODY FAT DISTRIBUTION; CELL DAMAGE; CONGENITAL GENERALIZED LIPODYSTROPHY; FATTY ACID OXIDATION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; INSULIN RESISTANCE; LETTER; LIPID STORAGE; LIPOGENESIS; MITOCHONDRION; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RISK FACTOR;

ADIPOCYTES; FATTY ACIDS; HUMANS; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; OXIDATION-REDUCTION; UNCOUPLING AGENTS;

EID: 41849141522     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-008-0963-6     Document Type: Letter

References (10)

1. Capeau J, Magré J, Lascols O et al (2005) Diseases of adipose tissue: genetic and acquired lipodystrophies. Biochem Soc Trans 33:1073-1077
2. Brinkman K, Smeitink JA, Romijn JA, Reiss P (1999) Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy. Lancet 354:1112-1115
3. Maassen JA, Romijn JA, Heine RJ (2007) Fatty acid-induced mitochondrial uncoupling in adipocytes as a key protective factor against insulin resistance and beta cell dysfunction: a new concept in the pathogenesis of obesity-associated type 2 diabetes mellitus. Diabetologia 50:2036-2041
4. Kaaman M, Sparks LM, van Harmelen V et al (2007) Strong association between mitochondrial DNA copy number and lipogenesis in human white adipose tissue. Diabetologia 50:2526-2533
5. Frayn KN, Langin D, Karpe F (2008) Fatty acid-induced mitochondrial uncoupling in adipocytes is not a promising target for treatment of insulin resistance unless adipocyte oxidative capacity is increased. Diabetologia (in press). DOI 10.1007/s00125-007-0901-z
6. Coppack SW, Fisher RM, Gibbons GF et al (1990) Postprandial substrate deposition in human forearm and adipose tissues in vivo. Clin Sci (Lond) 79:339-348
7. Baril JG, Junod P, Leblanc R et al (2005) HIV-associated lipodystrophy syndrome: a review of clinical aspects. Can J Infect Dis Med Microbiol 16:233-243
8. 2 consumption of human adipose tissue. Am J Physiol 256:E467-E474
9. Sjöström L, Björntorp P, Vrána J (1971) Microscopic fat cell size measurements on frozen-cut adipose tissue in comparison with automatic determinations of osmium-fixed fat cells. J Lipid Res 12:521-530
10. Nedergaard J, Bengtsson T, Cannon B (2007) Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol 293:E444-E452