Histiocytic sarcoma of the spleen: Case report of asymptomatic onset of thrombocytopenia and complex imaging features

International Journal of Hematology

Volumn 87, Issue 1, 2008, Pages 83-87

  Kobayashi, Shinichi ^a   Kimura, Fumihiko ^a   Hama, Yukihiro ^a   Ogura, Kazuto ^b   Torikai, Hiroki ^a   Kobayashi, Ayako ^a   Ikeda, Takashi ^a   Sato, Ken ^a   Aida, Shinsuke ^a   Kosuda, Shigeru ^a   Motoyoshi, Kazuo ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^b AOMORI PREFECTURAL CENTRAL HOSPITAL   (Japan)

Author keywords

Anemia; Hemophagocytosis; Histiocytic sarcoma; Imaging; Splenic neoplasms; Thrombocytopenia

Indexed keywords

CD163 ANTIGEN; CD68 ANTIGEN; GADOLINIUM PENTETATE; GALLIUM 67; STEROID;

AGED; ARTICLE; AUTOPSY; BONE MARROW BIOPSY; CASE REPORT; CHRONIC DISEASE; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DISEASE COURSE; ECHOGRAPHY; ERYTHROPHAGOCYTOSIS; FEMALE; HEPATOMEGALY; HISTIOCYTE; HOSPITAL DISCHARGE; HOSPITAL READMISSION; HUMAN; HUMAN TISSUE; LABORATORY TEST; MALIGNANT HISTIOCYTOSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PALLIATIVE THERAPY; PHYSICAL EXAMINATION; PROTEIN EXPRESSION; RADIATION DOSE; SARCOMA; SPLENOMEGALY; THROMBOCYTOPENIA; WHOLE BODY SCINTISCANNING;

AGED, 80 AND OVER; DIAGNOSTIC IMAGING; FEMALE; HISTIOCYTIC SARCOMA; HUMANS; PALLIATIVE CARE; SPLENIC NEOPLASMS; THROMBOCYTOPENIA;

EID: 41849104581     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12185-007-0008-9     Document Type: Article

References (13)

1. Jaffe E. Histiocytic and dendritic cell neoplasms. In: Jaffe ESHN, Stein H, Vardiman JW, editors. World health organization classification of tumours: pathology and genetics of tumours of haematopoietic and lymphoid tissues. Lyon: IARC; 2001. pp. 273-7.
2. Pileri SA, Grogan TM, Harris NL, et al. Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the international lymphoma study group based on 61 cases. Histopathology. 2002;41(1):1-29.
3. Kimura H, Nasu K, Sakai C, et al. Histiocytic sarcoma of the spleen associated with hypoalbuminemia, hypo-gamma-globulinemia and thrombocytopenia as a possibly unique clinical entity-report of three cases. Leuk Lymphoma. 1998;31(1-2):217-24.
4. Audouin J, Vercelli-Retta J, Le Tourneau A, et al. Primary histiocytic sarcoma of the spleen associated with erythrophagocytic histiocytosis. Pathol Res Pract. 2003;199(2):107-12.
5. Franchino C, Reich C, Distenfeld A, Ubriaco A, Knowles DM. A clinicopathologically distinctive primary splenic histiocytic neoplasm. Demonstration of its histiocyte derivation by immunophenotypic and molecular genetic analysis. Am J Surg Pathol. 1988;12(5):398-404.
6. Vos JA, Abbondanzo SL, Barekman CL, Andriko JW, Miettinen M, Aguilera NS. Histiocytic sarcoma: a study of five cases including the histiocyte marker CD163. Mod Pathol. 2005;18(5):693-704.
7. Nguyen TT, Schwartz EJ, West RB, Warnke RA, Arber DA, Natkunam Y. Expression of CD163 (hemoglobin scavenger receptor) in normal tissues, lymphomas, carcinomas, and sarcomas is largely restricted to the monocyte/macrophage lineage. Am J Surg Pathol. 2005;29(5):617-24.
8. Lau SK, Chu PG, Weiss LM. CD163: a specific marker of macrophages in paraffin-embedded tissue samples. Am J Clin Pathol. 2004;122(5):794-801.
9. Mikami M, Sadahira Y, Suetsugu Y, Wada H, Sugihara T. Monocyte/Macrophage-specific marker CD163+ histiocytic sarcoma: case report with clinical, morphologic, immunohistochemical, and molecular genetic studies. Int J Hematol. 2004;80(4):365-9.
10. Hornick JL, Jaffe ES, Fletcher CD. Extranodal histiocytic sarcoma: clinicopathologic analysis of 14 cases of a rare epithelioid malignancy. Am J Surg Pathol. 2004;28(9):1133-44.
11. Abbott RM, Levy AD, Aguilera NS, Gorospe L, Thompson WM. From the archives of the AFIP: primary vascular neoplasms of the spleen: radiologic-pathologic correlation. RadioGraphics. 2004;24(4):1137-63.
12. Levy AD, Abbott RM, Abbondanzo SL. Littoral cell angioma of the spleen: CT features with clinicopathologic comparison. Radiology. 2004;230(2):485-90.
13. Ramani M, Reinhold C, Semelka RC, et al. Splenic hemangiomas and hamartomas: MR imaging characteristics of 28 lesions. Radiology. 1997;202(1):166-72.